蛇打结是常见的状况，在无须人类及外力的帮助下，蛇都会自我打结。一般情况下，蛇自我打结实有以下几种原因：1、躲避捕食者2、帮助蜕皮3、摆脱寄生虫4、患疯蛇病蛇打结时，不会跟绳子一般软绵，它们身上的肌肉会绷紧，所以蛇本身不能够打成“死结”。蛇的肌肉极为发达，它们通过肌肉的收缩往前移动，通过收缩肌肉解开结轻而易举。加上它们表面的鳞片十分光滑，并不像绳子一般十分粗糙有很大的摩擦力。因此，一般情况下，蛇都可以在不损伤脊柱的情况下，轻而易举地将身上的结解开。美国蛇类专家研究发现，但患上“疯蛇病”的蟒蛇因感染了啮齿类动物的病毒，会出现两眼长时间呆望天空、像喝醉酒一样行动不便、用身体打结等异常行为，这种情况下，蛇是打不开结的。患病的蛇，它们自己会把自己打结得紧紧的，肌肉紧绷无法解开，直到生命的最后一刻还保持着一样的姿态。
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