Cardiology Trials
Episodes
Summary and discussion of NICE-SUGAR, TRITON-TIMI 38, TRILOGY ACS, PLATO and ATLAS ACS 2-TIMI 51
29 Apr 2024
Contributed by Lukas
See our substack for full review of these trials https://cardiologytrials.substack.com/ Get full access to Cardiology Trial’s Substack at cardiology...
Review of the TACT Trial
25 Apr 2024
Contributed by Lukas
JAMA. 2013;309(12):1241-1250Background Case reports as early as the 1950s suggested chelation of lead might reduce angina. The popularity of chelatio...
Review of the ATLAS ACS 2-TIMI 51 trial
23 Apr 2024
Contributed by Lukas
N Engl J Med 2012;366:9-19Background Following an acute coronary syndrome, individuals have a substantially elevated risk of recurrent events, compare...
Review of the CURRENT-OASIS 7 trial
18 Apr 2024
Contributed by Lukas
N Engl J Med 2010;363:930-942Background By 2010, dual antiplatelet therapy had been established as beneficial during and after percutaneous coronary ...
Review of the TRILOGY ACS trial
16 Apr 2024
Contributed by Lukas
N Engl J Med 2012;367:1297-1309Background: In patients with acute coronary syndrome, clinical guidelines recommend early angiography particularly in ...
Review of the PLATO Trial
04 Apr 2024
Contributed by Lukas
N Engl J Med 2009;361:1045-57.Background Similar to Prasugrel, Ticagrelor is a direct-acting oral antagonist of the adenosine diphosphate receptor P2Y...
Review of the TRITON-TIMI 38 Trial
02 Apr 2024
Contributed by Lukas
Note to readers: Since going live with Cardiology Trials Substack in January of 2024 we have been exclusively covering trials that we have categorized...
Review of the HORIZONS-AMI trial
28 Mar 2024
Contributed by Lukas
N Engl J Med 2008; 358:2218-2230Background The use of percutaneous coronary intervention (PCI) is associated with improved outcomes in patients with S...
Review of the OASIS-6 trial
26 Mar 2024
Contributed by Lukas
JAMA. 2006;295(13):1519-1530Background Previous trials demonstrated that aspirin and thrombolytic therapy improve prognosis in patients with ST elevat...
Review of the OASIS-5 trial
12 Mar 2024
Contributed by Lukas
N Engl J Med 2006; 354:1464-1476Background: Prior studies showed that combined antiplatelets and anticoagulants reduce ischemic events in patients wit...
Summary and discussion of CURE and DIGAMI 2
11 Mar 2024
Contributed by Lukas
Two trials in acute coronary syndrome - CURE (clopidogrel in acute coronary syndrome) and DIGAMI 2 (glucose control in acute coronary syndrome) Get fu...
Review of DIGAMI 2
07 Mar 2024
Contributed by Lukas
European Heart Journal, Volume 26, Issue 7, 2005, 650–661Background Patients with diabetes have a higher risk of death after myocardial infarction...
Review of the CURE Trial
05 Mar 2024
Contributed by Lukas
N Engl J Med 2001;345:494-502.Background The established medical treatments for acute coronary syndrome reviewed so far include aspirin and thrombolyt...
Summary and discussion of MIRACL and PROVE IT-TIMI 22
04 Mar 2024
Contributed by Lukas
Two trials of statin therapy in acute coronary syndrome. See https://cardiologytrials.substack.com/ for more details. Get full access to Cardiology Tr...
Review of the PROVE IT-TIMI 22 Trial
29 Feb 2024
Contributed by Lukas
NEJM 2004;350:1495-504.Background The benefit of cholesterol lowering with statins compared to placebo had been demonstrated in multiple trials across...
Review of the MIRACL Trial
27 Feb 2024
Contributed by Lukas
JAMA 2001;285:1711-18.Background Statin therapy had been shown to improve blood cholesterol and improve long-term outcomes in patients with stable cor...
Summary and discussion of DIGAMI and FRISC
26 Feb 2024
Contributed by Lukas
Two trials of blood glucose lowering and low-molecular-weight heparin in patients with acute coronary syndrome.See https://cardiologytrials.substack.c...
Review of the FRISC trial
22 Feb 2024
Contributed by Lukas
Lancet 1996;347:561-68.Background In most of the prior AMI trials presented here, patients with non_ST-segment myocardial infarction (NSTEMI) and/or u...
Review of the DIGAMI trial
20 Feb 2024
Contributed by Lukas
J Am Coll Cardiol 1995;26:57-65.Background Patients with diabetes have higher short- and long-term rates of mortality following acute myocardial infar...
Summary and discussion of TRACE and EPHESUS
19 Feb 2024
Contributed by Lukas
Two of important trials of ACE inhibition and aldosterone blockade post myocardial infarction. See https://cardiologytrials.substack.com/ for more det...
Review of the EPHESUS Trial
15 Feb 2024
Contributed by Lukas
NEJM 2003;348:1309-21.Background In patients with chronic systolic heart failure, aldosterone blockade reduced death and cardiovascular hospitalizatio...
Review of the TRACE Study
13 Feb 2024
Contributed by Lukas
NEJM 1995;333:1670-6.Background Up to this point in history, a series of trials had been conducted using ACEi’s in post-MI patients. A small to mode...
Summary and discussion of CAPRICORN and COMMIT
12 Feb 2024
Contributed by Lukas
Two important trials of beta-blockers in patients with acute myocardial infarction. See https://cardiologytrials.substack.com/ for full details. Get f...
Review of the COMMIT Trial
08 Feb 2024
Contributed by Lukas
Lancet 2005;366:1622-32Background Beta blockers were routinely used for the early management of patients with AMI; however, their efficacy and safety ...
Review of the CAPRICORN Trial
06 Feb 2024
Contributed by Lukas
Lancet 2001;357:1385-90.Background While beta blockers were frequently used in patients with acute myocardial infarction complicated by heart failure,...
Summary and discussion of SAVE and AIRE
05 Feb 2024
Contributed by Lukas
Two seminal trials of ACEi in patients with acute myocardial infarction complicated by heart failure or left ventricular systolic dysfunction. See htt...
Review of Acute Infarction Ramipril Efficacy (AIRE) Trial
01 Feb 2024
Contributed by Lukas
Lancet 1993;342:821-28.Background The Survival After Ventricular Enlargement (SAVE) trial demonstrated that administration of the angiotensin converti...
Review of Survival and Ventricular Enlargement (SAVE) Trial
30 Jan 2024
Contributed by Lukas
NEJM 1992;327:669-77 Background After a large heart attack, cardiac hemodynamics are altered, which leads to a series of changes in the heart muscle i...
Summary and discussion of GISSI-3 and ISIS-4
29 Jan 2024
Contributed by Lukas
Discussion of two landmark trials of ACEi and nitrates in acute coronary syndrome. ISIS-4 had also an arm for magnesium. The story of magnesium is ver...
Review of the ISIS-4 Trial
25 Jan 2024
Contributed by Lukas
Lancet 1995;345:669-685.Background The premises for ISIS-4 were similar to GISSI-3 with the notable exception of adding an arm to test the effect of m...
Review of the GISSI-3 Trial
23 Jan 2024
Contributed by Lukas
Lancet 1994;343:1115-22.Background By the time GISSI-3 was undertaken, evidence had emerged suggesting afterload reduction with angiotensin-converting...
Summary and discussion of CAST and ISIS-3
22 Jan 2024
Contributed by Lukas
Discussion of the historic CAST and ISIS-3 trials. See https://cardiologytrials.substack.com/ for more details Get full access to Cardiology Trial’s...
Review of the ISIS-3 Trial
18 Jan 2024
Contributed by Lukas
Lancet 1992;339:753-770.Background Results from the GISSI and ISIS-2 trials demonstrated a clear benefit for the early opening of acutely blocked arte...
Review of the Cardiac Arrhythmia Suppression Trial (CAST)
16 Jan 2024
Contributed by Lukas
NEJM 1991;324:781-788Background A hallmark of post-myocardial infarction (MI) care in the 1980’s was the monitoring and suppression of premature ven...
Summary and discussion of GISSI-1, 2 and ISIS-2
15 Jan 2024
Contributed by Lukas
A discussion of the historic trials of thrombolysis in myocardial infarction. See cardiologytrials.substack.com for more details. Get full access to C...
Review of the GISSI-2 Trial
12 Jan 2024
Contributed by Lukas
Lancet 1990;336:65-71.Background Large trials up to this point had established the role of thrombolytic therapy and aspirin in patients with acute MI....
Review of the ISIS-2 Trial
10 Jan 2024
Contributed by Lukas
Lancet 1988;349-360Background The introduction to the ISIS-2 manuscript opens with a remarkable statement from the authors:Reductions in mortality tha...
Review of the GISSI-1 Trial
08 Jan 2024
Contributed by Lukas
Lancet 1986;397-401Background This study by the Italian Group for the Study of Streptokinase in Myocardial Infarction (GISSI) is the first large trial...
BHAT and ISIS-I trials
05 Jan 2024
Contributed by Lukas
An exploration of the pivotal BHAT and ISIS-I trials. Both of which significantly impacted physicians' use of beta-blockers in patients with acute myo...