New Primary Aldosteronism Guidelines – Endocrine Society 2025; Episode 4

This episode reviews the Endocrine Society’s 2025 guideline updates on managing primary aldosteronism after initial screening.• When suppression testing is indicated or unnecessary• Cortisol cosecretion in adrenal adenomas and surgical planning• Role of adrenal vein sampling (AVS) in determining laterality, with rare exceptions• Treatment strategies for unilateral vs bilateral disease• MRA therapy, titration approach, and importance of renin response

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