MeSsy with Christina Applegate & Jamie Lynn Sigler

A Conversation with Jamie’s Therapist

05 May 2026

Contributed by Lukas

This week, Jamie sits down with her therapist, Ana Maria Rodriguez, who is a licensed clinical mental health therapist and the founder and owner of Se...

The Friendship Episode

28 Apr 2026

Contributed by Lukas

This week, Jamie is joined by her two best friends, Becca Tobin and Odette Annable. They discuss navigating friendships in all seasons of life, giving...

A Conversation with Jamie's Husband

21 Apr 2026

Contributed by Lukas

This week, Jamie is joined by her husband, Cutter Dykstra. They discuss his experience as her partner and caregiver, the role he's played in Jamie's ...

A MeSsy Update!

31 Mar 2026

Contributed by Lukas

We’re taking a short break for the next few weeks while Jamie and Christina focus on their book launches. We’ll be back soon with brand new episod...

Olivia Munn

24 Mar 2026

Contributed by Lukas

This week, Christina and Jamie are joined by Olivia Munn. They discuss Olivia’s breast cancer diagnosis, how she was finally able to shed her armor,...

Carl Radke

17 Mar 2026

Contributed by Lukas

This week, Christina and Jamie are joined by Carl Radke, Summer House cast member and  host of "More Life with Carl Radke.” They discuss his journe...

How to Heal Your Relationship With Life

10 Mar 2026

Contributed by Lukas

This week, Christina and Jamie are joined by Jamie’s friend Ryan Weiss. They discuss how he helped her through a difficult time, the power of dance,...

We Don’t Want to Be Defined by This

03 Mar 2026

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss the fragility of life, fighting against your body, and more, Executive Producers: C...

Kelly Ripa

24 Feb 2026

Contributed by Lukas

This week, Christina and Jamie are joined by their friend Kelly Ripa. They discuss Kelly's career and how it began at a toy fair, the processing she h...

Stop Talking About It for a Minute

17 Feb 2026

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss skincare products from childhood, crazy animal stories, not thinking too far into the ...

How You Feel on the Inside Can Be Up to You

10 Feb 2026

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss the Married... with Children reunion, catch up on their TV shows, Jamie opens up abou...

I Can't Worry About Tomorrow

03 Feb 2026

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss MS fatigue, finding little moments of self care, how to better communicate with friend...

Bobbi Brown

27 Jan 2026

Contributed by Lukas

This week, Christina and Jamie are joined by Bobbi Brown. They discuss overcoming obstacles, how to elevate your mood, taking baby steps, and much mo...

I’m a F**king Warrior

20 Jan 2026

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss Jamie’s recent trip, pregnancy and MS, asking for help, and more. Executive Produ...

The Impact of Inflammation with Dr. Will Cole

13 Jan 2026

Contributed by Lukas

This week, Christina and Jamie are joined by Dr. Will Cole, a functional medicine expert. They discuss how to calm inflammation, medical gaslighting, ...

This Is Not Your Fault

06 Jan 2026

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss repeat reality stars, being a mother with MS, not blaming yourself, and more. Execu...

There’s a Lot of Unknown in Life

30 Dec 2025

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss Christmas elves, setting goals, reclaiming your voice, and more. Executive Producer...

Are You Mad At Me? with Meg Josephson

16 Dec 2025

Contributed by Lukas

This week, Christina and Jamie are joined by Meg Josephson, author of “Are You Mad at Me?: How to Stop Focusing on What Others Think and Start Livin...

Montel Williams

09 Dec 2025

Contributed by Lukas

This week Christina and Jamie are joined by Montel Williams. They discuss his experience living with MS, bedside manner, why being ill doesn’t make...

We're All Crushing It

02 Dec 2025

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss perspective, not stuffing your feelings down, journaling, and much more. Executive...

How to Feel Safe in Your Body with Deb Dana (Re-Release)

25 Nov 2025

Contributed by Lukas

This week, Christina and Jamie are revisiting their conversation with Deb Dana, LCSW, a clinician and speaker specializing in complex trauma. They dis...

You Don’t Deserve to Feel Guilt

18 Nov 2025

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss big feelings, reality dating shows, guilt, and more. Executive Producers: Christina...

Best of MeSsy: Edie Falco, Jean Smart, and Katey Sagal

11 Nov 2025

Contributed by Lukas

This week, we revisit conversations with three incredible guests: Edie Falco, Jean Smart, and Katey Sagal. Executive Producers: Christina Applegat...

Robert Iler

04 Nov 2025

Contributed by Lukas

This week, Christina and Jamie are joined by Robert Iler, who starred on "The Sopranos" with Jamie. They discuss memories from their time on the show,...

How Vulnerable Can I Be? with Craig Thomas

28 Oct 2025

Contributed by Lukas

This week Christina and Jamie are joined by Craig Thomas, an author and  Co-Creator, Executive Producer and Writer of How I Met Your Mother. He share...

We Don’t Move Past It, We Move With It

21 Oct 2025

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss aging, being able to express emotions authentically, where to turn when you’re feeli...

Everybody’s Got Something

14 Oct 2025

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss dynamic disability, not being alone in your struggles, the meaning we attach to things...

It’s Okay to Be Yourself with Baylen Dupree

07 Oct 2025

Contributed by Lukas

This week Christina and Jamie are joined by Baylen Dupree. She opens up about having Tourette syndrome, the importance of being yourself, why it's cru...

Megan Mullally

30 Sep 2025

Contributed by Lukas

This week Christina and Jamie are joined by Megan Mullally. They discuss how her role as Karen on Will & Grace came to be, understanding family trauma...

Do What You Can When You Can

23 Sep 2025

Contributed by Lukas

This week Christina and Jamie are joined by Christina’s friend, Cindy Locke. They share how they first connected online and discuss the impact of tr...

Fraser Olender

16 Sep 2025

Contributed by Lukas

This week, Christina and Jamie are joined by Fraser Olender from “Below Deck.” They discuss what his job as chief stew actually entails, his journ...

We Are Not the Things That Happen to Us

09 Sep 2025

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss conditional friends, not identifying as the things that happen to us, staying honest, ...

Change Your Brain, Change Your Pain with Dr. Daniel Amen

02 Sep 2025

Contributed by Lukas

This week, Christina and Jamie are joined by Dr. Daniel Amen, a physician, double board-certified psychiatrist, and award-winning researcher. They dis...

We Have to Pivot

26 Aug 2025

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss their kids starting the new school year, the power of manifestation, accepting reality...

I Just Wanna Be Stoned

19 Aug 2025

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss hormones, housewives, acknowledging the struggle, and more. Executive Producers: Chri...

Ed Helms

12 Aug 2025

Contributed by Lukas

This week, Christina and Jamie are joined by Ed Helms. They discuss working together on "Vacation," his love of comedy, the importance of curiosity, a...

Live From the Hospital

05 Aug 2025

Contributed by Lukas

This week, Christina joins Jamie live from the hospital in LA. They discuss what Christina’s going through, her recent trip abroad, their upcoming m...

Jenny Mollen

29 Jul 2025

Contributed by Lukas

This week, Christina and Jamie are joined by Jenny Mollen, a New York Times bestselling author and actor. They discuss the feeling of not being in con...

Easy on My Nervous System

22 Jul 2025

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss wins and losses, shows that are easy on the nervous system, why people don't understan...

Any Movement Counts with Doctor Gretchen

15 Jul 2025

Contributed by Lukas

This week, Christina and Jamie are joined by Dr. Gretchen Hawley, an MS-certified specialist and physical therapist. They discuss what to do if you're...

Life Is Like an Episode of Chopped

08 Jul 2025

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss body work, Christina’s new obsession, and much more. Executive Producers: Christin...

Clea Shearer

01 Jul 2025

Contributed by Lukas

This week, Christina and Jamie are joined by Clea Shearer. They discuss how The Home Edit came to be, Clea’s breast cancer diagnosis, and the import...

There Are All Kinds of Heartbreak

24 Jun 2025

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss how connected our bodies are with our emotions, friendship heartbreaks, starting a fam...

Judd Apatow

17 Jun 2025

Contributed by Lukas

This week, Christina and Jamie are joined by Judd Apatow. They discuss working on "Anchorman," parenting advice, spirituality, and much more.  Exe...

How Could You Not Like Pizza?

10 Jun 2025

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss New York pizza, the trick to finding lost jewelry, how brain inflammation affects us, ...

Kaitlyn Bristowe

03 Jun 2025

Contributed by Lukas

This week, Christina and Jamie are joined by Kaitlyn Bristowe. They discuss starting over, the impact of therapy, their love of dance, and much more. ...

F Our Lives... Let’s Read Some Emails

27 May 2025

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss being the “everything” friend, feeling validated in what you’re going through, f...

David Faustino

20 May 2025

Contributed by Lukas

This week, Christina and Jamie are joined by Christina’s TV brother, David Faustino. They share their memories from “Married... with Children,”...

Conan O'Brien

13 May 2025

Contributed by Lukas

This week, Christina and Jamie are joined by Conan O'Brien. They discuss perspective, the importance of having morals, the circle of life, and much mo...

Let the Mess Out

06 May 2025

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss “Bad Moms,” princess cake, EMDR therapy, and more. Executive Producers: Christi...

JoAnna Garcia Swisher

29 Apr 2025

Contributed by Lukas

This week, Christina and Jamie are joined by JoAnna Garcia Swisher, who is an actress, the co-founder of The Happy Place, and one of Jamie’s best fr...

Everybody Walks Too Fast

22 Apr 2025

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss the feeling of cleaning your closet, the difference between healing and fixing, doing ...

Diana-Maria Riva

15 Apr 2025

Contributed by Lukas

This week, Christina and Jamie are joined by Diana-Maria Riva, who was Christina’s co-star on “Dead to Me.” They discuss their experience workin...

You Don’t Have to Be Perfect at Life

08 Apr 2025

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss how to open up about your diagnosis, the stress of trying to be perfect, finding balan...

Mel Robbins

01 Apr 2025

Contributed by Lukas

This week, Christina and Jamie are joined by bestselling author and podcast host, Mel Robbins. They discuss pushing through obstacles, how to apply t...

Andy Cohen

25 Mar 2025

Contributed by Lukas

This week, Christina and Jamie are joined by Andy Cohen. They indulge in their Bravo obsession and discuss why reality TV helps when you’re going t...

One Year of MeSsy

18 Mar 2025

Contributed by Lukas

This week, on the one year anniversary of MeSsy’s launch, Christina and Jamie read listener emails. They also discuss going where the love is, payin...

Katey Sagal

11 Mar 2025

Contributed by Lukas

This week, Christina and Jamie are joined by Katey Sagal. They share their perspectives from “Married... with Children,” and discuss walking thro...

Heels and Hats

04 Mar 2025

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss giving yourself a little push, finding ways to enjoy life, setting achievable goals, ...

How to Make Your Own Community with Allie Signorelli

25 Feb 2025

Contributed by Lukas

This week, Christina and Jamie are joined by Allie Signorelli, a Young Onset Parkinson’s patient and advocate. They discuss her journey to getting d...

Reimagining Your Dreams with Chad King

18 Feb 2025

Contributed by Lukas

This week, Christina and Jamie are joined by musician Chad King. They discuss his diagnosis, the burden of living in a state of flight or fight, A Gre...

I Don’t Want to Feel Like I’m Broken Anymore

11 Feb 2025

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss mobility aids, going out of your comfort zone, the impact of stress, and more.  Exec...

How to Feel Safe in Your Body with Deb Dana

04 Feb 2025

Contributed by Lukas

This week, Christina and Jamie are joined by Deb Dana, LCSW, a clinician and speaker specializing in complex trauma. They discuss how to understand ou...

Christian Siriano

28 Jan 2025

Contributed by Lukas

This week, Christina and Jamie are joined by fashion designer Christian Siriano. They discuss how he came to work with Christina, inclusivity in fashi...

John King

21 Jan 2025

Contributed by Lukas

This week, Christina and Jamie are joined by John King, CNN's chief national correspondent. He shares why he finally decided to stop hiding his MS dia...

We Love LA

14 Jan 2025

Contributed by Lukas

This week, Christina and Jamie share their thoughts on the Los Angeles wildfires, and discuss disclosing disabilities in the workplace, dating with MS...

How Trauma Gets Stored in the Body with Dr. Scott Lyons

07 Jan 2025

Contributed by Lukas

This week, Christina and Jamie are joined by Dr. Scott Lyons, a licensed holistic psychologist, educator, and author. They discuss how trauma gets st...

Roses and Thorns

31 Dec 2024

Contributed by Lukas

This week, Christina and Jamie reflect on their roses and thorns from the year, and discuss how to handle kids and bullying, the power of words, and m...

You Don’t Know What Anyone Else Is Going Through with Jesse Solomon

24 Dec 2024

Contributed by Lukas

This week, Christina and Jamie are joined by their first bravolebrity, Jesse Solomon, who is also a two-time testicular cancer survivor. They discuss...

The Permission to Cry

17 Dec 2024

Contributed by Lukas

This week, Christina and Jamie read listener letters and discuss being your messiest self, figuring it out as you go, keeping track of the good things...

Putting Life on Paper with Liz Feldman

10 Dec 2024

Contributed by Lukas

This week, Christina and Jamie are joined by Liz Feldman, the creator of “Dead to Me.” They discuss what it was like on set when Christina receive...

Take a Break and Bravo

03 Dec 2024

Contributed by Lukas

This week, Christina and Jamie discuss their holiday traditions, sitting with feelings, believing in miracles, and more.  Executive Producers: Christ...

No Time for Inauthenticity with Amber Lewis

26 Nov 2024

Contributed by Lukas

This week, Christina and Jamie are joined by Amber Lewis, founder of Amber Interiors, who is also living with MS. They discuss her dramatic perspectiv...

Ball of Trauma

19 Nov 2024

Contributed by Lukas

This week, Christina and Jamie discuss the different trauma responses we have, the importance of bedside manner, living minute to minute, medical gasl...

Kathy Bates

12 Nov 2024

Contributed by Lukas

This week, Christina and Jamie are joined by Kathy Bates. They discuss Kathy's incredible career, how our pain is our power, feeling invisible as we a...

The Beauty of the Invisible Disease with Rory Kandel

05 Nov 2024

Contributed by Lukas

This week, Christina and Jamie are joined by Rory Kandel, founder of Rory’s Bakehouse, who was also recently diagnosed with MS. They discuss Rory’...

When It’s Good, Let It Be Good

29 Oct 2024

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss sitting in joy, doing inner child work, the importance of recovery, and more. Executiv...

Acceptance Doesn’t Mean You Have to Like It with Brooke Eby

22 Oct 2024

Contributed by Lukas

This week, Christina and Jamie are joined by Brooke Eby (@limpbroozkit), who is living with ALS. She shares her long diagnosis process, and they discu...

It Doesn’t Define Us, but It’s a Part of Us

15 Oct 2024

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss uncertainty, why we hide our diagnoses, the comfort of television, and more. Executive...

An Honest Conversation About Grief with Jessica Klepser

08 Oct 2024

Contributed by Lukas

This week, Christina and Jamie are joined by Christina’s best friend, Jessica Klepser. After losing her two daughters and their father in a tragic a...

Throw out Your Kites

01 Oct 2024

Contributed by Lukas

This week, Christina and Jamie read listener emails and discuss mindfulness, invisible diseases, not knowing what others are dealing with, and much mo...

Minka Kelly

24 Sep 2024

Contributed by Lukas

This week, Christina and Jamie are joined by Minka Kelly. They discuss the process of telling your own story, acknowledging how something has changed...

When There’s a Will, There’s a Way

17 Sep 2024

Contributed by Lukas

This week, Christina and Jamie read listener emails. Jamie shares an update on Beau, and they also discuss mindset shifts, saying no, and more. Execut...

Lance Bass

10 Sep 2024

Contributed by Lukas

This week, Christina and Jamie are joined by their good friend, Lance Bass. They share how they each met, and discuss gratitude, staying grounded, sil...

Give Yourself This Grace

03 Sep 2024

Contributed by Lukas

This week, Christina and Jamie discuss bucket list items, the many types of healing, and they answer some listener questions. This episode was recorde...

Ed O'Neill

27 Aug 2024

Contributed by Lukas

This week, Christina and Jamie are joined by Ed O’Neill. They share memories from “Married... with Children,” discuss how their friendship has ...

I Love When People Cancel

20 Aug 2024

Contributed by Lukas

This week, Christina and Jamie discuss the joy of missing out, pushing past your limit, feeling forced to be a certain way because of circumstance, an...

Robin Roberts

13 Aug 2024

Contributed by Lukas

This week, Christina and Jamie are joined by Robin Roberts. Robin shares what she learned from being both a patient and a caregiver. They also discuss...

The Power of Beau

06 Aug 2024

Contributed by Lukas

This week, Jamie shares an update about what's been going on with her son, Beau. She and Christina also discuss the power of mothers, why it's crucial...

See Ya Shame!

30 Jul 2024

Contributed by Lukas

This week, Christina and Jamie discuss aging, the brief moments that have a big impact, how to deal with shame, and more. Executive Producers: Christ...

Reverend Michael Beckwith

23 Jul 2024

Contributed by Lukas

This week, Christina and Jamie are joined by Reverend Michael Beckwith, founder of the Agape International Spiritual Center. They discuss spirituality...

I Have MS... Google It

16 Jul 2024

Contributed by Lukas

This week, Christina and Jamie discuss learning how to rest and slow down, being child actors, and more. Christina also shares some behind-the-scenes ...

Will Ferrell

09 Jul 2024

Contributed by Lukas

This week, on the 20th anniversary of “Anchorman,” Christina and Jamie are joined by Will Ferrell. They share memories from filming the movie and ...

The Only Guarantee in Life Is Change

02 Jul 2024

Contributed by Lukas

This week, Christina and Jamie discuss the ups and downs of living with a chronic illness, acceptance, the importance of paying attention to your body...

Sadie

25 Jun 2024

Contributed by Lukas

This week, Christina and Jamie are joined by a very special guest... Christina's daughter Sadie. She opens up about some of her own health challenges,...

Sh*t Happens

18 Jun 2024

Contributed by Lukas

This week, Christina and Jamie discuss the importance of not holding things in, the stages of grief, finding people to lean on, and more. Executive P...

Jennifer Esposito

11 Jun 2024

Contributed by Lukas

This week, Christina and Jamie are joined by Jennifer Esposito. Jennifer opens up about her celiac disease and the struggle she went through to get a ...

You Get What You Give

04 Jun 2024

Contributed by Lukas

This week, Christina and Jamie discuss feeling trapped, missing high heels, their favorite shows that they’ve worked on, and more. This episode was ...

Katie Couric

28 May 2024

Contributed by Lukas

This week, Christina and Jamie are joined by Katie Couric. They discuss the importance of community and honesty, why we need more collaboration over c...

Jean Smart

21 May 2024

Contributed by Lukas

This week, Christina and Jamie are joined by Jean Smart. They share memories from when Christina and Jean worked together, and discuss taking back you...