Olen O.: Cancer Risk in PIBD

A short hop from Stockholm to Helsinki, site of the 2025 ESPGHAN annual meeting, where this interview with Prof Ola Olén was recorded – in Finland, or East Sweden, as it was known until 1809, when the Treaty of Fredrikshamn / Hamina ceded both Finland and parts of both North and West Bothnia to Russia… Only in 1917 was the Grand Duchy of Finland pried away from the fragmenting Russian empire, and, mind you, the Russians, wearing their Soviet hat, stole Karelia back in 1940. Thinking of the state of the world today, we forget history at our peril; it’s never been easy to be a Finn. Sweden, though, is where Prof Olén is based, and where he mines clinical registries of children with inflammatory bowel disease to identify risks and risk factors for susceptibilities and complications. His particular interest is the question of whether or not the risk of cancer is increased in pediatric inflammatory bowel disease, and if so – what cancers, why, and to what extent, absolute and relative? Of course this raises an important corollary question: What are physicians and families to do with the estimates of risk that his work produces? An introduction to that work is provided in the references below. LiteratureOlén O et al. Childhood onset inflammatory bowel disease and risk of cancer: A Swedish nationwide cohort study 1964–2014. BMJ 2017 Sep 20; 358:j3951. Doi: 10.1136/bmj.j3951. PMID: 28931512. PMCID: PMC5605779 Everhov Å et al. Colorectal cancer in childhood-onset inflammatory bowel disease: A Scandinavian register-based cohort study, 1969–2017. J Pediatr Gastroenterol Nutr 2022 Oct 1; 75(4):480–484. Doi: 10.1097/MPG.0000000000003574. Epub 2022 Aug 18. PMID: 36125530 Olén O et al. Increasing risk of lymphoma over time in Crohn’s disease but not in ulcerative colitis: A Scandinavian cohort study. Clin Gastroenterol Hepatol 2023 Nov; 21(12):3132–3142. Doi: 10.1016/j.cgh.2023.04.001. Epub 2023 Apr 13. PMID: 37061104 Everhov Å et al. Cancer incidence in patients with ulcerative colitis naïve to or treated with thiopurine and targeted therapies – a cohort study 2007 to 2022 with comparison to the general population. J Crohns Colitis 2025 Jun 2:jjaf091. Doi: 10.1093/ecco-jcc/jjaf091. Online ahead of print. PMID: 40455688 Dr. Olen´s favourite song: Bara bada bastu” with KAJ. ESPGHAN favourite Songs can be found on Spotify:https://open.spotify.com/playlist/0YIHKjxITLEm9XNyHyypTo

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