From First Principles
Episodes
FFP EP. 20 | The Physics Behind Fusion’s Biggest Problem (Season Finale)
23 Dec 2025
Contributed by Lukas
Hosted by Lester Nare and Krishna Choudhary, this Season Finale closes out Season 1 with a deep dive into the physics behind fusion’s biggest bottle...
FFP EP. 19 | The Race to the Double Helix — Watson, Crick, Franklin & the Real Story of DNA
04 Dec 2025
Contributed by Lukas
Hosted by Lester Nare and Krishna Choudhary, this single-story deep dive tells the full story of how humanity uncovered the structure of DNA — and t...
FFP EP. 18 | 3I/ATLAS Explained, Forensic Fingerprints & Alzheimer’s Breakthrough
27 Nov 2025
Contributed by Lukas
Hosted by Lester Nare and Krishna Choudhary, this episode spans astrophysics, forensic chemistry, and neuroimmunology. We begin with a deep dive into ...
FFP EP. 17 | Hypersonic Physics, Deep Sea Life & Princeton’s Millisecond Qubits
22 Nov 2025
Contributed by Lukas
Hosted by Lester Nare and Krishna Choudhary, this episode dives into three breakthroughs stretching across aerospace engineering, astrobiology, and qu...
FFP EP. 16 | Octopus Camouflage, Orcas vs. Sharks, Civet Coffee & Sub-Diffraction Telescope Tech
13 Nov 2025
Contributed by Lukas
Hosted by Lester Nare and Krishna Choudhary, this super-episode spans four wildly different frontiers: bioengineers hijacking bacterial evolution to m...
FFP EP. 15 | AI-Generated Genomes, Retinal Implants, and Palomar’s Mystery Lights Explained
06 Nov 2025
Contributed by Lukas
AI, Eyes, and the Sky — From Synthetic Genomes to Restored Vision and Cosmic MysteriesHosted by Lester Nare and Krishna Choudhary, this episode of F...
FFP EP. 14 | Chen Ning Yang — The Man Who Unlocked Symmetry
31 Oct 2025
Contributed by Lukas
Hosted by Lester Nare and Krishna Choudhary, this episode tells the story of Nobel laureate Chen Ning Yang and how his ideas on symmetry and gauge the...
FFP EP. 13 | Portable Muon Beams, Sodium Batteries, and the Secret to Long Life
23 Oct 2025
Contributed by Lukas
Aloha internet — Lester Nare and Krishna Choudhary return with three extraordinary research stories: portable muon beams, sodium-ion batteries, and ...
FFP EP. 12 | From Princeton to the Nobel Prizes — How FFP Started + 2025 Nobel Recap
15 Oct 2025
Contributed by Lukas
After a packed week of Nobel Prize coverage, Lester and Krishna look back on how From First Principles began and why they built it as an “ESPN for S...
FFP EP. 11 | From Cells to Circuits to Crystals — 2025 Nobel Prizes Unpacked
09 Oct 2025
Contributed by Lukas
Hosted by Lester Nare and Krishna Choudhary, this one-episode special brings all three 2025 Nobel Prizes in the sciences into a single listen: Medicin...
FFP EP. 10 | AI Supercharges CRISPR & LIGO (Nobel Prize Week Preview)
02 Oct 2025
Contributed by Lukas
Hosted by Lester Nare and Krishna Choudhary, this two-story, 2.5-hour special sets the table for Nobel Prize Week with deep dives into two recent Nobe...
FFP EP. 9 | China’s AI Breakthrough, Time Crystals, Hidden Viruses, & Brightest Cosmic Signal
23 Sep 2025
Contributed by Lukas
Lester Nare and Krishna Choudhary return for Episode 9 of From First Principles, breaking down the latest breakthroughs across AI, physics, biology, a...
FFP EP. 8 — Strongest Evidence for Alien Life? (Mars, K2-18b & JWST)
16 Sep 2025
Contributed by Lukas
NASA just dropped what they’re calling the strongest evidence yet for biosignatures on Mars, so we spun up an emergency pod. We break down what the ...
FFP EP. 7 | Interstellar Visitor 3I/Atlas, Human Longevity Plateau, New No-Sort Plastic & Analog AI
09 Sep 2025
Contributed by Lukas
Hosted by Lester Nare and Krishna Choudhary, Episode 7 of From First Principles covers four stories at the frontier of science and technology. This we...
FFP EP. 6 | New Supernova, Virus+Bacteria vs Cancer, Electron Spin, Bee Superfood
02 Sep 2025
Contributed by Lukas
Hosted by Lester Nare and Krishna Choudhary, Episode 6 of From First Principles covers four groundbreaking stories in science—from rare cosmic explo...
FFP EP. 5 | Hacking The Human Brain, Unlocking Our DNA, Unbreakable Diamonds & The Quantum Magician
26 Aug 2025
Contributed by Lukas
This week we break down four big stories—no PhD required.Reading “inner speech”: Invasive brain–computer interfaces record neurons in motor co...
FFP EP. 4 | 3rd Interstellar Visitor, Rubin’s Sky Camera, AI CRISPR Boost & T. rex Blood Vessels
19 Aug 2025
Contributed by Lukas
Interstellar visitor #3 is here. We unpack 3I ATLAS (why it’s moving so fast, why we finally saw a tail, and how Hubble/JWST—and maybe even Juno—...
FFP EP. 3 | Oldest Molecule, Programmable Proteins, Europa Radar & Light’s Double Life
14 Aug 2025
Contributed by Lukas
We go from the universe’s first chemistry to tomorrow’s designer biology, swing by Mars to tune Europa Clipper’s ice radar, and finish with a fr...
FFP EP. 2 | Hidden Star in Betelgeuse, Dancing Atoms, Ultra-High-Energy Cosmic Rays & VR Immunity
05 Aug 2025
Contributed by Lukas
Lester and Dr. Krishna dive into:• Beetlejuice & “Bracelet” – why a red super-giant may soon swallow its tiny partner• Atomic Harlem Sha...
FFP EP. 1 | Earth’s 1-ms Day, Baby Solar Systems, Record Black Hole Crash, CRISPR Cancer Hack & AI Indiana Jones
01 Aug 2025
Contributed by Lukas
Last week the Earth finished a full rotation one millisecond early – but that’s just the opener.In this week’s From First Principles we dive int...