Reason with Science

Understanding metabolism and aging | Charles Brenner | Reason with Science | NAD system | Anti-aging

13 Nov 2022

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This episode is with Charles Brenner. He is the Alfred E Mann Family Foundation Chair in the department of Diabetes and Cancer Metabolism. His research focuses on disturbances in nicotinamide adenine dinucleotide (NAD), the central catalyst of metabolism, in diseases and conditions of metabolic stress. Here we talk about what is metabolism?, NAD system, factors affecting NAD system, ageing, anti-ageing research and how NAD system can be used in health? Guest info: Website: https://www.brennerlab.net/ Twitter: https://twitter.com/CharlesMBrenner?s=20&t=sP8HvddsdScE8qzeQN_t3Q Google scholar: https://scholar.google.com/citations?user=XgEjtucAAAAJ&hl=en Episode links: Website: https://www.reasonwithscience.com/home/understanding-metabolism-and-aging-with-charles-brenner Youtube: https://youtu.be/DHh_E3BbtmI Spotify: https://open.spotify.com/episode/4q1tqsDiIuwi3jNtdZP2UM?si=QB1KgNMxQpu5dJvlNGLqWQ Apple podcast: https://podcastsconnect.apple.com/my-podcasts/show/reason-with-science/407cd478-4271-4319-8318-fc378d4e7ccb/episode/understanding-metabolism-and-aging-|-charles-brenner-|-reason-with-science-|-nad-system-|-anti-aging/8ca959ec-8bbe-466b-a4e5-d2399d40a452 Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw/episode/YmUxZmQyZDEtMjI1ZC00N2FlLWJjMjAtNjVmZDZkZDRiYzc1?sa=X&ved=0CAUQkfYCahcKEwiou6WW76v7AhUAAAAAHQAAAAAQLA Follow Reason with Science: Website: https://www.reasonwithscience.com/ Youtube: https://www.youtube.com/channel/reasonwithscience Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/id1641776894 Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw Timestamps: 00:00:00 Introduction 00:00:51 What is metabolism? 00:01:40 Metabolism at cellular level 00:02:44 Different metabolic processes 00:04:50 NAD (Nicotinamide adenine diamide) system 00:08:20 Food to NAD system 00:13:09 Evolutionary history of NAD system 00:15:44 Molecular description of NAD system 00:20:51 Synthesis of NAD 00:23:21 What is metabolic stress? 00:28:23 Consequences of metabolic stress on NAD system 00:29:45 Conditions caused by NAD deficiency 00:34:23 Impact of food on metabolic stress 00:35:51 Different types of foods and NAD levels 00:40:01 NAD levels and circadian rythem 00:40:50 Genetic predisposition to NAD levels 00:42:40 Are there population wide changes in NAD systems? 00:47:25 Importance of NAD levels in the blood and how much of these can enter in the cell? 00:50:08 Are there modified NMN compounds which can enter in the cell? 00:52:01 NAD system and aging 01:02:25 Objection against 'Sirtuins as drivers of aging' 01:04:29 How do we understand aging? 01:08:25 Biochemical explanation of aging 01:12:20 What kind of biomarkers can help is in studying aging? 01:15:33 Charles' work on NAD system 01:17:05 What sort of system can help us study aging? 01:23:37 Lifestyle and NAD system 01:26:07 NR (Nicotinamide Ribose) as supplements 01:27:19 Thank you! #reasonwithscience #health #aging

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13:00H | 21 DIC 2025 | Fin de Semana

01 Jan 1970

Fin de Semana

10:00H | 21 DIC 2025 | Fin de Semana

01 Jan 1970

Fin de Semana

12:00H | 20 DIC 2025 | Fin de Semana

01 Jan 1970

Fin de Semana

2ª PARTE | 06 ENE 2026 | EL PARTIDAZO DE COPE

01 Jan 1970

El Partidazo de COPE

3ª PARTE | 22 ENE 2026 | EL PARTIDAZO DE COPE

01 Jan 1970

El Partidazo de COPE

3ª PARTE | 04 MAR 2026 | EL PARTIDAZO DE COPE

01 Jan 1970

El Partidazo de COPE

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Reason with Science

Understanding metabolism and aging | Charles Brenner | Reason with Science | NAD system | Anti-aging

This episode hasn't been transcribed yet

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13:00H | 21 DIC 2025 | Fin de Semana

10:00H | 21 DIC 2025 | Fin de Semana

12:00H | 20 DIC 2025 | Fin de Semana

2ª PARTE | 06 ENE 2026 | EL PARTIDAZO DE COPE

3ª PARTE | 22 ENE 2026 | EL PARTIDAZO DE COPE

3ª PARTE | 04 MAR 2026 | EL PARTIDAZO DE COPE

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