The Peter Attia Drive

#275 - AMA #52: Hormone replacement therapy: practical applications and the role of compounding pharmacies

16 Oct 2023

Audio

Description

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter’s Weekly Newsletter In this "Ask Me Anything" (AMA) episode, the discussion zeroed in on the practical application of hormone replacement therapy in women. Peter walks through the signs, symptoms, and hormonal changes in women approaching – and going through – menopause. He provides an overview of the FDA-approved HRT formulations and explains how women might go about choosing the right option for themselves. Peter also describes the significant changes in testosterone levels in women over time and the options, as well as the considerations and challenges of testosterone replacement therapy (TRT) for women. Lastly, Peter highlights the necessary role of compounding pharmacies in HRT, underscores concerns regarding the quality and sterility of compounded drugs, and offers guidance on locating a trustworthy pharmacy. If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #52 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: Why hormone replacement therapy is such an important topic [2:00]; The onset of menopause: symptoms, blood tests, and when to consider HRT [6:00]; Tests that may provide indications of perimenopause and their implications for fertility [9:15]; Vasomotor symptoms: hormonal changes that cause hot flashes/night sweats, and HRT therapies that can help [13:45]; The role of estrogen in menopausal HRT [17:30]; The limited role of progesterone in HRT protocols [25:15]; What is a “bioidentical” hormone? [28:30]; Overview of the FDA-approved HRT formulations [31:45]; Determining HRT dosing and considerations for perimenopausal women [37:45]; Choosing the right HRT formulation: pros and cons [43:30]; Examining the link between certain forms of estrogen and breast cancer [46:45]; Changes in testosterone levels in women over time and why it matters [50:00]; Recognizing low testosterone in women: common symptoms and diagnosis [53:45]; Testosterone replacement therapy for women: options, considerations, and challenges [57:30]; The long-term use of testosterone in women: examining the limited data [1:00:15]; What is a compounding pharmacy? [1:09:30]; Reasons to opt for a compounding pharmacy over a pharmacy that adheres to stricter regulations [1:16:00]; The tragic incidents that heightened concerns about compounding pharmacies [1:20:45]; Tips for finding a reputable compounding pharmacy [1:27:45]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Transcription

This episode hasn't been transcribed yet

Help us prioritize this episode for transcription by upvoting it.

0 upvotes

🗳️ Sign in to Upvote

Popular episodes get transcribed faster

Other episodes from The Peter Attia Drive

Transcribed and ready to explore now

#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.

08 Dec 2025

The Peter Attia Drive

#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

01 Dec 2025

The Peter Attia Drive

#372 - AMA #77: Dietary fiber and health outcomes: real benefits, overhyped claims, and practical applications

10 Nov 2025

The Peter Attia Drive

#370 - AMA #76: Peter evaluates longevity drugs, aspirin for CVD, and strategies to improve muscle mass — promising, proven, fuzzy, noise, or nonsense?

27 Oct 2025

The Peter Attia Drive

#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.

20 Oct 2025

The Peter Attia Drive

#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.

The Peter Attia Drive

#275 - AMA #52: Hormone replacement therapy: practical applications and the role of compounding pharmacies

This episode hasn't been transcribed yet

Other episodes from The Peter Attia Drive

#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.

#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

#372 - AMA #77: Dietary fiber and health outcomes: real benefits, overhyped claims, and practical applications

#370 - AMA #76: Peter evaluates longevity drugs, aspirin for CVD, and strategies to improve muscle mass — promising, proven, fuzzy, noise, or nonsense?

#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.

#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.

Sign in to Audioscrape

Share this moment