Pulse Field Ablation: Promise, Peril, and the AI Revolution in EP: EP Edge Newsletter May 2025

Pulse field ablation (PFA) has been hailed as the next frontier in atrial fibrillation therapy—nonthermal, ultra-selective, and lightning fast. But as new data emerges, important questions are rising about its systemic effects, cerebral safety, and vascular complications.In this episode of EP Edge, Dr. Niraj Sharma unpacks the latest findings from the NEMESIS-PFA registry, explores silent cerebral lesion data, reviews a rare case of catastrophic coronary spasm, and introduces how AI—through models like DeePRISM—is changing how we think about ablation strategy.Whether you’re in the lab, in clinic, or leading research, this episode offers a critical look at where the field is heading next.For: Source data/infographics see EPEDGE Newsletter on LinkedInFor feedback, collaborations, or questions, email Dr. Niraj Sharma at [email protected] connect on LinkedIn

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