A Cheaper Way to Make Drugs?

The cost of prescription drugs is high—particularly in the US where consumers pay nearly three times more than those in 33 other nations in the Organization for Economic Cooperation and Development. One factor in prices is fluorination, which plays a crucial role in the production of many widely-used pharmaceuticals. Driven by the high cost of reagents needed for the trifluoromethyl (CF₃) group, the process is expensive—and hard on the natural environment. If there was a way to make fluorination more accessible, sustainable, and affordable—it could reshape how we approach drug synthesis—and much else in chemistry.Chemist and Harvard Griffin GSAS PhD candidate Brandon Campbell has developed an innovative method of fluorination that could do just that. Using silver and visible light, Campbell’s pioneering approach promises a cost-effective and eco-friendly alternative to traditional synthetic methods.

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