471: Phage Fight Foils Fitness

This episode: A phage both kills bacterial pathogens and selects for reduced virulence! Download Episode (6.3 MB, 9.9 minutes) Show notes: Microbe of the episode: Helminthosporium victoriae 145S virus   News item   Takeaways Using bacteria-killing viruses to treat bacterial infections, or phage therapy, can be a good alternative to antibiotics in some situations when there are no effective antibiotics for a particular infection. But bacteria can evolve resistance to phages as well as antibiotics, often with little cost to their fitness. In this study, a phage not only could treat an infection by attacking the bacteria, but the bacterial hosts that do evolve resistance to the phage do so by getting rid of certain structures that help them to cause more serious infection. Thus, therapy with this phage may both reduce the bacterial load and also make those remaining less virulent.   Journal Paper: Kortright KE, Done RE, Chan BK, Souza V, Turner PE. 2022. Selection for Phage Resistance Reduces Virulence of Shigella flexneri. Appl Environ Microbiol 88:e01514-21. Other interesting stories: Plastic-eating bacteria could produce biodegradable plastic Harmless variant of acne bacteria could help prevent more serious skin infection   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

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