The End of Everything, Bright Fluorescence, Gene Editing a Squid. August 7, 2020, Part 2

When it comes to the eventual end of our universe, cosmologists have a few classic theories: the Big Crunch, where the universe reverses its expansion and contracts again, setting the stars themselves on fire in the process. Or the Big Rip, where the universe expands forever—but in a fundamentally unstable way that tears matter itself apart. Or it might be heat death, in which matter and energy become equally distributed in a cold, eventless soup. These theories have continued to evolve as we gain new understandings from particle accelerators and astronomical observations. As our understanding of fundamental physics advances, new ideas about the ending are joining the list. Take vacuum decay, a theory that’s been around since the 1970s, but which gained new support when CERN confirmed detection of the Higgs Boson particle. The nice thing about vacuum decay, writes cosmologist Katie Mack in her new book, The End of Everything: (Astrophysically Speaking), is that it could happen at any time, and would be almost instantaneous—painless, efficient. Mack joins Ira to talk about the diversity of universe-ending theories, and how cosmologists like her think about the big questions, like where the universe started, how it might end, and what happens after it does.  Over the years, researchers have created thousands of chemical dyes that fluoresce in every color of the rainbow—but there’s a catch. Most of those dyes fluoresce most brightly when they’re in a dilute liquid solution. Now, researchers say they’ve created what they call a “plug-and-play” approach to locking those dyes into a solid form, without dimming their light.   The new strategy uses a colorless, donut-shaped molecule called a cyanostar. When combined with fluorescent dye, cyanostar molecules insulate the dye molecules from each other, and allow them to pack closely together in an orderly checkerboard—resulting in brightly-fluorescing solid materials.  Amar Flood, a professor of chemistry at Indiana University, says the new materials can be around thirty times brighter than other materials on a per-volume basis, and the approach works for any number of off-the-shelf dyes—no tweaking required. Flood joins SciFri’s Charles Bergquist to discuss the work and possible applications for the new technology. Scientists at Woods Hole Marine Biological Laboratory recently thrilled the genetics world by announcing they’ve successfully knocked out a gene in squid for the first time.  “I’m like a kid in a candy store with how much opportunity there is now,” says Karen Crawford, one of the researchers and a biology professor at St. Mary’s College of Maryland. Crawford explains this modification has huge implications for the study of genetics: Squids’ big brains mean this work could hold the key to breakthroughs in research for human genetic diseases, like Huntington’s disease and cystic fibrosis. Joining Ira to talk about the news are Crawford and her co-lead on the research, Josh Rosenthal, a senior scientist at the Marine Biological Laboratory in Woods Hole, Massachusetts.  Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

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