Journal Club: Exploring breakthroughs in multiple sclerosis bladder health treatment with noninvasive brain Stimulation

Bladder symptoms are extremely common in individuals with MS. These symptoms include urinary frequency, urgency, incontinence or difficulty voiding or both. Voiding dysfunction (VD), a common neurogenic lower urinary tract symptom in individuals with multiple sclerosis (MS), often leads to urinary retention. The current primary management for MS patients with VD involves catheterization. Our team has explored the safety and therapeutic effects of a multi focal transcranial magnetic stimulator, a noninvasive, portable neuromodulator capable of simultaneously stimulating or inhibiting multiple brian regions and modulating the strength of their functional connections called  Transcranial Rotating Permanent Magnet Stimulator (TRPMS).  In this study, MS women with VD underwent functional magnetic resonance imaging concurrently with a urodynamic study (fMRI/UDS) before and after ten 40-minute TRPMS sessions. Baseline fMRI/UDS scans identified regions of interest (ROIs) associated with voiding initiation, guiding microstimulator placement. Post-treatment, patients exhibited increased activation in these ROIs, a significant decrease in % post-void residual/bladder capacity (%PVR/BC), and reported improved bladder symptoms including more effective bladder emptying. Individuals seeking further information visit  khavariresearch.com, reach out via email at [email protected], or locate details on clinicaltrials.gov where it is registered.

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