当你带着薯片坐火车从内地进入高原，会发现随着海拔升高，薯片越来越鼓胀，甚至会突然爆开，这就是薯片的“高原反应”。薯片包进入高原会膨胀是因为气压差异，袋内气压不变，环境气压降低，于是袋内空气开始膨胀。这种现象不仅会发生在薯片、面包、方便面等密封包装的食物上，化妆品也不能幸免，有网友表示自己带到云南的化妆品，刚打开就被喷了一脸。想要避免这样的情况，可以在海拔升高的途中把包装打开，让气压平衡。就像人一样，先适应一段时间，高原反应就会减轻了。不过人体是不会膨胀的，因为人体并不是一个密闭的环境，随着人的呼吸，人体内的气压会随着外界气压的改变而改变，内外压相同，就不会发生膨胀。除非在极端环境下，例如人体由标准大气压的环境突然进入到真空状态，肺部就可能会发生爆炸。很多人到了高原确实会发现自己的四肢出现肿胀，甚至脸都是肿的，但这与气压无关，这种肿胀是因为机体缺氧而产生的水肿，比如高原肺水肿和脑水肿病。
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