POLY-HF & the Potential of Polypills in HF, With Ambarish Pandey, MD

Welcome back to Don't Miss a Beat! In this episode of Don’t Miss a Beat, cohosts Steven Green, MD, and Muthu Vaduganathan, MD, MPH, sit down with Ambarish Pandey, MD, from UT Southwestern, to discuss the landmark POLY-HF trial, presented at the 2025 American Heart Association Scientific Sessions in New Orleans. The discussion centers on the novel concept of a “polypill” approach for patients with heart failure with reduced ejection fraction (HFrEF), aiming to simplify guideline-directed medical therapy (GDMT) and improve adherence while maintaining safety and efficacy. Key Timestamps 00:00:00 Introduction 00:00:45 Polypills in cardiovascular medicine 00:02:32 Structuring the POLY-HF trial 00:05:00 Mechanics of POLY-HF 00:07:43 The patient population in POLY-HF 00:09:47 Dosing other medications in POLY-HF 00:11:54 Results of POLY-HF 00:14:57 Reaching endpoints in POLY-HF 00:18:52 Safety in POLY-HF 00:22:09 Upcoming studies 00:23:54 Outro 

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