Questioning Medicine
Episodes
Episode 325: 324. METHODS MONDAY
29 Jul 2024
Contributed by Lukas
What is the different between Absolute and Relative risk reduction
Episode 324: 323. Is Calcium Bad For You? Calcium Supplementation? Eating Calcium?
26 Jul 2024
Contributed by Lukas
https://heart.bmj.com/content/108/12/964https://www.ahajournals.org/doi/10.1161/JAHA.116.003815We have a study that says leads to increase all cause d...
Episode 323: 322. Follow-up to Adolescence after Early Peanut Introduction for Allergy Prevention
24 Jul 2024
Contributed by Lukas
https://evidence.nejm.org/doi/full/10.1056/EVIDoa2300311Peanut consumption, starting in infancy and continuing to age 5 years, provided lasting tolera...
Episode 322: 321. Long-Term Outcomes in Patients with Low Risk Prostate Cancer
23 Jul 2024
Contributed by Lukas
https://jamanetwork.com/journals/jama/article-abstract/2819352Conclusions and Relevance In this study, 10 years after diagnosis, 49% of men remained...
Episode 321: 320. What is the Association of Blood Lipids, Lipoproteins, and Apolipoproteins With Risk of Coronary Heart Disease
19 Jul 2024
Contributed by Lukas
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11179824/This study did something smart in that they broke it down by white black Chinese and then also h...
Episode 320: 319. President Biden has COVID, Should the First Lady Take Paxlovid?
18 Jul 2024
Contributed by Lukas
https://www.nejm.org/doi/full/10.1056/NEJMoa2309002In this placebo-controlled trial, postexposure prophylaxis with nirmatrelvir–ritonavir for 5 or 1...
Episode 319: 318. Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide
17 Jul 2024
Contributed by Lukas
Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutidethis paper out in JAMA makes you think this is an issue but ...
Episode 318: 317. METHODS MONDAY- What is a Confounder?
15 Jul 2024
Contributed by Lukas
Be careful, most observational data have a large amount of confounders not accounted for and even when accounted for you can never account for all the...
Episode 317: 316. Guideline for the Management of Lower Extremity Peripheral Artery Disease
10 Jul 2024
Contributed by Lukas
https://www.ahajournals.org/doi/10.1161/CIR.0000000000001251. Diagnosis:To establish a PAD diagnosis, the resting ankle–brachial index (ABI) remain...
Episode 316: 315. Prognostic Value of Cardiovascular Biomarkers in the Population
09 Jul 2024
Contributed by Lukas
https://jamanetwork.com/journals/jama/article-abstract/2818624Conclusion--“Cardiovascular biomarkers were strongly associated with fatal and nonfata...
Episode 315: 314. METHODS MONDAY! What Is A C-Score?
08 Jul 2024
Contributed by Lukas
What are c statisticsC-statistic gives the probability a randomly selected patient who experienced an event (e.g. a disease or condition) had a higher...
Episode 314: 313. Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19
05 Jul 2024
Contributed by Lukas
https://pubmed.ncbi.nlm.nih.gov/38598573/In fully vaccinated adults with a risk factor or unvaccinated patients without a risk factor who have symptom...
Episode 313: 312. Trial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size
03 Jul 2024
Contributed by Lukas
https://www.nejm.org/doi/10.1056/NEJMoa2314063Randomized trials have shown the benefit of endovascular thrombectomy in patients with acute stroke due ...
Episode 312: 311. Risk of Stroke in Women Using Levonorgestrel-Releasing Intrauterine Device for Contraception
02 Jul 2024
Contributed by Lukas
https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.124.047438We studied the risk of IS and ICH in women using LG-IUDs—aka mirana-- compared to w...
Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial
01 Jul 2024
Contributed by Lukas
A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existin...
Episode 310: 309. Hospital-Associated Venous Thromboembolism Prophylaxis Use by Risk Assessment
28 Jun 2024
Contributed by Lukas
https://shmpublications.onlinelibrary.wiley.com/doi/abs/10.1002/jhm.13350Xu J et al. Hospital-associated venous thromboembolism prophylaxis use by ris...
Episode 309: 308. Mailed feedback to Primary Care Physicians on Antibiotic Prescribing
27 Jun 2024
Contributed by Lukas
https://www.bmj.com/content/385/bmj-2024-079329Overprescription of antibiotics by primary care clinicians is a major modifiable driver of antibiotic r...
Episode 308: 307. Switch to long-acting cabotegravir and rilpivirine in virologically suppressed adults with HIV in Africa (CARES)
25 Jun 2024
Contributed by Lukas
Kityo C et al. Switch to long-acting cabotegravir and rilpivirine in virologically suppressed adults with HIV in Africa (CARES): Week 48 results from ...
Episode 307: 306. METHODS MONDAY! What is the 95% Confidence Interval?
24 Jun 2024
Contributed by Lukas
95% CI does NOT mean there is a 95% chance the true value is in the interval. It means that if you continually resample, 95% of your confidence interv...
Episode 306: 305. Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline
21 Jun 2024
Contributed by Lukas
https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgae290/7685305?login=trueChildren aged 1-18 years to prevent rickets and to potentia...
Episode 305: 304. METHODS MONDAY- What is Power?
17 Jun 2024
Contributed by Lukas
What is the power of a study—what is the power calculation? Often say it is the number of people in a study. Power is the probably to correctly r...
Episode 304: 303. Associations Between Surrogate Markers and Clinical Outcomes
14 Jun 2024
Contributed by Lukas
Question What is the strength of association between surrogate markers used as primary end points in clinical trials to support Food and Drug Admini...
Episode 303: 302. Effects of statin therapy on diagnoses of new-onset diabetes
13 Jun 2024
Contributed by Lukas
The incidence of new-onset diabetes was basically the same but statistically significantly higher for those individuals on low-to-moderate–intensity...
Episode 302: 301. Development and Validation of the American Heart Association's PREVENT Equations
12 Jun 2024
Contributed by Lukas
At change in c stats of 0.007 or 0.0009 is not a meaningful change so I cant say we should use this over the PCE—yes this new calculator has the ben...
Episode 301: 300. A New Trial On Beta Blockers and COPD
11 Jun 2024
Contributed by Lukas
The problems with observation data is real— randomized trial, U.K. researchers identified 519 patients (mean age, 68) with mostly moderate COPD (...
Episode 300: 299. When Do You Use a Cluster RCT?
07 Jun 2024
Contributed by Lukas
When you want to do an RCT but you realize there might be some cross contamination so instead of randomizing individuals you randomize cluters or grou...
Episode 299: 298. Do We Have a Reversal Drug for DOACs? ANNEXA or Andexanet
06 Jun 2024
Contributed by Lukas
1° outcome: hemostatic efficacy = which was defined as;(A) Hematoma expansion ≤ 35% at 12h(B) increase in NIHSS ≤ 7 at 12h(C) No rescue therapy 3...
Episode 298: 297. Which one of the CHADVASC is worse?
05 Jun 2024
Contributed by Lukas
In patients with atrial fibrillation (AF), how do CHA2DS2-VASc 1 subgroups compare with one another 64 141 patients with a first AF diagnosis ...
Episode 297: FIXED! 296. Is There a Drug That Will Keep Alcoholics Out of the Hospital?
30 May 2024
Contributed by Lukas
Bottom line Do I think if you stop drinking alcohol in the next thirty days you are less likely to come to the hospital for a heart attack? A stroke?...
Episode 296: 295. What is the Best Blood Pressure In the Nursing Home?
29 May 2024
Contributed by Lukas
In a retrospective cohort study of Veterans Affairs (VA) nursing home residents during 2006 to 2019, researchers identified 13,000 residents who initi...
Episode 295: 294. SGLT2 Inhibitors and Stage 5 CKD
28 May 2024
Contributed by Lukas
SGLT-2 inhibitors have not been evaluated in patients with stage 5 CKD (CKD 5; eGFR, ≤15 mL/minute/1.73 m2). Investigators in Taiwan retrospectively...
Episode 294: 293. Should GLP-1 Agonist be Held Prior to Procedure or Surgery?
24 May 2024
Contributed by Lukas
glucagon-like peptide-1 (GLP-1) receptor agonists can delay gastric emptying, the American Society of Anesthesiologists (ASA) say For patients on dail...
Episode 293: 292. An Antibiotic RCT for Community Acquired Pneumonia
23 May 2024
Contributed by Lukas
But now we have RCT data—278 adults with moderate CAP who were hospitalized (but not in intensive care) to receive either a β-lactam antimicrobial ...
Episode 292: 291. Does CHATGPT Have a Career In Pathology?
22 May 2024
Contributed by Lukas
AI technology was highly accurate at identifying malignancies and tumor origins — as accurate as senior pathologists, and significantly more accurat...
Episode 291: 290. When Should You Use IV Albumin?
21 May 2024
Contributed by Lukas
HERE IS WHEN IT IS RECOMMENDED TO USE ALBUMIN In patients with cirrhosis and spontaneous bacterial peritonitis, to substantially limit kidney impairme...
Episode 290: 289. Which GLP-1 is the Best Weight Loss Drug?
20 May 2024
Contributed by Lukas
The results for weight loss was Tirzepatide also known as mounjaro – 8.5 kg Semaglutide also known as Ozempic -3.1 kg lost Liraglutide aka Vi...
Episode 289: 288. An RCT for Time Restricted Eating!
17 May 2024
Contributed by Lukas
41 adults (mean age, 59) with obesity (mean weight, 99 kg) and prediabetes or diet-controlled diabetes – everyone got the same diet. Same micro- a...
Episode 288: 287. A New FDA Approved Drug for Chronic Rhinosinusitis
16 May 2024
Contributed by Lukas
recipients were more likely than placebo recipients to report much or very much improvement (55% vs. 25%) which isn’t shocking because half of the p...
Episode 287: 286. Does Hypokalemia cause Heart Badness?
15 May 2024
Contributed by Lukas
https://onlinelibrary.wiley.com/doi/10.1111/joim.13757ECG abnormalities were present in 40% of hypokalemic patients and included t-wave flattening/inv...
Episode 286: 285. Does Exercise Improve Hip OA?
14 May 2024
Contributed by Lukas
https://www.acpjournals.org/doi/10.7326/M23-3225researchers randomized 160 patients with mostly unilateral hip OA to two 60-minute sessions weekly for...
Episode 285: 284. Do Electronic Cigarettes Increase Smoking Cessation?
13 May 2024
Contributed by Lukas
adult smokers who are given e-cigarettes are significantly more likely to be abstinent at 6 months from a target quit date with a (NNT = 8) but thos...
Episode 284: 283. New Guidelines from American College of Cardiology on Atrial Fibrillation
09 May 2024
Contributed by Lukas
However, screening is not recommended because it has not been shown to improve patient outcomes.. Lifestyle recommendations include moderating alcoho...
Episode 283: 282. New Guidelines For Management of Acute Pancreatitis
03 May 2024
Contributed by Lukas
https://journals.lww.com/ajg/fulltext/2024/03000/american_college_of_gastroenterology_guidelines_.14.aspx2 of the 3 following criteria: (i) abdominal ...
Episode 282: 281. What Do You Do With Elevated Childhood Cholesterol?
02 May 2024
Contributed by Lukas
Bottom line-Elevated cholesterol as a child into an adult is bad but we still don’t know if treating children with medication improves this badness ...
Episode 281: 280. How Much Weight Does an Obese Mother Need to Gain?
01 May 2024
Contributed by Lukas
Weight gain <5 kg was not associated with risk for the composite outcome among women with class 1 and 2 obesity (BMIs, ≥30–39.9 kg/m2). Weight...
Episode 280: 279. Does Sitting In a Chair Improve Patient Stay in the Hospital?
29 Apr 2024
Contributed by Lukas
Chair placement was not associated with a difference in patients’ ability to name their physician (P=1.0), ability to successfully identify their re...
Episode 279: 278. Does a Swiss Ball Help During Labor and Delivery?
26 Apr 2024
Contributed by Lukas
primary outcome was Duration of the first stage of labor was the primary outcome. AND It was 179 minutes shorter (95% CI 146 - 213) in the interventi...
Episode 278: 277. What Do You Do With Subclinical Hypothyroidism?
25 Apr 2024
Contributed by Lukas
In older adults, mildly elevated TSH levels normalized in about 50% of cases during 1 to 2 years of observation.https://academic.oup.com/jcem/article/...
Episode 277: 276. REDUCE-MI Trial- Should we still Give BBlockers Post-MI?
24 Apr 2024
Contributed by Lukas
A study that was done before the widespread use of troponin only measurements for ACS (and certainly before high sensitively trop EVER EXISTED), a t...
Episode 276: 275. Do SSRI Increase The Rate Of Bleeding With Anticoagulants?
23 Apr 2024
Contributed by Lukas
This translates into an absolute excess risk of ≈9 events per 1000 person-years or 1 per 110 person years. Sad differently if you treat 110 people f...
Episode 275: 274. Do Your Genes ACTUALLY Make You Obese?
22 Apr 2024
Contributed by Lukas
During follow-up participants walked on average 8300 steps and those individuals in the lowest genetic risk score developed obesity defined as a BMI g...
Episode 274: 273. Does Telerehabilitation Work For Chronic Knee Pain?
19 Apr 2024
Contributed by Lukas
And in the end it did not really matter because at 3 months individuals only reported a 0.16 difference in pain and a 1.6 difference in function which...
Episode 273: 272. Does Bariatric Surgery Work in Diabetics For Cardiovascular Events
18 Apr 2024
Contributed by Lukas
At 1 year 50% of those individuals who had bariatric surgery were able to achieve diabetic remission but after 12 years the very same individuals that...
Episode 272: 271. Cologaurd Has a New Test? How Good is it?
17 Apr 2024
Contributed by Lukas
The company that developed Cologuard also developed this “next generation” multitarget stool DNA test, and has applied for U.S. FDA approval. The ...
Episode 271: 270. Aprocitentan, How Well Does it Work for Resistant Hypertension?
16 Apr 2024
Contributed by Lukas
730 Patients were randomized to receive daily oral aprocitentan or placebo, plus a fixed-dose combination of amlodipine, valsartan, and hydrochlorothi...
Episode 270: 269. What is the Harm in Aspirin?
15 Apr 2024
Contributed by Lukas
The trial was terminated after 1015 patients with atrial cardiopathy had been randomized to receive either apixaban or aspirin for a mean follow-up ...
Episode 268: 268. New Guidelines For Total Hip and Knee Joint Replacement
12 Apr 2024
Contributed by Lukas
TJA should not be delayed for trials of physical therapy, anti-inflammatory drug use, bracing, intra-articular steroid injections, or hyaluronic ac...
Episode 269: 267. Beta Blockers DON'T Help Post-MI
11 Apr 2024
Contributed by Lukas
randomized trial comparingbeta-blocker therapy (metoprolol or bisoprolol) with no beta-blocker in 5020 patients who had a normal left-ventricular ejec...
Episode 267: 266. How Many Years Of Smoking Cessation Do You Need?
10 Apr 2024
Contributed by Lukas
During a mean 11 years of follow-up, current smokers' risks for cardiovascular-, cancer-, and respiratory-related deaths were 2, 3, and 13 times highe...
Episode 266: 265. Semaglutide and Cardiovascular Events in Non-Diabetics (secondary prevention) SELECT TRIAL
09 Apr 2024
Contributed by Lukas
The primary cardiovascular end point was a composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke in a time...
Episode 265: 264. Does a Lidocaine Patch Work for Neck Pain?
05 Apr 2024
Contributed by Lukas
Bottom line(ZTLido 1.8%) is a brand name lidocaine patch currently approced for postherpetic neuralgia and will stay that why for now as it did not be...
Episode 264: 263. Rates of Atrial Fibrillation 12 months After Onset of Hospitalized Transient AF
04 Apr 2024
Contributed by Lukas
patients who have new-onset transient AF detected during a hospitalization for noncardiac surgery or medical illness and are discharged in sinus rhy...
Episode 263: 262. Does Omalizumab Help For Peanut Allergy?
03 Apr 2024
Contributed by Lukas
Bottom line Omalizumab does seem to improve allergic reactions to peanuts but comes at a steep price tag. Likely only allergist will prescribe this d...
Episode 262: 261. Are Combined Oral Contraceptives Effective for Treating Acne?
02 Apr 2024
Contributed by Lukas
At ~24 weeks, ~80-90% of females report improvement in their acne with COCs, compared to 50-80% placebo, and 30-50% will have clear-almost clear skin ...
Episode 260: QM on Spring Break
20 Mar 2024
Contributed by Lukas
QM on Spring Break-- but do you like the new format? [email protected]
Episode 261: 260. SGLT2 Summary Recap
19 Mar 2024
Contributed by Lukas
Diabetic patient- Empagliflozin prevents death from cardiovascular causes: NNT 46 per 3.1 yrs ($600 a month, 1 million dollars per life saved)-HFpEF- ...
Episode 259: 259. EMPULSE Trial- Empagliflozin and Win Ratios
18 Mar 2024
Contributed by Lukas
These findings indicate that initiation of empagliflozin in patients hospitalized for acute heart failure is well tolerated and results in significant...
Episode 258: 258. SOLOIST-WHF -- Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure
15 Mar 2024
Contributed by Lukas
Primary Outcome: Composite of deaths from cardiovascular causes or hospitalizations and urgent visits for heart failureDeath was not improved!NNT of 5...
Episode 257: 256. EMPEROR-Reduced- Cardiovascular Outcomes with Empagliflozin in Heart Failure
14 Mar 2024
Contributed by Lukas
NNT of 20 to prevent 1 hospitalization at 16 months of follow upThey composite outcome was driven by decrease hospitalizations NOT deathhttps://www.ne...
Episode 256: 256. DAPA-HF- Dapagliflozin and Heart Failure with Reduced Ejection Fraction - DAPA-HF
13 Mar 2024
Contributed by Lukas
NNT of 21 over 18 months to prevent a composite of worsening heart failure or cardiovascular deathNNT for hospitalization = 27NNT for Cardiovascular D...
Episode 255: 255. Dapagliflozin and Heart Failure with Preserved Ejection Fraction
12 Mar 2024
Contributed by Lukas
Dapagliflozin and HFpEF did happen to improve the composite outcome but this was based mainly on hospitalizations not on death and comes at a big pric...
Episode 254: 254. Empagliflozin For Heart Failure with Preserved Ejection Fraction- EMPEROR-Preserved
08 Mar 2024
Contributed by Lukas
Hospitalization for heart failure occurred in 8.6% of patients in the empagliflozin group and 11.8% patients in the placebo group (hazard ratio, 0.71;...
Episode 253: 253. EMPA-REG OUTCOME - Type 2 Diabetes and Empagliflozin- How Much Money To Save How Many People?
07 Mar 2024
Contributed by Lukas
EMPA-REG OUTCOME back in 2015 this was the first SGLT2 trial to set the world on fire with Primary Outcome: death from cardiovascular causes: NNT 46 ...
Episode 252: 252. After Admission to the ICU How Many Patients Remain on a PPI?
06 Mar 2024
Contributed by Lukas
Forty-two percent of patients had a PPI on their medication list without indication 8 weeks after discharge, and more than half of these patients stil...
Episode 251: 251. Does Weight/BMI Change DOAC Efficacy?
05 Mar 2024
Contributed by Lukas
These results are reassuring for management of both underweight and overweight patients with AF. That said, I would still have reservations about pre...
Episode 250: 250. Do Nurse Practitioners Prescribe More or Less Medications From the Beers List?
01 Mar 2024
Contributed by Lukas
Nurse Practitioners prescribe medications off the beers list at the same rate at primary care physicians, hard to tell what this means for patient car...
Episode 249: 249. Is There A Way To Predict Your Risk Of Dementia?
29 Feb 2024
Contributed by Lukas
Using the Brain Care Score seem to be effective in predicting the risk of dementia For participants under 50, each five-point higher BCS is associated...
Episode 248: 248. Should DAPT To Be Started >24hours After Minor Stroke OR High Risk TIA?
28 Feb 2024
Contributed by Lukas
Even when starting DAPT within 72hours of symptom onset for individuals with minor stroke or TIA the benefit of DAPT for the first 21 days was still s...
Episode 247: 247. Should Patients With Cancer Be On Primary Prevention VTE Prophylaxis?
27 Feb 2024
Contributed by Lukas
In those high risk patients -- usually with lung or GI cancer they did benefit from primary prevention VTE prophalaxis with a NNT of 6-7 for VTE and d...
Episode 246: 246. In Giant Cell Arteritis How Soon Do You Need To Get A Biopsy After Starting Steroids?
23 Feb 2024
Contributed by Lukas
Just get he biopsy at less than 6 weeks after starting therapy as the yield was the same at 2 weeks as it was at 4-6 weekshttps://pubmed.ncbi.nlm.nih....
Episode 245: 245. Do Baby Walkers Cause Developmental Delays?
22 Feb 2024
Contributed by Lukas
Evidence against baby walker is not enough regarding its negative effect on child development. This subject needs to be addressed more, considering a ...
Episode 244: 244. Does Testosterone CAUSE Prostate Cancer?
20 Feb 2024
Contributed by Lukas
During average follow-up of in this study the incidence of prostate cancer was less than 1% — and not significantly different Remember most of th...
Episode 243: 243. Can Testosterone Improve or Treat Depression?
19 Feb 2024
Contributed by Lukas
From a mean score of 45 points at baseline, mood improved by about 5 points in the placebo group and 6 points in the testosterone group — a statisti...
Episode 242: 242. Does Testosterone Improve Sexual Function and Erectile Dysfunction?
16 Feb 2024
Contributed by Lukas
Erectile disfunction should be treated with the appropriate medications like the PDE5 inhbitors—not testosterone—testosterone may make it so you f...
Episode 241: 241. Does Testosterone Therapy Prevent or Cause Fractures?
15 Feb 2024
Contributed by Lukas
even at very small some would argue barely even treating doses of testosterone patients had an increase rate of fractures with a NNH of 100—when you...
Episode 240: 240. Does Testosterone Prevent the Progression of Pre-diabetes to Diabetes?
14 Feb 2024
Contributed by Lukas
Risk of progression from prediabetes to diabetes did not differ significantly between testosterone and placebo groups- and they looked for a change at...
Episode 239: 239. TRAVERSE Study...Is Testosterone Therapy Safe for the Heart?
13 Feb 2024
Contributed by Lukas
Take awayThe drug companies will say look how safe testosterone therapy is there was no difference in death from cardiovascular causes or myocardial i...
Episode 238: 238. What to do With Low Risk Pulmonary Embolism?
12 Feb 2024
Contributed by Lukas
Use the PE Severity Index. If low risk and that is the only reason for admission, then the patient is safe for dischargehttps://www.thelancet.com/jour...
Episode 237: 237. Big Take Away from ACP Update to Colon Cancer Screening
09 Feb 2024
Contributed by Lukas
american college of physicians says- No need to start colon cancer screening prior to 50. stop at age 75 or with 10 yrs of life left and FIT testing ...
Episode 236: 236. Is Weight Loss Beneficial For Hip Osteoarthritis?
08 Feb 2024
Contributed by Lukas
While weight loss may be beneficial for individuals with knee osteoarthritis, it does not see to have a protective or beneficial effect for those with...
Episode 235: 235. When Should A Patient With HIV Be Started On Statin Therapy?
07 Feb 2024
Contributed by Lukas
In patients with HIV and cv risk score of 4.5% there was a NNT of 106 at 5 yrs of follow up to prevent 1 MACEhttps://www.acpjournals.org/doi/10.7326/M...
Episode 234: 234. Does Size Matter...BP Cuff Size
06 Feb 2024
Contributed by Lukas
A cuff 1-2 sizes too large underestimated bp by 4-9mm Hg BUT a cuff 1-2 sizes too small overestimated the BP 4-20mm Hghttps://jamanetwork.com/journals...
Episode 233: 233. Do GLP1 agonist actually delay gastric emptying?
05 Feb 2024
Contributed by Lukas
GLP1 agonist likely lead to retained gastric products but this effect is larger for once weekly injections than once daily pills.https://www.ncbi.nlm....
Episode 232: 232. Is the HPV vaccine that good?
02 Feb 2024
Contributed by Lukas
During 28 months of follow-up, absolute risks for progression from CIN2 to CIN3 (or worse) were as follows: 23% among women vaccinated before age 15 3...
Episode 231: 231. Is Cancer Actually Associated with Weight Loss?
01 Feb 2024
Contributed by Lukas
>10% unintentional weight loss is most likely associated with gastrointestinal, liver, pancreatic, and biliary cancers (relative risks, 3.1–7.4...
Episode 230: 230. Are PDE5i Bad for Your Health and Cardiovascular Disease?
31 Jan 2024
Contributed by Lukas
PDE5i are bad if your health if you have cardiovascular disease and a provider that didn't read the paper and only looked at the abstract. Go ahead an...
Episode 229: 229. The Treatment of Chalmydia is...Not Azithromycin
30 Jan 2024
Contributed by Lukas
Doxy 100mg BID x7days for chlamydia- and consider treating the partner unless you live in West Virginia. https://www.cdc.gov/std/treatment-guidelines...
Episode 228: 228. Is Herpes Zoster Vaccine Efficacy Actually 97.2%?
29 Jan 2024
Contributed by Lukas
Overall incidence of zoster (defined as the presence of the specific diagnostic code in the medical record, accompanied by a prescription for acyclovi...
Episode 227: 227. NEW--Complications of Lung Cancer Screening
26 Jan 2024
Contributed by Lukas
Compared with complication rates in the National Lung Screening Trial, this real-world study had approximately twice the rate of procedural complicati...
Episode 226: 226. Aspirin for Primary Prevention
25 Jan 2024
Contributed by Lukas
Ask about and stop aspirin in patients taking it for primary preventionLi DK et al. Trends in upper gastrointestinal bleeding in patients on primary p...