Talking About Tumors with Ryann and Ryan - A medical oncology podcast
Episodes
05_02 Neuroendocrine Tumors
03 May 2025
Contributed by Lukas
1. Nomenclature, unique considerations2. Secretory Syndromes3. Somatostatin directed therapy4. Peptide Receptor Radionucleotide TherapyCitationsAs alw...
05_01 Hepatocellular carcinoma
19 Dec 2024
Contributed by Lukas
1. Etiologies and epidemiology2. Staging and local/regional considerations3. Systemic Therapy4. Differences in immune checkpoint sensitivity by etiolo...
04_10 Testicular Cancer II
27 Oct 2024
Contributed by Lukas
1. Stage II Disease2. Overview of BEP, EP, VIP3. Advanced, refractory disease4. Survivorship considerationsCitationsAs always, citations, and source...
04_09 Testicular Cancer I
18 Sep 2024
Contributed by Lukas
1. Background, work up2. Staging of seminoma and NSGCT3. Young Adult/Adolescent Oncology4. Management of Stage I Disease CitationsAs always, citation...
04_08 Metastatic Renal Cell Carcinoma
02 Aug 2024
Contributed by Lukas
1. Historical Approach (cytoreduction, IFN-a, sunitinib2. Prognostic risk scores3. Evidence for modern doublet regimens4. Later line therapyCitationsA...
04_07 Localized Renal Cell Carcinoma
06 Jul 2024
Contributed by Lukas
1. Risk Factors and Presentation2. Staging and Paraneoplastic syndromes3. Localized Therapy Options and Considerations4. Evidence and Limitations for ...
04_06 Metastatic Urothelial Cancer
24 May 2024
Contributed by Lukas
1. Immunohistochemistry of urothelial cancer2. History of systemic therapy in advanced and metastatic disease3. Pembrolizumab and Enfortumab Vedotin4....
04_05 Muscle Invasive Bladder Cancer
20 Apr 2024
Contributed by Lukas
1. Etymology, presentation, and work-up of bladder/urothelial cancer2. Role of perioperative systemic therapy3. Tri-modality therapy (bladder sparin...
01_14 Ampullary Carcinoma (Mini Discussion)
11 Apr 2024
Contributed by Lukas
1. Clinical presentation and work-up2. Intestinal and pancreatobiliary subtypes3. Role of perioperative therapy4. Considerations for metastatic dis...
04_04 Castrate Resistant Metastatic Prostate Cancer
22 Feb 2024
Contributed by Lukas
1. On continuation of ADT and ARAT switch2. Systemic therapy options after progression3. Improper mandated crossover4. PARP inhibitors in prostate ...
04_03 Metastatic Castrate Sensitive Prostate Cancer
04 Feb 2024
Contributed by Lukas
1. The chemotherapy revolution in prostate cancer2. Role of ARATs in earlier disease states3. Triple therapy (chemotherapy, ADT, and ARAT)4. Considera...
04_02 Adjuvant Options for Prostate Cancer
08 Jan 2024
Contributed by Lukas
1. Physiology, efficacy and toxicities of androgen deprivation2. Evidence for adjuvant intervention after definitive surgery or radiation3. Role of ab...
04_01 Fundamentals of Localized Prostate Cancer
18 Dec 2023
Contributed by Lukas
1. Background and presentation of prostate Cancer2. Evidence behind PSA screening and hallmarks of a screening test3. Staging and risk stratification ...
03_13 Head and Neck Cancer – Locally advanced and metastatic
29 Nov 2023
Contributed by Lukas
1. Role for definitive chemotherapy and radiation2. Controversy on induction chemotherapy3. Considerations for nasopharyngeal cancer4. Approach to met...
03_12 Head and Neck Cancer – Background and adjuvant considerations
01 Nov 2023
Contributed by Lukas
1. Anatomy, diagnostic work-up and staging2. Field cancerization3. Indications for adjuvant concurrent chemoradiation4. Evidence to support weekly cis...
03_11 Mesothelioma and a bit of Large Cell Neuroendocrine Carcinoma
12 Oct 2023
Contributed by Lukas
1. Presentation, and considerations for regional mesothelioma2. Systemic therapy options for advanced mesothelioma3. Corticosteroids for pemetrexed, p...
03_10 Small cell lung cancer
17 Sep 2023
Contributed by Lukas
1. Background on SCLC2. Approach to treatment by stage3. Emerging discussion on prophylactic cranial irradiation4. Brief review of basket and umbrella...
03_09 Stage III NSCLC for the Medical Oncologist
31 Aug 2023
Contributed by Lukas
1. Refresher on T+N staging for Stage III2. Evidence for concurrent chemoradiation3. PACIFIC Trial4. Encourage cessation regardless of stage of Lung C...
03_08 ADAURA Trial
16 Aug 2023
Contributed by Lukas
1. Background on adjuvant EGFR therapy2. Discussion of initial and updated results3. Hazard Ratios and Context4. When crossover and access limit gener...
03_07 (Neo)Adjuvant NSCLC
27 Jul 2023
Contributed by Lukas
1. Considerations with surgery, radiation, rate of relapse2. Adjuvant chemotherapy3. Adjuvant immune checkpoint inhibition4. Emerging neoadjuvant tria...
03_06 Driver Mutations in Advanced NSCLC
07 Jul 2023
Contributed by Lukas
1. EGFR inhibitors2. ALK inhibitors3. Less common molecular targets4. Role of KRAS inhibitors and evidence for sotorasib CitationsAs always, citation...
03_05 NSCLC metastatic without driver mutations
21 Jun 2023
Contributed by Lukas
1. Evidence to support platinum doublets2. The tale of pemetrexed3. Immune checkpoint inhibitors alone and in combination4. Second Line, approach in p...
03_04 Overview of Lung Cancer
31 May 2023
Contributed by Lukas
1. Presentation and Work-up2. Staging and how to memorize staging algorithms3. SVC Syndrome, an oncologic emergency4. Variations by histology and mole...
03_03 Metastatic Melanoma
10 May 2023
Contributed by Lukas
1. Patterns of recurrence and approach to stage IV disease2. Immunotherapy and BRAF/MEK considerations3. Cross trial comparisons4. Later line and emer...
03_02 Localized Melanoma
15 Apr 2023
Contributed by Lukas
1. Background, staging and work-up of regional melanoma2. Evidence for adjuvant and neoadjuvant immunotherapy3. Adjuvant BRAF/MEK inhibitor 4. Consid...
03_01 The era of immune checkpoint inhibitors
28 Mar 2023
Contributed by Lukas
1. History of Immunotherapy2. Modern immune checkpoint inhibitors (ICIs)3. Unique considerations with ICIs4. Immune related adverse events and immorta...
02_10 BRCA Positive Breast Cancer in the Clinic
14 Mar 2023
Contributed by Lukas
1. BRCA 1/2 genes and relation to malignancy2. Family history taking and identifying patients for genetic testing3. Risk reduction strategies for brea...
02_09 Triple Negative Breast Cancer
02 Mar 2023
Contributed by Lukas
1. Clinical considerations2. Neoadjuvant and adjuvant regimens3. Immunotherapy in localized and metastatic disease4. Later line options in metastatic ...
02_08 Early HER-2 positive breast cancer
14 Feb 2023
Contributed by Lukas
1. Role of adjuvant HER-2 Agents and during of therapy2. Chemotherapy backbone considerations3. Pathologic complete response4. Neoadjuvant systemic th...
02_07 HER-2 positive breast cancer: Considerations in advanced disease
19 Jan 2023
Contributed by Lukas
1. Anti-HER2 agent classes2. Cleopatra Trial3. Later line options4. Leptomeningeal carcinomatosis CitationsAs always, citations, and sources include ...
02_06 HER-2 Low Breast Cancer and Sacutuzumab Govetecan
29 Dec 2022
Contributed by Lukas
1. HER-2 Testing Algorithm2. Trastuzumab Deruxtecan in HER-2 Low MBC3. 2:1 Randomization, Treatment of Provider Choice4. Sacutuzumab Govetacan for lat...
02_05 Management of Metastatic Hormone Positive Breast Cancer
06 Dec 2022
Contributed by Lukas
1. Endocrine Resistance: Definition and Mechanism2. Role of AI with and without CDK4/6 inhibitors3. Later line managemen...
02_04 Recurrence risk scores and CDK inhibitors for Early Breast Cancer
19 Nov 2022
Contributed by Lukas
1. Recurrence Risk Scores2. TailorRx, RxPonder, MINDACT Trials Overview3. Introduction to CDK 4/6 inhibitors4. ...
02_03 Adjuvant endocrine therapy for early breast cancer
29 Oct 2022
Contributed by Lukas
1. Tamoxifen, its development, mechanism and benefits2. Aromatase inhibitors and their benefit in post-menopausal state3. ...
02_02 Chemotherapy Options and Bisphosphonates in Early Breast Cancer
11 Oct 2022
Contributed by Lukas
1. First, second, and third generation chemotherapy regimens2. Considerations for anthracyclines 3. Considerations for ...
02_01 An Overview of Considerations for Early Breast Cancer
27 Sep 2022
Contributed by Lukas
1. History of surgery and radiation for breast cancer2. Indication and goal of adjuvant systemic therapy (incl cell-kill hypothesi...
01_13 Anal Squamous Cell Carcinoma
14 Sep 2022
Contributed by Lukas
1. Overview of disease site2. Management of localized disease3. Surveillance4. Metastatic DiseaseCitationsAs a...
01_12 Rectal Cancer – TNT (Total Neoadjuvant Therapy) and Immunotherapy
01 Sep 2022
Contributed by Lukas
1. RAPIDO Trial 2. PRODIGE-23 Trial 3. OPRA Trial 4. Evidence for non-operative potential in MSI-H tumors w...
01_11 Rectal Cancer – An Overview of the Challenges and Basics of Management
18 Aug 2022
Contributed by Lukas
1. Anatomy, definitions, and unique considerations vs colon cancer2. Surgical modalities and patterns of failure3. Perio...
01_10 Localized Cholangiocarcinoma
04 Aug 2022
Contributed by Lukas
1. Overview of intrahepatic, perihilar, distal cholangiocarcinoma2. Overview of gall bladder adenocarcinoma3. Adjuvant c...
01_09 Metastatic Cholangiocarcinoma
17 Jul 2022
Contributed by Lukas
1. Overview of nomenclature, etiology and presentation2. Management of symptoms and prognosis3. Systemic therapy in the ...
01_08 Localized Pancreatic Cancer
28 Jun 2022
Contributed by Lukas
1. Differential for pancreatic lesion, staging of adenocarcinoma2. Surgical considerations, post-surgical complications3. ...
01_07 Metastatic Pancreatic Cancer – An Overview
14 Jun 2022
Contributed by Lukas
1. Natural history of disease, presentation, and diagnosis2. Principles of management3. Landmark clinical trials4. Tar...
01_06 Metastatic Gastroesophageal Cancer
23 May 2022
Contributed by Lukas
1. Principles of management2. Key chemotherapy tegimens3. Immunotherapy/HER-2 Directed Approach4. Alpha spending, hier...
01_05 Localized Esophageal and Gastric Cancer
10 May 2022
Contributed by Lukas
1. Anatomy of the Upper GI Tract2. Diagnosis, Staging Work-up3. Neoadjuvant Chemoradiation for Esophageal/EGJ4. ...
01_04 IDEA Trial Discussion
21 Apr 2022
Contributed by Lukas
IDEA Trial Discussion1. Background/Methods2. Non-inferiority Trial DesignCitationsAs always, citations, and sources include education ...
01_03 Localized Colon Cancer
04 Apr 2022
Contributed by Lukas
1. Clinical Presentation, Pathology Evaluation2. Chemotherapy Regimens in Adjuvant Setting3. Approach to Stage 34. App...
01_02 Latest and greatest in metastatic colon cancer – mAbs, MSI status, sidedness and controversies
04 Apr 2022
Contributed by Lukas
1. Background on molecular targeted agents2. VEGF-inhibitors3. EGFR inhibition4. Left vs Right sided colon cancer5. ...
01_01 Metastatic Colon Cancer, An Overview of Management and Fundamentals of Systemic Therapy
04 Apr 2022
Contributed by Lukas
1. Clinical presentations of metastatic colon cancer2. ECOG performance status3. 5-fluorouracil and capecitabine4. Dou...
Introduction (Updated 12.17.23)
04 Apr 2022
Contributed by Lukas
Overview of our podcast and goal.