Oncology for the Inquisitive Mind

199. Back to Basics - Metastatic Colorectal Cancer - last line options

03 May 2026

Contributed by Lukas

Good therapeutic options for metastatic colorectal cancer are limited after the fluoropyrimidine-based options are exhausted. This week, we explore th...

198. Back to Basics - Early Oesophageal Cancer

26 Apr 2026

Contributed by Lukas

Today's episode, like several of the greatest cult classics, comes a bit earlier than anticipated. Before we wrap up our epic recap of the colorectal ...

197. Back to Basics - Metastatic Colorectal Cancer - HER2 positive disease and PI3K mutations

18 Apr 2026

Contributed by Lukas

Metastatic Colorectal Cancer has a dearth of targetable mutations that have effective outcomes. This week, Michael and Josh see whether the wonder dru...

196. Back to Basics - Metastatic Colorectal Cancer - BRAFV600E and KRAS

09 Apr 2026

Contributed by Lukas

While Michael dreams of getting a haircut, this week we discuss the role of more targeted agents in metastatic colorectal cancer. KRAS and BRAF mutati...

195. Back to Basics - Metastatic Colorectal Cancer - Targeted Therapy

28 Mar 2026

Contributed by Lukas

Historically, colorectal cancer treatment has been fairly standard, but this has shifted over the past decade with the introduction of targeted therap...

194. Metastatic Colorectal Cancer

21 Mar 2026

Contributed by Lukas

Metastatic colorectal cancer is one of the most common causes of death in the cancer world, as well as one of the most common types of cancer. Chemoth...

193. Prof Jonathan E Rosenberg MD and Genitourinary Cancers

14 Mar 2026

Contributed by Lukas

Professor Jonathan E. Rosenberg, MD, serves as the Chief of the Genitourinary Oncology Service at Memorial Sloan Kettering Cancer Centre (MSKCC). He i...

192. Back to Basics - Early Colorectal Cancer - Part 2!

07 Mar 2026

Contributed by Lukas

The DYNAMIC duo are back, with Michael climbing the "Everest" of oncology and exploring the role of CTDNA in stage two colorectal cancer. Josh has the...

191. Back to Basics - Early Colorectal Cancer

28 Feb 2026

Contributed by Lukas

This week, we explore early colorectal cancer. Maybe it’s just this week, but there were plenty of “IDEAS” around. Michael highlights the import...

190. Back to Basics - Mesothelioma

21 Feb 2026

Contributed by Lukas

Mesothelioma can strike at any time, but it most commonly affects those in their 70s, with cases continuing well into the 2030s. The time from exposur...

189. Back to Basics - Extensive Stage Small Cell Lung Cancer

16 Feb 2026

Contributed by Lukas

This week, we return to our regular programming with a back-to-basics exploration of extensive small-cell lung cancer. A notorious killer and an aggre...

188. Gastrointestinal Cancer and Professor Jenny Seligmann

11 Feb 2026

Contributed by Lukas

Today, our guest is a transformative figure in bowel cancer treatment. Professor Jenny Seligmann, a Consultant Medical Oncologist and Professor of Gas...

187. ESMO Awards - Episode 7

02 Feb 2026

Contributed by Lukas

In our final take on ESMO 2025, we talk about Genitourinary Cancers. This was a dense area with numerous trials. Today we explore distimiab vedotin in...

186. ESMO Awards - Episode 6

25 Jan 2026

Contributed by Lukas

ESMO Episode 6 is here! The longest award ceremony in the world continues. This episode covers colorectal cancer, a cancer stream that has relied heav...

185. ESMO Awards - Episode 5

21 Jan 2026

Contributed by Lukas

We're back, baby! Michael and Josh predicted their ESMO journey would have eons to run, and they weren't wrong! For our first episode back in 2026, we...

184. ESMO Awards - Episode 4

13 Dec 2025

Contributed by Lukas

This week, we discuss neuroendocrine tumours and melanoma as our ESMO 25 journey continues. Trials for neuroendocrine cancers include HIF-2 alpha inhi...

183. ESMO Awards - Episode 3

05 Dec 2025

Contributed by Lukas

For our third instalment of ESMO 2026, we explore lung cancer in all its glory, including small cell, mesothelioma and non-small cell lung cancer. Stu...

182. ESMO Awards - Episode 2

26 Nov 2025

Contributed by Lukas

ESMO 2025 continues this week with coverage including early breast cancer, metastatic breast cancer and gynaecological malignancies. A mammoth episode...

182. ESMO Awards - Episode 1

15 Nov 2025

Contributed by Lukas

After a short break for some pretty major life changes (more details in the episode), Josh and Michael return to tackle the best and brightest of ESMO...

181. Back to Basics - Limited Stage Small Cell Lung Cancer

18 Oct 2025

Contributed by Lukas

In this episode, the focus shifts away from the more "garden-variety" non-small cell lung cancer and to its less common, frequently more aggressive si...

180. Back to Basics - Metastatic NSCLC feat. KRAS and MET mutations

12 Oct 2025

Contributed by Lukas

On this week's episode, Josh and Michael exchange the established treatment landscape of EGFR and ALK mutant NSCLC for the developing management of di...

179. Back to Basics - Metastatic NSCLC feat. EGFR and ALK Driver Mutations

05 Oct 2025

Contributed by Lukas

In this episode, Michael and Josh take a dive into the world of driver mutations, looking at two of the most clinically consequential: EGFR and ALK mu...

178. Back to Basics - Metastatic Non Small Cell Lung Cancer (mNSCLCa)

27 Sep 2025

Contributed by Lukas

Advanced or Metastatic Non Small Cell Lung Cancer (mNSCLCa), is one of the most common causes of death worldwide. This week, Michael provides an excel...

177. Back to Basics - Early Non Small Cell Lung Cancer

13 Sep 2025

Contributed by Lukas

To Josh's immense displeasure, our series on genitourinary cancer is done. For now, at least. In this episode, Michael and Josh step into the heavy sh...

176. Back to Basics - Germ Cell Tumours (part 2)

06 Sep 2025

Contributed by Lukas

In this episode, Michael and Josh continue to unpick the thorny question of germ-cell tumours, focusing this week on more advanced and relapsed diseas...

175. Back to Basics - Germ Cell Tumours (part 1)

30 Aug 2025

Contributed by Lukas

This episode is the first of a two-part mini-series where Michael and Josh attempt to untangle the complex topic of germ cell tumours, an area that re...

174. Back to Basics - Non Clear-Cell Renal Cell Cancer (RCC)

24 Aug 2025

Contributed by Lukas

In this episode, Josh and Michael take a trip down a road less travelled by both patients and researchers, and examine the evidence (or lack thereof) ...

173. NECTA (New South Wales Early Phase Clinical Trials Alliance) - The Origin Story

17 Aug 2025

Contributed by Lukas

How do you increase access to phase 1 trials for a state with a population of 8 million people spread across 800,000 km^2? You collaborate! In this co...

172. Back to Basics - Advanced ccRCC

09 Aug 2025

Contributed by Lukas

Unlike the adjuvant space, treatment of advanced clear cell renal cell cancer has been a success story potentially only surpassed by advanced melanoma...

171. Back to Basics - Early Clear Cell Renal Cell Cancer (ccRCC)

02 Aug 2025

Contributed by Lukas

Continuing on their Back to Basics GU extravaganza, Josh and Michael progress to the subject of kidney cancer, and bring you the answer to a question ...

170. Back to Basics - Adjuvant Urothelial Cancer

26 Jul 2025

Contributed by Lukas

Josh and Michael return to their normal scheduled broadcast, continuing their never-ending Back to Basics series. In this episode, they discuss severa...

169. ASCO 2025 - Colorectal Cancer with Prof Jeanne Tie

05 Jul 2025

Contributed by Lukas

In our final ASCO 2025 episode, Michael is joined by Prof Jeanne Tie, colorecal cancer lead at Peter MacCallum Cancer Centre to discuss some of the ma...

168. ASCO 2025 - Early Breast Cancer with Dr. Belinda Yeo

03 Jul 2025

Contributed by Lukas

In this episode, Michael goes it alone, welcoming an old friend of the show, Dr Belinda Yeo, to discuss highlights in early breast cancer from ASCO 20...

167. ASCO 2025 - Upper GI and Hepatobiliary Cancer with Dr. James McCracken

30 Jun 2025

Contributed by Lukas

Today, hosts Michael and Josh are joined by the wonderful Dr James McCracken to discuss highlights from ASCO 2025 in the areas of upper GI and hepatob...

166. ASCO 2025 - Gynecological Oncology with Dr. Prachi Bhave

28 Jun 2025

Contributed by Lukas

Today, we discuss the latest advancements in gynecological oncology presented at ASCO 2025, featuring insights from Dr. Prachi Bhave. The conversation...

165. ASCO 2025 - Palliative Care with Dr. Janet Abrahm

23 Jun 2025

Contributed by Lukas

In this episode, Dr. Janet Abrahm shares transformative insights from ASCO 2025, focusing on palliative care and supportive care in oncology. Topics d...

164. ASCO 2025 - Lung Cancer with Dr. Ned McNamee

22 Jun 2025

Contributed by Lukas

In this episode, Dr. Ned McNamee discusses the latest advancements in lung cancer treatment presented at ASCO 2025, focusing on significant studies su...

163. ASCO 2025 - Genitourinary Cancers (Bladder and Renal) with Dr. Enrique Grande

19 Jun 2025

Contributed by Lukas

Today, we cover ASCO 2025 in the genitourinary space, specifically bladder and renal cancer. Dr. Enrique Grande, a renowned oncologist and Program and...

162. ASCO 2025 - Genitourinary Cancers (Prostate) with Dr. Anthony Joshua

16 Jun 2025

Contributed by Lukas

Today, we’re joined by Professor Anthony Joshua, head of Medical Oncology at St. Vincent’s Hospital, Sydney, and a global leader in prostate cance...

161. ASCO 2025 - Breast Cancer with Dr. Adam Brufsky

15 Jun 2025

Contributed by Lukas

In this episode, we unpack game-changing insights from ASCO 2025 with a spotlight on breast cancer. Joining us is Dr. Adam Brufsky, a trailblazing onc...

160. ASCO 2025 - Plenary Part 2

11 Jun 2025

Contributed by Lukas

In our second plenary episode, we're spotlighting two pivotal phase 3 trials: SERENA-6, which explores ctDNA-guided treatment with camizestrant to del...

159. ASCO 2025 - Plenary Part 1

07 Jun 2025

Contributed by Lukas

This year, Michael and Josh bring you the American Society of Clinical Oncology (ASCO) 2025. To keep it fresh, we're doing things a little differently...

158. Back to Basics - Metastatic Urothelial (Bladder) Cancer

31 May 2025

Contributed by Lukas

This week, we talk about metastatic bladder cancer. The last two years have seen drastic changes in this space, with the addition of immunotherapy and...

157. Back to Basics - Early Bladder Cancer

24 May 2025

Contributed by Lukas

This week, we explore muscle-invasive bladder cancer (MIBC). This space has made significant progress with the completion of two pivotal trials. The f...

156. Back to Basics - Prostate Cancer - Biochemical Recurrence and Oligometastatic Disease Control

17 May 2025

Contributed by Lukas

As we "EMBARK" on our next Prostate Cancer adventure via the "SOLAR" system to "SATURN," Michael and Josh explore the idea of biochemical recurrence i...

155. Back to Basics - Theranostics and Prostate Cancer

10 May 2025

Contributed by Lukas

Marie Curie's life work laid the foundations for theranostics. This week, we talk about Lutetium, a rare earth metal, and its role in Prostate Cancer....

154. Back to Basics - Non Metastatic and Metastatic Prostate Cancer - The Journey Continues

03 May 2025

Contributed by Lukas

Prostate Cancer has a multitude of presentations, but when metastatic, it usually spreads directly to the lymph nodes or the bones. This episode focus...

153. Inflammatory Breast Cancer with Dr Massimo Cristofanilli, M.D.

26 Apr 2025

Contributed by Lukas

This week, we interview Dr. Cristofanilli, a globally recognised expert in inflammatory breast cancer research and precision medicine. With decades of...

152. Back to Basics - High Volume Metastatic Prostate Cancer

05 Apr 2025

Contributed by Lukas

Today, we discuss the role of triplet therapy (ie, chemotherapy and androgen receptor signalling inhibitor and ADT) in high-volume metastatic hormone-...

151. Back to Basics - Androgen Receptor Pathway Inhibitors in Metastatic Prostate Cancer

29 Mar 2025

Contributed by Lukas

The rise and rise of Androgen Receptor Pathway (or Signalling) Inhibitors has changed the world of metastatic prostate cancer forever. What was once a...

150. Back to Basics - Recurrence-Score Assays in Early Breast Cancer

22 Mar 2025

Contributed by Lukas

Our final breast cancer episode is here! Today, we are talking about the role of Gene Expression Assays in early hormone receptor-positive breast canc...

149. Back to Basics - Metastatic Hormone Sensitive Prostate Cancer

15 Mar 2025

Contributed by Lukas

This week, we prematurely dive into prostate cancer (one breast episode remaining - whoops!), where we explore the early pivotal trials, including the...

148. Back to Basics - Metastatic Triple Positive (HER2) Breast Cancer

08 Mar 2025

Contributed by Lukas

As our breast cancer journey comes close to finishing, it was always the destiny of your cohost's on Oncology for the Inquisitive Mind to talk about H...

147. Back to Basics - Metastatic Triple Negative Breast Cancer

01 Mar 2025

Contributed by Lukas

Metastatic Triple Negative Breast Cancer is one of the most challenging breast cancer subtypes to treat. Recurrence rates can be as high as 40%. This ...

146. Back to Basics - BRCA mutation and Breast Cancer Management

22 Feb 2025

Contributed by Lukas

It's been an "Olympic" ride to get here, and this is our penultimate breast cancer episode! Today, we talk about the BRCA mutations and how they impac...

145. Back to Basics - Metastatic Hormone Receptor Positive Breast Cancer

15 Feb 2025

Contributed by Lukas

Metastatic Hormone Receptor-Positive Breast Cancer truly represents the frontier of Medical Oncology, with life expectancy creeping up to and beyond f...

144. Back to Basics - Early Triple Negative Breast Cancer

08 Feb 2025

Contributed by Lukas

Early Triple Negative Breast Cancer remains an aggressive variant of all breast cancers, affecting those under 40 more and has a higher propensity for...

143. San Antonio Breast Cancer Symposium 2024 - Part 2

01 Feb 2025

Contributed by Lukas

Our second SABCS (San Antonio Breast Cancer Symposium) episode covers everything (else) you need to know from 2024. In this episode, we dive into the ...

142. San Antonio Breast Cancer Symposium 2024 - Part 1

26 Jan 2025

Contributed by Lukas

Welcome back to Oncology for the Inquisitive Mind, where we head back to late 2024 and cover some pivotal trials and ideas from the San Antonio Breast...

141. Back to Basics - The role of endocrine therapy in Breast Cancer

21 Dec 2024

Contributed by Lukas

Before immunotherapy, targeted chemotherapy (ADCs) and precision oncology, there was endocrine therapy, the forefather (or mother) of effective treatm...

140. Back to Basics - Adjuvant HER2 Breast Cancer (Part 2)

14 Dec 2024

Contributed by Lukas

HER2 Breast Cancer is complicated, and this week, we explore those with residual disease post neoadjuvant therapy (KATHERINE) and the idea of de-escal...

139. Back to Basics - Early HER2 Breast Cancer

08 Dec 2024

Contributed by Lukas

Human epidermal growth factor receptor 2 (HER2) is overexpressed in multiple cancers, including breast, gastric, colorectal, and epithelial ovarian ca...

138. Back to Basics - Adjuvant CDK4/6 inhibitors in Early Breast Cancer

30 Nov 2024

Contributed by Lukas

Early Breast Cancer had one of its defining moments in the 1990s, when five years of adjuvant tamoxifen reduced the recurrence risk of invasive breast...

137. Back to Basics - High Risk Breast Cancer

23 Nov 2024

Contributed by Lukas

Breast Cancer is complex, as are the treatment options that clinicians and patients must traverse. Stage III breast cancer has up to a 57% chance of r...

136. Evolving landscape of Genitourinary Cancers (Bladder Cancer) - Prof Enrique Grande

16 Nov 2024

Contributed by Lukas

Prof Enrique Grande, a medical oncologist from Madrid, Spain, is our guest on Oncology for the Inquisitive Mind this week. Enrique is not your average...

135. ESMO 2024 - Breast Cancer with Dr Adam Brufsky

09 Nov 2024

Contributed by Lukas

In our final ESMO 2024 analysis this week, we bring back Dr. Adam Brufsky, "a giant among men (and women)" in breast cancer research and management. H...

134. ESMO 2024 - Lung Cancer with Dr Ned McNamee

02 Nov 2024

Contributed by Lukas

Lung cancer treatment has changed seismically since 2018 and the NEJM publication of Keynote 189. This week, we have Dr. Ned Mcnamee on the show to gi...

133. ESMO 2024 - Genitourinary Cancers with Prof Anthony Joshua

26 Oct 2024

Contributed by Lukas

ESMO 2024 was the year genitourinary cancer took front and centre stage with many exciting updates, trials, and tribulations. This week, OFTIM brings ...

132. ESMO 2024 - Colorectal Cancer with Dr Geoffrey Chong

19 Oct 2024

Contributed by Lukas

With ESMO 24 firmly in the rearview mirror, the dust settling, and the end of the year closing in, Michael and Josh take one final look at the trials ...

131. ESMO 2024 - Plenary Special

18 Sep 2024

Contributed by Lukas

We have finally come to the end of ESMO 2024, and as is now tradition, Michael and Josh conclude their epic journey with a special episode highlightin...

130. ESMO 2024 - Day 4

17 Sep 2024

Contributed by Lukas

The end of the road approaches, and ESMO 2024 will soon be in the rearview mirror. However, each new day brings new, incredible advances in the treatm...

129. ESMO 2024 - Day 3

16 Sep 2024

Contributed by Lukas

Day three of the European Society of Medical Oncology Congress had many exciting and potentially practice-changing trials in the genitourinary space. ...

128. ESMO 2024 - Day 2

15 Sep 2024

Contributed by Lukas

Josh and Michael's Spanish Sojourn continues with their review of Day 2 of the European Society of Medical Oncology. Your hosts have been on their fee...

127. ESMO 2024 - Day 1

14 Sep 2024

Contributed by Lukas

The European Society of Medical Oncology Congress has begun, and Michael and Josh are on the ground, bringing you breaking studies and heartbreaks alo...

126. Ocular Melanoma and Prostate Cancer with A/Prof Anthony Joshua

24 Aug 2024

Contributed by Lukas

Oncology for the Inquisitive Mind has been privileged to interview some truly brilliant specialists, and this week's guest is no exception. Professor ...

125. Spotlight - Biotech ImmVirX with Dr Malcolm McColl and Prof Darren Shafren

17 Aug 2024

Contributed by Lukas

Oncolytic viruses thrive in cancer cells and can replicate rapidly, destroying the cells and enabling the immune system to attack tumours. This week, ...

124. Metastatic HER2- positive breast cancer

10 Aug 2024

Contributed by Lukas

Metastatic HER2-positive breast cancer continues to dominate headlines, and new therapeutic options continue to be found for those afflicted with the ...

123. Spotlight: MARIPOSA for EGFRmut Lung Cancer

03 Aug 2024

Contributed by Lukas

The discovery of EGFR as a driver mutation and the development of medications to take advantage of this mutation changed the treatment of non-small ce...

122. Palliative Care with Dr Janet Abrahm

27 Jul 2024

Contributed by Lukas

It is rare on any show to be able to interview a true pioneer. On today's episode of Oncology for the Inquisitive Mind, we have the privilege of inter...

121. Dr Elias Chandran, the NCI and Urothelial Caricinoma

20 Jul 2024

Contributed by Lukas

This week, we interview Dr Elias Chandran, a medical oncologist and emerging research juggernaut who is an assistant research physician at the Nationa...

120. Artificial Intelligence & Cancer with Professor Meredith Broussard

13 Jul 2024

Contributed by Lukas

Today, Michael and Josh interview Professor Meredith Broussard to discuss Artificial Intelligence (AI), its role in cancer diagnosis, her journey with...

119. ASCO 2024 - Plenary Session

17 Jun 2024

Contributed by Lukas

"Here at last, at the edge of the sea, comes the end of our Fellowship." So said Gandalf the White at the conclusion of J.R.R Tolkien's epic The Lord ...

118. ASCO 2024 - Sarcoma

16 Jun 2024

Contributed by Lukas

Today is the penultimate episode in our ASCO 2024 Odyssey. Michael and Josh have neglected sarcoma to date, but today is the day@ Sarcoma is rare, whe...

117. ASCO 2024 - Central Nervous System

15 Jun 2024

Contributed by Lukas

Some consider the number 13 unlucky; fear of the number has its own name, "triskaidekaphobia." So it is perhaps somewhat fitting that day 13 of our AS...

116. ASCO 2024 - Early Lung Cancer & Mesothelioma

14 Jun 2024

Contributed by Lukas

ASCO 2024 beat many attendees' expectations with interesting and thought-provoking lung cancer and mesothelioma studies. While not all of these will c...

115. ASCO 2024 - Head and Neck Cancer

13 Jun 2024

Contributed by Lukas

Our coverage of ASCO 2024 has rounded the final bend, and the finish line is in sight. Today, Josh and Michael examine four studies in the head and ne...

114. ASCO 2024 - Early Colorectal Cancer

12 Jun 2024

Contributed by Lukas

ASCO 2024 never seems to end, and today, Michael and Josh do a bit of a backflip and report on the advancements in early colorectal cancer. Forever a ...

113. ASCO 2024 - Metastatic Colorectal Cancer

11 Jun 2024

Contributed by Lukas

Our 2024 ASCO epic trundles onto its next generation, advanced colorectal cancer. Over the last 10 years, treatment in this area has made incremental ...

112. ASCO 2024 - Upper Gastrointestinal and Hepatobiliary Cancers

10 Jun 2024

Contributed by Lukas

Some oncologists may have already started counting down to ASCO 2025. However, Michael and Josh are still digesting the interesting world of ASCO 2024...

111. ASCO 2024 - Genitourinary Cancers (Prostate/Penile)

09 Jun 2024

Contributed by Lukas

The second of our two GU ASCO 2024 episodes focusses on prostate and penile cancer, two diseases at different ends of the therapeutic spectrum. Prosta...

110. ASCO 2024 - Genitourinary Cancers (Bladder/Kidney)

08 Jun 2024

Contributed by Lukas

Genitourinary Cancers dominated ASCO24 this year, and Josh and Michael's ASCO Odyssey needed two episodes to fit it all in. Join them as they board th...

109. ASCO 2024 - Early Breast Cancer

07 Jun 2024

Contributed by Lukas

Unbeknownst to Josh, we are already at Day 5 of our ASCO Odyssey, and like Odysseus arriving at Circe's island of Aeaea, we have arrived at the episod...

108. ASCO 2024 - Metastatic Breast Cancer

06 Jun 2024

Contributed by Lukas

Today, Michael and Josh approach a singular destiny to present their take on Metastatic Breast Cancer at ASCO 2024. Long has Breast Cancer been one of...

107. ASCO 2024 - Gynaecological Cancer

05 Jun 2024

Contributed by Lukas

Day 3 of Oncology for the Inquisitive Mind's ASCO Odyssey and our hosts show no sign of flagging under this immense pressure, although Josh has starte...

106. ASCO 2024 - Melanoma

04 Jun 2024

Contributed by Lukas

As the sun rises on another day at ASCO, Michael and Josh are ready to hit the ground running to bring you the latest and greatest in all things oncol...

105. ASCO 2024 - Metastatic Non Small Cell Lung Cancer

03 Jun 2024

Contributed by Lukas

"Tell me, Muse, the story of that resourceful man who was driven to wander far and wide after he had sacked Troy. He saw the cities of many people and...

104. Metastatic Gastric and GOJ Cancer

01 Jun 2024

Contributed by Lukas

With ASCO upon us, Michael and Josh squeeze one more episode of their regular schedule to bring you an important update on gastric cancer. For context...

103. Metastatic Colorectal Cancer

25 May 2024

Contributed by Lukas

Oncology research never sits still, nor does the desire for better treatment options for metastatic colorectal cancer. Fifty percent of diagnosed case...

102. Hepatocellular Carcinoma

18 May 2024

Contributed by Lukas

Hepatocellular carcinoma (HCC) is the sixth most prevalent cancer in the world and the third or fourth leading cause of death (depending on where you ...

Oncosnacks 14: Bevacizumab Toxicity (Part 1)

14 May 2024

Contributed by Lukas

In many parts of the world, Bevacizumab is an important component of the treatment of glioblastoma, colorectal, hepatocellular and ovarian cancers. Ho...