Journal of Clinical Oncology (JCO) Podcast
Episodes
Sorting Through Early Melanomas to Identify Those at Higher Risk for Metastases
12 Mar 2012
Contributed by Lukas
This podcast partitions patients with early melanoma into those with very favorable features and compares them to those with a higher risk for dying o...
Sedation for the Management of Refractory Suffering
12 Mar 2012
Contributed by Lukas
Incorporating the information form Dr Marconi's systematic review on the question "Does sedation at the end of life hasten death", I will provide use...
The Role of the Estrogen Receptor (ER) in Selecting Women, Diagnosed with DCIS for Adjuvant Therapy with Tamoxifen
05 Mar 2012
Contributed by Lukas
This podcast describes the results from a subgroup of 732 women in the NSABP B-24 trial for the treatment of DCIS, where ER status was available, and ...
How Cooperative Group Trials Impact Breast Cancer Care in United States
05 Mar 2012
Contributed by Lukas
In this podcast, I will review a JCO article showing that the publication of CALGB C9343 trial results had little influence in practice patterns in th...
What's Different Between One Colorectal Cancer and Another? It's All in the Genes
05 Mar 2012
Contributed by Lukas
This podcast will discuss the current role of characterizing KRAS and BRAF in the management of colorectal cancer as well as a manuscript by Popovici ...
Molecular Tumor Analyses Followed by First Line Oral Tyrosine Kinase Inhibitors in Lung Adenocarcinomas with Driver Abnormalities
28 Feb 2012
Contributed by Lukas
Patients with epidermal growth factor receptor (EGFR) gene mutations should receive EGFR tyrosine kinase inhibitors as 1st line therapy because they p...
Placing the P Value into Perspective: Does Paclitaxel Add Value to Gemcitabine and Cisplatin in Advanced Urothelial Cancers?
28 Feb 2012
Contributed by Lukas
This JCO Podcast provides observations and commentary on the JCO article, "Randomized Phase III study comparing Paclitaxel Cisplatin Gemcitabine and ...
Early Stage Hodgkin Lymphoma -- How Much is Enough?
21 Feb 2012
Contributed by Lukas
The management of patients with early stage Hodgkin lymphoma with unfavorable characteristics remains a topic for study.
The Rich Get Richer: Another Efficacious Option for Refractory Hairy Cell Leukemia
21 Feb 2012
Contributed by Lukas
This podcast reports on a phase I/II trial investigating novel anti-CD22, moxetumomab pasudotox, in the treatment of patients with refractory hairy ce...
Rethinking Our Use of CSFs in the Adjuvant Treatment of Women Who Have Estrogen Receptor Positive Cancers
06 Feb 2012
Contributed by Lukas
When dose dense treatment was first described we were greatly enthusiastic for all women with breast cancer. As the experience has matured we now real...
Recurrence and Survival Results of the GOG Lap2 Trial Confirm Safety of the Laparoscopic Approach to Surgical Staging and Treatment for Uterine Cancer
30 Jan 2012
Contributed by Lukas
This podcast summarizes and discusses the outcome results of the GOG Lap2 trial which shows safety and clinical benefits of laparoscopy as compared to...
"Anything You Can't Do, I Can't Do Either": Transplantation for High Risk AML
30 Jan 2012
Contributed by Lukas
This is a commentary on a report from the EBMT demonstrating a higher relapse rate after allogeneic transplantation in AML patients with FLT3 ITD muta...
Safety and Efficacy of Sequential Adjuvant AI Therapy in ER Positive Breast Cancer
19 Jan 2012
Contributed by Lukas
Long-term follow-up of efficacy and toxicity outcomes from the IES study of adjuvant aromatase inhibitor therapy in postmenopausal estrogen receptor p...
The Role of Ovarian Suppression for Fertility Preservation in Women Receiving Adjuvant Breast Cancer Chemotherapy
09 Jan 2012
Contributed by Lukas
This podcast discusses the findings from the manuscript by Munster et al. regarding the use of ovarian suppression for fertility preservation in young...
Using BCR-ABL Transcript Levels After 3 Months of Therapy on Imatinib is the Best Way to Predict Long-Term Outcome for Patients with CML Treated with Imatinib
09 Jan 2012
Contributed by Lukas
The study by Marin et al is another milestone in our understanding how to manage CML patients on tyrosine kinase inhibitors.
The Importance of Tumor Biopsies for Analysis of Mechanisms of Response and Resistance in Prostate Cancer
19 Dec 2011
Contributed by Lukas
This podcast will summarize the results of Efstathious et al and discuss possible mechanisms of resistance to castration based therapies in prostate c...
Targeting the Angiopoietin-Tie2 Axis: A Promising Alternative Antiangiogenic Strategy for Epithelial Ovarian Cancer
19 Dec 2011
Contributed by Lukas
Targeting the Angiopoietin-Tie2 axis is a promising alternative antiangiogenic strategy for the treatment of ovarian cancer that exhibits non-overlapp...
Interim PET Scans in Diffuse Large B-Cell Lymphoma - More Than Another Biomarker?
12 Dec 2011
Contributed by Lukas
This podcast reviews data from a recent publication on the use of "early" interim PET scanning in diffuse large B-cell lymphoma and comments on the c...
To Biopsy or Not to Biopsy? That is the Question
07 Dec 2011
Contributed by Lukas
Biopsy of presumed metastatic breast cancer sites confirms the diagnosis in most women and alters therapy in 14% of women in a prospective study of 12...
Disparities in Systemic Therapy for Breast Cancer
05 Dec 2011
Contributed by Lukas
This podcast provides a commentary on the article by Wu et al that addresses disparities in systemic therapy for breast cancer.
Adjusting for Treatment Cross-Over to Enable Analysis of Longer Term Outcomes in the MA.17 Trial
28 Nov 2011
Contributed by Lukas
This Podcast reviews the background of the MA.17 trial, the results of the present manuscript and provides perspective on the current findings.
Obesity and Colorectal Cancer: What's the Big Deal?
28 Nov 2011
Contributed by Lukas
This podcast summarizes the findings of this JCO article and provides commentary on its applicability to practice.
Combinations or Single Agents, Crossover or No Crossover: Considering Chemotherapy Strategies in the Multi-Chaptered Story of Metastatic Breast Cancer
14 Nov 2011
Contributed by Lukas
This podcast will critically review randomized phase III trial data examining the relative role of taxane monotherapy versus combination therapy as fi...
Medical Oncologist Attitudes and Practice in Cancer Pain Management: A National Survey
14 Nov 2011
Contributed by Lukas
This podcast discusses findings and implications of a recent survey study on attitudes and knowledge about cancer pain among medical oncologists
Is a "Wait and See" Nonoperative Approach Justified after Chemoradiation for Rectal Cancer
07 Nov 2011
Contributed by Lukas
This podcast will explore the feasibility of a nonoperative "wait and see" approach based on strict selection criteria in patients with locally advanc...
Predictive Testing for BRCA1/2 Mutations: The Value of the "True"Negative
31 Oct 2011
Contributed by Lukas
This podcast reviews the evidence that women testing negative for known familial BRCA1/2 mutations should adhere to current population breast cancer s...
Trastuzumab in the Adjuvant Setting - Sequential versus Concurrent: Will We Ever Know the Full Answer?
31 Oct 2011
Contributed by Lukas
This Podcast provides observation and commentary on the JCO article "Sequential versus concurrent trastuzumab in adjuvant chemotherapy for breast canc...
Solving the Mystery of Recurrence in "Surgical Cures" for Early Non-Small Cell Lung Cancer
11 Oct 2011
Contributed by Lukas
Podcast to review the article "Occult Metastases in Length Nodes Predict Survival In Resectable Non-Small Cell Lung Cancer: Report of the ACOSOG Z4004...
Comorbidity Data in Cooperative Trials: Feasible and Non Ignorable
11 Oct 2011
Contributed by Lukas
The ATAC investigators collected comorbidity data on more than 9000 women and this article illustrates that it provides key information.
Gender Equity and HPV-Associated Cancers in the United States
29 Sep 2011
Contributed by Lukas
Rapid, dramatic shifts are ongoing in the population-level epidemiology of oropharynx cancer in the United States.
Biomarker Selection for Maintenance Therapy in Advanced NSCLC
29 Sep 2011
Contributed by Lukas
EGFR mutation is a predictive biomarker for maintenance erlotinib but its clinical application is limited. This podcast will explain why.
Osteonecrosis in Pediatric Acute Lymphoblastic Leukemia
26 Sep 2011
Contributed by Lukas
This podcast summarizes the incidence and long-term outcome of osteonecrosis in a large prospective study of children treated for acute lymphhoblastic...
R-CHOP Chemotherapy as Upfront Treatment for Advanced Stage Follicular Non-Hodgkin Lymphoma
15 Sep 2011
Contributed by Lukas
This podcast evaluates the context and reviews results of a randomized phase III trial comparing R-CHOP given at conventional 21 day intervals with R-...
Venlafaxine and Clonidine for Treatment of Hot Flashes in Women with Breast Cancer
12 Sep 2011
Contributed by Lukas
This podcast reviews the randomized double-blind placebo-controlled trial reported by Boekhout et al. that evaluates venlafaxine and clonidine for the...
Response to Neoadjuvant Systemic Therapy for Breast Cancer in BRCA Mutation Carriers and Non-Carriers: A Single Institution Experience
31 Aug 2011
Contributed by Lukas
This podcast reviews the retrospective study by Arun et al. and discusses the lack of consensus regarding the relative chemosensitivity of breast canc...
Individualizing the Risk of Cardiovascular Mortality Following Androgen Deprivation Therapy for Prostate Cancer
15 Aug 2011
Contributed by Lukas
Androgen deprivation therapy may not be associated with an increase in cardiovascular mortality in all men but only those with a prior cardiac event d...
High Risk Stage II Colon Cancer: What is the Role of Adjuvant Chemotherapy?
21 Jul 2011
Contributed by Lukas
Stage II colon cancer with high risk factors is often treated with adjuvant therapy, however new data raise questions about the usefulness of this pra...
Is Genotype Guided Tamoxifen Dosing Ready for Prime Time?
18 Jul 2011
Contributed by Lukas
Commentary on a successful study in which genotype-guided tamoxifen dosing increased endoxifen concentrations in women with reduced CYP2D6 metabolism.
Menopausal Hormone Therapy, Mammographic Density and Breast Cancer
23 Jun 2011
Contributed by Lukas
Estrogen plus progestin and estrogen alone have different effects on mammographic density and breast cancer.
The Growing Value of Risk Calculators for Men Considering Prostate Cancer Screening
20 Jun 2011
Contributed by Lukas
This is a commentary on a recent study comparing two risk calculators for use in the setting of prostate cancer screening.
Interpretation of the Biomarker Analysis and Final Overall Survival Results from IPASS
13 Jun 2011
Contributed by Lukas
This podcast describes the analysis of the IPASS study population by EGFR mutation and EGFR FISH biomarker status, and also discusses the results and ...
Curing Leukemia with a Single Drug
06 Jun 2011
Contributed by Lukas
The use of arsenic trioxide as a single agent can produce long lasting remissions and a significant cure rate in patients with acute promyelocytic leu...
Vaccination with an Autologous Idiotype Based Vaccine Following a Chemotherapy Induced Remission Holds Promise in the Treatment of Patients with Follicular Lymphoma
31 May 2011
Contributed by Lukas
In this podcast, results of randomized phase III clinical trial evaluating the effects of a patient specific idiotype tumor vaccine in patients with f...
Pathologic Complete Response and Toxicity Results from the STAR-01 Trial Evaluating the Addition of Oxaliplatin to Neodjuvant Chemoradiation for Locally Advanced Rectal Cancer
23 May 2011
Contributed by Lukas
The addition of oxaliplatin to fluorouracil-based neoadjvuant chemoradiation for locally advanced rectal cancer significantly increases toxicity but d...
MEK Inhibitors
16 May 2011
Contributed by Lukas
The term targeted therapy is often used in cancer drug development. This podcast will discuss the study of a mEK inhibitor where the investigators ac...
Angiogenic Therapy in Breast Cancer: Axitinib with Chemotherapy Joins the Crowd
09 May 2011
Contributed by Lukas
Commentary on a new small molecule inhibitor of angiogenesis in combination with chemotherapy for metastatic breast cancer.
Advanced Radiation Therapy Technology Improves Survival in Lung Cancer
02 May 2011
Contributed by Lukas
This SEER based study demonstrated that the advanced radiation therapy technique of three-dimensional conformal radiation therapy improved survival co...
The Dark Side of del(5q) MDS
25 Apr 2011
Contributed by Lukas
This podcast will discuss the basic background of myelodysplastic syndromes and the clinical implications of TP53 mutations predicting outcomes in del...
Neoadjuvant Chemotherapy for Muscle Invasive Bladder Cancer: Is it Ready for Prime Time?
18 Apr 2011
Contributed by Lukas
This podcast describes the long term outcomes of patients treated with chemotherapy first, followed by either cystectomy or radiation therapy. It prov...
Are Lung Cancers with BRAF Mutations Another Molecularly Defined Subgroup of Patients?
11 Apr 2011
Contributed by Lukas
In this week's podcast, Dr. Jaine discusses the recent manuscript by Paik and colleagues evaluating BRAF mutations in patients with advanced lung canc...
Targeting the VEGF Receptor in Colon Cancer: Lessons Learned from Negative Trials
04 Apr 2011
Contributed by Lukas
In this podcast, Dr. Neal J. Meropol provides his perspective on two large randomized studies of vatalanib in patients with metastatic colorectal canc...
The Performance of Breast MRI Screening Among Women with BRCA1/2 Mutations
28 Mar 2011
Contributed by Lukas
By Mary Daly. Stage at diagnosis of breast cancer among women with BRCA1/2 mutations was available for women enrolled in a multi-modality screening p...
Circulating Tumor Cells in Resectable Colorectal Cancer
24 Mar 2011
Contributed by Lukas
By David Ryan. This JCO Podcast provides observations and commentary on the JCO article, "Clinical Significance of Circulating Tumor Cells Including ...
Results From a Phase I Trial of TG101348, a Selective JAK2 Inhibitor with Significant Activity in Symptomatic Myelofibrosis Patients
17 Mar 2011
Contributed by Lukas
By Reed Drews. This JCO Podcast provides observations and commentary on the JCO article, "Safety and Efficacy of TG101348, a Selective JAK2 Inhibitor,...
RIBBON-1 Revisited
17 Mar 2011
Contributed by Lukas
By Lisa Carey. The randomized Phase III trial, Ribbon-1, was designed to examine whether the benefit of bevacizumab added to chemotherapy in metastat...
Noninferiority of Denosumab As Compared With Zolendronic Acid With Respect to the Ability to Delay Skeletal Events in Patients With Solid Tumors and Multiple Myeloma
17 Mar 2011
Contributed by Lukas
By David Avigan. This podcast describes a phase III randomized study comparing the efficacy and toxicity of Denosumab with Zolendronic Acid for the p...