423: Roundworm Riders Route Rootworm Resistance

This episode: Helping insect-killing bacterial symbionts of nematodes evolve resistance to chemicals that major corn pests use to defend themselves! Download Episode (10.0 MB, 14.0 minutes) Show notes: Microbe of the episode: Listeria virus PSA Takeaways Interactions between species and even kingdoms in nature can be complex and multilayered. This means that when we want to intervene to cause a particular outcome, there may be multiple points at which we can act, but the consequences may be hard to predict.   In this study, action was taken to counteract the damage the Western corn rootworm causes to corn crops, using a tiny roundworm that attacks the insect pest with deadly bacteria. The rootworm defends itself by accumulating plant-produced toxins that inhibit the bacteria. Directed evolution was used to make the bacteria more resistant, and this led to more effective killing of the pest. Journal Paper: Machado RAR, Thönen L, Arce CCM, Theepan V, Prada F, Wüthrich D, Robert CAM, Vogiatzaki E, Shi Y-M, Schaeren OP, Notter M, Bruggmann R, Hapfelmeier S, Bode HB, Erb M. 2020. Engineering bacterial symbionts of nematodes improves their biocontrol potential to counter the western corn rootworm. 5. Nat Biotechnol 38:600–608. Other interesting stories: Altering pathogenic bacteria to reduce disease with genome-integrating phage (paper) Bacteria could inhibit fungus that causes deadly disease of bananas (paper)   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

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