This Week in Cardiology

Mar 20 2026 This Week in Cardiology

20 Mar 2026

Contributed by Lukas

Listener feedback, the huge CLOSURE-AF trial of LAAC vs best medical therapy, previews of CHAMPION AF, and the controversial ACC/AHA lipid treatment g...

Mar 13 2026 This Week in Cardiology

13 Mar 2026

Contributed by Lukas

Beta-blocker in non-obstructive hypertrophic cardiomyopathy, a head-to-head apixaban vs rivaroxaban RCT, diltiazem vs metoprolol combined with DOAC, a...

Mar 06 2026 This Week in Cardiology

06 Mar 2026

Contributed by Lukas

Listener feedback, urgent AF ablation, AF ablation as a stroke-reducing therapy, implantable loop recorder accuracy, and HF management in the setting ...

Feb 27 2026 This Week in Cardiology

27 Feb 2026

Contributed by Lukas

A superb note on CPR and DNR orders, patients' vs doctors' preferences for statins, more on GLP-1s, another LAAC story, and some closing cautionary no...

Feb 20 2026 This Week in Cardiology

20 Feb 2026

Contributed by Lukas

EVOLUT Low Risk data, a provocative meta-analysis, DNR orders, targeted hypothermia, good news in HFpEF evidence, and GLP-1s as AF drugs are the topic...

Feb 13 2026 This Week in Cardiology

13 Feb 2026

Contributed by Lukas

Ticagrelor vs prasugrel, a new LAAC device, pulsed field ablation AF results, lifestyle intervention in AF, the term "provider" vs "doctor," and coffe...

Feb 06 2026 This Week in Cardiology

06 Feb 2026

Contributed by Lukas

Problems with the PREVENT score, a breakthrough in lipid-lowering therapy, a surprising benefit in stroke care, and more thoughts on statins and preve...

Jan 30 2026 This Week in Cardiology

30 Jan 2026

Contributed by Lukas

Listener feedback, huge news in the rapidly expanding world of PFA AF Ablation, obesity, and a beautiful trial studying an AI-enhanced diagnostic tool...

Jan 23 2026 This Week in Cardiology

23 Jan 2026

Contributed by Lukas

Listener feedback, the value of procedural volume for TAVR and MTEER, ventricular arrhythmia in older athletes, and the Goldilocks time horizon for pr...

Jan 16, 2026 This Week in Cardiology

16 Jan 2026

Contributed by Lukas

Some great listener feedback, one of the best studies of the year in atrial fibrillation and heart failure, imaging to exclude left atrial thrombus, a...

Jan 09 2026 This Week in Cardiology

09 Jan 2026

Contributed by Lukas

The limits of knowing coronary artery disease anatomy, fish oil and AF risk, a new drug for PSVT, and maybe I was wrong about a drug for AF conversion...

Dec 19 2025 This Week in Cardiology

19 Dec 2025

Contributed by Lukas

The MI paradox of risk scores, the CELEBRATE trial of a new subcutaneous glycoprotein IIb/IIIA inhibitor (with its funny endpoint), the SURPASS CVOT t...

Dec 12 2025 This Week in Cardiology

12 Dec 2025

Contributed by Lukas

An elegant study in post-TAVI atrioventricular block, a PSA for my structural colleagues, revascularization in women, and a CTO PCI trial are the topi...

Dec 05 2025 This Week in Cardiology

05 Dec 2025

Contributed by Lukas

Less is more after PCI, the TARGET-FIRST trial, a negative blood pressure trial that is actually positive, aspirin vs OAC for bleeding, AEDs, and Fact...

Nov 21 2025 This Week in Cardiology

21 Nov 2025

Contributed by Lukas

Listener feedback, huge news in the world of carotid disease with the CREST-2 publication, prasugrel beats ticagrelor again, and a big coffee trial ar...

Nov 14 2025 This Week in Cardiology

14 Nov 2025

Contributed by Lukas

Listener feedback on the PISCES trial, AHA news (including a big PCSK9i trial), beta-blockers post MI, LAAC, and post-AF ablation OAC use are the topi...

Nov 07, 2025 This Week in Cardiology

07 Nov 2025

Contributed by Lukas

Listener feedback on non-culprit PCI in STEMI, a major cardiac result in patients on hemodialysis, news on GLP-1 agonists, a dubious stroke trial, and...

Oct 31 2025 This Week in Cardiology

31 Oct 2025

Contributed by Lukas

Four pillars of cardiology today, stable coronary artery disease, severe aortic stenosis, the evaluation of chest pain, and best therapies for atrial ...

Oct 24 2025 This Week in Cardiology

24 Oct 2025

Contributed by Lukas

The PREVENT score in hypertension, GLP-1 mechanism of action in cardiovascular disease, CAD type and statin benefit, and the problem with hospitalizat...

Oct 17 2025 This Week in Cardiology

17 Oct 2025

Contributed by Lukas

Another knock against the antiplatelet/anticoagulant combo, polypills in HF, the physical exam of the future, and the problem of underpowered trials t...

Oct 10 2025 This Week in Cardiology

10 Oct 2025

Contributed by Lukas

GLP-1 use in HFrEF, left atrial posterior wall isolation during AF ablation, peri-device leaks for LAAO, new findings in post-cardiac surgery AF, and ...

Oct 03 2025 This Week in Cardiology

03 Oct 2025

Contributed by Lukas

Two great stories of translation science leading to beneficial drugs in terrible diseases of the heart and the Sisyphean task of predicting the need f...

Sep 26 2025 This Week in Cardiology

26 Sep 2025

Contributed by Lukas

A bold trial in valvular heart disease, a CV prevention trial whose message is humility, VTE dogma challenged, more news on oral GLP-1 agonists, and a...

Sep 19 2025 This Week in Cardiology

19 Sep 2025

Contributed by Lukas

More trials at ESC, including PARACHUTE HF, DAPA ACT HF-TIMI 68, AMALFI, and a super-interesting modeling study of when to start oral anticoagulants i...

Sep 12 2025 This Week in Cardiology

12 Sep 2025

Contributed by Lukas

More from ESC including: Valvular HD guidelines, a new drug class for HTN, myosin inhibition in HCM, vericiguat, and digoxin are the topic discussed b...

Sep 05 2025 This Week in Cardiology

05 Sep 2025

Contributed by Lukas

The big beta-blocker story from ESC, dual pathway therapy with aspirin and OAC, stopping OAC after successful AF ablation, and DANCAVAS II trial are t...

Aug 29 2025 This Week in Cardiology

29 Aug 2025

Contributed by Lukas

CAC 0 takes a gut punch, ICD therapies cannot be surrogates for benefit, and two important trials from ESC are the topics John Mandrola, MD, discusses...

Aug 22 2025 This Week in Cardiology

22 Aug 2025

Contributed by Lukas

John Mandrola discusses conduction system pacing vs standard pacing, withdrawing HF meds when AF is corrected and patient selection in LAAO. This podc...

Aug 15 2025 This Week in Cardiology

15 Aug 2025

Contributed by Lukas

Big new hypertension guidelines, ultraprocessed foods, coronary sinus reduction and evidence-based medicine, and more news on pulsed field ablation fo...

Aug 08 2025 This Week in Cardiology

08 Aug 2025

Contributed by Lukas

Listener feedback on SURPASS CVOT, AF ablation and the limits of meta-analyses, a Watchman alert from FDA, and oral anticoagulation choices in elderly...

Aug 01 2025 This Week in Cardiology

01 Aug 2025

Contributed by Lukas

Exercise and CV outcomes, aldosterone modulation, AI for ECG reading, GLP-1 comparisons, end-of-life decisions, and another well-meaning policy that c...

July 25 2025 This Week in Cardiology

25 Jul 2025

Contributed by Lukas

The VENTOUX study of endurance athletes, the 10,000 step myth was not busted, rate vs rhythm control for AF, and GLP1 drugs and observational studies ...

Jul 18 2025 This Week in Cardiology

18 Jul 2025

Contributed by Lukas

Finerenone, what not to consider when choosing treatment of AS, brain health after atrial fibrillation ablation, early rhythm control for AF, and Watc...

Jul 11 2025 This Week in Cardiology

11 Jul 2025

Contributed by Lukas

Approval of first-generation devices, the ticagrelor controversy, ICD longevity, the PRAGUE-25 trial (one of the most important trials of the year), a...

Jun 27 2025 This Week in Cardiology

27 Jun 2025

Contributed by Lukas

FDA approves triple-drug polypill, a change of opinion, a deep dive into invasive pulmonary embolism therapies, heart disease trends, and diabetes car...

Jun 20 2025 This Week in Cardiology

20 Jun 2025

Contributed by Lukas

A big, deep dive into CTA and fractional flow reserve CT, and a sobering report on the new EVOQUE valve are discussed by John Mandrola, MD, in this we...

Jun 13 2025 This Week in Cardiology

13 Jun 2025

Contributed by Lukas

Listener feedback on cardiac sarcoidosis, SA node ablation, surgical AF ablation, chronic kidney disease protection, and recruiting for clinical trial...

Jun 06 2025 This Week in Cardiology

06 Jun 2025

Contributed by Lukas

Listener feedback on cardiac sarcoidosis, out-of-hospital cardiac arrest, less is more when it comes to post-stent antiplatelets, lipoprotein(a), and ...

May 30 2025 This Week in Cardiology

30 May 2025

Contributed by Lukas

Listener feedback, CRT vs CSP, important clues on the ECG, beta-blocker interruption after myocardial infarction, novel approaches to LDL-C lowering, ...

May 23 2025 This Week in Cardiology

23 May 2025

Contributed by Lukas

Listener feedback on sports "disqualification," big digoxin news, Brugada syndrome, another positive finerenone study, and unblinded transcatheter tri...

May 16 2025 This Week in Cardiology

16 May 2025

Contributed by Lukas

The BedMed trial of nighttime BP meds, SURMOUNT-5, Troponin URL, gene tests in patients with no disease, and guideline-directed medical therapy for HF...

May 09 2025 This Week in Cardiology

09 May 2025

Contributed by Lukas

The controversial KETO-CTA study, tough decisions in subclinical AF, and another potentially huge benefit for GLP-1 agonist drugs are discussed by Joh...

May 02, 2025 This Week in Cardiology

02 May 2025

Contributed by Lukas

The FDA approval of TAVR for asymptomatic AS, digital health, subcutaneous vs transvenous ICD, and cryptogenic stroke in young adults are discussed by...

Apr 25 2025 This Week in Cardiology

25 Apr 2025

Contributed by Lukas

AI and ECGs, novel ways to treat hypertension, combined lipid-lowering therapy after myocardial infarction, PFA and silent stroke, a move toward accou...

Apr 18 2025 This Week in Cardiology

18 Apr 2025

Contributed by Lukas

The FAME 3 trial 5-year results, TAVR at 5 years, pacers after TAVR, and mavacamten not a wonder drug are the topics John Mandrola, MD, discusses in t...

April 11, 2025 This Week in Cardiology Podcast

11 Apr 2025

Contributed by Lukas

The TAP-IT, STRIDE, FreshUP, and SINGLE SHOT CHAMPION trials are discussed by John Mandrola, MD, in this week's podcast. This podcast is intended for ...

Apr 04 2025 This Week in Cardiology

04 Apr 2025

Contributed by Lukas

Trials from the 2025 American College of Cardiology scientific sessions, including the WARRIOR, PROTECT TAVI, DAPATAVI, and SOUL are reviewed by John ...

Mar 28 2025 This Week in Cardiology

28 Mar 2025

Contributed by Lukas

Stopping oral anticoagulation after AF ablation, the core problem with paradoxes like the smoker's paradox, chronic total occlusion PCI, and an ACC/EH...

Mar 21 2025 This Week in Cardiology

21 Mar 2025

Contributed by Lukas

A large trial in cardiac pacing finally published, PVCs and cardiomyopathy, cannabis, CV risk and the danger of observational studies, and the tale of...

Mar 14 2025 This Week in Cardiology

14 Mar 2025

Contributed by Lukas

Listener feedback, resistant hypertension, K-binders for MRA use in heart failure, nutritional epidemiology, and a positive study for vitamin D are th...

Mar 07 2025 This Week in Cardiology

07 Mar 2025

Contributed by Lukas

Listener feedback on asymptomatic aortic stenosis (AS), transcatheter aortic valve replacement (TAVR) vs surgical aortic valve replacement (SAVR), cor...

Feb 28 2025 This Week in Cardiology

28 Feb 2025

Contributed by Lukas

The treatment of asymptomatic aortic stenosis, the move to composite endpoints in trials, IFR vs FFR and high-frequency low tidal volume ventilation f...

Feb 21 2025 This Week in Cardiology

21 Feb 2025

Contributed by Lukas

Blanking period after AF ablation, periprocedural MI after PCI in non-STEMI, predicting AF after ischemic stroke, and the proper standards for mitral ...

Feb 14 2025 This Week in Cardiology

14 Feb 2025

Contributed by Lukas

Silent cerebral embolism after LAAC, AI in ECG rhythm analysis, anti-thrombotic strategies in patients with AF and CAD, and subclinical AF are the top...

Feb 07 2025 This Week in Cardiology

07 Feb 2025

Contributed by Lukas

Sugar-sweetened beverages, the epidemiology of driving after an ICD, BP measurements, and massive EBM lesson in EVT for acute stroke are the topics Jo...

Jan 31 2025 This Week in Cardiology

31 Jan 2025

Contributed by Lukas

Another negative AF ablation trial, predicting AF after stroke, the value of RCTs, troponin testing in the ED and surgical aortic valve choice are the...

Jan 24 2025 This Week in Cardiology

24 Jan 2025

Contributed by Lukas

Familial hypercholesterolemia, cardiac arrest therapy, Factor XI inhibition, and tricuspid valve interventions are the topics John Mandroa, MD, discus...

Jan 17 2025 This Week in Cardiology

17 Jan 2025

Contributed by Lukas

Renal denervation, the obesity paradox, JACC and the FINEARTS trial of finerenone in HFpEF, a setback for a PFA system, and coffee are the topics Jon ...

Jan 10 2025 This Week in Cardiology

10 Jan 2025

Contributed by Lukas

Alcohol and cancer, GLP-1 trial representativeness, diagnosing CAD, changing stroke rates in patients with AF, blanking periods after AF ablation are ...

Dec 20 2024 This Week in Cardiology

20 Dec 2024

Contributed by Lukas

Listener feedback, multiple studies in AF ablation, a DANISH trial substudy of ICDs in NICM, and more data on eye complications of GLP-1 agonists are ...

Dec 13 2024 This Week in Cardiology

13 Dec 2024

Contributed by Lukas

US doc's pay, the ticagrelor controversy and new RCTs, clopidogrel beats ASA, holding antiplatelets for non-cardiac surgery, and Prof Cleland and ASA ...

Dec 06 2024 This Week in Cardiology

06 Dec 2024

Contributed by Lukas

Tirzepatide vs semaglutide in obesity; GLP1a use is complicated; HF outcomes; the misuse of meta-analyses in HF; and a breakthrough in HF care are the...

Nov 22 2024 This Week in Cardiology

22 Nov 2024

Contributed by Lukas

An AHA review: the OPTION, SUMMIT, VANISH 2, SARAH, and CLEAR trials are the topics John Mandrola, MD, discusses in this week's podcast. This podcast ...

Nov 15 2024 This Week in Cardiology

15 Nov 2024

Contributed by Lukas

Tirzepatide, AF screening, and an AHA preview, including VT ablation, LAAC at the time of AF ablation, BP targets, and GLP1 agonists in HF are the top...

Nov 08 2024 This Week in Cardiology

08 Nov 2024

Contributed by Lukas

The EARLY TAVR trial, colchicine after MI, and the TRISCEND II trial of tricuspid valve replacement are the topics John Mandrola, MD, covers in this w...

Oct 25 2024 This Week in Cardiology

25 Oct 2024

Contributed by Lukas

Listener feedback on PFA and STEMI/NSTEMI paradigm, oral semaglutide, symptomatic vs asymptomatic AF, and the win-ratio are the topics John Mandrola, ...

Oct 18 2024 This Week in Cardiology

18 Oct 2024

Contributed by Lukas

Listener feedback on the c-statistic, atherosclerotic plaque imaging, WATCHMAN implant decisions in the US, and deprescribing are the topics John Mand...

Oct 11 2024 This Week in Cardiology

11 Oct 2024

Contributed by Lukas

Reader feedback on cardiac devices and PFA, a new paradigm in the language of MI, sudden cardiac death, and measuring blood pressure are the topics Jo...

Oct 04 2024 This Week in Cardiology

04 Oct 2024

Contributed by Lukas

Reader feedback on LGE pre-ICDs, PFA for AF ablation, CTO-PCI, endovascular ablation of the greater splanchnic nerve in HFpEF, and data sharing are th...

Sep 27 2024 This Week in Cardiology

27 Sep 2024

Contributed by Lukas

Surgical clearance, NICM assessment, dueling perspectives on PCI as first-line therapy for angina, GDMT in HFrEF are the topics John Mandrola, MD, dis...

Sep 20 2024 This Week in Cardiology

20 Sep 2024

Contributed by Lukas

Listener feedback, K levels post cardiac surgery, cardiac device safety, disparities in preventive care, stopping trials early, and a SHAM-PVI update ...

Sep 13 2024 This Week in Cardiology

13 Sep 2024

Contributed by Lukas

More from ESC: the SCOFF trial and fasting before cardiac cath, MATTERHORN, humbling data with AI, plus a reflection on the work of being a patient ar...

Sep 06 2024 This Week in Cardiology

06 Sep 2024

Contributed by Lukas

Feedback on ABYSS and beta-blockers, more ESC recap, including SHAM-PVI, FINEARTS-HF, and RESHAPE HF2 trials are the topics John Mandrola, MD, discuss...

Aug 30 2024 This Week in Cardiology

30 Aug 2024

Contributed by Lukas

From ESC: post-MI beta blockers, a new therapy for ATTR-CM, holding RASi before non-cardiac surgery, good news in HFpEF, and an ESC preview are the to...

Aug 23 2024 This Week in Cardiology

23 Aug 2024

Contributed by Lukas

Suicidal ideation and GLP-1 agonists, a repeat of PARADIGM HF in Chagas CM, CASTLE HTx critical appraisal, and primary prevention of SCD in HF are the...

Aug 16 2024 This Week in Cardiology

16 Aug 2024

Contributed by Lukas

Diuretic therapy in HFrEF, AF ablation, TACT 2 and the story of subgroups, and SGLT2 inhibitor underuse are the topics John Mandrola, MD, discusses in...

Aug 09 2024 This Week in Cardiology

09 Aug 2024

Contributed by Lukas

Prediction models vs clinical judgement, CCTA quantification of atherosclerosis, AF ablation plus LAAO, atrial shunt devices, and HF medical therapy a...

Aug 02 2024 This Week in Cardiology

02 Aug 2024

Contributed by Lukas

Two downsides of PFA including autonomic tone and hemolysis, a bad surrogate in AF care, and controversies in defining cardiac risk are the topics Joh...

Jul 26, 2024 This Week in Cardiology Podcast

26 Jul 2024

Contributed by Lukas

Health and income, high BP in the hospital, and more on subclinical AF and when to use anticoagulants are the topics John Mandrola, MD, discusses in t...

Jul 19 2024 This Week in Cardiology

19 Jul 2024

Contributed by Lukas

Vulnerable plaque and scientific method; industry payments to trainees; tirzepatide or semaglutide; trial interpretation; and PFA are the topics John ...

Jul 12 2024 This Week in Cardiology

12 Jul 2024

Contributed by Lukas

Venous closure devices, GLP1-s linked to blindness and cancer, resisting the urge to do an ECG, and transcatheter edge-to-edge repair (TEER) for secon...

Jun 28 2024 This Week in Cardiology

28 Jun 2024

Contributed by Lukas

Screening echo, multivitamins, wasteful research, another PA sensor for HF, vascular closure devices, and GLP-1 marketing as science research are the ...

Jun 21 2024 This Week in Cardiology

21 Jun 2024

Contributed by Lukas

MRAs in HF with renal dysfunction, coronary autoregulation, the hubris of US doctors, NSTEMI in older patients, survival after STEMI, and new leaders ...

Jun 14 2024 This Week in Cardiology

14 Jun 2024

Contributed by Lukas

Listener feedback, statin eligibility and Yogi Berra, evidence-based medicine and heterogenous treatment effects, and MRAs in HF are the topics John M...

Jun 07 2024 This Week in Cardiology

07 Jun 2024

Contributed by Lukas

Cannabis and CV outcomes, post-CABG AF, embolic protection devices, emulation of randomization, and a preview heterogenous treatment effects are the t...

May 31 2024 This Week in Cardiology

31 May 2024

Contributed by Lukas

The FLOW trial of semaglutide, the DANCAVAS CV screening trial, non-invasive tests for chest pain, and conflicts of interest on social media are the t...

May 24 2024 This Week in Cardiology

24 May 2024

Contributed by Lukas

Clues in SCAF, a DOAC antidote trial, another negative lytic trial in stroke, JAMA changes to observational studies, and BP in stroke care are the top...

May 17 2024 This Week in Cardiology

17 May 2024

Contributed by Lukas

An Impella update, another TAVI vs SAVR trial, two studies on angina and PCI, another null substudy from REVIVED-BCIS, and semaglutide are the topics ...

May 10 2024 This Week in Cardiology

10 May 2024

Contributed by Lukas

Inclisiran, sodium-channel blocker safety, analytic flexibility, the work-up of patients with HF, and BP in older patients are the topics John Mandrol...

May 03 2024 This Week in Cardiology

03 May 2024

Contributed by Lukas

The DEDICATE trial of TAVR vs SAVR, more on renal denervation, inclisiran, and marketing disguised as science are the topics John Mandrola, MD, discus...

Apr 26 2024 This Week in Cardiology

26 Apr 2024

Contributed by Lukas

A listener defends colored boxes in guidelines; mysteries of non-culprit coronary lesions during PCI, and of AF ablation; and surrogate markers are th...

Apr 19 2024 This Week in Cardiology

19 Apr 2024

Contributed by Lukas

ACC Part 2: The TACT2 trial of chelation, inter-atrial shunts for HF, and triglyceride lowering; plus diltiazem and Factor Xa anticoagulants are the t...

Apr 12 2024 This Week in Cardiology

12 Apr 2024

Contributed by Lukas

ACC Recap #1: DanGer Shock (plus a sobering JAMA research letter on Impella use), REDUCE-AMI, PREVENT, and EMPACT-MI are the topics John Mandrola, MD,...

Apr 05 2024 This Week in Cardiology

05 Apr 2024

Contributed by Lukas

Statins and diabetes, AAD in patients with heart disease, tricuspid valve interventions, and an ACC preview are the topics John Mandrola, MD, discusse...

Mar 29, 2024 This Week in Cardiology Podcast

29 Mar 2024

Contributed by Lukas

Intermittent fasting, anticoagulation decisions, heterogenous treatment effects, frailty in HF, the importance of the ECG, and industry conflicts are ...

Mar 22 2024 This Week in Cardiology

22 Mar 2024

Contributed by Lukas

pObesity drugs as ASCVD-modifiers, HR monitors, when journals publish obvious facts, and effect scores and sorting out signals from RCTs are the topic...

Mar 08 2024 This Week in Cardiology

08 Mar 2024

Contributed by Lukas

Plastics and heart disease, MINT trial letters-to-the-editor and Bayes theorem, and Brugada syndrome are the topics John Mandrola, MD, discusses in th...

Mar 1 2024 This Week in Cardiology

01 Mar 2024

Contributed by Lukas

The Western AF meeting, aspirin, cannabis use, LVEF in athletes, and shared decision making before ICD implantation are the topics John Mandrola, MD, ...

Feb 23 2024 This Week in Cardiology

23 Feb 2024

Contributed by Lukas

Reading incidental CAC on chest CT scans, exercise benefits in women vs men, PCI with or without imaging, and trial non-reporting are the topics John ...

Feb 16 2024 This Week in Cardiology

16 Feb 2024

Contributed by Lukas

An update in trial interpretation, CI, and P-values; percutaneous tricuspid Interventions; and news on HDL and humility in Medicine are the topics Joh...