Pharmacy - Emergency Medicine Deep Dive Podcast
Episodes
Is Ondansetron Really Dangerous? A Deep Dive into the Data
27 Apr 2026
Contributed by Lukas
Ondansetron is a widely used antiemetic, but concerns have long circulated about its potential to prolong the QT interval and trigger dangerous arrhyt...
Safety of Co-administering Olanzapine and Benzodiazepines for Acute Agitation
23 Apr 2026
Contributed by Lukas
In this episode, we unpack the long-standing controversy around combining IM olanzapine with benzodiazepines like lorazepam in the management of acute...
Corticosteroids in Severe Pneumonia: The CAPE COD Debate
17 Apr 2026
Contributed by Lukas
In this episode, we break down the landmark CAPE COD trial and what it means for treating severe community-acquired pneumonia. Discover how early hydr...
Hypertonic Saline and Furosemide in Acute Heart Failure Management
06 Apr 2026
Contributed by Lukas
What if a simple shift in how we use fluids and diuretics could transform outcomes in acute heart failure? In this episode, we explore the emerging st...
CCM 2026 Surviving Sepsis Campaign Guidelines: Precision Pharmacotherapy Unpacked
30 Mar 2026
Contributed by Lukas
Sepsis care is entering a new era, as the 2026 CCM Surviving Sepsis Guidelines shift practice away from “throw everything at it” toward precision ...
Essential Clinical Pearls for DOAC Therapy
23 Mar 2026
Contributed by Lukas
Choosing the right DOAC is not just about preventing clots, it is about maximizing safety for every patient. In this episode, we unpack the latest evi...
Critical Care Antibiotic Pharmacokinetics and Dosing Strategies
16 Mar 2026
Contributed by Lukas
What happens to antibiotics when the body is in crisis? In this episode, we dive into the fascinating and often unpredictable pharmacokinetic changes ...
Ketamine for Rapid Control of Excited Delirium
09 Mar 2026
Contributed by Lukas
When a patient arrives in the emergency department in a state of extreme agitation or excited delirium, every second counts. In this episode, we explo...
ACLS Medications 2025: What the AHA Guidelines Really Say
02 Mar 2026
Contributed by Lukas
In this episode, we unpack the 2025 ACLS medication updates from the American Heart Association and what they mean for real-world cardiac arrest care....
Still Febrile: When Ongoing Fevers Don’t Mean Treatment Failure
06 Feb 2026
Contributed by Lukas
The fever persists but does that mean treatment is failing? Not necessarily. In this episode we unpack why ongoing fevers do not automatically signal ...
When Medications Fail: Can Keto Stop Seizures?
25 Jan 2026
Contributed by Lukas
Drug resistant status epilepticus and seizures are some of the highest stakes emergencies in the ED. In this episode, we explore the ketogenic diet as...
Ketamine and Second-Line Agents in Status Epilepticus Management
25 Jan 2026
Contributed by Lukas
Status epilepticus is a true neurologic emergency where every minute matters. In this episode, we review modern emergency management strategies, start...
From Rate to Rhythm: Why Early Treatment Changes Atrial Fibrillation Outcomes
19 Jan 2026
Contributed by Lukas
Rate control has long been the default strategy for atrial fibrillation, reserving rhythm control primarily for symptom management. In this episode, w...
When Heart Failure Improves...What Comes Next?
12 Jan 2026
Contributed by Lukas
Heart failure looks better on paper but is it really gone? In this episode, we explore the landmark TRED HF trial and why a recovered ejection fractio...
Ketamine as a Neuroprotective Agent Following Cardiac Arrest
05 Jan 2026
Contributed by Lukas
In this episode, we explore the potential of ketamine as a neuroprotective therapy for patients recovering from cardiac arrest. Brain injury after arr...
Medetomidine: Clinical Realities of a New Illicit Drug Toxidrome
31 Dec 2025
Contributed by Lukas
This episode explores the emergence of medetomidine, a powerful veterinary sedative, now appearing in the illicit opioid supply and rapidly replacing ...
Rethinking Rate Versus Rhythm Control in Atrial Fibrillation
23 Dec 2025
Contributed by Lukas
When managing atrial fibrillation, clinicians face a pivotal choice...control the heart rate or restore normal rhythm. In this episode, we explore eme...
The RSI Trial: Ketamine Versus Etomidate
14 Dec 2025
Contributed by Lukas
In this episode, we dive into the RSI Trial, a groundbreaking study comparing ketamine and etomidate for rapid sequence intubation in critically ill a...
Sodium Content in Common ED Antibiotics: A Hidden Risk in CHF
08 Dec 2025
Contributed by Lukas
When patients arrive with acute decompensated heart failure, IV antibiotics are often started “just in case.” But what if that precaution is doing...
Lithium Toxicity, Interactions, and SILENT Syndrome
01 Dec 2025
Contributed by Lukas
Dive into the complex world of lithium management as we explore how the drug is processed in the body, how common medications affect its levels, and t...
The Imperfections of Creatinine Clearance in Drug Dosing
25 Nov 2025
Contributed by Lukas
Renal drug dosing is more complex than most clinicians expect. This episode examines why common creatinine based measures such as creatinine clearance...
Rethinking Beta-Blockers After MI
14 Nov 2025
Contributed by Lukas
In this episode, we explore the growing debate around the role of beta blockers after myocardial infarction, especially for patients who have a preser...
Optimizing Piperacillin-Tazobactam Dosing for Pseudomonas
08 Nov 2025
Contributed by Lukas
In this episode, we dive into the evolving strategies for treating Pseudomonas aeruginosa infections with piperacillin-tazobactam (PTZ). Challenging t...
Drug Protein Binding and Clinical Implications
27 Sep 2025
Contributed by Lukas
In this episode, we dive into the critical role of drug protein binding in pharmacokinetics and why it matters for patient care. Only the unbound, or ...
Rocketamine vs. Keturonium: Managing Rapid Sequence Intubation
20 Sep 2025
Contributed by Lukas
In this episode, we dive into a critical and controversial aspect of rapid sequence intubation (RSI)...the optimal order of administering rocuronium, ...
Anticoagulation in Chronic Kidney Disease
08 Sep 2025
Contributed by Lukas
Managing anticoagulation in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) is a complex clinical challenge. In this epi...
SQuID Protocol in Mild-Moderate DKA
01 Sep 2025
Contributed by Lukas
What if treating diabetic ketoacidosis didn’t always require IV drips, ICU beds, or long hospital stays? In this episode, we explore the SQuID proto...
Rapid Antiseizure Medication Administration
29 Aug 2025
Contributed by Lukas
When every second counts, speed matters. But how fast is too fast when it comes to giving intravenous antiseizure medications? In this episode, we div...
Warfarin and Antibiotic Interactions
22 Aug 2025
Contributed by Lukas
Dive into the world of pharmacology as we explore how warfarin interacts with antibiotics at a molecular level. This episode highlights the crucial ro...
Tranexamic Acid Unpacked: Evidence vs. Expectations
18 Aug 2025
Contributed by Lukas
Tranexamic acid (TXA) has been hailed as a game-changer in bleeding management...but does the evidence really support its widespread use? In this epis...
Tranexamic Acid: The 90-Minute Trauma Window?
17 Aug 2025
Contributed by Lukas
In this episode, we dive into a groundbreaking exploratory analysis from the Annals of Emergency Medicine examining the PATCH-Trauma trial. Researcher...
BRASH Syndrome
08 Aug 2025
Contributed by Lukas
BRASH syndrome is more than the sum of its parts. In this episode, we unpack this complex clinical entity defined by bradycardia, renal failure, AV no...
Sliding Scale Furosemide for CHF
06 Aug 2025
Contributed by Lukas
In this episode, we explore an innovative approach to managing congestive heart failure (CHF) in the Emergency Department: the use of a patient-direct...
Pharmacotherapy for Insomnia
31 Jul 2025
Contributed by Lukas
What exactly qualifies as insomnia...and how does it differ from the occasional restless night? In this episode, we unpack the clinical definition of ...
Anticoagulation in Cirrhosis
19 Jul 2025
Contributed by Lukas
Patients with hepatic cirrhosis are uniquely at risk for both bleeding and clotting, making anticoagulation decisions complex. In this episode, we exp...
Gabapentin vs. Pregabalin for Chronic Neuropathic Pain
14 Jul 2025
Contributed by Lukas
In this episode, we dive into the clinical nuances of using gabapentin and pregabalin for chronic neuropathic pain. Join us as we unpack the evolving ...
Antiemetics Uncovered: Side Effects, Interactions, and Clinical Pearls
10 Jul 2025
Contributed by Lukas
In this episode, we explore how a targeted approach to neurotransmitters such as serotonin, dopamine, and acetylcholine, can optimize antiemetic thera...
Status Epilepticus Treatment Approach
07 Jul 2025
Contributed by Lukas
In today’s episode, we explore the updated approach to managing status epilepticus. We walk through a practical, stepwise treatment strategy startin...
Aspirin for Venous Thromboembolism Prophylaxis in Orthopedic Trauma
05 Jul 2025
Contributed by Lukas
In this episode, we dive into the PREVENT CLOT trial, which compared aspirin to low-molecular-weight heparin (LMWH) for thromboprophylaxis in orthoped...
IV Push Antibiotics in the Emergency Department
01 Jul 2025
Contributed by Lukas
In this episode, we dive into the evolving practice of administering intravenous (IV) push antibiotics, a method gaining traction across emergency dep...
Rapid Buprenorphine Induction with Low-Dose Naloxone
28 Jun 2025
Contributed by Lukas
In this episode, we explore a groundbreaking case report introducing a novel approach to buprenorphine induction for patients with Opioid Use Disorder...
Anticoagulant and Antiplatelet Reversal
27 Jun 2025
Contributed by Lukas
This episode covers practical, evidence-informed strategies for reversing anticoagulant and antiplatelet medications in critical bleeding scenarios, i...
Liver Assessment and Drug Impact
24 Jun 2025
Contributed by Lukas
In this episode, we break down how to assess liver injury and understand its impact on drug therapy. We explore the difference between liver enzymes a...
Toxicology Key Principles
24 Jun 2025
Contributed by Lukas
This episode takes a deep dive into the fundamentals of medication overdose management in hospital and critical care settings. We explore the four key...
Pharmacists and Emergency Code Response
20 Jun 2025
Contributed by Lukas
This episode highlights the vital role of emergency pharmacists during high-stakes resuscitations such as cardiac arrests and trauma codes. We explore...
Diuretic Resistance in Congestive Heart Failure
19 Jun 2025
Contributed by Lukas
In this episode, we dive into the complex issue of diuretic resistance in congestive heart failure (CHF), focusing especially on loop diuretics. We br...
Levetiracetam Dosing for Refractory Status Epilepticus
18 Jun 2025
Contributed by Lukas
In this episode, we explore the role of levetiracetam (LEV) dosing in the management of benzodiazepine-refractory status epilepticus (BRSE), a life-th...
Phenobarbital for Alcohol Withdrawal
18 Jun 2025
Contributed by Lukas
In this episode, we examine phenobarbital monotherapy as an emerging approach to managing alcohol withdrawal syndrome. We discuss the advantages of ph...
ActionADE Unpacked
17 Jun 2025
Contributed by Lukas
In this episode, we explore ActionADE—a web-based application designed to prevent repeat adverse drug events (ADEs), a major cause of emergency room...
Acute GI Bleeding
17 Jun 2025
Contributed by Lukas
In this episode, we explore evidence-based pharmacological treatments for severe gastrointestinal bleeding, drawing from Cochrane systematic reviews. ...
Advanced Trauma Life Support
17 Jun 2025
Contributed by Lukas
In this episode, we focus on Advanced Trauma Life Support (ATLS) principles, with a special emphasis on the role of tranexamic acid (TXA) in trauma ca...
Hyponatremia
17 Jun 2025
Contributed by Lukas
In this episode, we explore hyponatremia, a common yet complex electrolyte disorder in hospitalized adults. We discuss causes, diagnostic approaches, ...
Status Epilepticus
17 Jun 2025
Contributed by Lukas
In this episode, we explore the urgent management of convulsive status epilepticus, focusing on the efficacy and safety of anticonvulsant medications....
ACLS_ Algorithms and Pharmacology for Cardiac Resuscitation
17 Jun 2025
Contributed by Lukas
In this episode, we dive into the latest updates on medications used in Advanced Cardiovascular Life Support (ACLS), focusing on epinephrine, amiodaro...
Diabetic Crises: DKA and HHS
17 Jun 2025
Contributed by Lukas
In this episode, we provide a thorough overview of Diabetic Ketoacidosis (DKA) and Hyperosmolar Hyperglycemic State (HHS), two critical diabetic emerg...
Sepsis, Shock, and Adrenal Insufficiency
17 Jun 2025
Contributed by Lukas
In this episode, we dive into the latest evidence-based guidelines for managing sepsis and septic shock from the Surviving Sepsis Campaign 2021. Topic...
Sublingual Levodopa
17 Jun 2025
Contributed by Lukas
In this episode, we explore an innovative approach to managing Parkinson’s symptoms in patients with swallowing difficulties. Hear the story of an 8...
Acute Stroke
17 Jun 2025
Contributed by Lukas
This episode explores key aspects of managing cerebrovascular events, with a focus on intracranial hemorrhage (ICH) and ischemic stroke. We review cli...
Rapid Sequence Intubation
17 Jun 2025
Contributed by Lukas
This episode provides a comprehensive overview of Rapid-Sequence Intubation (RSI), a vital procedure for securing a patient’s airway. It explores th...