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Less of You: Life on Semaglutide & Tirzepatide

Society & Culture Health & Fitness

Activity Overview

Episode publication activity over the past year

Episodes

Why you shouldn’t go off meds

27 Mar 2026

Contributed by Lukas

Kami goes off her GLP-1, stops her thyroid meds, and gains back 25 lbs. After 3 months of Eva being angry for no reason, it turns out she just needs h...

The Dryer Shrunk My Jeans

09 Jan 2026

Contributed by Lukas

Kami runs out of weight loss meds during the holidays, gains 10 pounds, and blames the dryer for shrinking her clothes. Eva overschedules everything, ...

I took a 4 week break from semaglutide and here’s what happened

14 Nov 2025

Contributed by Lukas

Eva gets ghosted in the middle of an important situation and spirals for a day. Kami stops her meds and finds out what it feels like to be hungry agai...

You Want Fries With That?

03 Oct 2025

Contributed by Lukas

After sewing a quilt on the floor, Kami’s back goes out. After kicking a dumbbell, her foot goes out too.New compounded meds including glycine and B...

Replacing one addiction with another?

05 Sep 2025

Contributed by Lukas

While working on a project about addiction, Eva realizes she went from drinking and smoking to a food addiction. But she’s not even sure what her “...

How to hide that you’re on a GLP-1

15 Aug 2025

Contributed by Lukas

If you want to keep your meds a secret from someone you live with, here’s how we would keep it secret. Kami’s cat, Leonardo Von Flouffe, makes hi...

Have we replaced food noise with mom guilt?

08 Aug 2025

Contributed by Lukas

How does being hungry seem to interfere with every activity? One child can’t stop eating sugar, the other starts yelling about being hungry while s...

Do GLP-1s Help With Binge Eating?

18 Jul 2025

Contributed by Lukas

Ashley tried everything. She tried all the diets: Weight Watchers, Nutrisystem, SlimFast, Houston Methodist Medical Weight Management program. Even af...

Not-So Texas Roadhouses

20 Jun 2025

Contributed by Lukas

Kami forgets to track her calories and take her meds. Eva sends her daughter to camp and Kami remembers getting left behind at camp at age 12, back wh...

Muffin Top, Sleep Apnea, Payment Plans

23 May 2025

Contributed by Lukas

Eva gained a few pounds back and got a muffin top. Kami vs. insurance: It should not be this hard to get sleep apnea treatment.Yep, you can get a pay...

No I Don’t Feel Totally Different Now

25 Apr 2025

Contributed by Lukas

Kami broke her foot, and can’t move. Eva ate 4 dark chocolate mini eggs and got sick (4 eggs, not 4 bags of eggs). We beat the question “Don’t y...

Teetering on the Edge of One-derland

14 Mar 2025

Contributed by Lukas

Kami finally busted through the plateau, now hovering at 200 at officially down 50 lbs. Eva’s creeping toward 100 lbs lost,  and had to try on size...

The GLP-1 and addiction connection no one’s talking about with Dr. Jason Giles

07 Mar 2025

Contributed by Lukas

In this special bonus episode, an excerpt from a conversation with Los Angeles Addictionologist Dr. Jason Giles about the potential for GLP-1s as a tr...

Debra’s 6 month progress update & tips for those with only 15 lbs to lose

14 Feb 2025

Contributed by Lukas

The Debra returns with a progress update and fills in for Kami, who’s out with the flu. She started at 168, now at 154, aiming for 150. It took alm...

Possibly The Worst Before Photo Ever

31 Jan 2025

Contributed by Lukas

Kami stalls at 203 and wonders if it’s time for a higher dose to make it to one-derland. Eva shares a jaw-dropping “before” pic from August 202...

Tips for Newbies: Getting Started on Semaglutide and Tirzepatide

03 Jan 2025

Contributed by Lukas

New to semaglutide or tirzepatide? Here are our tips for what to expect when you are just getting started.  We survived the mountains of Christmas f...

Even More Rear End Problems

13 Dec 2024

Contributed by Lukas

Thanksgiving chaos update, questionable ingredients brought by in-laws, a recurrence of rear-end issues, and how Eva got peer-pressured into tucking i...

If your weight loss progress is stalled on a GLP-1, here’s my advice

29 Nov 2024

Contributed by Lukas

Eva has lost 90 lbs, the equivalent of 9 gallons of paint according to the Lose It! app. It’s Kami’s birthday and she makes big plans for the nigh...

No plans to binge

15 Nov 2024

Contributed by Lukas

Still blowing money on groceries we end up tossing, planning the menu for Thanksgiving but not planning to binge eat, and excited to have full houses....

This is Halloween

08 Nov 2024

Contributed by Lukas

Eva feels fat and to feel better tries on the largest jeans she ever owned (size 20W).Kami gives a fire recovery update while wearing a fox costume fo...

Life keeps happening

01 Nov 2024

Contributed by Lukas

Kami’s 92-year-old neighbor’s house burns down, the 2nd fire in a year of serving on the HOA board. Eva forgets a full order of groceries in the c...

It’s just a number, it doesn’t mean anything

28 Oct 2024

Contributed by Lukas

Weigh yourself every day. Don’t weigh yourself every day. Only weigh yourself at the weigh-in. Weigh yourself in the morning after you go to the bat...

Oat-zempic

04 Oct 2024

Contributed by Lukas

Eva's 30 year high school reunion approaches with the same worries as high school, including what to wear and who will I know? Kami’s in full freak...

Body dysmorphia, self-injecting B12 & The Debra makes an appearance (Kami’s mom)

20 Sep 2024

Contributed by Lukas

Kami’s mom Debra joins with her own skinny shot update after 8 weeks. Kami’s endocrinologist breaks up with her because her thyroid is perfect. Ev...

Making weight loss medication affordable in Indiana with Cassie Layne, FNP [BONUS]

06 Sep 2024

Contributed by Lukas

Because Cassie Layne, FNP, knows the struggle of dealing with weight firsthand, she’s dedicated to making health and wellness accessible for everyon...

The MexiMelt is Coming Back

30 Aug 2024

Contributed by Lukas

Taco Bell’s Meximelt is coming back. Eva’s eyesight improves instead of getting worse for the first time since 8th grade. Kami catches a Facebook ...

Transportation and vacation

16 Aug 2024

Contributed by Lukas

Kami’s daughter’s school bus keeps skipping her stop in the morning. She gets a new job but is then un-hired two days later. While on family vacat...

Quit the medication so you can eat again

02 Aug 2024

Contributed by Lukas

Kami’s job as HOA president takes a stressful turn as she fights with State Farm to get construction moved forward on the 4 houses that burned down ...

Insurance coverage, bowel obstruction, stomach paralysis, and SO much more with Dr. Sulagna Misra [BONUS]

26 Jul 2024

Contributed by Lukas

After losing more than 70 lbs herself, Dr. Sulagna Misra changed her life and now uses her experience to help others do the same. Dr. Misra shares he...

More Rear End Problems

12 Jul 2024

Contributed by Lukas

Continuing our unintentional rear-end-themed mini series with a fissure while on vacation. Is all the weird stuff we talk about helping anyone? Please...

Meet the legend, Dr. Johnny Franco! [BONUS]

10 Jul 2024

Contributed by Lukas

Meet the man, the doctor, the legend, who heard about semaglutide and then took it himself, losing over 70 lbs. Realizing his success would help thous...

Shit My Pants

28 Jun 2024

Contributed by Lukas

After Kami forgot her medication at home (again) and didn’t have medication for 20 days, she invented her own plan for restarting and discovered the...

Finding One-derland

14 Jun 2024

Contributed by Lukas

Kami leaves for a 3+ week trip to Washington and forgets her meds at home and rediscovers the effects of marijuana, while Eva finally reaches the magi...

Please don’t take my drugs away

31 May 2024

Contributed by Lukas

Finally switching to tirzepatide after 4 months of stalled progress, Eva is quickly approaching “one-derland.”  Kami learns that the voices in he...

Trying on Swimsuits is Fun?

17 May 2024

Contributed by Lukas

Kami fails to prepare for a long trip out of town and runs out of medication.  Eva complains about random things like compliments from other people a...

My Vacation from the Medication

03 May 2024

Contributed by Lukas

Discussing the reactions to photos posted online, getting hit on by a lady valet while parking at SXSW, and whether or not it’s a good idea to take ...

My Life Goal Is To Be Just Overweight

19 Apr 2024

Contributed by Lukas

In the six weeks since Kami started semaglutide, she’s lost more weight than expected and describes the handful of side effects she’s experienced ...

Rule #373: Only take photos from 6 feet above

08 Apr 2024

Contributed by Lukas

On the mind games of how, when, and who we can take photos with and why… and what inspired (forced) Eva to finally share her previously unseen befor...

Chicken Burgers, Dead Birds, and the Aftermath of Kami’s 1st Shot

25 Mar 2024

Contributed by Lukas

Five days after Kami’s first semaglutide injection, we catch up on the weirdness of our lives and attempt to figure out why cookies are making Eva f...

How did we get so fat?

01 Mar 2024

Contributed by Lukas

As Kami anxiously awaits the arrival of her first semaglutide shot by mail and what's about to happen, Eva reflects on her eating habits going back to...

Introducing Less of You

08 Feb 2024

Contributed by Lukas

While losing weight with the help of semaglutide, Eva Sheie and Kami Gamlem confront our reasons for being obese.Eva - SW: 280 CW: 213 GW: ?Kami - SW:...