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Deep Dive - Frontier AI with Dr. Jerry A. Smith

Antifragile AI: When Regulatory Chaos Becomes the Teacher

23 Jul 2025

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Medium Article: https://medium.com/@jsmith0475/antifragile-ai-when-regulatory-chaos-becomes-the-teacher-4ab80e554a29 The article, by Dr. Jerry A. Smith, introduces the concept of antifragile AI, a paradigm shift for navigating complex and ever-changing regulatory landscapes, particularly within the pharmaceutical industry. It argues that traditional AI systems, designed for "perfect compliance," are brittle and prone to failure when faced with unpredictable regulatory changes, leading to significant financial losses and operational inefficiencies. Drawing inspiration from biological systems and neuroscience, the source proposes building AI that not only withstands stress but improves and strengthens with each new regulatory challenge, much like the human immune system or muscles. This approach emphasizes causal understanding, predictive adaptation, and continuous self-improvement, leading to a virtuous cycle of compounded intelligence that offers a significant competitive advantage and represents a substantial investment opportunity for private equity firms recognizing this undervalued capability.

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