Core IM | Internal Medicine Podcast

#196 Stories of Courage and Career Development with Horn Award

17 Dec 2025

Contributed by Lukas

We hope these stories resonate with anyone who has felt pulled between professional purpose and personal life, and remind you that you’re not alone ...

#195 Antibiotic Duration & BALANCE Trial: Beyond Journal Club with NEJM Group

10 Dec 2025

Contributed by Lukas

Antibiotic duration for bacteremia is something most of us learned by habit, not by trial data. In this episode, we walk through the BALANCE trial and...

#194: Severe Hypertriglyceridemia: 5 Pearls Segment

03 Dec 2025

Contributed by Lukas

How quickly can triglycerides rise? At what threshold are patients at risk of pancreatitis or cardiovascular adverse outcomes? What do you have to rul...

#193 Venous Congestion & VEXUS Interview with Dr. Ross Prager

19 Nov 2025

Contributed by Lukas

Why is venous congestion not the same as volume overload? How can looking at IVC as well as doppler on the hepatic vein, portal vein, and/or intrarena...

#192 Debate on First-Line Medications for Diabetes

05 Nov 2025

Contributed by Lukas

SGLT-2i vs. GLP-1? vs Metformin? How do you balance the cost and coverage of first-line options like metformin, SGLT-2, and GLP-1s? How do you choose ...

#191 Hepatorenal Syndrome Part 2 on Management: 5 Pearls Segment

22 Oct 2025

Contributed by Lukas

What really works when treating HRS? Vasoconstrictors like terlipressin vs. norepinephrine vs. midodrine: how do we decide which to use? Do you give a...

#190: Hepatorenal Syndrome Part 1: 5 Pearls Segment

15 Oct 2025

Contributed by Lukas

HRS-AKI vs. other causes of AKI in cirrhosis: What do serum or urine sodium clues, albumin challenges, and shifting diagnostic criteria actually revea...

#189 Bisphosphonates and Fracture Prevention Trial: Beyond Journal Club with NEJM Group

01 Oct 2025

Contributed by Lukas

Who’s really at risk for fractures, and how should we be treating them? Most fragility fractures occur in patients without osteoporosis. Should we ...

#188 Orthostatic Hypotension Part 2: Gray Matters Segment

22 Sep 2025

Contributed by Lukas

Medications for orthostatic hypotension! When to initiate treatment, how to use them safely, and what to do when new issues arise during treatment. Ho...

#187 Orthostatic Hypotension Part 1: Gray Matters Segment

11 Sep 2025

Contributed by Lukas

Learn specific, practical ways to counsel patients on non-pharmacologic interventions. What is our goal with OH treatment? Is it the blood pressure nu...

#186 Pneumothorax: 5 Pearls Segment

25 Aug 2025

Contributed by Lukas

Next time you’re squinting at a chest tube, feel confident you know exactly what to look for and why. Hear it explained in a way that really sticks!...

#185 Neutropenia: 5 Pearls Segment

13 Aug 2025

Contributed by Lukas

How do you work up neutropenia? When is neutropenia benign? When do neutrophils recover? How can you diagnose neutropenic fever in the first 15 minute...

#184 Stories for the Feels

28 Jul 2025

Contributed by Lukas

Have a good laugh and reflect deeply with these three stories that hit the feels in different ways.If you'd love to hear more stories from Dr. Mar...

#183 Diagnose the Clinician: Hoofbeats Segment

21 Jul 2025

Contributed by Lukas

What went wrong? What were the reasoning or contextual missteps that led us astray?🔹 Sponsor: NEJM Fellowship Program, click here to learn more ...

#182 Pleural Effusions: 5 Pearls Segment

09 Jul 2025

Contributed by Lukas

Imaging Pearls | (01:12)Deciding on Thoracentesis | (04:00)Light’s Criteria and Pseudoexudates | (07:00)Pleural Fluid Studies: pH and Cell Different...

#181 July Stories 3.0

02 Jul 2025

Contributed by Lukas

Listen for some good laughs and relatable stories!In this episode, we share raw and real stories from July — from rapid responses to unexpected kind...

#180 Beta-Blockers & REDUCE-AMI Trial: Beyond Journal Club Segment with NEJM Group

25 Jun 2025

Contributed by Lukas

How much do beta blockers help after a heart attack, even when the heart’s pumping well? In this episode, we revisit the origins of beta blockers in...

#179 Invasive Fungal Disease: 5 Pearls Segment

11 Jun 2025

Contributed by Lukas

🔹 What is invasive fungal disease, and who is most at risk for developing invasive fungal disease? (~ 02:46)🔹 What are the main classes of fungi...

#178 Continuous Glucose Monitor (CGM): 5 Pearls Segment

02 Jun 2025

Contributed by Lukas

🔹What are clinically relevant limitations of an A1c vs. a CGM (1:40)🔹What do the different parts of the ambulatory glucose profile tell you? (09...

#177 Interventional Radiology (IR) 101: 5 Pearls Segment

14 May 2025

Contributed by Lukas

🔹When is an U/S vs. CT vs. MRI helpful before consulting Interventional Radiology?🔹What factors go into an IR pre-op evaluation?🔹 When do dra...

#176 Constipation Medications: 5 Pearls Segment

30 Apr 2025

Contributed by Lukas

🔹 High-yield reversible causes of constipation? (02:26)🔹 Which type of fiber is more helpful? And is more hydration really better? And bulk-for...

#175 A Revolution in HIV Prevention & The PURPOSE Trials: Beyond Journal Club Segment with NEJM Group

16 Apr 2025

Contributed by Lukas

How good are we at preventing HIV? How do efficacy and effectiveness differ? We journey from oral pre-exposure prophylaxis (PrEP) to long-acting injec...

#174 Lp(a) and ASCVD Risk: 5 Pearls Segment

02 Apr 2025

Contributed by Lukas

What does Lipoprotein(a) tell us that a standard lipid panel doesn’t? Should we be testing everyone for it? Dive into the genetics, clinical implica...

#173 Hypercoagulability Workup: 5 Pearls Segment

19 Mar 2025

Contributed by Lukas

A new way to think of clots beyond provoked vs. unprovoked: Learn all about how important it is to think about reversibility! What patient states affe...

#172 Microplastics and Macro CV Health Problems: Beyond Journal Club on APACHe Study with NEJM Group

05 Mar 2025

Contributed by Lukas

What is the impact of microplastics on human health? How can we use observational data to support the argument that microplastics may lead to poor hea...

#171 Hospice Music Therapy: Bonus Episode

27 Feb 2025

Contributed by Lukas

What is the last sense to go? How can music create connection, ease anxiety, and help process emotions at the end of life? Join Dr. Jafar Al-Mondhiry,...

#170 ILD and High-Risk Medication Prescribing: Gray Matters Segment

05 Feb 2025

Contributed by Lukas

Incidental fibrosis on CT —what now? What does prone imaging tell you? Is it fibrosis, aspiration, or atelectasis? And once you diagnose ILD, does t...

#169 MGUS to Multiple Myeloma Diagnostics and Counseling: 5 Pearls Segment

22 Jan 2025

Contributed by Lukas

SPEP vs. UPEP? What does it tell you and not tell you? What is the role for immunofixation and free light chains in diagnosis? Learn about paraneoplas...

#168 Immune Checkpoint Inhibitor Adverse Events 2.0: 5 Pearls Segment

08 Jan 2025

Contributed by Lukas

How do you differentiate immune checkpoint inhibitor-related adverse events aka IrAEs from other conditions like infection? Join as we go through pne...

#167 Best of YouTube 2024: Anion Gap Metabolic Acidosis, Inhaler Use, Iron Deficiency in Pregnancy

30 Dec 2024

Contributed by Lukas

YouTube VideosAnion Gap Metabolic Acidosis: https://youtu.be/oE0lygmMANMInhaler Delivery Systems: https://youtu.be/yYPdjClm9BgIron Deficiency in Pr...

#166 Stress Ulcer Prophylaxis in the ICU and REVISE Trial: Beyond Journal Club with NEJM Group

11 Dec 2024

Contributed by Lukas

What’s the evidence been for the use of PPIs in mechanically ventilated patients? What do more recent studies reveal about PPIs and possible harmful...

#165 Peripheral Arterial Disease: 5 Pearls Segment

27 Nov 2024

Contributed by Lukas

Why are we missing peripheral arterial disease (PAD)? How is it diagnosed using the Ankle-Brachial Index (ABI)? What treatments improve symptoms and r...

#164 TPN/PPN Parenteral Nutrition: 5 Pearls Segment

14 Nov 2024

Contributed by Lukas

How is TPN and PPN similar and how is it different? When should each be used? How does bacterial overgrowth lead to complications? Does TPN cause diar...

#163 Urine Drug Screening Nuances: 5 Pearls Segment

30 Oct 2024

Contributed by Lukas

Limitations to urine drug screening (UDS) in primary care? What are common false positives and false negatives with the urine drug screen test?Tran...

#162 Hospice 102: Practical Tips and Nuances

16 Oct 2024

Contributed by Lukas

What if a patient can't afford hospice? Which medications do you deprescribe when on hospice? What happens when patients who are on hospice return...

#161 Transfusion Thresholds and the MINT Trial: Beyond Journal Club with NEJM Group

02 Oct 2024

Contributed by Lukas

Can the MINT trial change how we treat anemia in acute MI? The largest trial of its kind compared liberal vs. restrictive transfusion strategies in pa...

#160 Moral Distress Part 2: At the Bedside Segment

18 Sep 2024

Contributed by Lukas

Strategies to address moral distress and moral injury — hear from the experts on their work on the topic!Transcript and Show notesSubscribe to Core...

#159 Moral Distress Part 1: At the Bedside Segment

11 Sep 2024

Contributed by Lukas

What is moral residue vs. moral injury vs moral distress? How do these concepts impact us as clinicians?Sponsor: Whether you're looking to open y...

#158 Diuretics Resistance Cases

28 Aug 2024

Contributed by Lukas

Listen to 3 cardiorenal cases that highlight that “without flow it really doesn't matter what you're doing with the diuretic!”Sponsor: Fr...

#157 Handoffs: Contingency Planning

07 Aug 2024

Contributed by Lukas

Signouts! How can we do them better? Hear these memorable stories & ask yourself these FIVE questions when getting your handoff ready for the cove...

#156 Hospice 101: Nuts and Bolts

24 Jul 2024

Contributed by Lukas

Sponsor: Freed is an AI scribe that listens and writes your note in < 30 seconds. Freed learns your style over time and is HIPAA compliant! Us...

#155 Microskills: Small Actions, Big Impact

03 Jul 2024

Contributed by Lukas

Dive into 4 microskills from the book “Microskills: Small Actions, Big Impact” that offer tangible tools for navigating the professional world wit...

#154 Does Invitation To Screening Colonoscopy Save lives? Beyond Journal Club with NEJM Group on the NordICC Trial

19 Jun 2024

Contributed by Lukas

Does colonoscopy prevent colon cancer, and does it save lives? There has never been a randomized controlled trial on screening colonoscopies before No...

#153 HFpEF: 5 Pearls Segment

05 Jun 2024

Contributed by Lukas

Sponsor: Freed is an AI scribe that listens and writes your note in < 30 seconds. Freed learns your style over time and is HIPAA compliant! Us...

#152 Immune Checkpoint Inhibitors & IrAEs 101: 5 Pearls Segment

22 May 2024

Contributed by Lukas

Sponsor: At Panacea Financial, you don't need co-signers for personal loans and have reduced payments during training!Behind the Scenes YouTube...

#151 Cardiorenal Considerations: 5 Pearls Segment

13 May 2024

Contributed by Lukas

Sponsor: Freed is an AI scribe that listens and writes your note in < 30 seconds. Freed learns your style over time and is HIPAA compliant! Us...

#150 Rhythm Control in Afib: 5 Pearls Segment

24 Apr 2024

Contributed by Lukas

What are the benefits of early rhythm control versus rate control alone? When is electrical cardioversion used and what information can it tell us? Wh...

#149 Asthma Management and the MANDALA Trial: Beyond Journal Club with NEJM Group

10 Apr 2024

Contributed by Lukas

Should your patients be reaching for albuterol when their asthma flares up? Some of us may have been treating asthma exacerbations incorrectly for man...

#148 Iron Deficiency Treatment: 5 Pearls Segment

27 Mar 2024

Contributed by Lukas

How do you choose btw PO vs. IV iron? What is the best counseling for oral iron formulations? How do you choose between different IV iron formulation...

#147 Iron Deficiency: Grey Matters Segment

13 Mar 2024

Contributed by Lukas

What do the different iron labs mean?! How to interpret iron labs in the setting of inflammation? How to take a good menstrual history?Sponsor: Freed ...

#146 Tube Feeds: 5 Pearls Segment

28 Feb 2024

Contributed by Lukas

Uncover many blind spots on tube feeds!Sponsor: At Panacea Financial, every single customer gets their OWN 24/7 primary care banker who actually know...

#145 Heart Failure in Older Adults & Guardianship: Gray Matter Segment

14 Feb 2024

Contributed by Lukas

How do you manage GDMT in a frail older adult? When is a guardian needed and what is the process for obtaining guardianship?Sponsor: Echonous, the ma...

#144 RSV & What Makes Vaccine Trials Different: Beyond Journal Club on the RENOIR and AReSVi Trials

31 Jan 2024

Contributed by Lukas

How do you counsel patients eligible for the RSV vaccines? What do the results of the RENOIR and AReSVi trials tell us and how do they compare? How sh...

#143 Hypomagnesemia and Hypophosphatemia: 5 Pearls Segment

17 Jan 2024

Contributed by Lukas

When you see a low mag or a low phos, what are you thinking about? And do PPIs effect magnesium absorption? How much sodium and potassium are found in...

#142 Managing Conflict: At the Bedside Segment

27 Dec 2023

Contributed by Lukas

Sharpen your de-escalation skills!Sponsor: GlassHealth | Get unlimited A.I queries for 1 month with promo code: COREIM !Timestamps:02:26 Difficult Pat...

#141 Do Steroids Have a Role in Community-Acquired Pneumonia? Beyond Journal Club on the CAPE COD Trial

06 Dec 2023

Contributed by Lukas

In community-acquired pneumonia, can steroids improve mortality? Past studies of steroids in CAP have been conflicting, with some showing a mortality ...

#140 Bonus Pacemaker & ICDs: 5 Pearls Segment

29 Nov 2023

Contributed by Lukas

Syncope history, PPM/ICD prior to MRI or surgery, anticoagulation for pacemaker or ICD procedures and new cardiac devices and how they may look differ...

#139 CKD Staging (Cr vs. Cystatin C, Albuminuria & more): Mind The Gap Segment

08 Nov 2023

Contributed by Lukas

Is Cr or Cystatin C better to assess eGFR? What are pros & cons of each? Does eGFR tell the full picture of kidney function? What may cause false...

#138 Incorporating Cancer Genetics into Your Practice: Lynch Syndrome and Beyond!

25 Oct 2023

Contributed by Lukas

Check out the original interview on Youtube:Essentials on Genetic Counselor | Lynch SyndromeWho should be referred for genetic counseling? How can we ...

#137 Hypokalemia & Potassium Repletion: 5 Pearls Segment

18 Oct 2023

Contributed by Lukas

See some of the original interviews on Youtube!What is the evidence behind K+ repletion? What is a framework to think through for hypokalemia? What ar...

#136 How Did Diabetes Medications Become Obesity Meds? Beyond Journal Club on SURMOUNT-1 Trial

04 Oct 2023

Contributed by Lukas

What is the difference between semaglutide (ozempic) and tirzepatide (mounjaro) in outcomes and mechanism? How did we find out diabetes medications c...

#135 Guideline Directed Medical Therapy Part II: 5 Pearls Segment

20 Sep 2023

Contributed by Lukas

With progressing CKD & HFrEF, what GDMT medications can you start, continue or stop? What does the data on hydralazine/isosorbide tell us and what...

#134 Diagnostic Errors & Excellence

06 Sep 2023

Contributed by Lukas

What does medical education research say about improving diagnostic errors? What habits help in getting to diagnostic excellence?Timestamps01:00 Syste...

#133 Post-Kidney Transplant: 5 Pearls Segment

16 Aug 2023

Contributed by Lukas

What are side effects of tacrolimus and mycophenolate? And what are common medication interactions? What causes of acute kidney injury are unique to r...

#132 Does PCI Save Lives in Heart Failure and CAD? Beyond Journal Club on the REVIVED Trial

02 Aug 2023

Contributed by Lukas

In patients with heart failure with low ejection fraction and chronic coronary disease without unstable symptoms, does stenting open blocked coronary ...

#131 July Stories 2.0

19 Jul 2023

Contributed by Lukas

Laugh and be humbled along some of Dr. Maria Rosasco's most memorable July stories !Listen to the original July Stories: https://bit.ly/3Y4n8jGBeh...

#130 Cort (ACTH) Stim Test

06 Jul 2023

Contributed by Lukas

BONUS on Cosyntropin stimulation tests! What exactly is it? How do you interpret them? What is the difference between adrenal insufficiency and steroi...

#129 Steroids: 5 Pearls Segment

28 Jun 2023

Contributed by Lukas

How do you choose between the different steroids? At what dose and duration do you get concerned about worrisome complications? What types of prophyl...

#128 Cirrhosis Bleeding Risk, FFP and Indwelling Pleural Catheters: Gray Matters Segments

14 Jun 2023

Contributed by Lukas

In cirrhosis, what actually contributes to the bleeding vs. clotting risk? Does the INR capture it? What is in FFP? Do you have to give FFP prior to a...

#127 Radiation Oncology Side Effects: 5 Pearls Segment

31 May 2023

Contributed by Lukas

How long can fatigue last for after radiation? Are all patient post radiation immunocompromised?  What are the potential acute and long-term side ef...

#126 Radiation Oncology Part 1: 5 Pearls Segment

24 May 2023

Contributed by Lukas

What are the different types of radiation? What should we and shouldn’t we put in our one-liners? What makes palliative radiation different from cur...

#125 Learning Habits, Time Management, and Leadership: Wisdom from Dr. Kelly Graham

15 May 2023

Contributed by Lukas

What did you have to "unlearn" in your learning journey? How do you organize your time? Organize how you keep up with medical evidence? What i...

#124 A1c & Glucose Measurements: Mind the Gap Segment

26 Apr 2023

Contributed by Lukas

What does the HbA1c really measure? What are its limitations? How does fructosamine and glycated albumin work? What will falsely elevate or decrease i...

#123 Pacemakers & ICDs: 5 Pearls Segment

12 Apr 2023

Contributed by Lukas

When do you have a device interrogated? Do you know what kind of device your patient has? Do you know how to manage patients with a device who develop...

#122 Kidney Transplant Preparation: 5 Pearls Segment

29 Mar 2023

Contributed by Lukas

How does transplant compare to dialysis? Who is a good candidate for a kidney transplant? How long do patients have to wait for a deceased donor kidne...

#121 Trach Care: 5 Pearls Segment

08 Mar 2023

Contributed by Lukas

What is your approach to trach complications? What do all the words in the one liner of a trach patient mean? What are best practices for airway clear...

#120 Safety Net Hospitals, A Disproportionate Share Health Affairs Pathways Podcast

02 Mar 2023

Contributed by Lukas

Why are safety net hospitals barely surviving? What makes a hospital a safety net hospital? How essential are safety net hospitals in caring for low i...

#119 A 80F with Melena and AKI also with an Unresolved Pneumonia: Hoofbeats Episode

15 Feb 2023

Contributed by Lukas

How does your problem representation change as we get more history in this episode? How can we use Oxaam's razor & Hickman's dictum as pow...

#118 "Futility": At the Bedside Segment

01 Feb 2023

Contributed by Lukas

How do you approach requests for 'futile' care? What do we mean by futility? What kind of recovery do we think is meaningful? How do we evalua...

#117 Atrial Fibrillation: Gray Matters Segment

18 Jan 2023

Contributed by Lukas

Check out original interviews on our Youtube channel!What does the duration of afib tell you about the thromboembolic risk? When do you start anticoag...

#116 The Lipid Panel Reimagined: Mind the Gap Segment

15 Dec 2022

Contributed by Lukas

Is it enough to look at LDL-C? What is Apo-B? How do you use TG/HDL ratio to understand your patients cardiovascular risk? Do you need to get a fastin...

#115 Hope: At the Bedside Segment

23 Nov 2022

Contributed by Lukas

What are some ways you address unrealistic hopes with your patients? How can you build a portfolio of hope with your patients? Can you learn to guide ...

#114 Alcohol-Associated Hepatitis: 5 Pearls Segment

09 Nov 2022

Contributed by Lukas

What tests and history points help with the diagnosis of alcohol-associated hepatitis? What other etiologies should be ruled out? To steroid or not to...

#113 Aspirin for Primary Prevention: Mind the Gap Segment

19 Oct 2022

Contributed by Lukas

How do you educate your patients on aspirin use? For what reasons do you start, continue or stop aspirin? What does trial data tell us? How does aspir...

#112 ANA (Antinuclear Antibody) Test: 5 Pearls Segment

05 Oct 2022

Contributed by Lukas

Is a positive ANA always significant? What does the titer mean? Is the pattern of the ANA helpful? What patient histories should you not get an ANA fo...

#111 Discharges with Incidental Findings: Gray Matters Segment

21 Sep 2022

Contributed by Lukas

How do you decide which lung nodules should be worked up inpatient or outpatient? How common are incidental lung nodules? What considerations are the...

"Best of" | Struggles with with Clinical Reasoning Hoofbeats

17 Sep 2022

Contributed by Lukas

Can you identify where along the clinical reasoning pathway the learner is struggling? What coaching exercises can be helpful? What feedback do you ...

#110 Upstanders: Standing Up Against Microaggression: At the Bedside Episode​

24 Aug 2022

Contributed by Lukas

Hear personal stories about racial trauma or stereotype threat. How can we respond and how do we differentiate an up stander from a bystander? What ba...

#109 Hyponatremia Management Part 1: 5 Pearls Segment

03 Aug 2022

Contributed by Lukas

What are the 3 types of solutes you can use in hyponatremia? What are each of their drawbacks? How do loop diuretics work help in hyponatremia? What c...

"Best of" | Hyponatremia Diagnostics 5 Pearls

27 Jul 2022

Contributed by Lukas

What does each diagnostic test tell you? How do you interpret urine osmolality, urine sodium, or urine urea? What studies can be used to better assess...

#108 Drug Fever and Antibiotic-Associated Neurotoxicity: Gray Matters Segment

13 Jul 2022

Contributed by Lukas

Other than infection, what do you think about as other causes of fever? How can you distinguish sepsis from drug fever from antibiotics? What medicati...

#107 COPD: 5 Pearls Segment

22 Jun 2022

Contributed by Lukas

What are the 3 different types of inhaler devices and what should you educate patients about each? When do you stop the inhaled steroid in COPD? And ...

#106 Spirituality: At the Bedside Segment

15 Jun 2022

Contributed by Lukas

How do you ask about spiritual health? How is spirituality different from religion?Show notes, Transcript and References:https://www.coreimpodcast.com...

#105 Sickle Cell: 5 Pearls Segment

01 Jun 2022

Contributed by Lukas

What are the indications for a simple transfusion? And what the indications for an exchange transfusion? What is your approach to pain management in p...

#104 Guideline-Directed Medical Therapy for HFrEF Part 1: 5 Pearls Segment

11 May 2022

Contributed by Lukas

How do you counsel patients on beta blockers? Is one beta-blocker better than the other? What is preferred: ACEi, ARBs or ARNIs? What are the pros and...

#103 Fluids: 5 Pearls Segment

27 Apr 2022

Contributed by Lukas

How much of D5W vs. isotonic saline contributes to intravascular volume? How do you distinguish between oncotic pressure and tonicity? What balanced s...

#102 Echo in Pulmonary Hypertension: 5 Pearls Segment

06 Apr 2022

Contributed by Lukas

What do you include in your initial basic work-up for suspected pulmonary hypertension? Do you know how to calculate the PASP on the ECHO? What physio...

#101 Nutrition - 2021 SGIM Recap

27 Mar 2022

Contributed by Lukas

How can we use food as medicine? How can we best counsel our patients on their diets? Which pre-set diets can we recommend for or against? How can we ...

#100 Top 10 Telemedicine Tips - 2021 SGIM Recap

09 Mar 2022

Contributed by Lukas

What are some tricks to help you perform a virtual physical exam? What role do these visits play in our overall care for the patient? What tools do we...

#99 Bleeding vs. Clotting Risk: Gray Matters Segment

23 Feb 2022

Contributed by Lukas

How long should you anticoagulant for a PE? When can you safely stop anticoagulation for thrombogenic patients who need an urgent biopsy? Should an IV...