RhAPPcast

FAQ: How Long Has It Been Since the Last ACR LN Guideline Updates, and Why Is This Significant?

31 Jan 2025

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Join Amanda Mixon, PA-C, a physician assistant in Northern Colorado and President of RhAPP, as she unpacks the latest ACR guidelines for lupus nephritis. These updates mark a major shift in treatment, incorporating new therapies that enhance disease management while reducing medication toxicity.Previous guidelines relied heavily on high-dose steroids with mycophenolate mofetil (MMF) or cyclophosphamide for induction, followed by MMF maintenance. Now, with the approval of belimumab and voclosporin, treatment strategies emphasize a more targeted and sustained approach. These new options help preserve kidney function while limiting steroid exposure.The revised recommendations call for a lower-dose glucocorticoid regimen, starting at 0.5 mg/kg per day (max 40 mg) with tapering to 5 mg daily within six months. For Class III and IV lupus nephritis, triple therapy—including glucocorticoids, MMF, and belimumab or a calcineurin inhibitor—is now preferred. In Class V cases with significant proteinuria, MMF and a calcineurin inhibitor remain key components.Frequent monitoring, particularly urine protein assessments, is crucial for tracking disease progression and preventing irreversible kidney damage. With these updates, clinicians have clearer guidance on optimizing lupus nephritis care while minimizing long-term complications.Stay informed on the latest lupus nephritis treatment strategies by visiting RhAPP.org and exploring the RhAPP ACE App.

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13:00H | 21 DIC 2025 | Fin de Semana

01 Jan 1970

Fin de Semana

10:00H | 21 DIC 2025 | Fin de Semana

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12:00H | 20 DIC 2025 | Fin de Semana

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Fin de Semana

2ª PARTE | 06 ENE 2026 | EL PARTIDAZO DE COPE

01 Jan 1970

El Partidazo de COPE

3ª PARTE | 22 ENE 2026 | EL PARTIDAZO DE COPE

01 Jan 1970

El Partidazo de COPE

3ª PARTE | 04 MAR 2026 | EL PARTIDAZO DE COPE

01 Jan 1970

El Partidazo de COPE

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RhAPPcast

FAQ: How Long Has It Been Since the Last ACR LN Guideline Updates, and Why Is This Significant?

This episode hasn't been transcribed yet

Other recent transcribed episodes

13:00H | 21 DIC 2025 | Fin de Semana

10:00H | 21 DIC 2025 | Fin de Semana

12:00H | 20 DIC 2025 | Fin de Semana

2ª PARTE | 06 ENE 2026 | EL PARTIDAZO DE COPE

3ª PARTE | 22 ENE 2026 | EL PARTIDAZO DE COPE

3ª PARTE | 04 MAR 2026 | EL PARTIDAZO DE COPE

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