Practical AI

The mythos of Mythos and Allbirds takes flight to the neocloud

23 Apr 2026

Contributed by Lukas

In this Fully-Connected episode, Dan and Chris start with Anthropic's Mythos frontier model, parsing what is publicly known about its cybersecurity ca...

Open Source Self-Driving with Comma AI

16 Apr 2026

Contributed by Lukas

Autonomous driving is not just a big tech or closed-source game, it's becoming accessible through open innovation and real-world deployment. Dan and C...

Post-Mortem of Anthropic's Claude Code Leak

09 Apr 2026

Contributed by Lukas

In this fully connected episode, Dan and Chris break down the Anthropic Claude Code leak, what went wrong and what it reveals about agentic systems, A...

Agentic Coding and the Economics of Open Source

02 Apr 2026

Contributed by Lukas

AI is rapidly transforming how software is built, shifting economic incentives from open source code and collaboration toward on-demand, personalized ...

AI at the Edge is a different operating environment

25 Mar 2026

Contributed by Lukas

What does “AI at the edge” really mean in 2026, and why does it matter now more than ever before? In this episode, we’re joined by Brandon Shibl...

Humility in the Age of Agentic Coding

17 Mar 2026

Contributed by Lukas

What happens when an AI hater starts building with AI agents? In this episode, we talk with software engineer Steve Klabnik, known for his work on the...

AI policy and the battle for computing power

09 Mar 2026

Contributed by Lukas

AI is reshaping global power, from chip manufacturing and computing power to AI governance and US-China relations.  In this episode, Ben Buchanan, As...

Cognitive Synthesis and Neural Athletes

18 Feb 2026

Contributed by Lukas

As AI accelerates innovation and adoption, leaders are facing rising cognitive load, shifting systems, and new emotional realities inside their organi...

AI incidents, audits, and the limits of benchmarks

13 Feb 2026

Contributed by Lukas

AI is moving fast from research to real-world deployment, and when things go wrong, the consequences are no longer hypothetical. In this episode, Sean...

Inside an AI-Run Company

02 Feb 2026

Contributed by Lukas

AI agents are moving from demos to real workplaces, but what actually happens when they run a company? In this episode, journalist Evan Ratliff, host ...

How is AI shaping democracy?

27 Jan 2026

Contributed by Lukas

As AI increasingly shapes geopolitics, elections, and civic life, its impact on democracy is becoming impossible to ignore. In this episode, Daniel an...

Controlling AI Models from the Inside

20 Jan 2026

Contributed by Lukas

As generative AI moves into production, traditional guardrails and input/output filters can prove too slow, too expensive, and/or too limited. In this...

2025 was the year of agents, what's coming in 2026?

09 Jan 2026

Contributed by Lukas

In this start-of-year FC episode, Chris and Daniel break down what really mattered in AI in 2025, and what to expect in 2026. They explore the rise of...

Beyond chatbots: Agents that tackle your SOPs

17 Dec 2025

Contributed by Lukas

As AI reshapes the workplace, employees and leaders face questions about meaningful work, automation, and human impact. In this episode, Jason Beutler...

The AI engineer skills gap

10 Dec 2025

Contributed by Lukas

Chris and Daniel talk with returning guest, Ramin Mohammadi, about how those seeking to get into AI Engineer/ Data Science jobs are expected to come i...

Technical advances in document understanding

02 Dec 2025

Contributed by Lukas

Chris and Daniel unpack how AI-driven document processing has rapidly evolved well beyond traditional OCR with many technical advances that fly under ...

Chris on AI, autonomous swarming, home automation and Rust!

26 Nov 2025

Contributed by Lukas

This episode is a special crossover between the Practical AI podcast and The Changelog podcast. Chris was recently invited by longtime friends Jerod S...

Beyond note-taking with Fireflies

19 Nov 2025

Contributed by Lukas

Fireflies CEO, Krish Ramineni shares how the company is transforming AI-powered note-taking into a deeper layer of knowledge automation. He breaks dow...

Autonomous Vehicle Research at Waymo

13 Nov 2025

Contributed by Lukas

Waymo’s VP of Research, Drago Anguelov, joins Practical AI to explore how advances in autonomy, vision models, and large-scale testing are shaping t...

Are we in an AI bubble?

10 Nov 2025

Contributed by Lukas

Dan and Chris unpack whether today’s surge in AI deployment across enterprise workflows, manufacturing, healthcare, and scientific research signals ...

While loops with tool calls

30 Oct 2025

Contributed by Lukas

Dan and Chris sit down (again) with Jared Zoneraich, co-founder and CEO of PromptLayer, to discuss how prompt engineering has evolved into context eng...

Tiny Recursive Networks

24 Oct 2025

Contributed by Lukas

In this fully connected episode, Daniel and Chris explore the emerging concept of tiny recursive networks introduced by Samsung AI, contrasting them w...

Dealing with increasingly complicated agents

16 Oct 2025

Contributed by Lukas

As AI systems move from simple chatbots to complex agentic workflows, new security risks emerge. In this episode, Donato Capitella unpacks how increas...

The impact of AI on the workforce: A state-level case study

09 Oct 2025

Contributed by Lukas

Daniel sits down with Chelsea Linder, VP of Innovation and Entrepreneurship at TechPoint, to explore the what AI innovation and impact look like on th...

We've all done RAG, now what?

29 Sep 2025

Contributed by Lukas

Longtime friend of the show Rajiv Shah returns to unpack lessons from a year of building retrieval-augmented generation (RAG) pipelines and reasoning ...

Creating a private AI assistant in Thunderbird

23 Sep 2025

Contributed by Lukas

In this episode, Daniel and Chris are joined by Chris Aquino, software engineer at Thunderbird to hear the story of how they developed a privacy-prese...

Cracking the code of failed AI pilots

11 Sep 2025

Contributed by Lukas

In this Fully Connected episode, we dig into the recent MIT report revealing that 95% of AI pilots fail before reaching production and explore what it...

GenAI risks and global adoption

27 Aug 2025

Contributed by Lukas

Daniel and Chris sit with Citadel AI’s Rick Kobayashi and Kenny Song and unpack AI safety and security challenges in the generative AI era. They com...

Inside America’s AI Action Plan

19 Aug 2025

Contributed by Lukas

Dan and Chris break down Winning the Race: America's AI Action Plan, issued by the White House in July 2025.  Structured as three "pillars" — Accel...

Confident, strategic AI leadership

12 Aug 2025

Contributed by Lukas

Allegra Guinan of Lumiera helps leaders turn uncertainty about AI into confident, strategic leadership. In this conversation, she brings some actionab...

Educating a data-literate generation

08 Aug 2025

Contributed by Lukas

Dan sits down with guests Mark Daniel Ward and Katie Sanders from The Data Mine at Purdue University to explore how higher education is evolving to me...

Workforce dynamics in an AI-assisted world

01 Aug 2025

Contributed by Lukas

We unpack how AI is reshaping hiring decisions, shifting job roles, and creating new expectations for professionals — from engineers to marketers. T...

Reimagining actuarial science with AI

25 Jul 2025

Contributed by Lukas

In this episode, Chris sits down with Igor Nikitin, CEO and co-founder of Nice Technologies, to explore how AI and modern engineering practices are tr...

Agentic AI for Drone & Robotic Swarming

15 Jul 2025

Contributed by Lukas

In this episode of Practical AI, Chris and Daniel explore the fascinating world of agentic AI for drone and robotic swarms, which is Chris's passion a...

AI in the shadows: From hallucinations to blackmail

07 Jul 2025

Contributed by Lukas

In the first episode of an "AI in the shadows" theme, Chris and Daniel explore the increasing concerning world of agentic misalignment. Starting out w...

Finding Nemotron

02 Jul 2025

Contributed by Lukas

In this episode, we sit down with Joey Conway to explore NVIDIA's open source AI, from the reasoning-focused Nemotron models built on top of Llama, to...

AI hot takes and debates: Autonomy

27 Jun 2025

Contributed by Lukas

Can AI-driven autonomy reduce harm, or does it risk dehumanizing decision-making? In this “AI Hot Takes & Debates” series episode, Daniel and ...

Behind-the-Scenes: VC Funding for AI Startups

18 Jun 2025

Contributed by Lukas

It seems like we are bombarded by news about millions of dollars pouring into AI startups, which have crazy valuations. In this episode, Chris and Dan...

AI-Automated Film Making

12 Jun 2025

Contributed by Lukas

An recent article in Variety was titled: "Sylvester Stallone-Backed Largo.ai Teams With Brilliant Pictures for ‘World’s First Fully AI-Automated F...

Federated learning in production (part 2)

04 Jun 2025

Contributed by Lukas

Chong Shen from Flower Labs joins us to discuss what it really takes to build production-ready federated learning systems that work across data silos....

Federated learning in production (part 1)

30 May 2025

Contributed by Lukas

In this first of a two part series of episodes on federated learning, we dive into the evolving world of federated learning and distributed AI framewo...

Emailing like a superhuman

20 May 2025

Contributed by Lukas

Loïc Houssier, Head of Engineering at Superhuman, joins us to discuss how AI and LLMs are reshaping the email experience. He highlights challenges re...

Model Context Protocol Deep Dive

08 May 2025

Contributed by Lukas

In this episode, Daniel and Chris unpack the Model Context Protocol (MCP), a rising standard for enabling agentic AI interactions with external system...

Seeing beyond the scan in neuroimaging

30 Apr 2025

Contributed by Lukas

In this episode, we explore the intersection of AI, machine learning, and healthcare through the lens of neuroimaging and epilepsy diagnosis. Dr. Gavi...

Open source AI to tackle your backlog

17 Apr 2025

Contributed by Lukas

Vibe coding, agentic workflows, and AI-assisted pull requests? In this episode, Daniel and Chris chat with Robert Brennan and Graham Neubig of All Han...

Orchestrating agents, APIs, and MCP servers

14 Apr 2025

Contributed by Lukas

In this episode, Daniel sits down with Pavel Veller, EPAM’s Chief Technologist, to explore the practical challenges of orchestrating many AI agents ...

Software and hardware acceleration with Groq

02 Apr 2025

Contributed by Lukas

How do you enable AI acceleration (at both the hardware and software layers) that stays ahead of rapid industry shifts? In this episode, Dhananjay Sin...

AI-assisted coding with GitHub's COO

21 Mar 2025

Contributed by Lukas

Kyle Daigle, COO of GitHub, joins the hosts to discuss the evolving role of AI in software development, GitHub Copilot’s impact, and the challenges ...

Optimizing for efficiency with IBM’s Granite

14 Mar 2025

Contributed by Lukas

We often judge AI models by leaderboard scores, but what if efficiency matters more? Kate Soule from IBM joins us to discuss how Granite AI is rethink...

Build a workspace of AI agents

08 Mar 2025

Contributed by Lukas

How can every single person build a personal AI protégé and then accumulate (and share) a host of other assistants? In this episode, we dive into th...

GenAI hot takes and bad use cases

24 Feb 2025

Contributed by Lukas

It seems like all we hear about are the great use cases for GenAI, but where should you NOT be using the technology? On this episode Chris and Daniel ...

Tool calling and agents

14 Feb 2025

Contributed by Lukas

It seems like everyone is uses the term “agent” differently these days. In this episode, Chris and Daniel dig into the details of tool calling and...

Deep-dive into DeepSeek

31 Jan 2025

Contributed by Lukas

There is crazy hype and a lot of confusion related to DeepSeek’s latest model DeepSeek R1. The products provided by DeepSeek (their version of a Cha...

Video generation with realistic motion

23 Jan 2025

Contributed by Lukas

We seem to be experiencing a surge of video generation tools, models, and applications. However, video generation models generally struggle with some ...

Mozart to Megadeth at CHRP

19 Dec 2024

Contributed by Lukas

Daniel and Chris groove with Jeff Smith, Founder and CEO at CHRP.ai. Jeff describes how CHRP anonymously analyzes emotional wellness data, derived fro...

Sidekick is an AI Shopify expert

11 Dec 2024

Contributed by Lukas

Today, Chris explores Shopify Magic and other AI offerings with Mike Tamir, Distinguished ML Engineer and Head of Machine Learning, and Matt Colyer, D...

Full-duplex, real-time dialogue with Kyutai

04 Dec 2024

Contributed by Lukas

Kyutai, an open science research lab, made headlines over the summer when they released their real-time speech-to-speech AI assistant (beating OpenAI ...

Clones, commerce & campaigns

29 Nov 2024

Contributed by Lukas

Chris and Daniel dive into what Trump’s impending second term could mean for AI companies, model developers, and regulators, unpacking the potential...

scikit-learn & data science you own

19 Nov 2024

Contributed by Lukas

We are at GenAI saturation, so let’s talk about scikit-learn, a long time favorite for data scientists building classifiers, time series analyzers, ...

Creating tested, reliable AI applications

13 Nov 2024

Contributed by Lukas

It can be frustrating to get an AI application working amazingly well 80% of the time and failing miserably the other 20%. How can you close the gap a...

AI is changing the cybersecurity threat landscape

05 Nov 2024

Contributed by Lukas

This week, Chris is joined by Gregory Richardson, Vice President and Global Advisory CISO at BlackBerry, and Ismael Valenzuela, Vice President of Thre...

The path towards trustworthy AI

29 Oct 2024

Contributed by Lukas

Elham Tabassi, the Chief AI Advisor at the U.S. National Institute of Standards & Technology (NIST), joins Chris for an enlightening discussion ab...

Big data is dead, analytics is alive

24 Oct 2024

Contributed by Lukas

We are on the other side of “big data” hype, but what is the future of analytics and how does AI fit in? Till and Adithya from MotherDuck join us ...

Practical workflow orchestration

15 Oct 2024

Contributed by Lukas

Workflow orchestration has always been a pain for data scientists, but this is exacerbated in these AI hype days by agentic workflows executing arbitr...

Towards high-quality (maybe synthetic) datasets

09 Oct 2024

Contributed by Lukas

As Argilla puts it: “Data quality is what makes or breaks AI.” However, what exactly does this mean and how can AI team probably collaborate with ...

Understanding what's possible, doable & scalable

03 Oct 2024

Contributed by Lukas

We are constantly hearing about disillusionment as it relates to AI. Some of that is probably valid, but Mike Lewis, an AI architect from Cincinnati, ...

GraphRAG (beyond the hype)

25 Sep 2024

Contributed by Lukas

Seems like we are hearing a lot about GraphRAG these days, but there are lots of questions: what is it, is it hype, what is practical? One of our all ...

Pausing to think about scikit-learn & OpenAI o1

17 Sep 2024

Contributed by Lukas

Recently the company stewarding the open source library scikit-learn announced their seed funding. Also, OpenAI released “o1” with new behavior in...

Cybersecurity in the GenAI age

11 Sep 2024

Contributed by Lukas

Dinis Cruz drops by to chat about cybersecurity for generative AI and large language models. In addition to discussing The Cyber Boardroom, Dinis also...

AI is more than GenAI

05 Sep 2024

Contributed by Lukas

GenAI is often what people think of when someone mentions AI. However, AI is much more. In this episode, Daniel breaks down a history of developments ...

Metrics Driven Development

29 Aug 2024

Contributed by Lukas

How do you systematically measure, optimize, and improve the performance of LLM applications (like those powered by RAG or tool use)? Ragas is an open...

Threat modeling LLM apps

22 Aug 2024

Contributed by Lukas

If you have questions at the intersection of Cybersecurity and AI, you need to know Donato at WithSecure! Donato has been threat modeling AI applicati...

Only as good as the data

14 Aug 2024

Contributed by Lukas

You might have heard that “AI is only as good as the data.” What does that mean and what data are we talking about? Chris and Daniel dig into that...

Gaudi processors & Intel's AI portfolio

07 Aug 2024

Contributed by Lukas

There is an increasing desire for and effort towards GPU alternatives for AI workloads and an ability to run GenAI models on CPUs. Ben and Greg from I...

Broccoli AI at its best 🥦

31 Jul 2024

Contributed by Lukas

We discussed “🥦 Broccoli AI” a couple weeks ago, which is the kind of AI that is actually good/healthy for a real world business. Bengsoon Chua...

Hyperventilating over the Gartner AI Hype Cycle

24 Jul 2024

Contributed by Lukas

This week Daniel & Chris hang with repeat guest and good friend Demetrios Brinkmann of the MLOps Community. Together they review, debate, and poke...

The first real-time voice assistant

18 Jul 2024

Contributed by Lukas

In the midst of the demos & discussion about OpenAI’s GPT-4o voice assistant, Kyutai swooped in to release the first real-time AI voice assistan...

Vectoring in on Pinecone

10 Jul 2024

Contributed by Lukas

Daniel & Chris explore the advantages of vector databases with Roie Schwaber-Cohen of Pinecone. Roie starts with a very lucid explanation of why y...

Stanford's AI Index Report 2024

02 Jul 2024

Contributed by Lukas

We’ve had representatives from Stanford’s Institute for Human-Centered Artificial Intelligence (HAI) on the show in the past, but we were super ex...

Apple Intelligence & Advanced RAG

25 Jun 2024

Contributed by Lukas

Daniel & Chris engage in an impromptu discussion of the state of AI in the enterprise. Then they dive into the recent Apple Intelligence announcem...

The perplexities of information retrieval

19 Jun 2024

Contributed by Lukas

Daniel & Chris sit down with Denis Yarats, Co-founder & CTO at Perplexity, to discuss Perplexity’s sophisticated AI-driven answer engine. De...

Using edge models to find sensitive data

13 Jun 2024

Contributed by Lukas

We’ve all heard about breaches of privacy and leaks of private health information (PHI). For healthcare providers and those storing this data, knowi...

Rise of the AI PC & local LLMs

04 Jun 2024

Contributed by Lukas

We’ve seen a rise in interest recently and a number of major announcements related to local LLMs and AI PCs. NVIDIA, Apple, and Intel are getting in...

AI in the U.S. Congress

29 May 2024

Contributed by Lukas

At the age of 72, U.S. Representative Don Beyer of Virginia enrolled at GMU to pursue a Master’s degree in C.S. with a concentration in Machine Lear...

First impressions of GPT-4o

22 May 2024

Contributed by Lukas

Daniel & Chris share their first impressions of OpenAI’s newest LLM: GPT-4o and Daniel tries to bring the model into the conversation with humor...

Full-stack approach for effective AI agents

15 May 2024

Contributed by Lukas

There’s a lot of hype about AI agents right now, but developing robust agents isn’t yet a reality in general. Imbue is leading the way towards mor...

Autonomous fighter jets?!

08 May 2024

Contributed by Lukas

Yep, you heard that right. Autonomous fighter jets are in the news. Chris and Daniel discuss a modified F-16 known as the X-62A VISTA and autonomous v...

Private, open source chat UIs

30 Apr 2024

Contributed by Lukas

We recently gathered some Practical AI listeners for a live webinar with Danny from LibreChat to discuss the future of private, open source chat UIs. ...

Mamba & Jamba

24 Apr 2024

Contributed by Lukas

First there was Mamba… now there is Jamba from AI21. This is a model that combines the best non-transformer goodness of Mamba with good ‘ol attent...

Udio & the age of multi-modal AI

16 Apr 2024

Contributed by Lukas

2024 promises to be the year of multi-modal AI, and we are already seeing some amazing things. In this “fully connected” episode, Chris and Daniel...

RAG continues to rise

10 Apr 2024

Contributed by Lukas

Daniel & Chris delight in conversation with “the funniest guy in AI”, Demetrios Brinkmann. Together they explore the results of the MLOps Comm...

Should kids still learn to code?

02 Apr 2024

Contributed by Lukas

In this fully connected episode, Daniel & Chris discuss NVIDIA GTC keynote comments from CEO Jensen Huang about teaching kids to code. Then they d...

AI vs software devs

26 Mar 2024

Contributed by Lukas

Daniel and Chris are out this week, so we’re bringing you conversations all about AI’s complicated relationship to software developers from other ...

Prompting the future

20 Mar 2024

Contributed by Lukas

Daniel & Chris explore the state of the art in prompt engineering with Jared Zoneraich, the founder of PromptLayer. PromptLayer is the first platf...

Generating the future of art & entertainment

12 Mar 2024

Contributed by Lukas

Runway is an applied AI research company shaping the next era of art, entertainment & human creativity. Chris sat down with Runway co-founder / CT...

YOLOv9: Computer vision is alive and well

06 Mar 2024

Contributed by Lukas

While everyone is super hyped about generative AI, computer vision researchers have been working in the background on significant advancements in deep...

Representation Engineering (Activation Hacking)

28 Feb 2024

Contributed by Lukas

Recently, we briefly mentioned the concept of “Activation Hacking” in the episode with Karan from Nous Research. In this fully connected episode, ...

Leading the charge on AI in National Security

20 Feb 2024

Contributed by Lukas

Chris & Daniel explore AI in national security with Lt. General Jack Shanahan (USAF, Ret.). The conversation reflects Jack’s unique background a...

Gemini vs OpenAI

14 Feb 2024

Contributed by Lukas

Google has been releasing a ton of new GenAI functionality under the name “Gemini”, and they’ve officially rebranded Bard as Gemini. We take som...

Data synthesis for SOTA LLMs

06 Feb 2024

Contributed by Lukas

Nous Research has been pumping out some of the best open access LLMs using SOTA data synthesis techniques. Their Hermes family of models is incredibly...