Solving the Puzzle with Dr. Datis Kharrazian
Episodes
Episode 82: Micronutrient Deficiency Signs
07 Apr 2026
Contributed by Lukas
Today, we're diving into the often overlooked signs and symptoms of micronutrient deficiencies, from vitamins A, D, and K to magnesium, zinc, and beyo...
Episode 81: How Skin Reveals Deeper Health Issues and Nutritional Imbalances
01 Apr 2026
Contributed by Lukas
In this episode, we’re diving into the world of skin health, from what radiant, healthy skin should look like to the many signals our skin can send ...
Episode 80: Dr. Darla Booth DC, AFMC, Managing Autoimmune Patients Successfully
29 Mar 2026
Contributed by Lukas
In this Practitioner Spotlight episode, we sit down with Dr. Darla Booth, a seasoned chiropractor and functional medicine practitioner based in Los Ga...
Episode 79: Nutrition Focused Physical Assessment with Dr. Liz Lipsky
24 Mar 2026
Contributed by Lukas
In this episode, Dr. Liz Lipsky, a leader in clinical nutrition and author of Digestive Wellness dives into the foundational practice of nutrition-foc...
Episode 78: How Mitochondrial Dysfunction Drives Fatigue, Depression, and Chronic Pain Syndromes
17 Mar 2026
Contributed by Lukas
In today’s episode, we’re diving into the impact of mitochondria on chronic conditions like fatigue, pain, and depression. You’ll hear why optim...
Episode 77: The Root Causes of Chronic Fatigue and Pain Syndromes
11 Mar 2026
Contributed by Lukas
In this episode, Dr. Kharrazian dives into one of the most challenging and important topics facing both patients and practitioners: chronic fatigue an...
Episode 76: Practical Functional Medicine
03 Mar 2026
Contributed by Lukas
Dr. Dave Rakel introduces the ECHO model for medical decision making, a practical framework that evaluates four key factors: Efficacy (evidence of ben...
Episode 75: Dr. Dave Rakel on the Placebo Effect
25 Feb 2026
Contributed by Lukas
In this lecture, Dr. Dave Rakel explores the placebo effect—"the ability to stimulate self-healing without deception"—and reveals how perception, ...
Episode 74: Why Hypoglycemia Destroys Healing, Neurological Exams Save Lives & Protocols Don't Work
23 Feb 2026
Contributed by Lukas
In this Practitioner Spotlight, Dr. Dave Boyton—a Cincinnati-based functional medicine specialist—shares how he transformed his practice by integr...
Episode 73: Navigating Breast Implant Illness
17 Feb 2026
Contributed by Lukas
In this episode, our guest speaker, certified physician assistant Danielle Valoras explores breast implant illness (BII)—a clinical reality that rem...
Episode 72: How the Lymphatic System Impacts Women With Breast Implants
10 Feb 2026
Contributed by Lukas
In this episode, our guest speaker, certified physician assistant Danielle Valoras explores the essential role of the lymphatic system in women with b...
Episode 71: The Hidden Risks of Breast Implants
04 Feb 2026
Contributed by Lukas
In this episode, certified physician assistant Danielle Valores shares her expertise cultivated from over two decades in medicine—and a decade devot...
Episode 70: Nutrient-Dense Eating for Fatty Liver
27 Jan 2026
Contributed by Lukas
In this episode, Dr. Yousef Elyaman breaks down the essential nutritional strategies for reversing fatty liver disease—from macronutrient optimizati...
Episode 69: Ketogenic Diets and Fasting for Liver Health with Dr. Yousef Elyaman
20 Jan 2026
Contributed by Lukas
In this episode, Dr. Yousef Elyaman breaks down the essential mathematics of metabolism—from calculating basal metabolic rate to understanding the 3...
Episode 68: Understanding the Root Causes of Fatty Liver Disease in Functional Medicine
13 Jan 2026
Contributed by Lukas
In this episode, Dr. Yousef Elyaman, a leading functional medicine doctor, takes us into the pathogenesis of fatty liver disease, sharing his expertis...
Episode 67: Hallmarks of Aging and Disease
06 Jan 2026
Contributed by Lukas
In this episode, Dr. Datis Kharrazian explores longevity medicine and the hallmarks of aging and disease. How do early signs of loss of resilience—l...
Episode 66: Longevity and Wellness Optimization
30 Dec 2025
Contributed by Lukas
In this episode, Dr. Kharrazian covers the physiological mechanisms that drive aging and how you can take proactive steps to slow disease progression ...
Episode 65: Why You're Aging Faster Than You Should
24 Dec 2025
Contributed by Lukas
In this episode, Datis Kharrazian bridges complex science with practical strategies you can use right away, focusing on the fascinating concept of bio...
Episode 64: The Impact of Lifestyle and Environmental Factors on Depression and Mood Disorders
16 Dec 2025
Contributed by Lukas
In this episode, we dive into the environmental and lifestyle factors that impact mood disorders like depression and anxiety. You'll learn how screen ...
Episode 63: How Blood Sugar Imbalances and Stress Disrupt Brain Chemistry and Mood Disorders
09 Dec 2025
Contributed by Lukas
In today’s episode, Dr. Datis Kharrazian takes a dive into the intricate relationship between blood sugar stability—what he calls dysglycemia—an...
Episode 62: Mood Disorders Explained: Placebo, Polypharmacy, and the Future of Treatment
02 Dec 2025
Contributed by Lukas
In this episode, Dr. Kharrazian dives into the complex world of mood disorders, shining a light on why conditions like depression and anxiety have bec...
Episode 61: Transformative Power of Laser Therapy for Chronic Illness
25 Nov 2025
Contributed by Lukas
In this episode, Dr. Kirk Gair dives into the clinical power of laser therapy—bridging the science behind this technology with its practical applica...
Episode 60: The Power of Laser Therapy in Neurodegeneration and Autoimmunity
18 Nov 2025
Contributed by Lukas
In today’s episode, Dr. Kirk Gair shares how a routine imaging procedure turned his family's life upside down, sending his wife into a severe health...
Episode 59: Why Your GI Testing Might Be Wrong
11 Nov 2025
Contributed by Lukas
Most practitioners trust previous test results without question. But Dr. Steven Sandberg-Lewis reveals why SIBO breath tests, celiac testing, and panc...
Episode 58: The Hidden Gut Problem Causes Practitioners Miss
04 Nov 2025
Contributed by Lukas
In this episode, Dr. Steven Sandberg-Lewis reveals three commonly overlooked root causes of chronic digestive disorders: traumatic brain injury, hy...
Episode 57: Dr. Joseph Pizzorno’s Insights on Functional Medicine and Environmental Health
28 Oct 2025
Contributed by Lukas
In this episode, Dr. Kharrazian is joined by renowned physician Dr. Joseph Pizzorno, a pioneering voice in environmental medicine and toxicology. Toge...
Episode 56: Labs To Monitor In Patients With Hemochromatosis
10 Oct 2025
Contributed by Lukas
In today’s episode, Dr. Christy Sutton breaks down the crucial markers to monitor for iron overload, from classic liver enzymes and iron panels to t...
Episode 55: Navigating Anemia
06 Oct 2025
Contributed by Lukas
Anemia affects millions but is often misunderstood or oversimplified. Anemia isn’t just about having low iron. It means you don’t have enough heal...
Episode 54: Understanding Dyslexia and Childhood Processing Disorders
28 Sep 2025
Contributed by Lukas
In this episode, Dr. Kharrazian dives into childhood developmental disorders, with a special focus on dyslexia and processing challenges. Learn why ch...
Episode 53: Functional Medicine Approaches to Childhood Neurodevelopmental Disorders
16 Sep 2025
Contributed by Lukas
In this episode, Dr. Kharrazian dives into the rising rates and complexities of childhood developmental disorders, such as autism, ADHD, dyslexia, and...
Episode 52: The Impact of Bone and Joint Health on Chronic Illness Recovery
08 Sep 2025
Contributed by Lukas
In this episode, Dr. Datis Kharrazian explains what happens to our muscles as we age and why maintaining muscle mass is crucial for mobility, bone den...
Episode 51: How Bone, Joint, and Muscle Health Influences Chronic Disease Recovery
26 Aug 2025
Contributed by Lukas
In this episode, you’ll learn how movement directly influences your metabolism, immune system, brain function, and even the diversity of your gut mi...
Episode 50: The Role of Relationships and Support in Managing Autoimmunity
06 May 2025
Contributed by Lukas
In this episode, we dive into the environmental and lifestyle factors that impact autoimmunity. From evaluating case reviews to understanding the sign...
Episode 49: Navigating Parasitic Infections
10 Feb 2025
Contributed by Lukas
In this episode of "Solving the Puzzle with Dr. Datis Kharrazian," we dive into the intricate world of gastrointestinal health, focusing specifically ...
Episode 48: Neurological Health and Interventions with Randy Vawdry, NP-C
07 Feb 2025
Contributed by Lukas
In today's episode, Dr. Kharrazian interviews Randy Vawdry, NP-C, a respected nurse practitioner who has carved a niche in the realm of functional med...
Episode 47: Chronic Lyme Disease and Mold Illnesses
04 Jan 2025
Contributed by Lukas
This episode dives into the complex world of chronic infections, with a particular focus on the far-reaching impacts of Lyme disease and mold-related ...
Episode 46: Navigating Chronic Infections
12 Nov 2024
Contributed by Lukas
In this episode, Dr. Kharrazian discusses chronic infections and antibiotic resistance. Topics include hidden pathogen reservoirs, the role of biofilm...
Episode 45: Understanding Chronic Viral Infections
21 Oct 2024
Contributed by Lukas
In this episode Dr. Kharrazian explores the world of chronic infections, such as Epstein-Barr Virus (EBV), Hepatitis C, Covid, and Human Cytomegalovir...
Episode 44: Chronic Infections and the Immune System
19 May 2024
Contributed by Lukas
This episode explores the world of the immune system's response to pathogens and chronic infections. Dr. Kharrazian discusses the intricate mechanisms...
Episode 43: Hormonal Imbalance Overview
30 Apr 2024
Contributed by Lukas
In this episode, Dr. Datis Kharrazian discusses hormone disorders and their impact on puberty, perimenopause, menopause, and andropause. He discusses ...
Episode 42: Hormone Therapy Strategies
11 Mar 2024
Contributed by Lukas
In this episode, Dr. Kharrazian provides insights on growth hormone deficiency, testosterone replacement therapy, strategies for PCOS and infertility,...
Episode 41: Understanding Hormone Disorders
05 Mar 2024
Contributed by Lukas
In this episode we dive into the intricate web of hormone imbalances, menstrual disorders, and andropause. We explore the impact of estrogen and proge...
Episode 40: Hormone Balancing through Gut Health
19 Feb 2024
Contributed by Lukas
In this episode, Dr. Kharrazian delves into the world of hormone imbalances, microbiome diversity, and the impact of polyphenols and phytoestrogens. H...
Episode 39: Hormone Imbalance & Obesity
31 Jan 2024
Contributed by Lukas
In this episode, Dr. Kharrazian provides insight into the impact of obesity on male and female hormone imbalances, infertility, and the body's endocri...
Episode 38: Hormone Imbalance and Environmental Toxins
17 Jan 2024
Contributed by Lukas
In today's episode, we dive into the impact of hormone imbalance on overall health. From the critical role of adequate sleep in hormone regulation to ...
Episode 37: Personalized Strategies for Balancing Hormones
02 Jan 2024
Contributed by Lukas
In this episode, we take a deep dive into the intricate world of hormone imbalances and hormone replacement therapy. Dr. Kharrazian discusses the late...
Episode 36: How chronic systemic inflammation impacts the body and brain
31 Oct 2022
Contributed by Lukas
In this talk, Dr. Kharrazian reviews the many pathways through which inflammation impacts the body. In a nutshell, inflammation is like throwing ...
Episode 35: Is it really SIBO?
24 Aug 2022
Contributed by Lukas
The concept of small intestinal bacterial overgrowth is one that is becoming very popular but also widely misunderstood and confusing. Compared to the...
Episode 34: Brain problems cause gut problems
17 Aug 2022
Contributed by Lukas
Chronic gut health problems some people face can stem from brain-related dysfunction. Key groups of brain-related problems can cause gut problems: neu...
Episode 33: Glutathione: Your Most Important Defense
22 Apr 2022
Contributed by Lukas
Glutathione is the body’s master antioxidant, meaning it helps protect your cells from pathogens such as viruses. It also lowers the risk of develop...
Episode 32: What thyroid lab tests really tell you
15 Apr 2022
Contributed by Lukas
A complete thyroid panel can tell you about thyroid function, feedback loops, and how thyroid hormones are converting. The main thyroid markers a...
Episode 31: Hypothyroidism and gallbladder function
01 Apr 2022
Contributed by Lukas
If you have hypothyroidism, the first question you have to ask yourself is how long did it take to finally get diagnosed? Most people do not receive a...
Episode 30: Common autoimmune diseases among thyroid patients
30 Mar 2022
Contributed by Lukas
If you have hypothyroidism, there is a greater than 90% chance that Hashimoto's, an autoimmune disease, is the cause of your hypothyroidism. If you ha...
Episode 29: What thyroid antibody levels tell you about Hashimoto's
17 Mar 2022
Contributed by Lukas
The two main antibodies to screen for Hashimoto’s are thyroid peroxidase (TPO) antibodies and thyroglobulin (Tg) antibodies. It’s important to che...
Episode 28: Why is it so hard to get a hypothyroidism diagnosis
10 Mar 2022
Contributed by Lukas
Why is it so difficult to get diagnosed with hypothyroidism and Hashimoto's in the current healthcare system? As a healthcare practitioner, it's prett...
Episode 27: Which thyroid medication is the best?
25 Feb 2022
Contributed by Lukas
In this episode Dr. Kharrazian discusses the commonly asked question, which thyroid hormone replacement works best? The important thing to understand ...
Episode 26: How hypothyroidism affects blood sugar stability
16 Feb 2022
Contributed by Lukas
Do you feel sleepy after you eat? Or do you feel energized after eating? Both responses indicate blood sugar instability. Chronically high blood sugar...
Episode 25: Chelation therapy risks
26 Dec 2021
Contributed by Lukas
Today’s world is very toxic, and we all carry toxic chemicals and heavy metals in our bodies. Chelation is a popular therapy to lower heavy metal le...
Episode 24: Endotoxemia: A hidden landmine for multiple health disorders
15 Dec 2021
Contributed by Lukas
Endotoxemia happens when toxic byproducts from harmful gut bacteria escape through a leaky gut wall into the bloodstream. Here, they trigger significa...
Episode 23: How gluten impacts Hashimoto's & hypothyroidism
08 Dec 2021
Contributed by Lukas
Contrary to popular belief, gluten intolerance is not a fad. Rates of gluten intolerance have risen dramatically due to many factors of industrializat...
Episode 22: Hashimoto's and hypothyroidism Q&A -- Part 3
01 Dec 2021
Contributed by Lukas
In this video, Dr. Kharrazian answers questions from members of the course Hashimoto's: Solving the Puzzle (drknews.com). Topics include:The role of t...
Episode 21: Hashimoto's and hypothyroidism Q&A -- Part 2
24 Nov 2021
Contributed by Lukas
In this video, Dr. Kharrazian answers questions from members of the course Hashimoto's: Solving the Puzzle (drknews.com). Topics covered include: The ...
Episode 20: Hashimoto's and hypothyroidism Q&A -- Part 1
17 Nov 2021
Contributed by Lukas
In this video, Dr. Kharrazian answers questions from members of the course Hashimoto's: Solving the Puzzle (drknews.com). Topics covered include what ...
Episode 19: The vagus nerve and gut health
11 Nov 2021
Contributed by Lukas
In this video, Dr. Kharrazian explains how the vagus nerve affects digestion and other aspects of gut health, factors that can compromise vagus functi...
Episode 18: How hypothyroidism causes depression and anxiety
27 Oct 2021
Contributed by Lukas
If you struggle with chronic depression, anxiety, or other mood disorders, you may suffer from undiagnosed hypothyroidism. A thyroid hormone deficienc...
Episode 17: The best (and worst) supplements for Hashimoto's hypothyroidism
20 Oct 2021
Contributed by Lukas
Not all thyroid supplements are equally effective – in fact, some can actually make your hypothyroid symptoms worse. You might have come across the ...
Episode 16: The best diet for Hashimoto's hypothyroidism
13 Oct 2021
Contributed by Lukas
It’s an incredibly common question among hypothyroid patients: what’s the best diet for hypothyroidism? While specific diet plans can certainly ma...
Episode 15: Environmental chemicals and hypothyroidism
06 Oct 2021
Contributed by Lukas
You might not realize just how many chemicals you encounter on a day-to-day basis. Each of us is routinely exposed to thousands of different chemicals...
Episode 14: How hypothyroidism affects gut health
29 Sep 2021
Contributed by Lukas
If you’ve been diagnosed with hypothyroidism, you should know low thyroid function can impact your gut health. This is why it’s important to prope...
Episode 13: The #1 rule when working on gut health
15 Sep 2021
Contributed by Lukas
If you're like 3/4 of Americans, you suffer from IBS, diarrhea, acid reflux, constipation, abdominal pain, leaky gut, SIBO, bloating and gas, and so o...
Episode 12: "Leaky brain" in brain fog, fatigue, and depression
08 Sep 2021
Contributed by Lukas
You may have heard of leaky gut but did you know you can get leaky brain too? The most common symptoms are brain fog and slower mental speed, but an i...
Episode 11: Mold toxicity — a silent factor in chronic illness
01 Sep 2021
Contributed by Lukas
Mold toxicity is a silent factor a lot of people don’t consider when rooting out causes for chronic health issues. Because most of its signs and sym...
Episode 10: GI symptoms from low stomach acid and gallbladder sludge
25 Aug 2021
Contributed by Lukas
Low stomach acid and gallbladders sludge are very common gut issues in Americans. Low stomach acid can lead to symptoms such as acid reflux, heartburn...
Episode 9: Histamine and Mast Cell Activation Syndrome (MCAS)
18 Aug 2021
Contributed by Lukas
In this episode, Dr. Kharrazian goes over the primary mechanisms of histamine intolerance and mast cell activation syndrome (MCAS). But first, make su...
Episode 8: Causes and solutions for chronic bloating
11 Aug 2021
Contributed by Lukas
Chronic bloating and abdominal distention are common gut health complaints. In this podcast, Dr. Kharrazian covers the primary causes of bloating and ...
Episode 7: How hypothyroidism affects your appearance
04 Aug 2021
Contributed by Lukas
Hypothyroidism, or low thyroid function, impacts your skin, hair, nails, joints, body inflammation, systemic inflammation—all of which affect your p...
Episode 6: How hypothyroidism affects the body and causes a variety of symptoms
28 Jul 2021
Contributed by Lukas
What happens to your health when your thyroid hormones are low? In this episode, Dr. Kharrazian talks about the various conditions that can cause low ...
Episode 5: Gluten and Chronic Health Conditions
02 Jul 2021
Contributed by Lukas
Gluten is a much more complex topic than most people realize. First of all, most gluten sensitivity testing is extremely limited as it only tests alph...
Episode 4: Understanding PANS and PANDAS
02 Jul 2021
Contributed by Lukas
PANDAS and PANS are autoimmune brain disorders that affect children in the aftermath of a strep infection or other infections. Symptoms include sensor...
Episode 3: How Gluten Affects the Brain
02 Jul 2021
Contributed by Lukas
Do you suffer from fatigue, brain fog, depression, cognitive issues, mood or psychiatric issues, or memory loss? A gluten sensitivity manifests n...
Episode 2: The Top 10 Triggers of Autoimmune Disease and Flare Ups
02 Jul 2021
Contributed by Lukas
Many people think their autoimmune management depends on diet. While diet plays a key role, it does not go the full distance for everyone. The autoimm...
Episode 1: 10 Reasons Autoimmune Patients Don't Get Better
01 Jul 2021
Contributed by Lukas
It takes the average autoimmune patient 10 years and visiting 20 doctors before receiving an autoimmune diagnosis. There is very little medical traini...