ToxChats©
Episodes
Transitioning from Industry to Consulting, Independent vs. Firm Consultant
27 Feb 2026
Contributed by Lukas
In this episode, Tanya McDonnell and Hemraj Dodiya sit down with two highly regarded toxicologists, Ric Stanulis and Mary Ellen Cosenza, who transitio...
Human and Environmental Health Topic: Next Generation Risk Assessment
07 Nov 2025
Contributed by Lukas
In this episode, Aimee Altemus and Adelaide Frimpong speak with Dr. Gary Miller of Columbia University, a widely recognized leader in exposome researc...
The Science of Mentorship: A Conversation with Richard DiMarchi
15 Oct 2025
Contributed by Lukas
In this compelling ToxChats podcast episode, hosts Kristin DeSouza and Michael Dorato speak with renowned drug development scientist Richard DiMarchi ...
From RIF to Reboot: A Guide for Early to Mid-Career Toxicologists
30 Sep 2025
Contributed by Lukas
Laid off—or worried you might be—and wondering what's next? In this episode, hosts Sunjay Sethi and Sarah Benjamin partner with the Early Career P...
Discussing the FDA's Announcement to Phase Out Animal Testing in Monoclonal Antibody Development
17 Jul 2025
Contributed by Lukas
This podcast episode is designed to offer listeners a discussion about the FDA’s evolving stance on animal testing and exploring thoughts on its pot...
Specialty Tox Topic: In Vivo Dermal Drug Development
07 Jul 2025
Contributed by Lukas
In this episode, host Zac Lloyd engages with expert in the field Colleen Johnson to discuss critical considerations in designing in vivo nonclinical p...
Specialty Tox Topic: In Vitro Dermal Drug Development
23 Jun 2025
Contributed by Lukas
In this episode, we speak with Jean-Philippe Therrien, a senior director of R&D, to discuss critical considerations in designing nonclinical progr...
Occupational Toxicology and Product Quality: Navigating Impurities and Occupational Safety
05 May 2025
Contributed by Lukas
In this episode, Dr. Katie Sokolowski and Dr. Tanya McDonnell sit down with Dr. Jessica Graham, a leader in the fields of occupational toxicology and ...
The Past, Present, and Future of Safety Pharmacology
01 Apr 2025
Contributed by Lukas
In this podcast, Dr. Derek Leishman discusses the development of regulatory guidance (ICH and GLP) for safety pharmacology studies. He follows this di...
Career Path: Toxicologist in the Food Industry
03 Feb 2025
Contributed by Lukas
This podcast is part of a series on the different career paths in the field of toxicology. In this episode, we interview Dr. Alex Eapen on his career ...
Changing Approaches to Getting Drug Candidates into First-in-Human Clinical Trials: A Case Study
18 Dec 2024
Contributed by Lukas
Not every drug that has reached human clinical trials has needed preliminary nonclinical studies to demonstrate safety. This podcast episode is a case...
Career Path: Pharmaceutical Consultant in the Field of Toxicology
04 Nov 2024
Contributed by Lukas
This ToxChats© episode is part of a series on the different career paths in the field of toxicology. In this episode, we interview Dr. Marcus Delatte...
3D Printing Emissions and Potential Health Effects from a Consumer Perspective
02 Sep 2024
Contributed by Lukas
In this podcast, recent findings from toxicological studies on the emissions produced during fused filament fabrication (FFF) 3D printing are discusse...
Career Path: Pharmaceutical Consultant in the Field of Occupational, Environmental, and Quality Toxicology
16 Aug 2024
Contributed by Lukas
This podcast is part of a series on different career paths in the field of toxicology. In this episode, Dr. Chuck Schwartz, PhD, DABT, shares the care...
Discussions on Identifying Seizures Liability in Nonclinical Studies
01 Jul 2024
Contributed by Lukas
Drug-induced seizures are a major concern for central nervous system active pharmaceuticals during development. Currently, there are no guidelines for...
Alternative and Nontraditional Species Series: The Use of Transgenic and Disease Mouse Animal Models for Toxicology Studies
06 May 2024
Contributed by Lukas
In this ToxChats© podcast, we spoke with Dr. René Meisner, Head of Safety Assessment at Denali Therapeutics, on using both transgenic and disease mo...
Identifying an Appropriate Sponsor to Support Your Growth and Success in the Workplace
04 Mar 2024
Contributed by Lukas
Mentors meet with you, listen to you, and provide advice. Sponsors have influence, connections, and can speak to your talents, abilities, and potentia...
Alternative and Nontraditional Species Series: Fertilized Egg Model as an Alternative Species for Safety Assessment Studies
29 Jan 2024
Contributed by Lukas
In this podcast, Dr. Tetyana Cheairs gives a detailed overview of the fertilized egg model and how it is currently being used in safety assessment stu...
Alternative and Nontraditional Species Series: Advantages and Challenges of Using Rabbits
22 Jan 2024
Contributed by Lukas
In this ToxChats© podcast, Dr. Elise Lewis provides a thorough background on the use of rabbits in DART and the future direction of their use as alte...
Alternative and Nontraditional Species Series: Sheep as an Alternative Model for the Safety Evaluation of Medical Devices
15 Jan 2024
Contributed by Lukas
In this ToxChats© episode, we interview Dr. Chris Christou, Director of Preclinical Imaging and Research Laboratories at the South Australian Health ...
Alternative and Nontraditional Species Series: Mini Pig–Alternatives to Traditional Nonrodent Models in Nonclinical Safety Testing
08 Jan 2024
Contributed by Lukas
During the COVID-19 pandemic, there was a reduction in the availability of nonhuman primates available for conducting nonclinical toxicity assessments...
Medical Devices: Safety Evaluation and Becoming a Medical Device Toxicologist
28 Nov 2023
Contributed by Lukas
In this ACT ToxChats© episode, Dr. Shayne Gad and Samantha Gad of Gad Consulting Services host a question and answer follow-up discussion to the ACT ...
Interviewing and Negotiation 101 for Toxicologist Roles in the Biopharmaceutical Industry
05 Sep 2023
Contributed by Lukas
In this ACT ToxChats© episode, Dr. Meredith Steeves and Mr. Terry Leyden share their perspectives on the current hiring landscape for toxicologist ro...
The History and Future of Oligonucleotide Drug Development
05 Jul 2023
Contributed by Lukas
In this new ACT ToxChats© episode, Dr. Jeffrey Foy, Vice President of Toxicology at Pepgen and Dr. Scott Henry, Vice President of Nonclinical Develop...
The Opioid Crisis: Misconceptions, History, and Interventions
28 Apr 2023
Contributed by Lukas
One of the most common misconceptions about the opioid crisis is that it only affects people with a long history of drug abuse. Today, more than ever,...
Covid-19 Part 2: New Type of Antibody-Dependent Enhancement Associated with SARS-CoV-2 Virus: MIS-C, MIS-A, and MIS-N
03 Mar 2023
Contributed by Lukas
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Coronavirus Disease 2019 (COVID-19), Multisystem Inflammatory Syndrome in Chil...
Covid-19 Part 1: Antibody-dependent Enhancement of Disease
06 Jan 2023
Contributed by Lukas
The severity of COVID-19 varies by individual spanning from asymptomatic, mild, moderate, severe, critical, and chronic disease. Prior to the availabi...
Artificial Intelligence (AI) Use in Toxicology
03 Nov 2022
Contributed by Lukas
Dr. Thomas Hartung is a Professor at Johns Hopkins University and University of Konstanz in Germany, as well as the Director of the Center for Alterna...
Overview of mRNA Vaccines
08 Sep 2022
Contributed by Lukas
Dr. Cynthia Rohde is a Research Fellow at Pfizer, Pearl River, New York. As a drug safety representative on various project teams, she is responsible ...
Tips for Taking the ABT Exam
16 Jun 2022
Contributed by Lukas
In this interview, course organizers and experts in the field, Drs. Bill Brock and Mary Beth Genter share an overview of the annual ACT Advanced Compr...
Moving from Minion to Manager
26 May 2022
Contributed by Lukas
As you advance in your scientific career, you may have the opportunity to transition from the bench to a project or people management role. This trans...
Off the Beaten Path: The Nonclinical Development of Gene Therapy Products to Cure Monogenic Diseases
24 Mar 2022
Contributed by Lukas
The idea behind gene therapy is to introduce, remove, or change a portion of person’s genetic code in order to cure a disease. Several gene therapy ...
Digital Pathology
20 Jan 2022
Contributed by Lukas
In this episode of ToxChats, Dr. Daniel Rudmann, an ACVP board-certified investigative and toxicologic pathologist and translational medicine scientis...
Expedited FDA Programs
17 Jun 2021
Contributed by Lukas
The FDA is responsible for protecting the public health by ensuring the safety, efficacy, and security of human and veterinary drugs, biological produ...
Toxicology Salary Survey
13 May 2021
Contributed by Lukas
The toxicology salary survey began in 1988 to provide the profession with accurate salary information. Since then, the survey has continued to collect...
Pediatric Drug Development
04 Mar 2021
Contributed by Lukas
Drug development targeted at pediatric populations has been the subject of a great deal of careful thought and effort by clinical and nonclinical scie...
CAR/T: New Modalities Paving the Way for Cancer
06 Jan 2021
Contributed by Lukas
(CAR)T cells, also known as chimeric antigen receptor T cells, have transformed the landscape of cancer treatment. Instead of a standard chemotherapy,...
History and Risk Assessment of Vaccines—Q&A
05 Nov 2020
Contributed by Lukas
Drs. Lisa Plitnick and Alan Stokes recently presented an ACT Signature Webinar titled “History and Risk Assessment of Vaccines: A Practical Perspect...
Scientific Communication: Distilling and Rehearsing to Reach Your Audience
20 Aug 2020
Contributed by Lukas
In this episode, Dr. Nicholas Ponzio, master educator and professor of pathology, immunology, and laboratory medicine at Rutgers University's New Jers...
AI and Big Data for Safety Testing
27 Apr 2020
Contributed by Lukas
Dr. Thomas Hartung, is a professor at Johns Hopkins University and Director of the Center for Alternatives to Animal Testing. Dr. Hartung discusses so...
Shining a Light on the Science and Strategy of Phototoxicity Assessments
10 Apr 2020
Contributed by Lukas
In this episode, Dr. Doug Learn, Director of Toxicology at Charles River Safety Assessment in Horsham, Pennsylvania, was interviewed. Dr. Learn is con...
The Twists and Turns of GI Health and Medicine: An Interview with Dr. Alessio Fasano
10 Feb 2020
Contributed by Lukas
In this interview, during the ACT 40th anniversary Annual Meeting in Phoenix, Arizona, plenary speaker Dr. Alessio Fasano highlights the exciting adva...
The Scientific Approach to Address Uncommon Routes and Best Practices for Forming a Working Group
03 Oct 2019
Contributed by Lukas
In this episode, Dr. Armaghan Emami, a toxicologist with the Center for Drug Evaluation and Research at the US FDA and 2019 award winner of Best Paper...
CRISPR Then and Now: An Interview with Dr. Jacob Corn, ACT 2015 Plenary Speaker
16 Aug 2019
Contributed by Lukas
Dr. Jacob Corn, ACT’s 2015 Plenary Lecturer, is a Professor of Genome Biology at the Swiss Federal Institute of Technology in Zurich. The Corn Labo...
In Vitro and Alternative Models for Regulatory Submission
30 Nov 2018
Contributed by Lukas
In this two-chapter episode, in vitro and alternative models for regulatory submissions were explored from both an industry and government perspective...
Regulation of E-Cigarettes
19 Jul 2018
Contributed by Lukas
In this episode, Dr. Arianne Motter, a toxicologist with the Center for Drug Evaluation and Research at the US Food and Drug Administration, discusses...
The Opioid Epidemic
26 Apr 2018
Contributed by Lukas
In this episode of ToxChats, the opioid epidemic was discussed from a preclinical drug development perspective with Dr. Carrie Blum, Associate Directo...
Biomarkers
27 Sep 2017
Contributed by Lukas
The role of biomarkers and their qualification in nonclinical and clinical development is discussed with Dr. William Mattes. Dr. Mattes is Director of...
Microbiome
27 Jun 2017
Contributed by Lukas
Dr. Rodney Dietert has authored a number of books on the immune system and extensively published on the topics of noncommunicable diseases, immune dys...
Oligonucleotide Therapeutics
05 May 2017
Contributed by Lukas
Oligonucleotide therapeutics are all medications that utilize RNA- or DNA-based techniques as the effective entity. The nonclinical development of the...