One in Six Billion
Episodes
Special Episode 8: Steve Chapman, Andrew Hattersley and Maggie Shepherd. Final reflections on making the One in Six billion podcast.
28 Oct 2025
Contributed by Lukas
In the final episode of the One in Six Billion podcast Andrew and Maggie reflect with producer Steve Chapman on the fun they have had making 51 podcas...
Series 4 Episode 8. Rohini Bajekal and Shivani Misra. The challenge of diagnosing monogenic diabetes in South Asians
14 Oct 2025
Contributed by Lukas
Rohini Bajekal describes how she had years of receiving inappropriate lifestyle advice before Glucokinase MODY was diagnosed. Dr Shivani Misra’s r...
Series 4 episode 7. Sarah Richardson. Small extra-islet beta cells matter
30 Sep 2025
Contributed by Lukas
Sarah Richardson talks about her new exciting research on insulin producing beta-cells that are single cells or small clusters rather than in islets. ...
Series 4 episode 6: Hannah Robinson and Nick Thomas. Taking immunotherapy to delay adult-onset Type 1 diabetes
16 Sep 2025
Contributed by Lukas
Hannah Robinson was the first adult in the UK to be given the new immunotherapy drug Teplizumab, which aims to slow down the development of type 1 dia...
Series 4 episode 5. Jerry Gore and Rob Andrews. Living life on the edge with Type 1 diabetes.
02 Sep 2025
Contributed by Lukas
Jerry Gore has always lived life on the edge; he had tackled some of the highest, and most inhospitable mountain climbs in the world before he was dia...
Series 4 episode 4. Chris Bright and Rob Andrews. Type 1 diabetes and Elite Sport.
19 Aug 2025
Contributed by Lukas
Chris Bright was diagnosed with Type 1 diabetes aged 8 but this did not stop him having a very successful football career including playing internatio...
Series 4 episode 3: Hannah Robinson and Nick Thomas
05 Aug 2025
Contributed by Lukas
First steps in delaying adult-onset Type 1 diabetesWhen Hannah Robinson was diagnosed with gestational diabetes and found to have islet auto-antibodie...
Series 4 Episode 2. Rachel Besser. Identifying children before they develop Type 1 diabetes
22 Jul 2025
Contributed by Lukas
Dr Rachel Besser explains how new treatment options means it is now important to identify children before they get symptomatic Type 1 diabetes. Rach...
Series 4 Episode 1. Richard Oram. First steps towards preventing Type 1 diabetes
08 Jul 2025
Contributed by Lukas
Richard Oram explains how recent advances have meant we can now delay type 1 diabetes with immunotherapy. To do this we need to be able to identify ...
Series 3 Episode 17. Jennifer and Helen. Prader Willi syndrome: hunger that never goes away
24 Jun 2025
Contributed by Lukas
Jennifer and her mother Helen explain how being born Prader Willi syndrome has had a lifelong impact. One challenge is that Jennifer is continually ...
Special episode 7. Maggie Shepherd (part 2). Inspirational nurse researcher and educator
10 Jun 2025
Contributed by Lukas
Professor Maggie Shepherd reflects back on her career and how she made the massive steps from being a clinical nurse to becoming a nationally leading ...
Special episode 6. Andrew Hattersley (part 2). Building the Exeter diabetes research team
27 May 2025
Contributed by Lukas
Andrew Hattersley describes how teamwork and mutual support has helped the Exeter diabetes research team expand and flourish over the past 30 yearsSen...
Series 3 Episode 16. Grace Bervoets and Amanda Stride. Cystic Fibrosis related Diabetes
13 May 2025
Contributed by Lukas
Grace Bervoets talks about living with cystic fibrosis and cystic fibrosis related-diabetes. Amanada Stride, who works as a diabetes consultant help...
Series 3 Episode 15. Tom Staniford. MDP syndrome
29 Apr 2025
Contributed by Lukas
Tom Staniford talks about living with the MDP syndrome, an extremely rare genetic condition. MDP syndrome includes Mandibula hypoplasia, Deafness, and...
Series 3 Episode 14: Farah O'Regan and Matt Johnson. Down syndrome and very young onset diabetes
15 Apr 2025
Contributed by Lukas
Farah O'Regan talks about how her son who had Down syndrome and a severe congenital heart condition needing surgery diagnosed in pregnancy and th...
Series 3 Episode 13. Abby Gardener and Tim Barrett. Wolfram syndrome / WFS1 Spectrum disorder
01 Apr 2025
Contributed by Lukas
Abby Gardener describes how she was diagnosed with Wolfram syndrome after developing both insulin-treated diabetes and diabetes insipidus (when the ur...
Series 3 Episode 12. Cassi Connelly. Familial Partial Lipodystrophy
18 Mar 2025
Contributed by Lukas
Cassi Connelly talks about her experience of having familial partial lipodystrophy characterised by a loss of fat and muscular appearance of her arms ...
Series 3 Episode 11. Rebecca Goodman. Living well with Bardet-Biedl syndrome.
04 Mar 2025
Contributed by Lukas
Rebecca Goodman talks to Andrew and Maggie about what it is like to grow up with Bardet-Biedl syndrome. Features of Bardet-Biedl syndrome include extr...
Special episode 5. John Dennis. Research breakthrough in Type 2 diabetes treatment.
18 Feb 2025
Contributed by Lukas
We talk to John Dennis, a data science researcher working in the University of Exeter. He used data from 1 million people with Type 2 diabetes to disc...
Series 3 Episode 10. Julie Reynolds and Kash Patel. Maternally inherited diabetes and deafness
04 Feb 2025
Contributed by Lukas
Julie Reynolds describes how she gradually lost her hearing in her 30’s and developed diabetes in her 40’s these 2 conditions also developed in in...
Series 3 Episode 9. Ru Kovvuri and Rhian Clissold Cognitive and medical impacts of the HNF1B deletion syndrome
21 Jan 2025
Contributed by Lukas
Ru Kovvuri explains about her battle to get a diagnosis and support for her daughter who had multiple medical problems and learning difficulties as a ...
Series 3 episode 8. HNF1Beta syndrome: kidney disease, diabetes, liver dysfunction and much more
07 Jan 2025
Contributed by Lukas
Grant King talks about his diagnostic journey where his low birth weight, childhood kidney disease, diabetes, liver dysfunction and infertility were a...
Series 3 episode 7. Natalie Raphael and Alice Hughes Testing fetal genetics using mum’s blood in Glucokinase pregnancy
24 Dec 2024
Contributed by Lukas
Natalie Raphael was diagnosed as having glucokinase MODY at the end of her first pregnancy. In her second pregnancy she had a recently introduced bloo...
Series 3 episode 6. Gill Preston, Gill Spyer, and Ali Chakera The challenge of diagnosing and managing glucokinase MODY in pregnancy
10 Dec 2024
Contributed by Lukas
It was a great surprise for Gill Preston, who was active and slim, when she was diagnosed with gestational diabetes in her first pregnancy. Her raised...
Series 3 episode 5. Andrew Lotery and Amanda Stride: Glucokinase MODY – a mildly raised fasting glucose for life that should not be treated
26 Nov 2024
Contributed by Lukas
In this episode we talk to Andrew Lotery about how he was found to have a raised fasting glucose on an insurance medical. He was treated as Type 2 dia...
Series 3 episode 4. Janette and Alice: Big babies with dangerously low blood sugars in HNF4A MODY
12 Nov 2024
Contributed by Lukas
In this episode we talk to Janette and her daughter Alice who were both correctly diagnosed with HNF4A MODY having been initially told they had Type 1...
Series 3 episode 3. Mary Lee and Ewan Pearson: Finding the best treatment for HNF1A MODY
29 Oct 2024
Contributed by Lukas
Mary Lee was thought to have Type 1 diabetes for over 3 decades; she was finally diagnosed with HNF1A MODY and was able to stop her insulin injections...
Series 3 episode 2. Kevin Colclough and Bev Shields Making sure the right patients get the right genetic test for MODY
15 Oct 2024
Contributed by Lukas
Kevin Colclough describes how the genetic testing in diabetes has improved over the 2 decades he has worked in the Exeter NHS diagnostic lab. His wo...
Series 3 episode 1. Mary Humphries: The doctor didn’t listen! A delayed diagnosis of MODY
01 Oct 2024
Contributed by Lukas
Mary Humphries tells how her son Dan was diagnosed with diabetes aged 16 and it was assumed he had type 1 diabetes and treated with insulin. On insu...
Series 2 episode 9. Nick Thomas. Type 1 diabetes in the older adult
17 Sep 2024
Contributed by Lukas
Dr Nick Thomas talks about Type 1 diabetes in the older adult. In an iconoclastic study he showed most cases of Type 1 diabetes occur in adults rather...
Series 2 episode 8. Simon Goode and Angus Jones. Diagnosing Type 1 diabetes is difficult in older adults
03 Sep 2024
Contributed by Lukas
Simon Goode was diagnosed with Type 2 diabetes aged 28. He explains how it took 6 months of feeling unwell before it was realised he had Type 1 diab...
Series 2 Episode 7. Jean Claude Katte. Type 1 Diabetes in Africa: different in so many ways.
20 Aug 2024
Contributed by Lukas
Dr Jean Claude Katte explains how in Sub Saharan Africa diagnosis, treatment and monitoring of Type 1 diabetes in children and young adults is so much...
Series 2 episode 6. Mendy Korer and Matt Johnson. Type 1 diabetes in very young children: a massive challenge for families and scientists
06 Aug 2024
Contributed by Lukas
We hear from Mendy Korer about the enormous challenges of living with a child who was diagnosed with Type 1 diabetes aged 11 months. Matt Johnson, a r...
Series 2 Episode 5. Richard Oram . Genius genetics improves diagnosis and prevention of Type 1 diabetes
23 Jul 2024
Contributed by Lukas
Professor Richard Oram had the innovative idea of turning complex analysis of the genetic changes into a single number that estimate the likelihood ...
Series 2 Episode 4. Partha Kar. The super hero who made sure Type 1 diabetes technology was for everyone
09 Jul 2024
Contributed by Lukas
Professor Partha Kar has made sure the technical advances in measuring blood sugar are available to everyone living with Type 1 diabetes in the UK. ...
Series 2 Episode 3. Jean Dudderidge and Jill Epton. Living with Type 1 diabetes for over 50 years.
25 Jun 2024
Contributed by Lukas
Jean Dudderidge and Jill Epton talk about what it has been like to live with Type 1 diabetes for over 50 years. They discuss the massive advances in t...
Series 2 Episode 2. Moira Murphy and Mark McCarthy. Defining the genetic susceptibility to Type 2 diabetes
11 Jun 2024
Contributed by Lukas
Moira Murphy and Mark McCarthy talk about how a unified UK team of scientists came to be world leaders in decoding the genetic susceptibility to Type ...
Series 2 Episode 1. Tim Frayling and Rachel Freathy. Finding the Fat gene
28 May 2024
Contributed by Lukas
We talk to Tim Frayling and Rachel Freathy about how they discovered the “Fat gene”. Working with Oxford, the Exeter team showed a genetic chang...
Special episode 4. Tim Frayling – From PhD student to internationally famous polygenic team leader
14 May 2024
Contributed by Lukas
In this special episode, we hear from Professor Tim Frayling who was Andrew and Sian’s first PhD student in 1995. He rapidly became the head of the ...
Special episode 3. Sian Ellard – establishing a world leading genetics lab from scratch
30 Apr 2024
Contributed by Lukas
In this special episode, we hear from Professor Sian Ellard who, like Andrew and Maggie, started in Exeter in 1995. Sian set up the Exeter molecular...
Series 1 Episode 10: Imran Bashir and Elisa De Franco –the epic human and scientific journeys after a girl was born without a pancreas
16 Apr 2024
Contributed by Lukas
In this episode, Maggie and Andrew talk to Imran Bashir about the difficult journey he and his family have been on since his daughter was born without...
Series 1 Episode 9: Elisa De Franco –the world leading gene discoverer
02 Apr 2024
Contributed by Lukas
In this episode, Maggie and Andrew talk to Dr Elisa De Franco, the Exeter based genetic scientist whose research has discovered more genetic causes of...
Special episode 2: Maggie Shepherd - The journey to a career in Diabetes Research
19 Mar 2024
Contributed by Lukas
In this special episode Andrew Hattersley talks with co-presenter Maggie Shepherd to identify what led to her joining the Exeter team in 1995 and endi...
Series 1 Episode 8: Carsyn Underwood, Karla Underwood, Donna Taylor and Tim McDonald. Early correct treatment is excellent! How can we treat everyone early?
05 Mar 2024
Contributed by Lukas
In this episode, Maggie and Andrew start by talking to Carsyn Underwood and her mums Karla and Donna about Carsyn’s diagnosis of neonatal diabetes a...
Series 1 Episode 7: Pam Bowman – writing the next chapter in neonatal diabetes
20 Feb 2024
Contributed by Lukas
In this episode, Maggie and Andrew talk to Dr Pam Bowman, the doctor scientist, whose research has greatly advanced our understanding of neonatal diab...
Series 1 Episode 6: Dame Frances Ashcroft – scientist extraordinaire!
06 Feb 2024
Contributed by Lukas
In this episode Maggie and Andrew talk to Dame Frances Ashcroft the remarkable Oxford scientist who has dedicated her life to understanding the key ro...
Series 1 Episode 5: Laurie and Mike Jaffe: Spreading the word (USA)
23 Jan 2024
Contributed by Lukas
In this episode, we hear from Laurie and Mike Jaffe from Chicago, USA. They spread the word about neonatal diabetes to over 100M people around the w...
Series 1 Episode 4: Agnes Graja & Helen John – spreading the word (UK)
09 Jan 2024
Contributed by Lukas
In this episode we hear from Agnes Graja and Helen John, two of the national team of Genetic Diabetes Nurses that spread the news about neonatal diabe...
Special episode 1 : Andrew Hattersley - The journey to a career in Diabetes Research
26 Dec 2023
Contributed by Lukas
In this special episode Maggie Shepherd talks with co-presenter Andrew Hattersley exploring what led to him ending up as a research scientist and diab...
Series 1 Episode 3: Ewan Pearson - an unexpected and remarkable treatment
12 Dec 2023
Contributed by Lukas
In this episode we hear about how sulphonylurea tablets were discovered to be an unexpected. and remarkably effective, new treatment for neonatal diab...
Series 1 Episode 2: Anna Gloyn - the gene detective
28 Nov 2023
Contributed by Lukas
In this episode Maggie and Andrew talk to Anna Gloyn, the scientist who discovered the gene that was altered when very young babies were diagnosed w...
Series 1 Episode 1: Jack - a life transformed
13 Nov 2023
Contributed by Lukas
In this episode Andrew and Maggie are joined by Emma Matthews. Emma talks about her son Jack who was diagnosed with diabetes when 2 weeks old. Jack’...