The Chain: Protein Engineering Podcast
Episodes
Episode: 83 - Patrick Baeuerle and Jeffrey Miller on the Prospects of Immune Cell Engagement
17 Mar 2026
Contributed by Lukas
Immune cell engagement is gaining traction, but what makes it different from other therapies? Patrick Baeuerle, Ph.D., chief scientific advisor at Cul...
Episode: 82 - PANEL DISCUSSION: Future of Biologic Therapeutics: Will Half-Life Extended Peptides Replace Multispecific Antibodies?
10 Feb 2026
Contributed by Lukas
During last year’s PEGS Europe, industry experts gathered on a panel to discuss the future of biologic therapeutics. The panel kicked off with a pre...
Episode: 81 - Laszlo Radvanyi on Pushing Boundaries in Cancer Immunotherapy Research
13 Jan 2026
Contributed by Lukas
How has immunotherapy evolved in the last decade? In this episode of The Chain, Laszlo Radvanyi, professor of immunology at the University of Toronto,...
Episode: 80 - Vibha Jawa Discusses the Impact of Biologic Molecules and the Future of Immunogenicity
09 Dec 2025
Contributed by Lukas
December 13, 2025 | What is next for immunogenicity? In this episode of The Chain, Vibha Jawa, chief scientific officer at EpiVax, provides her though...
Episode: 79 - Conversation with Bahija Jallal on the Biggest Anticipated Transformations and Breakthroughs
11 Nov 2025
Contributed by Lukas
November 11, 2025 | What is the next modality to focus on in the next 10 years? For Bahija Jallal, CEO of Immunocore, it would be T-cell engagers. In ...
Episode: 78 - Shamit Shrivastava on an Interdisciplinary Approach to Antibody Biophysics and Developability
14 Oct 2025
Contributed by Lukas
As drug development pushes into more complex antibody formats, the big question is: how do you really assess developability? In this episode, host Nim...
Episode: 77 - Derek Lowe on AI and the US Biotech Ecosystem
16 Sep 2025
Contributed by Lukas
September 16, 2025 | With the rise of AI and automation, what is the core human skill in drug discovery that is and will be valuable in the future? De...
Alexey Lugovskoy Shares Decades of Experience in Starting Out and Founding Companies
12 Aug 2025
Contributed by Lukas
August 12, 2025 | Diagonal Therapeutics founder and CEO Alexey Lugovskoy discusses the key lessons learned over his illustrious career, starting from ...
Episode: 75 - Are Licensing Fees Required or Gatekeeping?
29 Jul 2025
Contributed by Lukas
July 15, 2025 | Are licensing fees required or gatekeeping? In this episode of The Chain, host Nimish Gera, vice president of Biologics at Mythic Ther...
Episode: 74 - Keith Flaherty, President-Elect of AACR, on Public and Private Collabs, AI Optimism, and More
11 Jun 2025
Contributed by Lukas
June 10, 2025 | In this bonus episode of The Chain, Daniel Chen, MD, PhD, founder and CEO of Synthetic Design Lab, returns for the Science Commune seg...
Episode: 73 - PANEL DISCUSSION: Near-Term Challenges for AI/ML in Biotherapeutic R&D
10 Jun 2025
Contributed by Lukas
June 10, 2025 | This episode of The Chain features a panel discussion from May’s PEGS Boston. Moderated by Peter Tessier, Albert M. Mattocks profess...
Episode: 72 - Pamela Barney on HR Lessons to Meet the Needs of Biotech
13 May 2025
Contributed by Lukas
In this episode of The Chain, host Tariq Ghayur, PhD, Tariq Ghayur Consulting, LLC, talks with Pamela Barney, former associate director of HR, AbbVie,...
PEGS Young Scientist Keynote Jessica Stark on the Role of Glycans in Cancer Research
15 Apr 2025
Contributed by Lukas
In this episode of The Chain, host Brandon DeKosky, associate professor, speaks with MIT colleague Jessica Stark, Underwood-Prescott career developmen...
Episode: 70 - Views on Machine Learning and AI in the Antibody and Protein Engineering Space
12 Mar 2025
Contributed by Lukas
March 11, 2025 | In this episode of The Chain, host Andrew Buchanan, principal scientist at AstraZeneca, and Andreas Plückthun, professor and head of...
Episode: 69 - Conversation with Sir Greg Winter on the 50th Anniversary of the Milstein and Köhler Paper
21 Feb 2025
Contributed by Lukas
February 21, 2025 | This episode marks the 50th anniversary of one of the most influential papers in biomedical science—the 1975 Milstein and Köhle...
Episode: 68 - Changing the Game of Protein-Protein Interactions With Randolph Lopez
10 Dec 2024
Contributed by Lukas
In this episode of The Chain, host Andrew Bradbury, CSO of Specifica, an IQVIA business, speaks with Randolph Lopez, CTO and co-founder of A-Alpha Bio...
Episode: 67 - Anthony Tolcher Discusses Oncology, Dual-Payload Technology, and the ADC Field
12 Nov 2024
Contributed by Lukas
November 12, 2024 | In this episode of The Chain, host Rakesh Dixit, PhD, DABT, president and founder of Bionavigen Oncology and Regio Biosciences, sp...
Episode: 66 - John Lambert on Antibody Drug Conjugates Then, Now, & Beyond
16 Oct 2024
Contributed by Lukas
October 15, 2024 | In this month’s episode of The Chain, host Rakesh Dixit, PhD, DABT, president and founder of Bionavigen Oncology and Regio Biosci...
Episode 65- Tariq Ghayur on the Renaissance of Bispecifics and ADCs, AI, and More
10 Sep 2024
Contributed by Lukas
September 10, 2024 | In this episode of The Chain, host Nimish Gera speaks with Tariq Ghayur, of Tariq Ghayur Consulting, LLC and Entrepreneur in Resi...
Episode: 64 - Peyton Greenside on AI’s Role in Antibody Engineering, Optimization, and More
13 Aug 2024
Contributed by Lukas
In this episode of The Chain, host Nimish Gera, Ph.D., vice president of biologics at Mythic Therapeutics, speaks with Peyton Greenside, CSO and co-fo...
Episode: 63 - Discussing Protein Signaling and Structural Biology With Andrew Kruse
16 Jul 2024
Contributed by Lukas
In this episode of The Chain, host Brandon DeKosky, associate professor at MIT, speaks with Andrew Kruse, PhD, professor of biological chemistry and m...
Episode: 62 - AI/ML in Antibody Discovery and Engineering: Reality, Hope, Future, and Hype
11 Jun 2024
Contributed by Lukas
his special episode of The Chain features a panel of industry experts who discussed AI and ML in antibody discovery and engineering at this year’s P...
Episode: 61 - Tomoyuki Igawa Discusses Leadership and His Experiences in Discovery and Development
14 May 2024
Contributed by Lukas
In this episode of The Chain, host Tariq Ghayur, PhD, consultant and entrepreneur in residence, FairJourney Biologics, speaks with Tomoyuki Igawa, PhD...
Episode: 60 - Lesley Millar-Nicholson on Technology Licensing, Navigating Patents, and Building Teams
09 Apr 2024
Contributed by Lukas
This month The Chain shares a recent episode of the Lab Rats to Unicorns podcast. Lab Rats to Unicorns, hosted by John Flavin, aims to demystify the p...
Episode: 59 - Gabriel Rocklin on Protein Biophysics and Protein Design
12 Mar 2024
Contributed by Lukas
In this month’s episode of The Chain, host Ben Hackel, professor of Chemical Engineering & Materials Science at the University of Minnesota, spe...
Episode: 58 - Janine Schuurman Reflects on the Key Lessons and Accomplishments of Her 20-Year Career
13 Feb 2024
Contributed by Lukas
How does one maintain innovation in the antibody industry? In this episode of The Chain, host Tariq Ghayur, PhD, consultant and entrepreneur in reside...
Episode: 57 - The Future of Bispecific Antibody Drug Conjugates With Rakesh Dixit, Ph. D.
16 Jan 2024
Contributed by Lukas
Bispecific antibody drug conjugates (ADCs) have been undergoing a renaissance in recent years. As big pharma continues to express more interest, what ...
Episode: 56 - Thomas Sakmar on the Golden Age for the Application of Biologics to GPCR Pharmacology
19 Dec 2023
Contributed by Lukas
What can we expect from GPCRs in antibodies and biologics? In this episode of The Chain, host Rajesh Sundaresan, PhD, Scientific Leader and GSK Fellow...
Episode: 55 - Tala Fakhouri Discusses AI/ML for Biologics Drug Discovery & Development
14 Nov 2023
Contributed by Lukas
In this episode of The Chain, Richard Bonneau, PhD, and Marcel Hop, PhD, of Genentech interview Tala Fakhouri, PhD, of the FDA on her thoughts on the ...
Episode: 54 - Enkelejda Miho on the Current State of AI: Drug Development, Research, and the Future
17 Oct 2023
Contributed by Lukas
With the whirlwind development of AI, it can be difficult to keep track of its uses in both research and the market. In this episode of The Chain podc...
Episode: 53 - Jonathan Sockolosky on Breaking Into Biotech and Making Real Progress in Ovarian Cancer Treatments
12 Sep 2023
Contributed by Lukas
What is the first step of getting into biotech? How do you make real progress in research? In honor of Ovarian Cancer Awareness Month, host Nimish Ger...
Episode 52: Entrepreneurship in Immunotherapy: Capstan’s Adrian Bot on Teambuilding
15 Aug 2023
Contributed by Lukas
In this episode of The Chain, Brandon Dekosky, Associate Professor at MIT, speaks with Adrian Bot, Founding Chief Scientific Officer and Executive Vic...
Episode: 51 - Setting the Right Strategy to Drive Engineering Parameters for Solid Tumor-Targeting T Cell-Engagers
11 Jul 2023
Contributed by Lukas
In this special episode of The Chain, G. Jonah Rainey, Senior Director of Protein Engineering at Eli Lilly and Company, hosts a panel at PEGS 2023 to ...
Episode: 50 - Pivoting Research with Antibody Drug Conjugates
13 Jun 2023
Contributed by Lukas
In this month’s episode of The Chain, Greg M. Thurber, associate professor of chemical engineering and biomedical engineering at the University of M...
Episode: 49 - Building a Next Generation Bioproduction Platform
09 May 2023
Contributed by Lukas
Kyron.Bio is revolutionizing drug production with its Next Generation Bioproduction Platform that will make the production of therapeutics easier, che...
Episode: 48 - A Conversation with Peter Tessier: Classifying Antibodies to Assess Biologics Developability Features Early in the Discovery Process
11 Apr 2023
Contributed by Lukas
In this month’s episode of the Chain, guest Peter Tessier, Albert M. Mattocks pharmaceutical sciences and chemical engineering professor at the Univ...
Episode: 47 - Bonus Episode with PEGS Young Scientist Keynote Dr. Andrew Anzalone on Engineering Prime Editor Proteins for Therapeutic Applications
28 Mar 2023
Contributed by Lukas
Dr. Andrew Anzalone, head of the Prime Editing Platform and scientific co-founder at Prime Medicine, is the winner of the PEGS Boston 2023 Young Scien...
Episode: 46 - Leveraging Albumin and IgG FcRn-Mediated Regulation in Therapeutic Development
14 Mar 2023
Contributed by Lukas
Jan Terje Andersen, professor of biomedical innovation in the Department of Pharmacology at the University of Oslo and research group leader in the De...
Episode: 45 - Advances in Targeted Protein Degradation
14 Feb 2023
Contributed by Lukas
In this month’s episode of the Chain, Jim Wells, professor of pharmaceutical chemistry and cellular and molecular pharmacology at the University of ...
Episode 44: Structure Forward: Using Structural Biology Pipelines to Achieve Favorable Antibody Responses
10 Jan 2023
Contributed by Lukas
Over the last two decades, cryogenic electron microscopy (cryo-EM) has transformed from what Dr. Andrew Ward calls the “outcast of structural biolog...
Episode: 43 - Evolution of Antibody Technologies
12 Dec 2022
Contributed by Lukas
Dame Jane Osbourn, chief scientific officer at Alchemab Therapeutics, speaks with Ahuva Nissim, antibody and therapeutic engineering professor at Quee...
Episode: 42 - Machine Learning Informatics for Antibody Discovery
08 Nov 2022
Contributed by Lukas
Charlotte Deane, professor of structural bioinformatics at the University of Oxford and upcoming speaker at the 14th Annual PEGS Europe Conference in ...
Episode: 41 - Introduction and Evolution of the Antibody Patent Landscape
11 Oct 2022
Contributed by Lukas
After over 25 years as an intellectual property (IP) attorney, Jane Remillard, Nelson Mullins patents and biotechnology IP senior partner, is well-ver...
Episode 40: Exploring Developability Concepts with Bispecific Antibodies
19 Oct 2021
Contributed by Lukas
Dr. Nimish Gera, Head of Biologics at Mythic Therapeutics, sits down with Christina Lingham, Executive Director of Conferences and Fellow at Cambridge...
Episode 39: René Hoet on Antibody Discovery and Following Your Heart
12 Aug 2021
Contributed by Lukas
Rene Hoet is working for over 20 years in Biotech and Pharma Industry focusing on Antibody Research and development.Since April 1 2021 Rene works as C...
Episode 38: Pivoting to Meet Protein Purification Needs with TriAltus
23 Jul 2021
Contributed by Lukas
A University of Alabama Birmingham researcher was frustrated with inconsistent solutions and processes for purifying unique proteins and set out to de...
Episode 37: Flashback Friday: COVID-19 Science-Sequence-Structure for Pandemic Preparedness
09 Jul 2021
Contributed by Lukas
The Chain looks back to earlier this year when researchers virtually convened on the one-year anniversary of the first documented case of COVID-19 in ...
Episode 36: Quality Control from Molecule to Organization
25 Jun 2021
Contributed by Lukas
Nancy Sajjadi joins The Chain to share her quality control knowledge and experience of adopting a quality-by-design approach for assays. We discuss ho...
Episode 35: NK Cells and the Science of Innate Immunity w/ Éric Vivier
10 Jun 2021
Contributed by Lukas
In this episode, Dr. Willem Overwijk returns for a conversation with Dr. Éric Vivier. Dr. Vivier is a professor of immunology at Aix-Marseille and a ...
Episode 34: Antibody and Vaccine Development for COVID-19 – Panel Discussion
28 May 2021
Contributed by Lukas
This episode of The Chain features a live panel discussion moderated by Erica Ollmann Saphire, PhD of La Jolla Institute for Immunology. Expert paneli...
Episode 33: Tackling COVID-19 Drug Discovery with Structural Genomics
14 May 2021
Contributed by Lukas
The Center for Structural Genomics of Infectious Diseases at Northwestern University was prepared for COVID-19 long before the United States economy s...
Episode 32: Young Scientist Spotlight: Cryo-EM to Uncover Structures of Coronavirus Spike Glycoproteins
07 May 2021
Contributed by Lukas
Linoleic acid is an essential free fatty acid in the human body and its metabolic pathway is central to immune regulation and inflammation – which a...
Episode 31: The Role of Tags in Your Purification Toolbox w/ Dennis Karthaus
30 Apr 2021
Contributed by Lukas
In this episode we talk with Dennis Karthaus of IBA Lifesciences about his early science interests and pursing his PhD. His passion for marine biology...
Episode 30: Recombinant Methods to Generate Antibodies Against COVID-19 – Roundtable Discussion
16 Apr 2021
Contributed by Lukas
In a roundtable discussion, three experts bring perspectives on different methods for generating antibodies, including generating antibodies from naiv...
Episode 29: Efficient Chromatography Devices for Purification Requirements
02 Apr 2021
Contributed by Lukas
The purification requirements in the biopharmaceutical industry will be even more demanding in the coming years due to increased awareness of product-...
Episode 28: Chasing Interleukin-2 from Academia to Industry w/ Willem Overwijk
19 Mar 2021
Contributed by Lukas
On this episode of The Chain, Dr. Willem Overwijk shares his personal experience of his recent transition from academia to industry, and the differenc...
Episode 27: Human VH Domains – Finding Antibodies to Treat COVID-19 and Beyond
05 Mar 2021
Contributed by Lukas
Dr. Dimiter Dimitrov, Director of the Center for Antibody Therapeutics at the University of Pittsburgh, sits down with The Chain to discuss his resear...
Episode 26: Science Commune: Role of Regulation in an Age of Acceleration
19 Feb 2021
Contributed by Lukas
Dan Chen returns for the Science Commune segment and speaks with Dr. Peter Marks, Director of the FDA’s Center for Biologics Evaluation and Research...
Episode 25: Innovations in Antibody Engineering to Generate Novel Cancer Immunotherapies
05 Feb 2021
Contributed by Lukas
Christian Klein is a longtime and key member of the protein and antibody community. In this episode, he speaks with Executive Conference Producer, Chr...
Episode 24: Taking Risks and Setting Precedent in Bioanalytical Assays for Cell & Gene Therapies
22 Jan 2021
Contributed by Lukas
There are no bad ideas in developing bioanalytical testing, says Jim McNally, CSO of BioAgilytix. Not all ideas will work, of course. But he has found...
Episode 23: Undruggable No More - Biologists & Engineers Unite to Successfully Deliver Potent RAS-Cleaving Enzyme
08 Jan 2021
Contributed by Lukas
There are some proteins that still evade scientists in the race for better therapeutics. Some of the most elusive drug targets in cancer research are ...
Episode 22: Science Commune: Embracing the Complexity of Glycobiology
18 Dec 2020
Contributed by Lukas
Carolyn Bertozzi grew up in a science family with a physicist father. But it was organic chemistry that “clicked” for Carolyn and started her down...
Episode 21: Science Commune: Inspiration and Growth from the Early Days of Microbiology
04 Dec 2020
Contributed by Lukas
What was science like before the shift to big data technology? How did biologists learn about cells before we could do high throughput gene analysis? ...
Episode 20: Science Commune: Problem-Solving and Innovation at the Intersection of Science and Engineering
08 Jul 2020
Contributed by Lukas
In this Science Commune segment, Dr. Daniel Chen and Dr. Pablo Umaña discuss what it means to be both a scientist and an engineer while utilizing pri...
Episode 19: Developing a Novel Self-Cleaving Tag Technology while Learning From Both Success and Failure
25 Jun 2020
Contributed by Lukas
Dr. David Wood is working on novel technology with self-cleaving tags, but he knows the importance of failure in the grand scheme of success, as well ...
Episode 18: Courage & Creativity: Entrepreneur of the Year Shares her Journey from Academia to Industry
01 May 2020
Contributed by Lukas
Sara Mangsbo is Entrepreneur of the Year, but her journey to success is much more than one title or one year. She shares the process and her biggest t...
Episode 17: Diagnostic Testing Approaches to the Coronavirus
22 Apr 2020
Contributed by Lukas
In the fight against Coronavirus, there have been many calls for widespread testing. Dr. Nathan Ledeboer explains the power diagnostic testing has whe...
Episode 16: Suppressing the Spread of Coronavirus from a Public Health Perspective
09 Apr 2020
Contributed by Lukas
The coronavirus has swept the globe, bringing governments, economies, and society to its knees. Infectious disease expert, Dr. Rita Rio discusses curr...
Episode 15: Cancer Immunotherapy Trends to Impact Patients and R&D
18 Mar 2020
Contributed by Lukas
Today’s episode features a conversation with Dr. Tatiana Novobrantseva, Co-Founder and CSO of Verseau Therapeutics. In this interview, we discuss ...
Episode 14: Science Commune: Biologists, Engineers, Artists, and Aha Moments w/ Bruce Keyt & Daniel Chen
03 Mar 2020
Contributed by Lukas
Science Commune is a segment of The Chain that goes beyond the science and explores the people making discoveries. We discuss their career paths, pass...
Episode 13: When Gene Editing Goes Too Far w/ Hank Greely
18 Feb 2020
Contributed by Lukas
Hank Greely, JD is a leading expert in law, and particularly its applications in scientific advancement, and the ethical concerns brought about by gen...
Episode 12: A Fireside Chat with Kathryn Hastie & Jamie Spangler - Part 2
04 Feb 2020
Contributed by Lukas
Today’s episode continues the conversation with the 2019 and 2020 PEGS Young Scientist Keynote speakers, focusing on the challenges of their day to ...
Episode 11: A Fireside Chat with Kathryn Hastie & Jamie Spangler - Part I
21 Jan 2020
Contributed by Lukas
Today’s episode features a conversation with the 2019 and 2020 PEGS Young Scientist Keynote presenters. We explore their work in protein science, it...
Episode 10: Intelligent Data Flow through Biotherapeutic Protein Development w/ Cenk Ündey, PhD
07 Jan 2020
Contributed by Lukas
Some scientists dream of genes. Cenk Ündey dreams of intelligent data flow through the value-added chain of biotherapeutic protein development. Ünde...
Episode 09: Engineered Multi-Specific Antibodies for Targeted Inhibition of Cancer Metastasis w/ Jamie Spangler
10 Dec 2019
Contributed by Lukas
One of the greatest afflictions associated with cancer is its spread throughout the body and organs, known as metastasis. What if a therapeutic could ...
Episode: 08 - Democratizing Cell-Free Protein Synthesis w/ Javin Oza, PhD
26 Nov 2019
Contributed by Lukas
Javin Oza observed the separation of scientists and engineers on university campuses, at conferences, and in classrooms. Yet he also noted that advanc...
Episode: 07 - From Sequence to Product: Exploring Role of Aggregation and Developability in Biologics Product Development with Paolo Arosio, PhD
12 Nov 2019
Contributed by Lukas
Dr. Paolo Arosio Professor of Biochemical Engineering at ETH Zurich speaks to Nandini Kashyap, Conference Director at CHI about his love for building ...
Bonus Episode: Versatope and the Universal Influenza Vaccine with Christopher Locher, PhD
08 Nov 2019
Contributed by Lukas
Versatope Therapeutics, Inc. was recently awarded up to $17.9 million by the NIH to develop a universal influenza vaccine. CEO and Co-Founder, Dr. Chr...
Bonus Episode: Research Technologies for Synthetic Immunology with Sai Reddy, PhD
05 Nov 2019
Contributed by Lukas
Today’s episode explores the growing field of systems immunology, and how new informatics tools will be used in this discipline to discover and deve...
Episode: 06 - Progress with Bispecific Vγ9Vδ2-T Cell Engagers w/ Dr. Paul Parren
29 Oct 2019
Contributed by Lukas
Dr Parren speaks about advances in the field of T cell engaging bispecifics. Recent advances in bispecific antibody production and clinic successes ...
Episode 05: Hot Topics in Continuous Chromatography for Protein Purification w/ Dr. Massimo Morbidelli
15 Oct 2019
Contributed by Lukas
Dr. Massimo Morbidelli is giving the Keynote Presentation in the “Protein Purification Technologies” conference that’s part of CHI’s 11th annu...
Episode 04: Toward in silico Lead Discovery – the Advent of AI and Machine Learning w/ Lars Linden, PhD, Head, Protein Biochemistry, Biologics Research, Bayer
01 Oct 2019
Contributed by Lukas
Dr. Lars Linden will be presenting during the Optimisation & Developability conference at PEGS Europe Summit, November 18-22, in Lisbon, Portugal....
Episode 03: Science Stories and the Return of Cell-Free Synthesis with Dr. Marco Casteleijn
17 Sep 2019
Contributed by Lukas
Over fifty years since its first use, Dr. Marco Casteleijn breaks down the resurgence of cell-free protein synthesis and its application across indust...
Episode 02: Science Commune with Daniel Chen and Teemu Junttila
03 Sep 2019
Contributed by Lukas
Science Commune is a segment of The Chain that goes beyond the science and explores the people making discoveries. We discuss their career paths, pass...
Episode 01: International Collaboration Yields Therapeutic Protein with Genome Engineered CHO Cells. Bjørn Voldborg, Technical University
21 Aug 2019
Contributed by Lukas
Bjørn Voldborg of the Technical University of Denmark speaks to CHI on July 18, 2019. He will be speaking during the Optimising Expression Platforms ...
Episode 0: Welcome to The Chain
21 Aug 2019
Contributed by Lukas
The Chain is a new podcast all about protein engineering and exploring the industry of biologics. We will learn from the experts what is new in the fi...