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Dr. Joseph Mercola - Take Control of Your Health

Does Melatonin Help Ease Migraines?

03 Oct 2025

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More than 1 billion people worldwide and 12% of Americans live with migraines, a disabling neurological condition that disrupts sleep, work, and daily life Melatonin does more than regulate sleep; it also shields your brain at a cellular level by neutralizing damaging free radicals and reducing inflammation linked to migraines Research shows melatonin reduces headache frequency by 51%, intensity by 53%, and duration by 46%, offering a powerful natural alternative to standard pharmaceutical drugs Adults with episodic migraines taking 3 mg of melatonin before bed experienced the strongest improvements, often cutting their migraine frequency by half or more Melatonin's safety profile is superior to common drugs like amitriptyline, with fewer and milder side effects, making it a well-tolerated option for migraine prevention

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