This Week in Virology

TWiV 1307: My heart breaks for flu

22 Mar 2026

Contributed by Lukas

TWiV reviews the structural basis for Rep-mediated adeno-associated virus DNA genome packaging, how influenza virus-infected myeloid cells travel to t...

TWiV 1306: Clinical update with Dr. Daniel Griffin

21 Mar 2026

Contributed by Lukas

In his weekly clinical update, Dr. Griffin and Vincent Racaniello chat about death of water fowl on Long Island, ‘renaming’ of the FDA adverse eve...

TWiV 1305: Lab leak idea called on the carpet

15 Mar 2026

Contributed by Lukas

TWiV introduces sunshine virus of carpet pythons and its effect snakes after experimental infection, and development of a new tool to distinguish betw...

TWiV 1304: Clinical update with Dr. Daniel Griffin

14 Mar 2026

Contributed by Lukas

In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss the global spread of the ‘eradicated’ poliovirus, the suggestion of RFK’...

TWiV 1303: Overachieving vaccines

08 Mar 2026

Contributed by Lukas

TWiV reviews an association between shingles vaccination and slower biological aging, and how mucosal immunization in mice provides protection against...

TWiV 1302: Clinical update with Dr. Daniel Griffin

07 Mar 2026

Contributed by Lukas

In his weekly clinical update, Dr. Griffin and Vincent Racaniello talk about the health misconceptions that RFK Jr continues to perpetuate and how to ...

TWiV 1301: Lost in giant virus translation

01 Mar 2026

Contributed by Lukas

TWiV reviews lymphocytic choriomeningitis virus seroprevalence among urban pregnant women and newborns in Philadelphia, and a functional translation i...

TWiV 1300: Clinical update with Dr. Daniel Griffin

28 Feb 2026

Contributed by Lukas

In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss several states and the governor of Pennsylvania suing HHS over changes in th...

TWiV 1299: Moth balls and blood clots

22 Feb 2026

Contributed by Lukas

TWiV explains how vaccine-induced thrombotic thrombocytopenia develops from antibodies to adenovirus and somatic hypermutation, and castration by a vi...

TWiV 1298: Clinical update with Dr. Daniel Griffin

21 Feb 2026

Contributed by Lukas

In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss reversal of last week’s no review decision on a flu mRNA vaccine by Vinjay...

TWiV 1297: Spillover squirrel

15 Feb 2026

Contributed by Lukas

TWiV explains the observation that filamentous virions act as non-infectious interfering particles to modulate papillomavirus infection, and transmiss...

TWiV 1296: Clinical update with Dr. Daniel Griffin

14 Feb 2026

Contributed by Lukas

In his weekly clinical update, Dr. Griffin and Vincent Racaniello are shocked by recent events, including Dr. Oz’s appeal for measles vaccination, V...

TWiV 1295: Are YOU willing to take one for the team?

08 Feb 2026

Contributed by Lukas

TWiV reviews a survey conducted in Cambodia's floating villages to explore measles vaccination perceptions and willingness to consider novel vaccinati...

TWiV 1294: Clinical update with Dr. Daniel Griffin

07 Feb 2026

Contributed by Lukas

In his weekly clinical update during Ground hog week, Dr. Griffin and Vincent Racaniello are back to discuss the measles outbreak in South Carolina, A...

TWiV 1293: The enemy of your parasite is your friend

01 Feb 2026

Contributed by Lukas

TWiV reviews the finding in Sweden that immunization against cervical cancer with human papillomavirus vaccine also protects the non-immunized, and me...

TWiV 1292: Clinical update with Dr. Daniel Griffin

31 Jan 2026

Contributed by Lukas

In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss with disgust the decline and fall of American public health and the rise of ...

TWiV 1291: A foot in the door for cytomegalovirus

25 Jan 2026

Contributed by Lukas

TWiV explains emergence of a neurovirulent double recombinant from the ‘improved’ nOPV2 in Uganda, and efficiency of viral entry determined whethe...

TWiV 1290: Clinical update with Dr. Daniel Griffin

24 Jan 2026

Contributed by Lukas

In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss screwworm, how the shingles vaccination slows biological aging (for all of y...

TWiV 1289: Building a better hepatitis B trap

18 Jan 2026

Contributed by Lukas

TWiV explains how the dengue virus protein NS1 alters Aedes aegypti midgut permeability and favors virus dissemination, and achieving a complete hepat...

TWiV 1288: Clinical update with Dr. Daniel Griffin

17 Jan 2026

Contributed by Lukas

In his weekly clinical update, Dr. Griffin and Vincent Racaniello are bewildered and dismayed by RFK Jr’s announced changes in the routine childhood...

TWiV 1287: Ancient herpesviruses and modern dementia

11 Jan 2026

Contributed by Lukas

TWiV explain the tracing of 2500 years of human betaherpesvirus 6A and 6B diversity through ancient human DNA, the effect of shingles vaccination at d...

TWiV 1286: Clinical update with Dr. Daniel Griffin

10 Jan 2026

Contributed by Lukas

In his weekly clinical update, Dr. Griffin and Vincent Racaniello are bewildered and dismayed by RFK Jr’s announced changes in the routine childhood...

TWiV 1285: Encapsidating viruses 2025

04 Jan 2026

Contributed by Lukas

TWiV reviews compelling virology themes for 2024, as heard in our 98 episodes, including 22 guests. Hosts: Vincent Racaniello and Kathy Spindler Su...

TWiV 1284: Clinical update with Dr. Daniel Griffin

03 Jan 2026

Contributed by Lukas

Recording after the ball drops, Dr. Griffin and Vincent Racaniello wish everyone a Happy New Year, discuss an evidence-based approach to teaching and ...

TWiV 1273: Myocarditis and mimicry

28 Dec 2025

Contributed by Lukas

TWiV explains studies which reveal that Inhibition of CXCL10 and IFN-γ mitgates myocarditis associated with SARS-CoV-2 mRNA vaccination, and identifi...

TWiV 1282: Clinical update with Dr. Daniel Griffin

27 Dec 2025

Contributed by Lukas

Calling out “Happy Christmas to all and to all a good-night,  Dr. Griffin and Vincent Racaniello discuss high path influenza in dairy herds in Wisc...

TWiV 1281: Sex, herpes, and plankton

21 Dec 2025

Contributed by Lukas

Vincent travels to Tegernsee, Germany for the Sixth Ringberg Symposium on Giant Viruses, where he talks with John Archibald, Susana Coelho, and Tom De...

TWiV 1280: Clinical update with Dr. Daniel Griffin

20 Dec 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin and Vincent Racaniello protest Vinjay Prasad, head of CBER FDA Nov memo stating administration of the COVID...

TWiV 1279: Let hepatitis b

14 Dec 2025

Contributed by Lukas

TWiV reviews considerations and perspectives on phage therapy, and the Nobel Prize-winning discovery of hepatitis b virus. Hosts: Vincent Racaniello,...

TWiV 1278: Clinical update with Dr. Daniel Griffin

13 Dec 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss the rise in norovirus infections, contamination of infant formula and botuli...

TWiV 1277: Vaccine talk with Jake Scott

07 Dec 2025

Contributed by Lukas

Infectious diseases physician Jake Scott returns to TWiV to discuss the dangerous anti-vaccine policies being established in the US and what RFK Jr. a...

TWiV 1276: Clinical update with Dr. Daniel Griffin

06 Dec 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss the positive side effect of the shingles vaccine on dementia outcomes and ho...

TWiV 1275: An amazing sequence and a gutsy therapy

30 Nov 2025

Contributed by Lukas

TWiV explains the Nobel Prize-winning discovery of pre-mRNA splicing, and engineering bacteriophage to deliver proteins to the human intestine. Hosts:...

TWiV 1274: Clinical update with Dr. Daniel Griffin

29 Nov 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin and Vincent Racaniello wish everyone a Happy Thanksgiving and then decry appointment of the Louisiana State...

TWiV 1273: EBV and lupus have not escaped our notice

23 Nov 2025

Contributed by Lukas

TWiV explains the 1953 paper by Watson & Crick proposing a structure for DNA, and the role of Epstein-Barr virus in triggering the autoimmune disease ...

TWiV 1272: Clinical update with Dr. Daniel Griffin

22 Nov 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin and Vincent Racaniello are dismayed by the changes on CDC vaccine website positively stating the link betwe...

TWiV 1271: Hokies go viral II

16 Nov 2025

Contributed by Lukas

Vincent visits Virginia Tech for the CeZAP Symposium and speaks with XJ Meng and Kylene Kehn-Hall about their research on hepatitis E virus and Rift V...

TWiV 1270: Clinical update with Dr. Daniel Griffin

15 Nov 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin and Vincent Racaniello record from the ASTMH meeting in Toronto and discuss continuing avian flu outbreaks,...

TWiV 1269: The smell of influenza in the morning

09 Nov 2025

Contributed by Lukas

TWiV reviews the passing of James D. Watson, the research that showed human papillomaviruses to be present in genital and laryngeal papillomas and in ...

TWiV 1268: Clinical update with Dr. Daniel Griffin

08 Nov 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello discusses the link between in utero SARS-CoV-2 infection and poor neurodevelopment ...

TWiV 1267: A cancer vaccine and an mpox treatment

02 Nov 2025

Contributed by Lukas

TWiV discusses the impact of vaccinating with Gardasil-9 adult women who are human papillomavirus positive or with confirmed squamous intraepithelial ...

TWiV 1266: Clinical update with Dr. Daniel Griffin

01 Nov 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin and Vincent Racaniello ponder the nomination of Casey Means for Surgeon General by President Trump, how mRN...

TWiV 1265: mRNA vaccines make cancer treatment great again

26 Oct 2025

Contributed by Lukas

TWiV explains studies showing that SARS-CoV-2 mRNA vaccines improve life span of cancer patients on checkpoint immunotherapy, and broad immunity confe...

TWiV 1264: Clinical update with Dr. Daniel Griffin

25 Oct 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello are distressed by the continuing government shutdown, first locally acquired chikun...

TWiV 1263: Dementia vaccine?

19 Oct 2025

Contributed by Lukas

TWiV reviews continuing US measles outbreak, host and genetic variations that regulate antibody responses to hepatitis C virus, and varicella-zoster r...

TWiV 1262: Clinical update with Dr. Daniel Griffin

18 Oct 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello are dismayed by the government shutdown, the firings at the CDC including EIS agent...

TWiV 1261: Must-see TVs

12 Oct 2025

Contributed by Lukas

TWiV covers a MacArthur Award for Jason McLellan, 2025 Nobel Prizes in Physiology or Medicine, first treatment for Huntington’s Disease, structure o...

TWiV 1260: Clinical update with Dr. Daniel Griffin

11 Oct 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello chat about Jane Goodall’s death and the Nobel prize in Physiology/Medicine for un...

TWiV 1259: Capricious flu and a tickborne clue

05 Oct 2025

Contributed by Lukas

TWiV reviews experiments to understand infection, pathogenesis, and transmission of avian H5N1 influenza virus in goats, and identification of a cellu...

TWiV 1258: Clinical update with Dr. Daniel Griffin

04 Oct 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello chat about the ongoing Ebola outbreak in DRC, increases in screwworm diagnoses, a p...

TWiV Special: Searching plane poop for viruses

01 Oct 2025

Contributed by Lukas

From ESCV 2025, Vincent speaks with Elke Wollants about a project to identify SARS-CoV-2 and other viruses in toilet waste from airplanes. Host: Vinc...

TWiV 1257: Better cocktails and CRISPR chicken

28 Sep 2025

Contributed by Lukas

TWiV explains experiments to create genetically modified chickens that are resistant to avian influenza infection, and discovery of combination antivi...

TWiV 1256: Clinical update with Dr. Daniel Griffin

27 Sep 2025

Contributed by Lukas

TWiV 1256: Clinical update with Dr. Daniel Griffin

27 Sep 2025

Contributed by Lukas

TWiV 1255: Virologists in Greece

21 Sep 2025

Contributed by Lukas

Vincent travels to Thessaloniki, Greece to attend the 27th meeting of the European Society for Clinical Virology, where he speaks with Pamela Vallely,...

TWiV 1254: Clinical update with Dr. Daniel Griffin

20 Sep 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello lament the anti-vaccine, anti-science composition of the ACIP, US cases of Chagas d...

TWiV 1253: Harvard virology is not retreating

14 Sep 2025

Contributed by Lukas

Vincent travels to Waterville Valley, NH to attend the Harvard virology retreat, where he speaks with Aaron Schmidt, Ben Gewurz, and Tatum Sass about ...

TWiV 1252: Clinical update with Dr. Daniel Griffin

13 Sep 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello discuss the continued Legionnaire’s outbreak in Harlem, invasive Asia longhorned ...

TWiV Special: David Baltimore, remembered

09 Sep 2025

Contributed by Lukas

TWiV re-issues our 100th episode which featured a discussion of viruses with David Baltimore, an exemplary scientist and Vincent’s exemplary mentor,...

TWiV 1251: Swedish models and agent 007

07 Sep 2025

Contributed by Lukas

TWiV reviews a study showing that the 2009 influenza pandemic virus disrupted biennial respiratory syncytial virus epidemics in northern Stockholm, an...

TWiV 1250: Clinical update with Dr. Daniel Griffin

06 Sep 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello is shocked by COVID vaccine restrictions and uncertainties such as pharmacy stock, ...

TWiV 1249: Demented and crAss

31 Aug 2025

Contributed by Lukas

TWiV reviews the major shakeup in CDC leadership, herpes simplex virus infection doubles the risk of dementia, and the prototypic crAssphage is a line...

TWiV 1248: Clinical update with Dr. Daniel Griffin

30 Aug 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello are dismayed about the recent attack on public health the firing of the director of...

TWiV 1247: In the company of vaccines with Stanley Plotkin

24 Aug 2025

Contributed by Lukas

Stanley Plotkin joins TWiV to recount his career as a vaccinologist, having participated in the development of vaccines for polio, rabies, and rubella...

TWiV 1246: Clinical update with Dr. Daniel Griffin

23 Aug 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello discusses outbreaks of Vibrio vulnificus and Legionnaire’s disease in Harlem, t...

TWiV 1245: Grabbing herpesvirus with both arms

17 Aug 2025

Contributed by Lukas

TWiV reviews fradulent science becoming an industry, FDA may not authorize Pfizer COVID vaccine for young kids, Kennedy won’t push strict pesticide ...

TWiV 1244: Clinical update with Dr. Daniel Griffin

16 Aug 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello discusses Vijay Prasad’s return to the FDA, revoking of COVID vaccine authorizati...

TWiV 1243: Capitalism, COVID, and cancer

10 Aug 2025

Contributed by Lukas

TWiV discusses the latest worrisome Executive Order on oversight of federal grantmaking, RFK Jr winds down mRNA viral vaccine development, Lenacapavir...

TWiV 1242: Clinical update with Dr. Daniel Griffin

09 Aug 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello re-address the dangers of drinking raw milk, the Legionnaire’s outbreak in Harlem...

TWiV 1241: The most beautiful experiment

03 Aug 2025

Contributed by Lukas

TWiV reports the administration putting a choke hold on billions of NIH health research funding, US Senators tell scientists they want to protect the ...

TWiV 1240: Clinical update with Dr. Daniel Griffin

02 Aug 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello chat about the recent Salmonella typhimurim outbreak, the ousting of another CBER d...

TWiV 1239: Aluminum and antibodies

27 Jul 2025

Contributed by Lukas

TWiV explains a cohort study of over one million Danish children which shows no evidence supporting an increased risk for autoimmune, atopic or allerg...

TWiV 1238: Clinical update with Dr. Daniel Griffin

26 Jul 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello chat about how flies and milk-snatching might contribute to influenza virus H5N1 am...

TWiV 1237: Hepatitis C and persistence with Charlie Rice

20 Jul 2025

Contributed by Lukas

From the 2025 annual meeting of the American Society for Virology, Charlie Rice, 2020 Nobel Laureate in Physiology or Medicine, talks with Vincent and...

TWiV 1236: Clinical update with Dr. Daniel Griffin

19 Jul 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello have a morning chat about the measles epidemic and H5N1 in cows before Dr. Griffin ...

TWiV 1235: Two sexy to eradicate

13 Jul 2025

Contributed by Lukas

David Barton, Brian Kemp, and Olve Peersen join TWiV to discuss RNA recombination among enteroviruses and its role in foiling poliovirus eradication. ...

TWiV 1234: Clinical update with Dr. Daniel Griffin

12 Jul 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello note that history is being rewritten for justification of changes in COVID vaccine ...

TWiV 1233: Long COVID and big bats

06 Jul 2025

Contributed by Lukas

TWiV covers FDA Director overriding scientists on COVID shots, NIH funded science must now be free to read instantly, Trump cuts subscriptions to Spri...

TWiV 1232: Clinical update with Dr. Daniel Griffin

05 Jul 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello are shocked at how vaccine safety is undercut by misrepresenting thimerosal safety...

TWiV 1231: What is a virus?

29 Jun 2025

Contributed by Lukas

TWiV discusses Sen. Cassidy calling for ACIP meeting delay, RFK Jr. abandons GAVI, millions of children at risk as global vaccination rates fall, RFK ...

TWiV 1230: Clinical update with Dr. Daniel Griffin

28 Jun 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello are alarmed at how RFK is breaking his promise of not altering vaccine policies, an...

TWiV 1229: Virology throughout Europe

22 Jun 2025

Contributed by Lukas

Rich travels to Dubrovnik for the European Congress of Virology 2025 and Vincent joins via Zoom to speak with Stéphane Blanc, Vanda Juranić Lisnić,...

TWiV 1228: Clinical update with Dr. Daniel Griffin

21 Jun 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss in shock how RFK is breaking his promise of not altering vaccine policies by...

TWiV Special: Long COVID and ME/CFS with David Tuller

17 Jun 2025

Contributed by Lukas

David Tuller returns to TWiV to discuss RFK Jr. and the trashing of American public health, rituximab and ME/CFS, The Sick Times, the Cochrane Mess, ...

TWiV 1227: How can antibody forget a pandemic?

15 Jun 2025

Contributed by Lukas

TWiV reviews the administrations dismantling of the committee that studies pandemic potential, firing of CDC vaccine advisory committee and replacing ...

TWiV 1226: Clinical update with Dr. Daniel Griffin

14 Jun 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello in horror examine dismantling of public infrastructure for establishing vaccine gui...

TWiV 1225: Poultry flu and SARS-CoV-2

08 Jun 2025

Contributed by Lukas

TWiV reviews the administration’s call for fools gold-standard science, NIH may publish in-house, avian influenza viruses in birds in China, and Omi...

TWiV 1224: Clinical update with Dr. Daniel Griffin

07 Jun 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello in dismay examine the MAHA-Make America Health Again-report and its inclusion of fi...

TWiV 1223: Someone is guano be sick

01 Jun 2025

Contributed by Lukas

TWiV reviews RFK Jr.”s MAGA report with non-existent literature citations, a new fungus that could further devastate North American bats, surveillan...

TWiV 1222: Clinical update with Dr. Daniel Griffin

31 May 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello discusses vaccination trends, the changes COVID-19 vaccine recommendations for chil...

TWiV 1221: Nonsense mediated decay

25 May 2025

Contributed by Lukas

TWiV reviews cuts in National Science Foundation budgets, cuts to Harvard University grants, judge blocks ban on Harvard enrolling international stude...

TWiV 1220: Clinical update with Dr. Daniel Griffin

24 May 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello debate the changes in FDA vaccine approval policy especially how it is applied to C...

TWiV 1219: Koalas sweep horse shift

18 May 2025

Contributed by Lukas

TWiV reviews pause in the use of Chikungunya vaccine, HHS to stop recommending COVID shots for pregnant women and children, molecular basis for shifte...

TWiV 1218: Clinical update with Dr. Daniel Griffin

17 May 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello wail about the attack on science within the US, cancellation of CDC’s committee o...

TWiV 1217: Alternative vax and pandemic origins

11 May 2025

Contributed by Lukas

TWiV reviews new CBER chief at FDA, ending of Gates Foundation in 2045, gain of function executive order, origins of bat viruses ancestral to SARS-CoV...

TWiV 1216: Clinical update with Dr. Daniel Griffin

10 May 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello bemoan the attack on science within the US, salt water controls for vaccines, retur...

TWiV Special: A shot of HepB with Thomas Tu

06 May 2025

Contributed by Lukas

From the 2024 International Hepatitis B virus meeting in Chicago IL, Rich Condit speaks with Thomas Tu about his experiences as a both a HepB scientis...

TWiV 1215: What's the worst that could happen?

04 May 2025

Contributed by Lukas

TWiV reviews universal vaccine initiative at NIAID, shut down of the Integrated Research Facility at Ft. Detrick, modeling the reemergence of infectio...

TWiV 1214: Clinical update with Dr. Daniel Griffin

03 May 2025

Contributed by Lukas

In his weekly clinical update, Dr. Griffin with Vincent Racaniello bewail the attack on science within the US and withdrawal from the global health co...

TWiV Special: A shot of HepB with Chari Cohen

29 Apr 2025

Contributed by Lukas

From the 2024 International Hepatitis B virus meeting in Chicago IL, Rich Condit speaks with Chari Cohen about her work as President of the Hepatitis ...