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Short Wave

Mental ‘Workouts’ Could Keep Your Brain Young

17 Nov 2025

Transcription

Chapter 1: What is the main topic discussed in this episode?

0.031 - 24.553 Dean Regas

Dean Regas here, astronomer and host of Looking Up. I journey to the far reaches of the universe, hearing from scientists, astronauts, and geeky celebs along the way. We cover everything from black holes to the latest in science fiction. Listen now to the Looking Up podcast from the NPR Network and Cincinnati Public Radio. You're listening to Shortwave from NPR.

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25.867 - 41.252 Regina Barber

Hey, Shore Wavers. Here's some advice for all you fitness fanatics. Never skip brain day. That's right. It's time to talk about improving your cognitive fitness. And here to lead today's masterclass is NPR's resident brain trainer, John Hamilton. Hey, John.

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41.612 - 47.622 John Hamilton

Hey, Gina. Just finishing up my prefrontal reps here. Got to keep the old cortex shredded.

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48.327 - 58.465 Regina Barber

All right. Let me add that to the list of images I can't unsee. Okay, John. So what's cognitive fitness exactly? Like, are we talking Wordle? You know, because I'm pretty good at Wordle.

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58.665 - 59.166 John Hamilton

Nope.

59.186 - 63.153 Regina Barber

Fine. What about quadratic equations? Numbers?

63.975 - 64.075

Nope.

65.033 - 68.738 Regina Barber

What about like a few races in Mario Kart? Maybe those Zelda puzzles that I do?

69.339 - 89.607 John Hamilton

Strike three. Those all focus on really narrow skills. You know, word recognition, number processing, throwing a turtle shell. Cognitive fitness is more of a whole brain workout. You're trying to build up these broad areas like working memory, processing speed, focus. By the way, those are functions that tend to get worse as we age.

Chapter 2: What is cognitive fitness and why is it important?

125.264 - 125.845 John Hamilton

It's easy, right?

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126.025 - 130.852 Unknown

Yeah, I can do this. I can do this. As you improve, the vehicles will disappear faster.

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131.633 - 137.016 Regina Barber

Okay, that one. Sign is here. Yep. That one. Sign's here.

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138.097 - 138.678 John Hamilton

This gets harder.

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138.858 - 156.162 Regina Barber

Okay, okay, okay. I wasn't looking. It's that one. Oh. Oh, I was way off. Oh, crap, crap, crap. Okay. That one. Sign's here. Happy brain training. Okay. That did get harder. It totally got harder.

156.209 - 160.215 John Hamilton

Yeah, I could see that. I could see the smoke coming out of your ears. It was it was real.

160.756 - 166.906 Regina Barber

I thought it was I was like it was like a false sense of security. I was like, oh, this is so easy. And then it just got like way harder.

166.926 - 178.163 John Hamilton

But I mean, you get the idea, though, right? This this kind of training is a lot like, you know, serious athletic training. It's all about going for the mental burn. You know, you got to think Stairmaster set to 20.

178.584 - 184.393 Regina Barber

It's all about reps, you know. Today on the show, cognitive workouts to keep your brain young.

Chapter 3: What brain exercises can help prevent cognitive decline?

206.937 - 212.524 Unknown

Get WISE. Download the WISE app today or visit WISE.com. T's and C's apply.

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213.82 - 233.988 Anita Rao

I'm Anita Rao, host of Embodied, your source for intimate conversations about sex, relationships, and health. Join me to meet people who will change the way you think about everything from disability to dating, and who will take you into their own lived experiences of how things like being a truck driver or dealing with chronic insomnia shape their identity and relationships.

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234.589 - 239.676 Anita Rao

Subscribe to the Embodied podcast from WUNC, part of the NPR Network.

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242.322 - 248.695 Regina Barber

So, John, this is where you tell me how my brain is going to stay young forever, just like my face.

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249.636 - 249.737 John Hamilton

Yeah.

Chapter 4: How does the double decision task improve cognitive function?

249.757 - 263.183 John Hamilton

Yeah. I mean, maybe not forever, but there is some cool new science here. Let me tell you about a study that provides the first really compelling evidence that cognitive training can cause biological changes in the brain.

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263.365 - 266.711 Regina Barber

OK, so like the brain's version of washboard abs.

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266.851 - 284.901 John Hamilton

Exactly. You've probably seen some of those brain training products on the Internet. You've got, you know, there's Lumosity, Elevate, Peak, Cognifit. And then there's the one that probably has the most science behind it. That is Brain HQ. They designed that training exercise that was making your head explode just a few minutes ago.

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285.421 - 304.408 John Hamilton

Until now, the evidence that those products actually work has been mostly from studies of cognitive performance. So, you know, maybe somebody was able to process information more quickly, focus for a longer period of time. This new study found changes in levels of a really important molecule in the brain. It's something called acetylcholine.

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304.658 - 307.461 Regina Barber

OK, I've never heard of that before, but it sounds cool.

307.481 - 308.142 John Hamilton

And now you have.

308.242 - 309.003 Regina Barber

OK, awesome.

309.023 - 326.743 John Hamilton

Acetylcholine is both a neurotransmitter and a neuromodulator. So what it does is it carries messages around the brain, but it also affects the behavior of neurons. It neuromodulates. Unfortunately, as we get older, the levels of acetylcholine in the brain start to go down. And if you get Alzheimer's, they go way down.

326.763 - 327.544 Regina Barber

Wow, OK.

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