Smart Biotech Scientist | The CMC and Bioprocessing Podcast for Process Development and Manufacturing Leaders

242: DMSO in Cell Therapy: Why Viability Scores Hide the Real Toxicity with Steve Oh - Part 2

09 Apr 2026

Contributed by Lukas

What if the solution to cell therapy’s biggest cold-chain challenge comes from the biology of Arctic fish?This conversation features Steve Oh, a lea...

241: DMSO in Cell Therapy: Why Viability Scores Hide the Real Toxicity with Steve Oh - Part 1

07 Apr 2026

Contributed by Lukas

Arctic fish survive in waters that would freeze most life solid. Not because they tolerate ice, but because their biology prevents crystals from formi...

240: Continuous Microbial Manufacturing: From Genetic Instability to 40-Day E. coli Processes with Juergen Mairhofer - Part 2

02 Apr 2026

Contributed by Lukas

Why do CDMOs keep building bigger stainless-steel facilities while their margins erode and Asian competitors undercut them on price? And what happens ...

239: Continuous Microbial Manufacturing: From Genetic Instability to 40-Day E. coli Processes with Juergen Mairhofer - Part 1

31 Mar 2026

Contributed by Lukas

What if continuous microbial manufacturing wasn't a pipe dream, but a reality quietly reshaping the foundations of bioprocessing?Meet Juergen Mai...

238: High-Throughput Microbial Screening: Avoiding Early Mistakes That Derail Scale-Up with Sebastian Blum - Part 2

26 Mar 2026

Contributed by Lukas

For many biotech innovators, high-throughput screening platforms promise faster discoveries and streamlined workflows. Yet beneath the surface, the re...

237: High-Throughput Microbial Screening: Avoiding Early Mistakes That Derail Scale-Up with Sebastian Blum - Part 1

24 Mar 2026

Contributed by Lukas

Why do so many promising biotech ideas stall long before they reach the clinic or marketplace? For many, the answer lies hidden in the earliest phase ...

236: Plant-Based Biomanufacturing: How Molecular Farming Produces Biopharmaceuticals in Weeks, Not Months with Waranyoo Phoolcharoen - Part 2

19 Mar 2026

Contributed by Lukas

For years, mammalian cells and microbial systems have dominated the biotech landscape, shaping the economics and access to life-saving biologics. Yet,...

235: Plant-Based Biomanufacturing: How Molecular Farming Produces Biopharmaceuticals in Weeks, Not Months with Waranyoo Phoolcharoen - Part 1

17 Mar 2026

Contributed by Lukas

Imagine producing life-saving antibodies or vaccines not in sprawling stainless steel facilities, but in sunlit greenhouses, inside living, breathing ...

234: Why Most Bioprocess Automation Projects Fail Before the Robot Is Even Ordered with Anthony Catacchio - Part 2

12 Mar 2026

Contributed by Lukas

Picture a new bioprocess automation project: ambitious, expensive, and packed with promise. But after months of development, your team discovers a fla...

233: Why Most Bioprocess Automation Projects Fail Before the Robot Is Even Ordered with Anthony Catacchio - Part 1

10 Mar 2026

Contributed by Lukas

Many bioprocess automation projects fail, not because the technology is wrong, but because no one clearly defined the problem before buying the robot....

232: From IND to BLA: The Biologics CMC Decisions That Determine Regulatory Success with Henri Kornmann - Part 2

05 Mar 2026

Contributed by Lukas

How solid is your CMC foundation—and what happens if it cracks under pressure?David Brühlmann welcomes Henri Kornmann, former Head of Biologics Inn...

231: From IND to BLA: The Biologics CMC Decisions That Determine Regulatory Success with Henri Kornmann - Part 1

03 Mar 2026

Contributed by Lukas

Seventy percent of FDA Complete Response Letters have a CMC root cause. Most of those failures trace back to decisions made years earlier. Decisions t...

230: Cyanobacteria Biomanufacturing: Achieving Carbon-Neutral Production at Lower Cost Than Fermentation with Tim Corcoran - Part 2

26 Feb 2026

Contributed by Lukas

What if the future of sustainable manufacturing required no sugar feedstocks, generated minimal waste, and operated carbon-neutral from day one? Ocean...

229: Cyanobacteria Biomanufacturing: Achieving Carbon-Neutral Production at Lower Cost Than Fermentation with Tim Corcoran - Part 1

24 Feb 2026

Contributed by Lukas

The chemicals industry remains locked into carbon-intensive, fossil-based manufacturing. Even engineered microbes like yeast or E. coli depend on expe...

228: Media-Based Glycan Engineering for Biosimilars: Your Rapid Implementation Guide

17 Feb 2026

Contributed by Lukas

How early in process development should you address glycosylation? This episode presents the case for co-optimizing glycan profiles with productivity ...

227: Media-Based Glycan Engineering for Biosimilars: Achieving Reference Product Match

10 Feb 2026

Contributed by Lukas

When your biosimilar analytical data shows 1.4% high mannose against a 6% reference product specification, you face limited options: process temperatu...

226: Mastering Radiopharmaceutical Development: Preclinical Model Selection for Clinical Success with Bryan Miller - Part 2

05 Feb 2026

Contributed by Lukas

Hard-to-treat cancers like pancreatic ductal adenocarcinoma (PDAC) have long defied conventional therapies. Radiopharmaceuticals, combining targeted t...

225: Mastering Radiopharmaceutical Development: Preclinical Model Selection for Clinical Success with Bryan Miller - Part 1

03 Feb 2026

Contributed by Lukas

Imagine treating cancer with the precision of a guided missile—delivering radioactive payloads directly to tumor cells. Radiopharmaceuticals are res...

224: From Cultivated Meat to Chocolate: Rethinking Cellular Agriculture Scale-Up with Steven Lang - Part 2

29 Jan 2026

Contributed by Lukas

The cultivated meat industry has captured headlines and struggled with economics. Meanwhile, plant cell biomanufacturing is quietly solving the cost e...

223: From Cultivated Meat to Chocolate: Rethinking Cellular Agriculture Scale-Up with Steven Lang - Part 1

27 Jan 2026

Contributed by Lukas

What if the chocolate industry's reliance on equatorial farms—and the deforestation that comes with it—could be eliminated entirely? Plant ce...

222: From 2D Cultures to Advanced 3D Cell Models for Preclinical Research with Catarina Brito - Part 2

22 Jan 2026

Contributed by Lukas

What happens when we move beyond oversimplified cell cultures and truly embrace the complexity of human biology? In this episode of the Smart Biotech ...

221: From 2D Cultures to Advanced 3D Cell Models for Preclinical Research with Catarina Brito - Part 1

20 Jan 2026

Contributed by Lukas

What if the failure rate in clinical trials isn't about picking the wrong drug candidates—but about testing them in the wrong models?When you m...

220: From 10,000 Structures to 1.8 Billion Interactions: Breaking the Data Bottleneck to Engineer Efficacious Therapeutics with Troy Lionberger - Part 2

15 Jan 2026

Contributed by Lukas

The biotech industry stands on the verge of a radical transformation thanks to artificial intelligence (AI) and machine learning (ML). But even the mo...

219: From 10,000 Structures to 1.8 Billion Interactions: Breaking the Data Bottleneck to Engineer Efficacious Therapeutics with Troy Lionberger - Part 1

13 Jan 2026

Contributed by Lukas

Antibody therapeutics have transformed modern medicine, but for many scientists, developing new candidates still feels like searching for a needle in ...

218: Silkworm Biomanufacturing: From Ancient Silk Production to Phase I Vaccine Trials with Masafumi Osawa - Part 2

08 Jan 2026

Contributed by Lukas

For generations, silkworm pupae were discarded as waste from silk production. Now, KAICO is proving these organisms can function as highly efficient p...

217: Silkworm Biomanufacturing: From Ancient Silk Production to Phase I Vaccine Trials with Masafumi Osawa - Part 1

06 Jan 2026

Contributed by Lukas

For over 4,000 years, silkworms have connected civilizations through ancient trade routes. Now, KAICO Ltd., a Japanese biotech spin-off from Kyushu Un...

216: From Data Silos to Autonomous Biomanufacturing: Digital Twins and AI-Driven Scale-Up with Ilya Burkov - Part 2

18 Dec 2025

Contributed by Lukas

Biomanufacturing has always dealt with the challenge of turning vast, complex datasets and intricate production steps into life-changing therapies. Bu...

215: From Data Silos to Autonomous Biomanufacturing: Digital Twins and AI-Driven Scale-Up with Ilya Burkov - Part 1

16 Dec 2025

Contributed by Lukas

Across biotech labs, researchers swim in oceans of process data: sensor streams, run records, engineering logs, and still, crucial decisions get stuck...

214: From Developability to Formulation: How In Silico Methods Predict Stability Issues Before the Lab with Giuseppe Licari - Part 2

11 Dec 2025

Contributed by Lukas

Computational methods can predict stability issues before the lab. But how do you actually implement these approaches in your formulation workflow? Fr...

213: From Developability to Formulation: How In Silico Methods Predict Stability Issues Before the Lab with Giuseppe Licari - Part 1

09 Dec 2025

Contributed by Lukas

What if you could predict formulation failures before ever touching a pipette? Computational approaches are revolutionizing biologics development, rep...

212: When the Innovator Becomes the Patient: Manufacturing Reality vs. Patient Urgency with Jesús Zurdo - Part 2

04 Dec 2025

Contributed by Lukas

What happens when cell therapy innovation meets real patient urgency? In this conversation, the barriers between scientist and patient all but vanish,...

211: When the Innovator Becomes the Patient: Manufacturing Reality vs. Patient Urgency with Jesús Zurdo - Part 1

02 Dec 2025

Contributed by Lukas

Real progress in cell and gene therapy shouldn’t be measured solely by scientific innovation, but by whether those innovations actually reach the pa...

210: From Batch to Continuous: Building Innovation Culture in Conservative Biotech Environments with Irina Ramos - Part 2

27 Nov 2025

Contributed by Lukas

From pandemic-speed vaccine deployment to AI-powered process control, what separates hype from real manufacturing transformation?The biotech industry ...

209: From Batch to Continuous: Building Innovation Culture in Conservative Biotech Environments with Irina Ramos - Part 1

25 Nov 2025

Contributed by Lukas

The biotech industry operates under constant tension: we work with products that directly impact human lives, demanding rigorous controls and validati...

208: Cryogenic Infrared Ion Spectroscopy: From Mass Spec Limitations to Molecular Precision with Tom Rizzo - Part 2

20 Nov 2025

Contributed by Lukas

What if you could analyze every metabolite, glycan variant, and unknown impurity in your bioprocess sample—not just the targets you're looking ...

207: Cryogenic Infrared Ion Spectroscopy: From Mass Spec Limitations to Molecular Precision with Tom Rizzo - Part 1

18 Nov 2025

Contributed by Lukas

What if you could identify every structural variant in your biologics—without ambiguity, without massive sample requirements, and without the guessw...

206: Process Economics Decoded: How to Model Biomanufacturing Costs From Clinical to Commercial Scale with Niklas Jungnelius - Part 2

13 Nov 2025

Contributed by Lukas

Carbon neutrality goals are everywhere in biopharma. But how do you actually measure and reduce your true environmental impact when data gaps and base...

205: Process Economics Decoded: How to Model Biomanufacturing Costs From Clinical to Commercial Scale with Niklas Jungnelius - Part 1

11 Nov 2025

Contributed by Lukas

Your Manufacturing Decisions Are Costing You More Than You ThinkEvery bioreactor decision. Every scale-up choice. Every facility investment. They&apos...

204: Mastering CRO Selection: Essential Questions for CMC Analytical Development with Daniel Galbraith - Part 2

06 Nov 2025

Contributed by Lukas

Cell and gene therapies are transforming modern medicine, but their path to market is fast and complex. They often jump from small trials to global la...

203: Mastering CRO Selection: Essential Questions for CMC Analytical Development with Daniel Galbraith - Part 1

04 Nov 2025

Contributed by Lukas

Finding an analytical CRO that's truly invested in your success, not just processing samples, makes all the difference in CMC development. In thi...

202: Fighting Antimicrobial Resistance: How AI Cuts Phage Therapy Access from 6 Months to 5 Days with José Bila - Part 2

30 Oct 2025

Contributed by Lukas

What if the answer to battling antibiotic-resistant infections isn’t a new antibiotic, but harnessing viruses that have been quietly dominating bact...

201: Fighting Antimicrobial Resistance: How AI Cuts Phage Therapy Access from 6 Months to 5 Days with José Bila - Part 1

28 Oct 2025

Contributed by Lukas

Antibiotic resistance isn’t just a looming problem. It’s a global crisis. Every year, more than one million people die directly from resistant inf...

200: Mastering Quality by Design: From Product Failures to Commercial Success in Biologics CMC Development - Part 2

23 Oct 2025

Contributed by Lukas

Your process works perfectly at two-liter bench scale. Then you hit fifty liters and titer drops 20%. By two hundred liters, aggregation appears and c...

199: Mastering Quality by Design: From Product Failures to Commercial Success in Biologics CMC Development - Part 1

21 Oct 2025

Contributed by Lukas

Over 40% of biotherapeutic failures during clinical development stem from stability problems—and most trace back to protein aggregation that could h...

198: Mastering ADC Development: CDMO Strategies for Analytics and Scale-Up with Amanda Hoertz - Part 2

16 Oct 2025

Contributed by Lukas

What happens when the most complex molecules in biotech meet the organizational challenge of managing 300+ analytical scientists? The answer lies not ...

197: Mastering ADC Development: CDMO Strategies for Analytics and Scale-Up with Amanda Hoertz - Part 1

14 Oct 2025

Contributed by Lukas

What if the key to unlocking ADC manufacturing success lies in abandoning the platform mindset entirely?Antibody-drug conjugates represent biotech&apo...

196: Monolithic Chromatography Innovations: Solving High-Capacity Purification for Gene Therapy Vectors with Alois Jungbauer - Part 2

09 Oct 2025

Contributed by Lukas

What if solving tomorrow’s bioprocessing challenges meant questioning the very physics of chromatography and reimagining downstream processing from ...

195: Monolithic Chromatography Innovations: Solving High-Capacity Purification for Gene Therapy Vectors with Alois Jungbauer - Part 1

07 Oct 2025

Contributed by Lukas

In this episode, host David Brühlmann is joined by Alois Jungbauer, Professor Emeritus at BOKU University, Vienna, and Scientific Advisor at BioChrom...

194: Viral Vector CDMO Mastery: Singapore's Answer to Cell and Gene Therapy Supply Shortages with Lucas Chan - Part 2

02 Oct 2025

Contributed by Lukas

What if the future of affordable, life-changing cell and gene therapies comes down to one critical yet often overlooked factor: manufacturing efficien...

193: Viral Vector CDMO Mastery: Singapore's Answer to Cell and Gene Therapy Supply Shortages with Lucas Chan - Part 1

30 Sep 2025

Contributed by Lukas

Viral vectors are the backbone of cutting-edge cell and gene therapies, delivering life-altering treatments to patients with genetic diseases. But mak...

192: Process Intensification Secrets: A Process Engineer's Decision Framework with Andreas Castan - Part 2

25 Sep 2025

Contributed by Lukas

Is continuous manufacturing delivering the transformative results everyone promised, or are you being sold an expensive solution to the wrong problem?...

191: Process Intensification Secrets: A Process Engineer's Decision Framework with Andreas Castan - Part 1

23 Sep 2025

Contributed by Lukas

What if process intensification could transform your bioprocessing economics without the complexity most engineers fear? Getting 3x productivity gains...

190: Why Smart Biotech Founders Plan CMC First (While Competitors Burn Cash Later) - Part 2

18 Sep 2025

Contributed by Lukas

Still think you can "figure out CMC later"? Your competitors just implemented a systematic framework that cuts their IND timeline in half wh...

189: Why Smart Biotech Founders Plan CMC First (While Competitors Burn Cash Later) - Part 1

16 Sep 2025

Contributed by Lukas

Think you can crack the science first and worry about CMC when you "need it"? That's exactly how promising therapies die in regulatory ...

188: From Biology Is Messy to Designable: The Smart Bioprocessing Transformation with Carmen Jungo Rhême - Part 2

11 Sep 2025

Contributed by Lukas

For too long, biotech innovators have viewed biological systems as inherently messy, unpredictable, and full of “black box” mysteries. But what if...

187: From Biology Is Messy to Designable: The Smart Bioprocessing Transformation with Carmen Jungo Rhême - Part 1

09 Sep 2025

Contributed by Lukas

Almost every corner of modern medicine and sustainable food production today is facing a massive challenge: how do we outpace drug-resistant “superb...

186: How Generative AI Accelerates Protein Design for Biotech Discovery with Elise de Reus - Part 2

04 Sep 2025

Contributed by Lukas

Imagine unlocking a world where designing custom proteins is not only feasible - but faster, smarter, and more powerful than ever before, thanks to ar...

185: How Generative AI Accelerates Protein Design for Biotech Discovery with Elise de Reus - Part 1

02 Sep 2025

Contributed by Lukas

For decades, protein design has hinged on painstaking rounds of wet lab mutagenesis and trial-and-error, a process limited not by human ingenuity, but...

184: From Lab to Market: Secrets to Commercializing Cutting-Edge Biotech Innovations with Chervee Ho - Part 2

28 Aug 2025

Contributed by Lukas

What’s the secret to turning a cutting-edge scientific breakthrough into a commercial biotech success?For every inspiring lab discovery, countless p...

183: From Lab to Market: Secrets to Commercializing Cutting-Edge Biotech Innovations with Chervee Ho - Part 1

26 Aug 2025

Contributed by Lukas

Every year, cutting-edge biomedical technologies are left stranded in the lab, not for lack of innovation, but because they miss the crucial leap from...

182: Innovating Continuous Bioprocessing with Vibrating Membrane Filtration with Jarno Robin - Part 2

21 Aug 2025

Contributed by Lukas

What if the secret to making continuous bioprocessing practical, sustainable, and far simpler has been shaking - literally - just beneath our feet?For...

181: Innovating Continuous Bioprocessing with Vibrating Membrane Filtration with Jarno Robin - Part 1

19 Aug 2025

Contributed by Lukas

What if one of biotech’s biggest production breakthroughs was hiding in plain sight? Not in a new gene or a wonder drug, but in the way we process a...

180: How Mesenchymal Stromal Cells Are Transforming Care for Diabetes and Autoimmune Diseases with Lindsay Davis - Part 2

14 Aug 2025

Contributed by Lukas

The promise of advanced cell therapies is undeniable, but as demand skyrockets, the challenges of taking a living drug from bench to bedside have neve...

179: How Mesenchymal Stromal Cells Are Transforming Care for Diabetes and Autoimmune Diseases with Lindsay Davies - Part 1

12 Aug 2025

Contributed by Lukas

The key to conquering autoimmune diseases and type 1 diabetes may lie not in replacing lost cells, but in retraining the immune system using cells alr...

178: Rethinking Cultivated Meat Production: Scale and Media Optimization Strategies Slashing Manufacturing Costs with Richard Alldread - Part 2

07 Aug 2025

Contributed by Lukas

The promise of cultured food is undeniable: delicious, sustainable meat and fish grown without the need for traditional farming. But the journey from ...

177: Rethinking Cultivated Meat Production: Scale and Media Optimization Strategies Slashing Manufacturing Costs with Richard Alldread - Part 1

05 Aug 2025

Contributed by Lukas

What if the secrets to feeding the planet - and democratizing access to future protein - were hiding in the core toolkit of biopharma?The worlds of bi...

176: How Virtual Reality Training Solves Europe's Bioproduction Talent Shortage with Sandrine Lemoine - Part 2

31 Jul 2025

Contributed by Lukas

What if the missing link to resilient European bioproduction is not just another breakthrough technology, but the ability to continuously learn, adapt...

175: How Virtual Reality Training Solves Europe's Bioproduction Talent Shortage with Sandrine Lemoine - Part 1

29 Jul 2025

Contributed by Lukas

What if the road to bioproduction mastery started not in the lab, but with how you train your people?Traditional biotech education often ends at theor...

174: Mastering Hybrid Model Digital Twins: From Lab Scale to Commercial Bioprocessing with Krist Gernaey - Part 2

24 Jul 2025

Contributed by Lukas

How do you transform hybrid model digital twins from promising lab concepts into commercial bioprocessing game-changers that actually deliver ROI?As b...

173: Mastering Hybrid Model Digital Twins: From Lab Scale to Commercial Bioprocessing with Krist Gernaey - Part 1

22 Jul 2025

Contributed by Lukas

Are you struggling to bridge the gap between lab-scale models and commercial bioprocessing reality? For many biotech innovators, the promise of digita...

172: Reimagining Chromatography for Advanced Therapies: From Diffusion to Convection with Scott Wheelwright - Part 2

17 Jul 2025

Contributed by Lukas

Downstream processing remains one of the most complex and critical steps in biomanufacturing, especially as new therapeutic modalities like cell and g...

171: Reimagining Chromatography for Advanced Therapies: From Diffusion to Convection with Scott Wheelwright - Part 1

15 Jul 2025

Contributed by Lukas

For decades, chromatographic purification has made use of bead-based diffusion - a reliable but limiting approach, especially as new modalities like g...

170: Why Your DNA Is a Terrible Disease Predictor (And How Multi-Omics Changes Everything) with Mo Jain - Part 2

10 Jul 2025

Contributed by Lukas

For years, disease diagnosis and treatment have focused on a few biomarkers, overlooking thousands of vital biological signals. Despite biotech advanc...

169: Why Your DNA Is a Terrible Disease Predictor (And How Multi-Omics Changes Everything) with Mo Jain - Part 1

08 Jul 2025

Contributed by Lukas

What if the secret to truly personalized precision medicine lies not in your genetic code, but in your zip code?For years, biotech has focused on geno...

168: How Generative AI Is Revolutionizing Biotech Regulatory Compliance with Abhijeet Satwekar - Part 2

03 Jul 2025

Contributed by Lukas

The promise of generative AI in pharma and biotech is huge, but it's also fraught with complexity, especially when it comes to integrating these ...

167: How Generative AI Is Revolutionizing Biotech Regulatory Compliance with Abhijeet Satwekar - Part 1

01 Jul 2025

Contributed by Lukas

Ever feel like you’re drowning in an ocean of constantly shifting regulatory guidelines? The world of biotech is a whirlwind of evolving standards, ...

166: Why Your Funding Pitches Fail Despite Brilliant Science (And How to Fix It) - Part 2

26 Jun 2025

Contributed by Lukas

Have you ever presented a major scientific breakthrough, only to be met with blank stares and distracted executives? You're not alone. In this ep...

165: Why Your Funding Pitches Fail Despite Brilliant Science (And How to Fix It) - Part 1

24 Jun 2025

Contributed by Lukas

Have you ever poured months of research into a brilliant innovation, only to watch executives’ eyes glaze over during your presentation? You’re no...

164: How Moss Enables Production of Unproducible Protein Therapeutics with Andreas Schaaf - Part 2

19 Jun 2025

Contributed by Lukas

From lab curiosity to commercial reality. Here's what happens when moss meets the brutal economics of bioprocessing.In Part 1, you've heard ...

163: How Moss Enables Production of Unproducible Protein Therapeutics with Andreas Schaaf - Part 1

17 Jun 2025

Contributed by Lukas

What if the future of "impossible" protein therapeutics is hiding in your backyard?For decades, CHO cells have ruled the biotech kingdom as ...

162: How to Achieve 85%+ Cell Recovery Without DMSO's Toxic Side Effects with Jeffrey Allen - Part 2

12 Jun 2025

Contributed by Lukas

The world of cell therapy is changing rapidly, with revolutionary advancements in cryopreservation and bioprocessing protocols leading the way. In a r...

161: How to Achieve 85%+ Cell Recovery Without DMSO's Toxic Side Effects with Jeffrey Allen - Part 1

10 Jun 2025

Contributed by Lukas

If you’ve ever worked in a cell therapy lab or handled biologics, you’ve probably experienced the pitfalls of cryopreservation. We’ve all mourne...

160: The Ultimate Guide to Accelerating Perfusion Process Development Using 96-Deep-Well Plates with Tom Valentin - Part 2

05 Jun 2025

Contributed by Lukas

In this concluding episode of our deep dive into miniaturized perfusion systems, we tackle the most challenging aspect: implementing meaningful proces...

159: The Ultimate Guide to Accelerating Perfusion Process Development Using 96-Deep-Well Plates with Tom Valentin - Part 1

03 Jun 2025

Contributed by Lukas

In bioprocess development, the ability to rapidly screen conditions and predict scale-up performance can mean the difference between a successful ther...

158: How to Detect Endotoxins Without Bleeding a Single Horseshoe Crab with Anika Hoffmann - Part 2

29 May 2025

Contributed by Lukas

In this concluding episode of our series on revolutionary endotoxin detection, we continue our conversation with Anika Hoffmann about transitioning fr...

157: How to Detect Endotoxins Without Bleeding a Single Horseshoe Crab with Anika Hoffmann - Part 1

27 May 2025

Contributed by Lukas

In biopharmaceutical manufacturing, endotoxins represent a silent but deadly threat – bacterial fragments capable of triggering severe immune respon...

156: The Hidden Economics of Continuous Processing That Most Biotech Companies Overlook

22 May 2025

Contributed by Lukas

The world of biologics manufacturing is undergoing a major transformation. Once dominated by traditional batch processes, the industry is now experien...

155: From Process Bottlenecks to Seamless Production: How Continuous Bioprocessing Changes Everything

20 May 2025

Contributed by Lukas

In this episode of the Smart Biotech Scientist Podcast, host David Brühlmann dives into continuous bioprocessing - a major shift in biologics manufac...

154: The Future of Bioprocessing: Industry 4.0, Digital Twins, and Continuous Manufacturing Strategies with Tiago Matos - Part 2

15 May 2025

Contributed by Lukas

In this episode, Tiago Matos, Associate Principal Scientist/Associate Director in Bioprocess Drug Substance and Commercialization at Merck & Co., ...

153: The Future of Bioprocessing: Industry 4.0, Digital Twins, and Continuous Manufacturing Strategies with Tiago Matos - Part 1

13 May 2025

Contributed by Lukas

As the biotechnology sector races toward digital transformation, the buzz around Industry 4.0 - with its promise of interconnected systems, automation...

152: Is an Indian CDMO the Right Move for Your Biologics Pipeline? with Abdelaziz Toumi - Part 2

08 May 2025

Contributed by Lukas

Is an Indian CDMO the right move for your biologics CMC development?Pulling back the curtain on what might be your next strategic manufacturing advant...

151: Is an Indian CDMO the Right Move for Your Biologics Pipeline? with Abdelaziz Toumi - Part 1

06 May 2025

Contributed by Lukas

Is an Indian CDMO the right move for your biologics pipeline?As Western biotech companies seek new strategic advantages, one question keeps surfacing:...

150: How to Leverage AI in Media Development Without Sacrificing Process Understanding with Tom Fletcher - Part 2

01 May 2025

Contributed by Lukas

As biotech labs rush to adopt AI tools for cell culture media development, a critical question emerges: Are we creating a generation of scientists who...

149: How to Leverage AI in Media Development Without Sacrificing Process Understanding with Tom Fletcher - Part 1

29 Apr 2025

Contributed by Lukas

From closely-guarded secrets to complex chemical interactions, cell culture media development has transformed from an afterthought to a critical compe...

148: Lab-Grown Blood: How Stem Cells Transform Transfusions with Ari Gargir - Part 2

24 Apr 2025

Contributed by Lukas

In the wake of the COVID-19 pandemic, the fragility of global blood supply systems became undeniably clear. Recognizing the urgent need for a more rel...

147: Lab-Grown Blood: How Stem Cells Transform Transfusions with Ari Gargir - Part 1

22 Apr 2025

Contributed by Lukas

Blood is critical to global healthcare - vital for surgeries, trauma care, cancer treatment, and maternal health. Yet despite 120 million donations ea...

146: Beyond ELISA: The 10-Minute Immunoassay Enabling Real-Time Bioprocess Control with Bruno Oesch - Part 2

17 Apr 2025

Contributed by Lukas

Stuck with outdated analytics while trying to develop cutting-edge therapies? Part 2 of our conversation with Bruno Oesch, CEO and founder of Elionova...

145: Beyond ELISA: The 10-Minute Immunoassay Enabling Real-Time Bioprocess Control with Bruno Oesch - Part 1

15 Apr 2025

Contributed by Lukas

Tired of waiting overnight for ELISA results? Serial entrepreneur Bruno Oesch reveals how his groundbreaking 10-minute immunoassay technology is elimi...

144: The Future of Biotech: Making Biotherapeutics More Accessible Faster

10 Apr 2025

Contributed by Lukas

Imagine a future where every patient can access life-saving therapies and sustainable, high-quality food is within everyone’s reach. In this episode...

143: Bioprocess Breakthroughs: How Smart Bioprocessing Is Democratizing Life-Saving Treatments

08 Apr 2025

Contributed by Lukas

In the rapidly evolving world of biotechnology, innovation is not just happening at the molecular level. Industry leaders are making groundbreaking ad...