393: Prokaryote Partner Prevents Pathogen Potency

This episode: Bacterial symbionts of amoebas help them survive bacterial infection, and prevent pathogens from spreading to others as much! Download Episode (7.5 MB, 8.1 minutes) Show notes: Microbe of the episode: Eubacterium dolichum News item Takeaways Amoebas are free-living, single-celled organisms, but they have some things in common with some cells of our immune system (macrophages). For example, certain bacterial pathogens can infect both in similar ways. So it can be useful to study the interactions of amoebas and bacteria to learn about our own immune defenses. In this study, the amoeba Acanthamoeba castellanii has another bacterial symbiont that helps it resist killing by the bacterial pathogen Legionella pneumophila. Once the amoebas recovered from the infection, they were more resistant to future challenges. Even better, the symbiont prevented the pathogen from transforming into a more spreadable form like it does when infecting amoebas alone. Journal Paper: König L, Wentrup C, Schulz F, Wascher F, Escola S, Swanson MS, Buchrieser C, Horn M. 2019. Symbiont-Mediated Defense against Legionella pneumophila in Amoebae. mBio 10:e00333-19. Other interesting stories: RNA-cutting CRISPR/Cas system induces bacterial dormancy to prevent phage replication Gut bacteria degrade/modify many different kinds of drugs (paper)   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook

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