Medtech Talk

Gelfand and Levin Share Lessons from Ardian’s Rise and Fall…and Rise Again. Would They Do It Again?

06 May 2019

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Howard Levin and Mark Gelfand, the principals of Coridea, return to the podcast to detail the trials and tribulations of Ardian. Ardian is one of the bigger #medtech #startup stories over the past two decades. In 2011, Medtronic agreed to pay $800 million upfront for this company that pushed the once crazy idea of ablating renal nerves to lower hypertension. Ardian had raised $70 million from a syndicate of blue chip investors after being forged in the Foundry incubator. VCs proudly shared that the earnouts for Ardian would push that price well over $1 billion. This was a HUGE win for Medtech when it desperately needed it. Three years later came the fall. A day before JP Morgan’s Healthcare Meeting in 2014, Medtronic announced early disappointing of SYMPLICITY HTN-3, a third and larger trial of Ardian’s renal denervation. Medtronic revised the trial, running Spryal HTN on patients who didn’t take any medication for their hypertension – a contrast from the Symplicity trial where patients were taking an average of five medications. In these revised trials, renal denervation is performing much better. The new results exonerated Ardian’s early backers – and perhaps Gelfand and Levin, specifically. This was the team, after all, that combed through medical libraries for clues about hacking the human body to beat back hypertension. The research turned up the discovery that surgeons once would treat extremely unresponsive hypertension by severing nerves near the kidney. The procedure worked, but it was dangerous. Levin and Gelfand saw ablating tissue as a safer path. And, after a lot of trudging up and down the Valley, finally found a willing partner in the team at The Foundry. Early clinical success led to a renal denervation gold rush. Nearly every VC and Strategic investor had a bet in this space. The 2014 debacle convinced many to close their programs and companies, but now Renal Denervation is back in favor. How did Howard Levin and Mark Gelfand enjoy the roller coaster ride? In this podcast, we’ll talk about Ardian, TAVR, the challenges facing Medtech VCs and the poor reception many surgeons give new interventional technologies.

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13:00H | 21 DIC 2025 | Fin de Semana

01 Jan 1970

Fin de Semana

10:00H | 21 DIC 2025 | Fin de Semana

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12:00H | 20 DIC 2025 | Fin de Semana

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2ª PARTE | 06 ENE 2026 | EL PARTIDAZO DE COPE

01 Jan 1970

El Partidazo de COPE

3ª PARTE | 22 ENE 2026 | EL PARTIDAZO DE COPE

01 Jan 1970

El Partidazo de COPE

3ª PARTE | 04 MAR 2026 | EL PARTIDAZO DE COPE

01 Jan 1970

El Partidazo de COPE

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Medtech Talk

Gelfand and Levin Share Lessons from Ardian’s Rise and Fall…and Rise Again. Would They Do It Again?

This episode hasn't been transcribed yet

Other recent transcribed episodes

13:00H | 21 DIC 2025 | Fin de Semana

10:00H | 21 DIC 2025 | Fin de Semana

12:00H | 20 DIC 2025 | Fin de Semana

2ª PARTE | 06 ENE 2026 | EL PARTIDAZO DE COPE

3ª PARTE | 22 ENE 2026 | EL PARTIDAZO DE COPE

3ª PARTE | 04 MAR 2026 | EL PARTIDAZO DE COPE

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