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DarshanTalks Podcast

Trump Administration’s NIH cuts: Will they cripple US medical research?

14 Feb 2025

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Darshan Kulkarni and Edye Edens discuss the recent controversy surrounding the Trump administration’s decision to cap NIH overhead funding (also known as indirect costs or F&A) at 15%. This sweeping change has already sparked significant backlash, with academic medical centers, particularly in Democratic states, filing lawsuits to challenge the policy. The cap threatens to disrupt funding structures that support essential research, potentially undermining the United States’ role as a global leader in medical innovation.They break down the impact of this decision, highlighting how research costs vary significantly based on location—conducting studies in Boston versus Oklahoma City, for example, involves vastly different expenses. A one-size-fits-all cap could have unintended consequences, particularly in an era where supply chain disruptions and rising costs are already straining research budgets.A major concern is how this will affect investigator-initiated and subsidized trials, which often operate at a loss but are crucial for rare diseases and specialized treatments. These trials provide hope to patients who might otherwise have no viable treatment options, and without adequate funding, such research could dwindle.The discussion also covers the broader legal and political landscape. The Association of American Medical Colleges (AAMC) has now filed a federal lawsuit seeking a nationwide temporary restraining order on enforcing the cap, marking a significant escalation in the legal battle. With past instances of the Trump administration disregarding court orders, Darshan and Edye explore the potential for a constitutional crisis if the executive branch ignores judicial rulings.Further, they examine the possible influence of private corporations on this policy shift. Many corporations that fund research typically limit their overhead contributions to around 15%, and some members of the administration have ties to these corporations. The hosts speculate that the policy may have been designed to align federal funding with corporate standards—potentially at the expense of public research institutions.Ultimately, they question whether these cuts truly support the administration’s “America First” philosophy. If the goal is to maintain U.S. dominance in scientific research, slashing funding without strategic adjustments could have the opposite effect, weakening the country’s ability to innovate and compete globally.With legal challenges underway and research institutions scrambling to adjust, this conversation is just the beginning of what promises to be a rapidly evolving and highly contentious issue.Support the show

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