Dr. Prash on Building a $100M+ Crypto Brokerage and Pioneering Psychedelic Therapy

Episode SummaryFrom surgeon to psychiatrist, Bitcoin investor to billion-dollar crypto brokerage founder, Dr. Prash Puspanathan has lived one of the most unconventional founder journeys in tech. After co-founding and scaling Caleb & Brown into a global crypto powerhouse, later acquired by SwiftX in 2025, Dr. Prash is now pioneering the future of mental health with Enosis Therapeutics, using VR to transform psychedelic-assisted therapy integration.In this episode of Perspective X, Dr. Prash shares how a single psilocybin experience completely reshaped his worldview, steering him away from surgery and into psychiatry, entrepreneurship, and eventually, crypto. He reveals the parallels between fiscal freedom in decentralized finance and cognitive freedom in mental health, the scrappy early days of arbitrage trading, and the challenges of scaling a white-glove brokerage to serve high-net-worth clients worldwide.We also dive into the future of psychedelic medicine, why integration is the “real work,” how technology can lower costs and increase access, and why prevention, not just treatment, will define the next era of mental health. From paradigm-shifting psychedelics to building billion-dollar ventures, this is a conversation about liberation, of thought, finance, and human potential.Time Stamps00:00 – Intro: Dr. Prash’s unconventional founder journey02:00 – From surgery to psychiatry: psychedelics as a turning point06:30 – The transformative psilocybin experience and shifting paradigms10:30 – Understanding psychedelic therapy and integration work16:00 – Why psychedelics challenge power structures and cultural norms22:00 – Fiscal freedom and cognitive freedom: psychedelics and Bitcoin30:00 – Founding Caleb & Brown and building a billion-dollar brokerage37:00 – Global scaling, high-net-worth clients, and leadership transitions42:00 – Preparing for acquisition: the 9-month journey to SwiftX50:00 – Running a dual life as psychiatrist and founder55:00 – Enosis Therapeutics: VR-powered integration for psychedelic therapy01:02:00 – Building tools for patients, therapists, and the future of mental health01:10:00 – The vision for a psychological digital twin01:15:00 – Psychedelics in the next 10–50 years: from treatment to prevention01:20:00 – Translating research into real-world impact and future missionResources💰 Caleb & Brown – Global crypto brokerage: https://calebandbrown.com🩺 Enosis Therapeutics – Tech for psychedelic-assisted therapy: https://www.enosistherapeutics.com/👤 Dr. Prash on LinkedIn: https://www.linkedin.com/in/drprash/Sponsors:Perspective X is supported by our wonderful sponsors:Vanta: Vanta is the all-in-one solution for startups to become compliant quickly and build a security foundation with ease. Startup customers get $1000 off Vanta at dayone.fm/vanta/paulineMighty Partners: Mighty Partners is a growth lender supporting ambitious Australian companies with bespoke debt funding solutions.Day One listeners are invited to book a complimentary venture debt consultation with Mighty Partners. To schedule your call, simply follow the link and mention "Day One Free Consult"dayone.fm/mighty Perspective X is part of Day One.Day One helps founders and startup operators make better business decisions more often. To learn more, join our newsletter to be notified of new Perspective X episodes and upcoming shows. Mentioned in this episode:Mighty Partners_PX_May 2025Vanta_PX_May 2025

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