SIGNIFICANT.
Episodes
Don't Die: AI Alignment, Part 1
13 May 2025
Contributed by Lukas
In this pivotal episode of Significant, Dr. David Filippi confronts the existential stakes of AI alignment with his signature blend of scientific rig...
Superintelligence: The Cat's Out of the Bag
07 Mar 2025
Contributed by Lukas
The only human skill that matters now is AI collaboration.Look at the timeline:Neurology mastery – 26 years.Launching a podcast – 6 months.Writ...
Stranger Tongues, Stranger Tides
16 Feb 2025
Contributed by Lukas
Communication isn’t just words—it’s connection. This episode starts with a blue jay who taught me a lesson in language, moves through my auti...
Cenotes of the Yucatán: Secrets of Life and Water
12 Jan 2025
Contributed by Lukas
Join your intrepid guide, Dr. David Filippi, on a deep dive - literally - into the Cenotes of the Yucatán. In this episode, we explore the geological...
The Alien Hand and the Shattered World
29 Dec 2024
Contributed by Lukas
How does the brain construct our sense of self—and what happens when it breaks apart? Come along for the ride as Dr. David Filippi delves into haunt...
Nobels, Nitrogen, Nutrition: The Nexus of Science and Industry (pt. 2)
15 Dec 2024
Contributed by Lukas
In this episode of SIGNIFICANT, Dr. David S. Filippi examines three pivotal moments where science and industry intersected to reshape the ...
Catalysts and Craters: The Collision of Science and Industry (Pt. 1)
01 Dec 2024
Contributed by Lukas
In this episode of SIGNIFICANT, we explore two astonishing tales where science and industry collided – with world-altering consequences. First...
Tackling CTE: Inside the NFL’s Concussion Crisis and the Fight for Change
17 Nov 2024
Contributed by Lukas
Dr. David S. Filippi pulls back the curtain on the NFL’s concussion crisis, where science, personal tragedy, and cultural shifts collide. Discover t...
Should Everyone Be On A GLP-1?
03 Nov 2024
Contributed by Lukas
Join Dr. David S. Filippi as he explores the cutting-edge science of GLP-1 agonists—medications originally designed for diabetes but now revolutioni...