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Einstein A Go-Go

Beta-blockers and anthracycline chemotherapy

15 May 2023

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Hosts: Dr Shane, Dr Jen, Dr Euan,News items: The symbiotic relationship between fungi and trees, using ultrasound to cross the blood-brain barrier, thanatosis, recolonisation of ants. In this episode the team was joined by Dr Aeson Chang from Monash University. Dr Chang’s current work is focused on exploring how beta-blockers interact with anthracycline chemotherapy with the goal to improve outcomes for triple negative breast cancer patients. In a study recently published in Science Translational Medicine, Dr Chang (study lead author) used mouse models of cancer and analysed large-scale patient clinical data to discover that anthracycline chemotherapy on its own, in the absence of a beta-blocker, induces nerve growth in tumours. However, adding a beta-blocker to chemotherapy inhibited nerve fibre activity in tumours and stopped the cancer from coming back after treatment. Also discussed, the process for allocating time for The James Webb Space Telescope, and the racial disparity in scientific research.Program page: Einstein-A-Go-GoFacebook page: Einstein-A-Go-GoTwitter: Einstein-A-Go-Go

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