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The Orthogonal Bet

Kenneth Stanley on the Disruptive Power of Open-Endedness 

09 Jul 2025

Description

In this episode, Samuel Arbesman speaks with Kenneth Stanley, a renowned computer scientist and AI researcher whose career spans academia, industry, and startup innovation. Stanley has been a professor, a cofounder of multiple companies, and a researcher at both OpenAI and Uber. He currently serves as the Senior Vice President of Open-Endedness at Lila Sciences. He is also the coauthor of Why Greatness Cannot Be Planned: The Myth of the Objective, a widely praised book exploring the nature of creativity and discovery.Arbesman and Stanley discuss the nuances of conducting research across a variety of organizational structures. Their conversation delves into the tradeoffs between traditional and novel research institutions, how to carve out space for exploratory or “weird” work within large organizations, and how research itself can serve as a tool for navigating disruption. The episode also explores the evolving role of open-endedness in AI research and what it reveals about the future of scientific and technological progress.

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