Harrison's PodClass: Internal Medicine Cases and Board Prep

Ep 193: A 40-Year-Old with Fevers, Congestion, and Cough

30 Apr 2026

Contributed by Lukas

This episode reviews the clinical manifestations and differential diagnosis of vasculitis syndromes.Read more on this topic in Harrison's.Harriso...

Ep 192: A 44-Year-Old Concerned about MEN Syndromes

23 Apr 2026

Contributed by Lukas

This episode reviews the clinical characteristics of multiple endocrine neoplasia (MEN) syndromes.Read more on this topic in Harrison'sHarrison&a...

Ep 191: A 38-Year-Old with Fever, Hypotension, and Confusion

17 Apr 2026

Contributed by Lukas

This episode goes through laboratory findings of critically ill patients, their etiologies, and the corresponding syndromes.Read more on this topic in...

Ep 190: A 45-Year-Old with Flank Pain

09 Apr 2026

Contributed by Lukas

This episode reviews the diagnosis, pathophysiology, treatment, and management of patients with nephrolithiasis.Read more on this topic in Harrison&ap...

Ep 189: A 52-Year-Old with Hypertension

02 Apr 2026

Contributed by Lukas

This episode reviews secondary causes of hypertension and the work-up and evaluation to determine the cause.Read more on this topic in Harrison's...

Ep 188: A 22-Year-Old with Abnormal Serum Bilirubin

26 Mar 2026

Contributed by Lukas

This episode reviews common causes of hyperbilirubinemia and how to differentiate among its various causes.Read more on this topic in Harrison's....

Ep 187: A 73-Year-Old with Complications from Renal Dysfunction

19 Mar 2026

Contributed by Lukas

This episode reviews common complications of renal dysfunction.Read more on this topic in Harrison's.Harrison's Principles of Internal Medic...

Ep 186: A 45-Year-Old with Elevated Calcium

12 Mar 2026

Contributed by Lukas

This episode reviews the workup and diagnosis of hypercalcemia.Read more on this topic in Harrison's.Harrison's Principles of Internal Medic...

Ep 185: An 89-Year-Old with Lack of Appetite and Weight Loss

05 Mar 2026

Contributed by Lukas

This episode discusses key concepts in the care of the geriatric patient.Read more on this topic in Harrison's.Harrison's Principles of Inte...

Ep 184: A 65-Year-Old with Anemia

26 Feb 2026

Contributed by Lukas

This episode reviews peripheral blood smears and how they guide diagnosis.Read more on this topic in Harrison's.Harrison's Principles of Int...

Ep 183: A 75-Year-Old with Acute Fever and Altered Mental Status

19 Feb 2026

Contributed by Lukas

This episode discusses the symptoms and laboratory findings seen in patients with West Nile virus.Read more on this topic in Harrison's chapters:...

Ep 182: A 64-Year-Old with Abnormal Colonoscopy

12 Feb 2026

Contributed by Lukas

Read more on this topic in Harrison's.Harrison's Principles of Internal Medicine, 22nd Edition

Ep 181: A 64-Year-Old with Fatigue and Low-Grade Fevers

05 Feb 2026

Contributed by Lukas

This episode discusses types of cardiac murmurs.Read more on this topic in Harrison's.Harrison's Principles of Internal Medicine, 22nd Editi...

Ep 180: A 64-Year-Old with Fever

22 Jan 2026

Contributed by Lukas

This episode discusses fever of unknown origin (FUO) and unexplained inflammation.Read more on this topic in Harrison's.Harrison's Principle...

Ep 179: A 62-Year-Old with Fatigue

15 Jan 2026

Contributed by Lukas

This episode reviews common causes of fatigue, and the additional history and physical findings needed for the next steps in evaluation.Read more on t...

Ep 178: A 57-Year-Old with Neck Pain

08 Jan 2026

Contributed by Lukas

This episode reviews the diagnostic approach to acute neck pain.Read more on this topic in Harrison's.Harrison's Principles of Internal Medi...

Ep 177: A Patient with Low Blood Pressure

18 Dec 2025

Contributed by Lukas

Part of our Physiology at the Bedside collection, this episode reviews the physiology of shock.Read more on this topic in Harrison's.Harrison&apo...

Ep 176: A 34-Year-Old Who Skipped Medications

11 Dec 2025

Contributed by Lukas

This is the next episode in our Physiology at the Bedside series and reviews complications that can arise when a patient forgets to take their medicat...

Ep 175: A 38-Year-Old with Cardiac Arrest

04 Dec 2025

Contributed by Lukas

Continuing our Physiology at the Bedside series, this episode examines the potential causes of pulseless electrical activity (PEA) arrest.Read more on...

Ep 174: A 65-Year-Old Man with Dyspnea on Exertion

28 Nov 2025

Contributed by Lukas

From our Physiology at the Bedside series, this episode reviews pulmonary function tests.Read more on this topic in Harrison's.Harrison's Pr...

Ep 173: A 48-Year-Old Woman with Heart Failure

20 Nov 2025

Contributed by Lukas

In this installment of our Physiology at the Bedside series, we cover heart failure and the physiology behind its different types.Read more on this to...

Ep 172: A 52-Year-Old Man with an Increased Respiratory Rate

13 Nov 2025

Contributed by Lukas

In this episode in our “Physiology at the Bedside” series, we discuss the causes and pathophysiology of acidosis.Read more on this topic in Harris...

Ep 171: A 19-Year-Old Woman with Lower Extremity Edema

06 Nov 2025

Contributed by Lukas

The first episode in the series, “Physiology at the Bedside” discussing the mechanisms of lower extremity edema.Read more on this topic in Harriso...

Ep 170: A 35-Year-Old with Changes in Vision

30 Oct 2025

Contributed by Lukas

This episode is a discussion with Harrison’s editor, Dr. Andrew Josephson, about multiple sclerosis.Read more on this topic in Harrison's.Harri...

Ep 169: A 65-Year-Old with Right-Sided Weakness

23 Oct 2025

Contributed by Lukas

This episode is a discussion with Harrison’s editor, Dr. Andrew Josephson, about the treatment of stroke.Read more on this topic in Harrison's....

Ep 168: A 52-Year-Old with Abdominal Pain and an Elevated Lipase

16 Oct 2025

Contributed by Lukas

This episode discusses the causes and evaluation of pancreatitis.Read more on this topic in Harrison's.Harrison's Principles of Internal Med...

Ep 167: A 23-Year-Old with Abdominal Pain and Diarrhea

09 Oct 2025

Contributed by Lukas

This episode reviews the differential diagnosis of abdominal pain in a young woman, along with the classification and treatment of the underlying cond...

Ep 166: A 64-Year-Old with Fatigue, Difficulty Sleeping, and Dyspnea on Exertion

02 Oct 2025

Contributed by Lukas

This episode reviews the diagnosis and acute management of tachycardia.Read more on this topic in Harrison's.Harrison's Principles of Intern...

Ep 165: A 63-Year-Old with an Elevated Hemoglobin

25 Sep 2025

Contributed by Lukas

This episode reviews the workup and differential diagnosis of a patient with an elevated hemoglobin (polycythemia), discovered on routine labs during ...

Ep 164: A 25-Year-Old Pregnant Woman Asking About Her Thyroid

18 Sep 2025

Contributed by Lukas

Today’s episode discusses thyroid testing and function in pregnancy.Read more on this topic in Harrison's.Harrison's Principles of Interna...

Ep 163: A 39-Year-Old with a Snakebite

11 Sep 2025

Contributed by Lukas

Today’s episode reviews different types of snakes and the clinical consequences of snakebites.Read more on this topic in Harrison's.Harrison&ap...

Ep 162: A 73-Year-Old Woman with Fever and Altered Mental Status

04 Sep 2025

Contributed by Lukas

This episode discusses a particular cause of sepsis and its treatment following a foodborne illness.Read more on this topic in Harrison's.Harriso...

Ep 161: A 28-Year-Old Pregnant Woman with an Abnormal Urinalysis

28 Aug 2025

Contributed by Lukas

In this episode, we discuss asymptomatic bacteriuria in a pregnant woman.Read more on this topic in Harrison's.Harrison's Principles of Inte...

Ep 160: A 32-Year-Old Pregnant Woman Seeking Advice on Exposures

21 Aug 2025

Contributed by Lukas

This episode reviews the epidemiology of lead exposure in the United States and its health implications.Read more on this topic in Harrison's.Har...

Ep 159: A 30-Year-Old at High Altitude

14 Aug 2025

Contributed by Lukas

This episode discusses the diagnosis and treatment of acute mountain sickness.Read more on this topic in Harrison's.Harrison's Principles of...

Ep 158: A 58-Year-Old with an Elevated PSA

07 Aug 2025

Contributed by Lukas

This episode talks about prostate-specific antigen (PSA) screening.Read more on this topic in Harrison's.Harrison's Principles of Internal M...

Ep 157: A 44-Year-Old with Cirrhosis and Shortness of Breath

31 Jul 2025

Contributed by Lukas

This episode reviews pleural effusions and how to distinguish between their different causes.Read more on this topic in Harrison's.Harrison'...

Ep 156: A 24-Year-Old Man with Noonan Syndrome and a Heart Murmur

24 Jul 2025

Contributed by Lukas

Today’s episode discusses congenital heart disease and reviews murmurs associated with particular valvular disorders.Read more on this topic in Harr...

Ep 155: An 18-Year-Old with Trauma to the Chest

17 Jul 2025

Contributed by Lukas

In this episode, we review the differential diagnosis of cardiac injuries.Read more on this topic in Harrison's.Harrison's Principles of Int...

Ep 154: A 58-Year-Old Going for Surgery

10 Jul 2025

Contributed by Lukas

Evaluation needed for a patient preparing for elective surgery.Read more on this topic in Harrison's.Harrison's Principles of Internal Medic...

Ep 153: A 55-Year-Old Here for an Annual Physical

03 Jul 2025

Contributed by Lukas

This episode discusses prostate cancer screening and risk-reducing strategies.Read more on this topic in Harrison's.Harrison's Principles of...

Ep 152: A 66-Year-Old with Inability to Speak

26 Jun 2025

Contributed by Lukas

This episode reviews the diagnosis, etiology, and treatment of strokes and transient ischemic attacks.22nd Edition of Harrison's – Now Availabl...

Ep 151: A 55-Year-Old with Cardiac Amyloid

19 Jun 2025

Contributed by Lukas

This episode reviews important concepts related to cardiac transplantation.Read more on this topic in Harrison's.Harrison's Principles of In...

Ep 150: Gas Exposure

12 Jun 2025

Contributed by Lukas

This episode examines toxic gas exposures—how they present, how to recognize them, and the antidotes that can save lives.Read more on this topic on ...

Ep 149: A 20-Year-Old with an Abnormal Chest X-Ray

05 Jun 2025

Contributed by Lukas

Read more on this topic on AccessMedicine.Harrison's Principles of Internal Medicine, 22nd Edition

Ep 148: A 55-Year-Old Man with Obesity

29 May 2025

Contributed by Lukas

This episode discusses the diagnosis of obesity, associated conditions, and treatment considerations.Read more on AccessMedicine.Harrison's Princ...

Ep 147: A 55-Year-Old with Hypertension

22 May 2025

Contributed by Lukas

In this episode, we explore non-pharmacologic strategies for controlling blood pressure.Read more on this topic on AccessMedicine.Harrison's Prin...

Ep 146: A 73-Year-Old Female with Lower Extremity Swelling

15 May 2025

Contributed by Lukas

This episode covers a woman experiencing subacute edema and anasarca due to renal disease, and reviews the possible underlying causes.Read more on thi...

Ep 145: A 45-Year-Old Snorer

08 May 2025

Contributed by Lukas

Today’s case is about a 45-year-old with suspected sleep apnea. We walk through the diagnostic workup and potential treatment options.Read more on A...

Ep 144: A 35-Year-Old with Burning Abdominal Pain

01 May 2025

Contributed by Lukas

We discuss a 35-year-old patient with burning abdominal pain due to H. pylori, covering the infection’s history, treatment, and follow-up care.Read ...

Ep 143: 5 Cases for Antibiotic Prophylaxis

24 Apr 2025

Contributed by Lukas

We discuss 5 cases for antibacterial prophylaxis, highlighting when it’s appropriate and the risks of overuse in different scenarios.Read more on Ac...

Ep 142: Infertility in a Couple of Reproductive Age

17 Apr 2025

Contributed by Lukas

In this episode, we explore the causes of infertility and the recommended initial evaluation.Harrison's Principles of Internal Medicine, 22nd Edi...

Ep 141: A 51-Year-Old with Stage 3 Breast Cancer

10 Apr 2025

Contributed by Lukas

A woman with a history of breast cancer presents with new back pain. This episode explores the differential diagnosis and diagnostic procedures.See mo...

Ep 140: A 45-Year-Old Man with Confusion After Running

03 Apr 2025

Contributed by Lukas

This episode discusses a patient with an elevated body temperature and explores heat-related illnesses.See more on this topic on AccessMedicineHarriso...

Ep 139: First Time Visit for a 73-Year-Old Man

27 Mar 2025

Contributed by Lukas

This episode reviews primary care principles for caring for older adults.See more on this topic on AccessMedicine.Harrison's Principles of Intern...

Ep 138: A 67-Year-Old Male After ICD Firing

20 Mar 2025

Contributed by Lukas

This episode covers implantable cardiac defibrillators and their management.See more on this topic on AccessMedicine.Harrison's Principles of Int...

Ep 137: A 21-Year-Old with Vaginal Discharge

13 Mar 2025

Contributed by Lukas

This episode reviews the differential diagnosis and diagnostic criteria for common conditions that would cause vaginal discharge.See more on this topi...

Ep 136: A 71-Year-Old Man with Prostate Cancer

06 Mar 2025

Contributed by Lukas

This episode covers a patient in a placebo-controlled clinical trial and explores the placebo effect.Read more on this topic on AccessMedicine.Harriso...

Ep 135: Elderly Couple Considering Home Renovations

27 Feb 2025

Contributed by Lukas

In this episode, we discuss the impact of ambient and household air pollutants, which may significantly affect respiratory and cardiac health.See more...

Ep 134: A 72-Year-Old Man with New-Onset Seizures

20 Feb 2025

Contributed by Lukas

In this episode, we discuss a 72-year-old man with new-onset seizures, exploring potential etiologies and initial treatment.See more on this topic on ...

Ep 133: A 45-Year-Old with Difficulty Climbing Stairs

13 Feb 2025

Contributed by Lukas

Today’s case features a young man presenting with shortness of breath and exercise-induced oxygen desaturation. The discussion delves into some gene...

Ep 132: A 72-Year-Old with Fatigue and Dyspnea on Exertion

06 Feb 2025

Contributed by Lukas

Today's patient is a woman who develops respiratory distress related to transfusion of red blood cells. Immunologic and non-immunologic complicat...

Ep 131: A 55-Year-Old with Differing Causes of Shortness of Breath

30 Jan 2025

Contributed by Lukas

How point-of-care ultrasound can be used in the clinic.Harrison's Principles of Internal Medicine, 22nd Edition

Ep 130: A 27-Year-Old with Penicillin Allergy

23 Jan 2025

Contributed by Lukas

A young woman with a history of penicillin allergy and an indication for penicillin treatment.  The discussion focuses on mechanisms of penicillin al...

Ep 129: A 68-Year-Old with Lower Abdominal Pain

16 Jan 2025

Contributed by Lukas

This episode talks about acute kidney injury, its complications, potential etiologies, and therapy.See more on this topic on AccessMedicineHarrison&ap...

Ep 128: A 72-Year-Old with Elevated White Blood Cell Count

09 Jan 2025

Contributed by Lukas

This episode presents a 72-year-old man with presumed non-infectious granulocytosis. The discussion focuses on the differential diagnosis and therapy....

Ep 127: A 65-Year-Old Male with a Spot on His Foot

02 Jan 2025

Contributed by Lukas

This episode presents a 65-year-old man with a new pigmented lesion on the sole of his foot. The discussion focuses on the differential diagnosis.See ...

Ep 126: A 60-Year-Old with Fever, Purulent Sputum, and Chest Pain

26 Dec 2024

Contributed by Lukas

This episode presents a 60-year-old man with acute respiratory symptoms and a cavitary lesion on chest CT. The discussion focuses on the likely etiolo...

Ep 125: A 19-Year-Old Man with Dysuria

19 Dec 2024

Contributed by Lukas

This case presents a 19-year-old man with new onset dysuria and purulent urethritis. The discussion focuses on likely diagnoses and appropriate therap...

Ep 124: A 64-Year-Old with Worsening Dyspnea and Cough

12 Dec 2024

Contributed by Lukas

This episode discusses a 64-year-old man who develops acute respiratory symptoms while climbing Mt. Kilamanjaro. The discussion focuses on the likely ...

Ep 123: 65-Year-Old Male with Hepatocellular Carcinoma (HCC)

22 Nov 2024

Contributed by Lukas

This episode presents a 65-year-old man recently who was diagnosed with hepatocellular carcinoma. We discuss environmental risk factors for the develo...

Ep 122: 45-Year-Old Healthy Man with Loss of Consciousness

31 Oct 2024

Contributed by Lukas

This episode presents a healthy 45-year-old who loses consciousness while playing tennis and is found to have focal neurologic findings. We discuss th...

Ep 121: Patient with Advanced Heart Failure

10 Oct 2024

Contributed by Lukas

This episode discusses recent advances in left ventricular assist devices and the clinical indications for this type of technological support.Harrison...

Ep 120: A 33-Year-Old with Dyspnea on Exertion

14 Feb 2024

Contributed by Lukas

Harrison's PodClass provides engaging, high-yield discussions of key topics commonly found on rotational and board exams in internal and family m...

Ep 119: A 75-Year-Old with Shock

14 Feb 2024

Contributed by Lukas

Harrison's PodClass provides engaging, high-yield discussions of key topics commonly found on rotational and board exams in internal and family m...

Ep 118: A 24-Year-Old with Facial Weakness

14 Feb 2024

Contributed by Lukas

Harrison's PodClass provides engaging, high-yield discussions of key topics commonly found on rotational and board exams in internal and family m...

Ep 117: A 62-Year-Old Male with Memory and Behavioral Problems

14 Feb 2024

Contributed by Lukas

Harrison's PodClass provides engaging, high-yield discussions of key topics commonly found on rotational and board exams in internal and family m...

Ep 116: A 35-Year-Old with an Elevated BMI

14 Feb 2024

Contributed by Lukas

Harrison's PodClass provides engaging, high-yield discussions of key topics commonly found on rotational and board exams in internal and family m...

Ep 115: A 50-Year-Old Perimenopausal Woman

10 Jan 2024

Contributed by Lukas

Harrison's PodClass provides engaging, high-yield discussions of key topics commonly found on rotational and board exams in internal and family m...

Ep 114: A 64-Year-Old Male with a Red Swollen Knee

10 Jan 2024

Contributed by Lukas

Harrison's PodClass provides engaging, high-yield discussions of key topics commonly found on rotational and board exams in internal and family m...

Ep 113: A 62-Year-Old with Pruritis

10 Jan 2024

Contributed by Lukas

Learn more about this in Chapter 355: Cirrhosis and Its ComplicationsIn this episode of Harrison's Podclass, Dr. Cathy Handy and Dr. Charlie Wien...

Ep 111: A 24-Year-Old with Pelvic Pain

20 Nov 2023

Contributed by Lukas

Harrison's Principles of Internal Medicine, 22nd Edition

Ep 110: A 67-Year-Old with Chronic Kidney Disease

20 Nov 2023

Contributed by Lukas

Harrison's Principles of Internal Medicine, 22nd Edition

Ep 112: A 23-Year-Old with Severe Anorexia

20 Nov 2023

Contributed by Lukas

Harrison's Principles of Internal Medicine, 22nd Edition

Ep 109: A 28-Year-Old Female with Worsening Dyspnea on Exertion

27 Oct 2023

Contributed by Lukas

Harrison's PodClass provides engaging, high-yield discussions of key topics commonly found on rotational and board exams in internal and family m...

Ep 108: A 70-Year-Old with Fatigue

27 Oct 2023

Contributed by Lukas

Harrison's PodClass provides engaging, high-yield discussions of key topics commonly found on rotational and board exams in internal and family m...

Ep 107: A 43-Year-Old with Eye Pain and Visual Changes

27 Oct 2023

Contributed by Lukas

Harrison's PodClass provides engaging, high-yield discussions of key topics commonly found on rotational and board exams in internal and family m...

Ep 106: A 21-Year-Old with ALL

14 Sep 2023

Contributed by Lukas

Harrison's PodClass provides engaging, high-yield discussions of key topics commonly found on rotational and board exams in internal and family m...

Ep 105: A 24-Year-Old Man with Altered Mental Status

14 Sep 2023

Contributed by Lukas

Harrison's PodClass provides engaging, high-yield discussions of key topics commonly found on rotational and board exams in internal and family m...

Ep 104: A 35-Year-Old with HIV

14 Sep 2023

Contributed by Lukas

Harrison's PodClass provides engaging, high-yield discussions of key topics commonly found on rotational and board exams in internal and family m...

Ep 103: A 57-Year-Old with a Swollen Knee

14 Sep 2023

Contributed by Lukas

Harrison's PodClass provides engaging, high-yield discussions of key topics commonly found on rotational and board exams in internal and family m...

Ep 102: A 54-Year-Old with Muscle Soreness

14 Sep 2023

Contributed by Lukas

Harrison's PodClass provides engaging, high-yield discussions of key topics commonly found on rotational and board exams in internal and family m...

Ep 101: A 27-Year-Old Woman with Right-Sided Weakness

14 Sep 2023

Contributed by Lukas

Harrison's PodClass provides engaging, high-yield discussions of key topics commonly found on rotational and board exams in internal and family m...

Ep 100: A 46-Year-Old Man with Vasculitis

23 May 2023

Contributed by Lukas

Harrison's PodClass provides engaging, high-yield discussions of key topics commonly found on rotational and board exams in internal and family m...

Ep 99: A 29-Year-Old Woman with Adenopathy

24 Apr 2023

Contributed by Lukas

Harrison's PodClass provides engaging, high-yield discussions of key topics commonly found on rotational and board exams in internal and family m...

Ep 98: A 68-Year-Old with Fatigue Intermittent Fevers and Night Sweats

12 Apr 2023

Contributed by Lukas

Harrison's PodClass provides engaging, high-yield discussions of key topics commonly found on rotational and board exams in internal and family m...

Ep 97: A 74-Year-Old with Thigh Pain

12 Apr 2023

Contributed by Lukas

Harrison's PodClass provides engaging, high-yield discussions of key topics commonly found on rotational and board exams in internal and family m...

Ep 96: A Patient with a Lung Mass

13 Sep 2022

Contributed by Lukas

Harrison's PodClass provides engaging, high-yield discussions of key topics commonly found on rotational and board exams in internal and family m...

Ep 95: Five Patients with Dyspnea

06 Sep 2022

Contributed by Lukas

Harrison's PodClass provides engaging, high-yield discussions of key topics commonly found on rotational and board exams in internal and family m...

Ep 94: A 15-Year-Old with Right Lower Quadrant Pain

30 Aug 2022

Contributed by Lukas

Harrison's PodClass provides engaging, high-yield discussions of key topics commonly found on rotational and board exams in internal and family m...