982-Trauma Related Brain Damage: Neurotoxicity of Stress

### Video Summary **Title:** Trauma Related Brain Damage, Glutamate, and Neurotoxicity   **Presenter:** Dr. Dawn-Elise Snipes   **Link:** [Watch the video](https://youtu.be/AFsqzW8DBYc?si=Asi1zJlYqabK-Vn6) --- #### Introduction - Overview of trauma's effect on brain glutamate levels - Discusses impact on HPA axis and neurotransmitter balance - Importance of glutamate in learning and synaptic plasticity #### Effects of Glutamate Imbalance - Role of glutamate and cortisol in brain function - Goldilocks principle: need for balanced neurotransmitter levels - Symptoms of too little and too much glutamate  - Too little: difficulty concentrating, fatigue, apathy  - Too much: excitotoxicity, anxiety, neurodegeneration #### Glutamate and Dopamine Interactions - Dopamine potentiates glutamate, increasing neurotoxicity - Impact of stimulants on glutamate release #### HPA Axis and Stress Response - Explanation of HPA axis function and stress response - Chronic stress leads to pathophysiological changes and neuronal death - Hypervigilance and its effects on cortisol and glutamate levels #### Impact of Trauma and PTSD - Trauma disrupts sense of safety, causing hypervigilance - Persistent hypervigilance leads to chronic high glutamate and cortisol - Stress-induced changes in prefrontal cortex and hippocampus affecting cognitive functions #### Neurotransmission Dysfunction - Glutamatergic dysfunction linked to stress-related mental and physical illnesses - Systemic inflammation associated with depression, anxiety, autoimmune diseases #### Interventions and Recovery - Glutamate antagonists and their effects - Importance of nutrients in normalizing glutamate levels - Role of adaptogens, neuro lipids, and essential oils - Behavioral strategies: creating safety, addressing intrusive thoughts, and flashbacks - Cognitive and acceptance-based therapies for trauma - Benefits of meditation and exercise in neurogenesis and stress reduction #### Summary - Glutamate is crucial for brain function but must be balanced - Chronic stress impacts glutamate regulation, leading to various health issues - Multiple interventions can help in managing glutamate levels and improving overall brain health --- ### Time Codes for Major Points 02:00 Overview of glutamate's role in the brain and effects of imbalance 07:45 Interaction between dopamine and glutamate, and impact of stimulants 13:30 Explanation of the HPA axis and its role in stress response 20:15 Impact of trauma and PTSD on glutamate and cortisol levels 25:50 Neurotransmission dysfunction and its link to mental and physical illnesses 35:30 Interventions for managing glutamate levels and improving brain health Learn more about your ad choices. Visit megaphone.fm/adchoices

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