Talk Python To Me

#543: Deep Agents: LangChain's SDK for Agents That Plan and Delegate

01 Apr 2026

Contributed by Lukas

When you type a question into ChatGPT, the model only has what you typed to work with. But tools like Claude Code can plan, iterate, test, and recover...

#542: Zensical - a modern static site generator

25 Mar 2026

Contributed by Lukas

If you've built documentation in the Python ecosystem, chances are you've used Martin Donath's work. His Material for MKDocs powers docs for FastAPI, ...

#541: Monty - Python in Rust for AI

19 Mar 2026

Contributed by Lukas

When LLMs write code to accomplish a task, that code has to actually run somewhere. And right now, the options aren't great. Spin up a sandboxed conta...

#540: Modern Python monorepo with uv and prek

13 Mar 2026

Contributed by Lukas

Monorepos -- you've heard the talks, you've read the blog posts, maybe you've seen a few tantalizing glimpses into how Google or Meta organize their m...

#539: Catching up with the Python Typing Council

06 Mar 2026

Contributed by Lukas

You're adding type hints to your Python code, your editor is happy, autocomplete is working great. But then you switch tools and suddenly there are re...

#538: Python in Digital Humanities

28 Feb 2026

Contributed by Lukas

Digital humanities sounds niche, until you realize it can mean a searchable archive of U.S. amendment proposals, Irish folklore, or pigment science in...

#537: Datastar: Modern web dev, simplified

21 Feb 2026

Contributed by Lukas

You love building web apps with Python, and HTMX got you excited about the hypermedia approach -- let the server drive the HTML, skip the JavaScript b...

#536: Fly inside FastAPI Cloud

10 Feb 2026

Contributed by Lukas

You've built your FastAPI app, it's running great locally, and now you want to share it with the world. But then reality hits -- containers, load bala...

#535: PyView: Real-time Python Web Apps

23 Jan 2026

Contributed by Lukas

Building on the web is like working with the perfect clay. It’s malleable and can become almost anything. But too often, frameworks try to hide the ...

#534: diskcache: Your secret Python perf weapon

13 Jan 2026

Contributed by Lukas

Your cloud SSD is sitting there, bored, and it would like a job. Today we’re putting it to work with DiskCache, a simple, practical cache built on S...

#533: Web Frameworks in Prod by Their Creators

05 Jan 2026

Contributed by Lukas

Today on Talk Python, the creators behind FastAPI, Flask, Django, Quart, and Litestar get practical about running apps based on their framework in pro...

#532: 2025 Python Year in Review

29 Dec 2025

Contributed by Lukas

Python in 2025 is in a delightfully refreshing place: the GIL's days are numbered, packaging is getting sharper tools, and the type checkers are multi...

#531: Talk Python in Production

18 Dec 2025

Contributed by Lukas

Have you ever thought about getting your small product into production, but are worried about the cost of the big cloud providers? Or maybe you think ...

#530: anywidget: Jupyter Widgets made easy

13 Dec 2025

Contributed by Lukas

For years, building interactive widgets in Python notebooks meant wrestling with toolchains, platform quirks, and a mountain of JavaScript machinery. ...

#529: Computer Science from Scratch

03 Dec 2025

Contributed by Lukas

A lot of people building software today never took the traditional CS path. They arrived through curiosity, a job that needed automating, or a late-ni...

#528: Python apps with LLM building blocks

30 Nov 2025

Contributed by Lukas

In this episode, I’m talking with Vincent Warmerdam about treating LLMs as just another API in your Python app, with clear boundaries, small focused...

#527: MCP Servers for Python Devs

10 Nov 2025

Contributed by Lukas

Today we’re digging into the Model Context Protocol, or MCP. Think LSP for AI: build a small Python service once and your tools and data show up acr...

#526: Building Data Science with Foundation LLM Models

01 Nov 2025

Contributed by Lukas

Today, we’re talking about building real AI products with foundation models. Not toy demos, not vibes. We’ll get into the boring dashboards that s...

#525: NiceGUI Goes 3.0

27 Oct 2025

Contributed by Lukas

Building a UI in Python usually means choosing between "quick and limited" or "powerful and painful." What if you could write modern, component-based ...

#524: 38 things Python developers should learn in 2025

20 Oct 2025

Contributed by Lukas

Python in 2025 is different. Threads really are about to run in parallel, installs finish before your coffee cools, and containers are the default. In...

#523: Pyrefly: Fast, IDE-friendly typing for Python

13 Oct 2025

Contributed by Lukas

Python typing got fast enough to feel invisible. Pyrefly is a new, open source type checker and IDE language server from Meta, written in Rust, with a...

#522: Data Sci Tips and Tricks from CodeCut.ai

06 Oct 2025

Contributed by Lukas

Today we’re turning tiny tips into big wins. Khuyen Tran, creator of CodeCut.ai, has shipped hundreds of bite-size Python and data science snippets ...

#521: Red Teaming LLMs and GenAI with PyRIT

29 Sep 2025

Contributed by Lukas

English is now an API. Our apps read untrusted text; they follow instructions hidden in plain sight, and sometimes they turn that text into action. If...

#520: pyx - the other side of the uv coin (announcing pyx)

23 Sep 2025

Contributed by Lukas

A couple years ago, Charlie Marsh lit a fire under Python tooling with Ruff and then uv. Today he’s back with something on the other side of that co...

#519: Data Science Cloud Lessons at Scale

18 Sep 2025

Contributed by Lukas

Today on Talk Python: What really happens when your data work outgrows your laptop. Matthew Rocklin, creator of Dask and cofounder of Coiled, and Nat ...

#518: Celebrating Django's 20th Birthday With Its Creators

29 Aug 2025

Contributed by Lukas

Twenty years after a scrappy newsroom team hacked together a framework to ship stories fast, Django remains the Python web framework that ships real a...

#517: Agentic Al Programming with Python

22 Aug 2025

Contributed by Lukas

Agentic AI programming is what happens when coding assistants stop acting like autocomplete and start collaborating on real work. In this episode, we ...

#516: Accelerating Python Data Science at NVIDIA

19 Aug 2025

Contributed by Lukas

Python’s data stack is getting a serious GPU turbo boost. In this episode, Ben Zaitlen from NVIDIA joins us to unpack RAPIDS, the open source toolki...

#515: Durable Python Execution with Temporal

11 Aug 2025

Contributed by Lukas

What if your code was crash-proof? That's the value prop for a framework called Temporal. Temporal is a durable execution platform that enables develo...

#514: Python Language Summit 2025

18 Jul 2025

Contributed by Lukas

Every year the core developers of Python convene in person to focus on high priority topics for CPython and beyond. This year they met at PyCon US 202...

#513: Stories from Python History

14 Jul 2025

Contributed by Lukas

Why do people listen to this podcast? Sure, they're looking for technical explorations of new libraries and ideas. But often it's to hear the story be...

#512: Building a JIT Compiler for CPython

02 Jul 2025

Contributed by Lukas

Do you like to dive into the details and intricacies of how Python executes and how we can optimize it? Well, do I have an episode for you. We welcome...

#511: From Notebooks to Production Data Science Systems

25 Jun 2025

Contributed by Lukas

If you're doing data science and have mostly spent your time doing exploratory or just local development, this could be the episode for you. We are jo...

#510: 10 Polars Tools and Techniques To Level Up Your Data Science

18 Jun 2025

Contributed by Lukas

Are you using Polars for your data science work? Maybe you've been sticking with the tried-and-true Pandas? There are many benefits to Polars directly...

#509: GPU Programming in Pure Python

11 Jun 2025

Contributed by Lukas

If you're looking to leverage the insane power of modern GPUs for data science and ML, you might think you'll need to use some low-level programming l...

#508: Program Your Own Computer with Python

06 Jun 2025

Contributed by Lukas

If you've heard the phrase "Automate the boring things" for Python, this episode starts with that idea and takes it to another level. We have Glyph ba...

#507: Agentic AI Workflows with LangGraph

02 Jun 2025

Contributed by Lukas

If you want to leverage the power of LLMs in your Python apps, you would be wise to consider an agentic framework. Agentic empowers the LLMs to use to...

#506: ty: Astral's New Type Checker (Formerly Red-Knot)

19 May 2025

Contributed by Lukas

See the full show notes for this episode on the website at talkpython.fm/506

#505: t-strings in Python (PEP 750)

13 May 2025

Contributed by Lukas

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#504: Developer Trends in 2025

05 May 2025

Contributed by Lukas

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#503: The PyArrow Revolution

28 Apr 2025

Contributed by Lukas

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#502: Django Ledger: Accounting with Python

21 Apr 2025

Contributed by Lukas

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#501: Marimo - Reactive Notebooks for Python

14 Apr 2025

Contributed by Lukas

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#500: Django Simple Deploy and other DevOps Things

10 Apr 2025

Contributed by Lukas

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#499: BeeWare and the State of Python on Mobile

31 Mar 2025

Contributed by Lukas

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#498: Algorithms for high performance terminal apps

24 Mar 2025

Contributed by Lukas

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#497: Outlier Detection with Python

21 Mar 2025

Contributed by Lukas

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#496: Scaf: Complete blueprint for new Python Kubernetes projects

14 Mar 2025

Contributed by Lukas

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#495: OSMnx: Python and OpenStreetMap

24 Feb 2025

Contributed by Lukas

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#494: Update on Flet: Python + Flutter UIs

21 Feb 2025

Contributed by Lukas

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#493: Quarto: Open-source technical publishing

09 Feb 2025

Contributed by Lukas

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#492: Great Tables

30 Jan 2025

Contributed by Lukas

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#491: DuckDB and Python: Ducks and Snakes living together

27 Dec 2024

Contributed by Lukas

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#490: Django Ninja

24 Dec 2024

Contributed by Lukas

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#489: Anaconda Toolbox for Excel and more with Peter Wang

20 Dec 2024

Contributed by Lukas

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#488: Multimodal data with LanceDB

12 Dec 2024

Contributed by Lukas

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#487: Building Rust Extensions for Python

01 Dec 2024

Contributed by Lukas

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#486: CSnakes: Embed Python code in .NET

22 Nov 2024

Contributed by Lukas

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#485: Secure coding for Python with SheHacksPurple

15 Nov 2024

Contributed by Lukas

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#484: From React to a Django+HTMX based stack

05 Nov 2024

Contributed by Lukas

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#483: Reflex Framework: Frontend, Backend, Pure Python

29 Oct 2024

Contributed by Lukas

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#482: Pre-commit Hooks for Python Devs

24 Oct 2024

Contributed by Lukas

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#481: Python Opinions and Zeitgeist with Hynek

17 Oct 2024

Contributed by Lukas

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#480: Ahoy, Narwhals are bridging the data science APIs

09 Oct 2024

Contributed by Lukas

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#479: Designing Effective Load Tests for Your Python App

06 Oct 2024

Contributed by Lukas

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#478: When and how to start coding with kids

25 Sep 2024

Contributed by Lukas

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#477: Awesome Text Tricks with NLP and spaCy

20 Sep 2024

Contributed by Lukas

See the full show notes for this episode on the website at talkpython.fm/477

#476: Unified Python packaging with uv

04 Sep 2024

Contributed by Lukas

See the full show notes for this episode on the website at talkpython.fm/476

#475: Python Language Summit 2024

24 Aug 2024

Contributed by Lukas

See the full show notes for this episode on the website at talkpython.fm/475

#474: Python Performance for Data Science

19 Aug 2024

Contributed by Lukas

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#473: Being a developer with ADHD

02 Aug 2024

Contributed by Lukas

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#472: State of Flask and Pallets in 2024

26 Jul 2024

Contributed by Lukas

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#471: Learning and teaching Pandas

22 Jul 2024

Contributed by Lukas

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#470: Python in Medicine and Patient Care

12 Jul 2024

Contributed by Lukas

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#469: PuePy: Reactive frontend framework in Python

08 Jul 2024

Contributed by Lukas

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#468: Python Trends Episode 2024

01 Jul 2024

Contributed by Lukas

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#467: Data Science Panel at PyCon 2024

20 Jun 2024

Contributed by Lukas

See the full show notes for this episode on the website at talkpython.fm/467

#466: Pydantic Performance Tips

14 Jun 2024

Contributed by Lukas

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#465: The AI Revolution Won't Be Monopolized

08 Jun 2024

Contributed by Lukas

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#464: Seeing code flows and generating tests with Kolo

29 May 2024

Contributed by Lukas

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#463: Running on Rust: Granian Web Server

25 May 2024

Contributed by Lukas

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#462: Pandas and Beyond with Wes McKinney

15 May 2024

Contributed by Lukas

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#461: Python in Neuroscience and Academic Labs

09 May 2024

Contributed by Lukas

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#460: Dropbase: Build Internal Tools with Python

02 May 2024

Contributed by Lukas

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#459: I Built A Python SaaS with AI

27 Apr 2024

Contributed by Lukas

See the full show notes for this episode on the website at talkpython.fm/459

#458: Serverless Python in 2024

24 Apr 2024

Contributed by Lukas

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#457: Software Supply Chain Security with Phylum

19 Apr 2024

Contributed by Lukas

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#456: Building GPT Actions with FastAPI and Pydantic

16 Apr 2024

Contributed by Lukas

See the full show notes for this episode on the website at talkpython.fm/456

#455: Land Your First Data Job

04 Apr 2024

Contributed by Lukas

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#454: Data Pipelines with Dagster

21 Mar 2024

Contributed by Lukas

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#453: uv - The Next Evolution in Python Packages?

13 Mar 2024

Contributed by Lukas

See the full show notes for this episode on the website at talkpython.fm/453

#452: Top Quart (async Flask) Extensions

10 Mar 2024

Contributed by Lukas

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#451: Djangonauts, Ready for Blast-Off

01 Mar 2024

Contributed by Lukas

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#450: Versioning Web APIs in Python

22 Feb 2024

Contributed by Lukas

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#449: Building UIs in Python with FastUI

13 Feb 2024

Contributed by Lukas

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#448: Full-Time Open Source Devs Panel

08 Feb 2024

Contributed by Lukas

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#447: Parallel Python Apps with Sub Interpreters

03 Feb 2024

Contributed by Lukas

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#446: Python in Excel

26 Jan 2024

Contributed by Lukas

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#445: Inside Azure Data Centers with Mark Russinovich

19 Jan 2024

Contributed by Lukas

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#444: The Young Coder's Blueprint to Success

02 Jan 2024

Contributed by Lukas

See the full show notes for this episode on the website at talkpython.fm/444