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每年，全球有数十万人死于心肌纤维化导致的疾病。作为心衰的重要诱导因素，心肌纤维化是指当心脏受损时，由于长期过量生产纤维材料，心脏组织变硬、出现瘢痕，影响了心脏的正常功能，目前，针对心肌纤维化的疗法非常有限。但是在近期《科学》杂志的封面文章中，宾夕法尼亚大学佩雷尔曼医学院的研究团队创新性地利用一次mRNA注射，在患心衰的小鼠体内实现CAR-T治疗，成功修复了小鼠心脏的功能。
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