Immune Deficiency Foundation
Episodes
Every piece adds strength: Interactive art at the 2026 National Conference
05 May 2026
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/Transcription%20-%20Art%20installations.pdf On this episode of the Immune Deficiency Founda...
2026 National Conference: What to Expect in San Antonio
05 Apr 2026
Contributed by Lukas
Emma Mertens and Megan Messick discuss the Immune Deficiency Foundation's upcoming 2026 National Conference. Click here to register: https://web.cven...
"Make your own path as you walk." | CEO Jorey Berry introduces medical director Dr. Paula Henao
25 Mar 2026
Contributed by Lukas
TRANSCRIPT: https://primaryimmune.org/sites/default/files/TRANSCRIPT%20Jorey%20and%20Paula.pdf On this episode, CEO Jorey Berry sits down with the fo...
Exploring "Compromised: Life Without Immunity" | Behind the documentary
20 Feb 2026
Contributed by Lukas
On February 27, the Immune Deficiency Foundation's first documentary feature ("Compromised: Life Without Immunity") will be available for all to watch...
Why PI affects the skin: Common rashes, infections, and immune dysregulation (dermatology deep dive)
03 Feb 2026
Contributed by Lukas
TRANSCRIPT: https://primaryimmune.org/sites/default/files/TRANSCRIPT%20-%20Dermatological%20issues%20podcast.pdf Dr. Alexandra Freeman and Dr. Heidi ...
Primary immunodeficiency & dental health: Protecting your mouth when your immune system is fragile
13 Jan 2026
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/TRANSCRIPT%20PI%20and%20oral%20health.pdf Click here to view a a PDF of this presentation: ...
Undiagnosed: Reuben & Sherri Johnson on CGD, chronic illness, and the fight for healthcare
17 Dec 2025
Contributed by Lukas
TRANSCRIPT: https://primaryimmune.org/sites/default/files/TRANSCRIPT.Undiagnosed.Reuben.pdf Reuben Johnson was diagnosed with chronic granulomatous d...
Cancer risk in primary immunodeficiency (PI): Lymphoma, screening, and treatment explained
02 Dec 2025
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/Transcription%20-%20PI%20and%20cancer.pdf Dr. Charlotte Cunningham-Rundles provides a prese...
Job Hunting With Primary Immunodeficiency: HR Advice on Disclosure, Accommodations & Benefits
24 Nov 2025
Contributed by Lukas
TRANSCRIPT: https://primaryimmune.org/sites/default/files/TRANSCRIPT%20Job%20hunting%20with%20PI.pdf On this episode of ChronicXTwenties, Myles Templ...
How FOXP3 changed immunology: Tregs, IPEX, and the Nobel Prize explained
19 Nov 2025
Contributed by Lukas
TRANSCRIPT: https://primaryimmune.org/sites/default/files/TRANSCRIPT%20Discussing%20Nobel%20Prize.pdf Dr. Troy Torgerson (Allen Institute for Immunol...
Bold Conversations: Food justice with Dr. Jennifer Oilver
03 Nov 2025
Contributed by Lukas
TRANSCRIPT: https://primaryimmune.org/sites/default/files/TRANSCRIPT%20-%20FOOD%20JUSTICE.pdf Dr. Jennifer Oliver of Manna Movement Collaborative dis...
Living well with PI: Caregiving for chronic illness
06 Oct 2025
Contributed by Lukas
Jocelyn Cooper (Program manager, Black Women's Health Imperative) and Holly Jones (Executive director, HERstory In Color) give a presentation on careg...
Foundation Focus | September 2025
29 Sep 2025
Contributed by Lukas
TRANSCRIPT: https://primaryimmune.org/sites/default/files/TRANSCRIPT%20Foundation%20Focus%20September%202025.pdf Immune Deficiency Foundation CEO Jor...
ChronicXTwenties: College and mental health roundtable
22 Sep 2025
Contributed by Lukas
**This conversation includes the topics of suicidal and self-harm ideation. We understand that not everyone is capable of hearing such conversations. ...
Foundation Focus | August 2025
25 Aug 2025
Contributed by Lukas
Transcript: file:///E:/2025/Podcasts/CEO%20Updates/Transcript%20-%20FF%20Aug%202025.pdf CEO Jorey Berry provides an update for the month of August 20...
Lunch and Learn: HLH with Dr. Michael Jordan
21 Aug 2025
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/TRANSCRIPT%20-%20HLH.pdf Dr. Michael Jordan of Cincinnati Children's provides an overview o...
Undiagnosed: The wounds that won't close
19 Aug 2025
Contributed by Lukas
Dionne Stalling's 45-year diagnosis journey started with a mosquito bite. Her quest for answers took her through some of the unflinching truths of the...
Foundation Focus | July 2025
28 Jul 2025
Contributed by Lukas
President and CEO Jorey Berry provides an update for the month of July. Topics include new programming, Walk for PI, new resources, and our organizati...
Bold Conversations: Misinformation with Dr. Cynthia Baur
23 Jul 2025
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/TRANSCRIPT%20Bold%20Conversations%20-%20Misinformation.pdf Cynthia Baur, PhD, is a health l...
ChronicXTwenties: Demystifying advocacy
17 Jul 2025
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/TRANSCRIPT%20Chronic%20Twenties%20Advocacy.pdf Immune Deficiency Foundation staff members R...
Foundation Focus: June 2025 update with CEO Jorey Berry
30 Jun 2025
Contributed by Lukas
This program is presented with support from CSL Behring, Takeda, and Grifols. Read a transcript of this episode: file:///E:/2025/Podcasts/CEO%20Updat...
Lunch & Learn: Understanding genetic variants in APDS
10 Jun 2025
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/APDS%20Lunch%20and%20Learn%20transcript.pdf Dr. Jolan Walter (University of South Florida, ...
Jorey's monthly wrap-up: May 2025
29 May 2025
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/Transcript%20-%20May%20CEO%20Update.pdf Immune Deficiency Foundation CEO Jorey Berry provid...
Problems in practice: Insurance with Dr. Marcus Shaker
06 May 2025
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/Transcript%20Shaker.pdf Dr. Marcus Shaker is a professor of pediatrics in medicine at Dartm...
Jorey's monthly wrap-up: April 2025
30 Apr 2025
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/April%20CEO%20Transcript.pdf Immune Deficiency Foundation president and CEO Jorey Berry pro...
SPECIAL LOOK: Advocacy Day 2025 Training
28 Apr 2025
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/Advocacy%20Day%20Training%20Transcript.pdf This week, 150 advocates will represent the Immu...
Living well with PI: Impact of federal policy changes on the PI community
24 Apr 2025
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/TRANSCRIPT%20Legislative%20webinar.pdf This panel discussion features Immune Deficiency Fo...
Bold Conversations: The elephant in the exam room
21 Apr 2025
Contributed by Lukas
https://primaryimmune.org/sites/default/files/Bold%20Conversations%203.2%20Transcript.pdf In this session from the 2024 PI Conference in Chicago, Dr....
Decoding PI: The science of gene therapy and gene editing
07 Apr 2025
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/01PROOF%20transcription%20gene%20editing%20webinar.pdf View a PDF of this presentation: htt...
Jorey's monthly wrap-up: March 2025
31 Mar 2025
Contributed by Lukas
Immune Deficiency Foundation CEO Jorey Berry provides an overview of updates for the community in March 2025.
Undiagnosed: Gaslit and Gatekept
25 Mar 2025
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/FOR%20WEB%20Undiagnosed%20Ilana%20Transcript.pdf TikTok personality and author of "Medical ...
ChronicXTwenties: Transitioning from pediatric to adult care with Riley and Nick
02 Mar 2025
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/Cx20%201.1%20transcript.pdf. Immune Deficiency Foundation volunteers Riley and Nick discuss...
Jorey's monthly wrap-up: February 2025
28 Feb 2025
Contributed by Lukas
Immune Deficiency Foundation president and CEO Jorey Berry provides updates to the community for February 2025
Bold Conversations: Health insurance
21 Feb 2025
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/Bold%20Conversations%203.1%20Transcript.pdf Jalisa Clark is a Research Fellow at the Center...
CEO update from Jorey Berry: January 2025
21 Jan 2025
Contributed by Lukas
CEO update from Jorey Berry: January 2025 primaryimmune.org/resources
Living well with PI: Mental health and wellness tips
21 Jan 2025
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/Mental%20health%20tips.pdf Becky Lenning is the owner and clinical director of Yellow Lotus...
Undiagnosed: The Businessman
29 Dec 2024
Contributed by Lukas
CONTENT WARNING: This episode contains discussions of suicide planning. If you need help, call the National Suicide Hotline at 988. Transcript: https...
Q&A: Protecting yourself against COVID, flu, and RSV
08 Dec 2024
Contributed by Lukas
TRANSCRIPT: https://primaryimmune.org/sites/default/files/Covid%2C%20Flu%2C%20RSV.pdf This informative Q&A session offers crucial insights for patien...
Decoding PI: Unraveling the GI Connection
07 Dec 2024
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/Transcript%20-%20GI%20Connection.pdf View a PDF of this presentation: https://primaryimmune...
Q&A: Antibody Deficiencies with Dr. Luke Wall
04 Nov 2024
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/LUKE%20WALL%20antibody%20deficiency%20q%26a.pdf Dr. Luke Wall discusses antibody deficienci...
ChronicXTwenties: Heartbreakingly beautiful (Part 2)
30 Oct 2024
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/Cx20%20ep%202%20transcript.pdf In part two of our pilot episode, Heartbreakingly Beautiful,...
ChronicXTwenties: Heartbreakingly beautiful (Part 1)
22 Oct 2024
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/TRANSCRIPT%20-%20ChronicxTwenties%201.1-1.pdf In this 2-part pilot episode, two members of...
Bold Conversations: CGD and medical immigration with Susanna Raj
08 Oct 2024
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/Transcript%20-%20BC%2002.02%20Susanna%20Raj.pdf Susanna Raj joins Dr. Nicole to discuss the...
Bold Conversations: Inclusion in practice at the 2024 PI Conference
29 Aug 2024
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/Bold%20Conversations%202.2%20Transcription.pdf Immune Deficiency Foundation staff members A...
Bold Conversations: Social determinants of health
15 Jul 2024
Contributed by Lukas
Season 2 premiere. Dr. Nicole Rochester discusses social determinants of health, as well as ideas for creating more equitable living conditions for op...
Ask the expert: PI and fatigue
21 Mar 2024
Contributed by Lukas
Dr. Joud Hajjar provides an explanation of the causes and potential treatments for symptoms of fatigue with primary immunodeficiency. The information...
The Student: Darcy Gott and the risk of experience
21 Feb 2024
Contributed by Lukas
Darcy Gott shares stories of risks involved with having PI as a college student, from mismanaged university health systems to pressure to fit in, and ...
Undiagnosed (feat. Dr. Kelley Hagerich): Two Different Traumas
19 Dec 2023
Contributed by Lukas
One of the most universal issues those with primary immunodeficiency face in the U.S. is simply navigating a complicated medical system. Getting a ref...
Young adult roundtable: College, mental health, and PI.
14 Dec 2023
Contributed by Lukas
**This conversation includes the topics of suicidal and self-harm ideation. We understand that not everyone is capable of hearing such conversations. ...
ADA-SCID Gene Therapy Update with Dr. Don Kohn
06 Dec 2023
Contributed by Lukas
Dr. Don Kohn of UCLA provides an update on emerging gene therapy treatments for ADA-SCID. The information, terminology, and opinions presented in thi...
Undiagnosed (feat. The Autism Dad): Father and Son
30 Nov 2023
Contributed by Lukas
Rob Gorski shaped the way we discuss parenting for neurodivergent children with his acclaimed blog, The Autism Dad. While all three of his sons are on...
Bold Conversations Part 5: Health disparities in primary immunodeficiency with Dionne Stalling
26 Oct 2023
Contributed by Lukas
Dionne Stalling, founder of Rare and Black, discusses her decades-long journey to PI diagnosis with Dr. Rochester.
October 2023 CEO update with Jorey Berry
24 Oct 2023
Contributed by Lukas
Immune Deficiency Foundation CEO Jorey Berry provides an update for October 2023.
Bold Conversations Part 4: Health disparities in PI with Dr. Vivian Hernandez-Trujillo
02 Oct 2023
Contributed by Lukas
Drs. Nicole Rochester and Vivian Hernandez-Trujillo discuss disparities in PI, language barriers, rebuilding trust, and the importance of meeting comm...
Bold Conversations Part 3: The business case for health equity
23 Aug 2023
Contributed by Lukas
Dr. Jay Bhatt, Deloitte's Managing Director Center for Health Solutions and Health Equity Institute, joins Dr. Rochester to discuss the business and e...
Fireside chat with Emily V. Gordon
17 Aug 2023
Contributed by Lukas
Academy Award-nominated writer and producer Emily V. Gordon joins Tracy Shaw during the 2023 PI Conference to discuss vulnerability, storytelling, lim...
Undiagnosed (ft. Ironmouse): "The Performer"
04 Aug 2023
Contributed by Lukas
The saga of popular Twitch personality Ironmouse's life reads much like the anime stories from which she finds inspiration: A talented young woman’s...
CDawgVA talks history, career, and philanthropy
20 Jun 2023
Contributed by Lukas
Popular YouTube and Twitch personality CDawgVA talks about his history growing up in Wales, moving to Japan to pursue voice acting, and how meeting hi...
Transitioning from pediatric to adult care with Dr. Lauren Sanchez
05 Jun 2023
Contributed by Lukas
Dr. Lauren Sanchez delivers a talk on the complicated and emotional process of SCID and PI patients transitioning from pediatric to adult care. Trans...
Undiagnosed Episode 2: "The Gardener"
01 May 2023
Contributed by Lukas
Transcript: https://primaryimmune.org/sites/default/files/TRANSCRIPT%20--%20Undiagnosed%20Episode%202.pdf A cut on the roof of your mouth. A step in ...
Community Q&A: Primary Immunodeficiency & Neurological Issues with Dr. Stacey Clardy
19 Apr 2023
Contributed by Lukas
Dr. Stacey Clardy (Associate Professor of Neurology at the University of Utah, Salt Lake City VHA) answers questions from the PI community about her c...
Bold Conversations Part 2: The roots of medical mistrust among Communities of Color
04 Apr 2023
Contributed by Lukas
Dr. Sherita Golden (Vice President and Chief Diversity Officer, Professor at Johns Hopkins Medicine) joins Dr. Rochester to discuss the roots of medic...
Undiagnosed Episode 1: "The Caretaker"
06 Mar 2023
Contributed by Lukas
Series premiere. On average, it takes nine to fifteen years of untreated illness to be diagnosed with and treated for a Primary Immunodeficiency. Rece...
Bold Conversations Part One: What is Health Equity?
06 Feb 2023
Contributed by Lukas
Series premiere. Dr. Nicole Rochester, IDF's Medical Advisor for Health Equity, discusses the differences between equality and equity, where dispariti...
Skilled Nursing Facilities with Dr. M. Elizabeth M. Younger
18 Jan 2023
Contributed by Lukas
Dr. M. Elizabeth M. Younger of Johns Hopkins University School of Medicine joins IDF's Lynn Albizo and Stephanie Steele to discuss issues surrounding ...
Community Q&A: Gastrointestinal Issues and Primary Immunodeficiency
15 Dec 2022
Contributed by Lukas
Sarah C. Glover DO (Professor of Medicine, University of Mississippi) answers community questions about the relationships between gastrointestinal iss...
The Connection Between Mental and Physical Health
30 Nov 2022
Contributed by Lukas
Dr. John W. Seymour, PhD, LMFT (Professor Emeritus and Distinguished Faculty Scholar at Minnesota State University, Mankato)discusses the links betwee...
A SCID Compass Retrospective
31 Oct 2022
Contributed by Lukas
Alissa Creamer (IDF's Director of Community Services) and Melissa Raspa (RTI's Senior Research Public Health Analyst) discuss the successes of the 4-y...
Navigating Access to Quality Care with Primary Immunodeficiency
28 Sep 2022
Contributed by Lukas
IDF's own Colleen Brock (RN, Manager of Medical Programs) and Stephanie Steele (Director of Payor Relations and Policy) give a presentation on making ...
Returning to In-Person Events
23 Aug 2022
Contributed by Lukas
Returning to In-Person Events IDF's Tammy Black and Alissa Creamer discuss the organization's return to in-person events, as well as the safety proto...
State of the States: 2022 Policy Advocacy Overview
25 Jul 2022
Contributed by Lukas
2022 is already more than half over, so we at IDF are reflecting on the goals we’ve set, and the progress we’ve made toward meeting them. On this ...
Immunoglobulin Replacement Therapy: As Individual As You with Dr. M. Elizabeth M. Younger
01 Jul 2022
Contributed by Lukas
M. Elizabeth M. Younger, CRNP, PhD, Assistant Professor of Pediatrics at Johns Hopkins University School of Medicine joined us at a recent IDF forum t...
Convalescent Plasma and COVID-19 with Dr. Arturo Casadevall
26 May 2022
Contributed by Lukas
Dr. Arturo Casadevall is a Bloomberg Distinguished Professor of Molecular Microbiology & Immunology and Infectious Diseases, as well as a recent induc...
Q&A with IDF's President and CEO, Jorey Berry
13 May 2022
Contributed by Lukas
Tammy Black sits down with IDF's new President and CEO, Jorey Berry, to discuss surprises and goals after her first few months with the organization.
Supporting Siblings Of Children With Chronic Illness
25 Feb 2022
Contributed by Lukas
When a child is diagnosed with Severe Combined Immunodeficiency or SCID, not only is the child affected but the family is as well. In this episode, we...
What To Ask Your Healthcare Provider
11 Feb 2022
Contributed by Lukas
Being diagnosed with a rare disease like PI can be intimidating, as well as confusing. Hear from panelists, Nicole Rochester, MD, Mary Hintermeyer, AP...
IDF Advocate Connections: Becoming A Rare Disease Advisory Council Member
31 Jan 2022
Contributed by Lukas
For those living with rare diseases, such as PI, it is important to have a strong voice in state government and advise policymakers on critical issues...
Opportunities For Young People Of Color In Science
29 Dec 2021
Contributed by Lukas
According to the Bureau of Labor Statistics, employment in science, technology, engineering, math fields (otherwise known as STEM), is projected to gr...
Living With CGD: A Discussion About BMT - A Diagnosis-Specific Episode
16 Dec 2021
Contributed by Lukas
Chronic Granulomatous Disease or CGD, one of the rare forms of primary immunodeficiency, causes an increased susceptibility to infections caused by ce...
Assessing Neurodevelopmental Outcomes In SCID Patients: A Collaborative Study By IDF And PIDTC
17 Nov 2021
Contributed by Lukas
In this SCID Compass episode, we will be talking with two research specialists, Virdette L. Brumm, Ph.D., and Sharon A. Kidd, MPH, Ph.D., from the Pri...
Swimming Upstream: Addressing Payer Challenges & Ensuring Access To Genetic Testing
28 Oct 2021
Contributed by Lukas
In this episode, we will be addressing payer challenges as well as discussing the ability to ensure access to genetic testing with Manish Butte, MD, P...
Clinical Research Trials & You
15 Oct 2021
Contributed by Lukas
Are you interested in learning more about clinical research trials that are available for you? In today’s episode, we will be discussing important i...
How One Family Navigates Isolation For SCID During COVID - Part Of The SCID Compass Series
30 Sep 2021
Contributed by Lukas
Undergoing treatment for Severe Combined Immunodeficiency or SCID involves months in the hospital as well as months of isolation. Today, we will be sp...
Teens & Vaccines - Part Of The Teen Series
17 Sep 2021
Contributed by Lukas
As the Coronavirus progresses, the COVID-19 vaccine continues to be our best form of protection against the deadly virus, especially for those living ...
Successful Fundraising & Team Building: Learning From An IDF Walk For PI Team Captain
31 Aug 2021
Contributed by Lukas
One of IDF’s many great initiatives, IDF Walk for Primary Immunodeficiency, unites all members of the PI community to help create better lives for t...
The Public Face of PI
23 Jul 2021
Contributed by Lukas
For those living with primary immunodeficiency, awareness about these rare, chronic disorders is crucial. Listen as influential leaders within the PI ...
Health Equity
16 Jul 2021
Contributed by Lukas
As our nation grapples with issues of bias and racism, we have an obligation to address racial disparities in the PI community, in medicine, and in so...
Plasma Ethics
09 Jul 2021
Contributed by Lukas
Plasma-derived therapies are used daily by thousands of individuals around the world with chronic, rare conditions. Because of its diverse and lifesav...
Q&A with Kathryn Stephens
11 Jun 2021
Contributed by Lukas
While we usually dive into topics that are medical in nature, we wanted to take the opportunity today to talk with a subject matter expert of a differ...
Low T Cell Counts In Babies - Part of the SCID Compass Series
26 May 2021
Contributed by Lukas
As part of the blood screening during a newborn screening at birth, doctors measure the T cell receptor excision circles or TRECs to test if they are ...
Wiskott-Aldrich Syndrome (WAS) - A Diagnosis-Specific Episode
30 Apr 2021
Contributed by Lukas
Wiskott-Aldrich Syndrome or WAS is a unique form of primary immunodeficiency. WAS primarily affects males because it’s an X-linked recessive conditi...
Pain Management: From Infusions To Everyday Life
31 Mar 2021
Contributed by Lukas
Many people living with primary immunodeficiency rely on injectable medical therapies such as immunoglobulin replacement therapy, or Ig, to maintain h...
Genetic Counseling - Part of the SCID Compass Series
18 Feb 2021
Contributed by Lukas
Receiving advice or support after diagnosis of a genetic condition can be overwhelming for families. One resource for information about the condition ...
A Year In Our Lives In The Age Of COVID-19 - Part Of The Teen Series
29 Jan 2021
Contributed by Lukas
As we continue to battle COVID-19 into 2021, everything around us seems to be changing - attending school is now virtual, seeing our friends is done s...
Importance Of Long-term Follow-up After Treatment - Part of the SCID Compass Series
14 Dec 2020
Contributed by Lukas
Severe Combined Immunodeficiency, or SCID, is a life-threatening primary immunodeficiency, typically diagnosed at birth. Early detection is critical f...
Telemedicine: Getting Healthcare Online
19 Nov 2020
Contributed by Lukas
Making in-person doctor’s appointments and checkups have always been the norm for all of us. However, with the spread of the coronavirus, many of us...
Navigating Flu Season
29 Oct 2020
Contributed by Lukas
During the fall and winter months, as we begin to bundle up for the cold weather, we must also remember it’s time to protect ourselves during flu se...
All About Plasma
25 Sep 2020
Contributed by Lukas
People living with a primary immunodeficiency, or PI are missing key parts of their immune system that help fight infections. Some types of PI leave p...
Being Independent - Part of the Teen Series
11 Aug 2020
Contributed by Lukas
Figuring out your journey through life can be tough, especially as you grow older and more independent. One of the best parts of being a teenager is h...
Common Variable Immune Deficiency (CVID) - A Diagnosis-Specific Episode
16 Mar 2020
Contributed by Lukas
Common Variable Immune Deficiency, or CVID, is just one of the more than 400 primary immunodeficiencies, characterized by low levels of serum immunogl...