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范德堡医学大学中心Mariana X. Byndloss教授团队和加利福尼亚大学戴维斯分校Andreas J. Bäumler教授团队，在《科学》期刊上发表了一项重要的研究成果。他们发现，高脂饮食会损害结肠上皮细胞线粒体的功能，导致肠道氧气和硝酸盐的浓度增加，促进大肠杆菌的生长以及对胆碱的分解，导致三甲胺 水平增加，最终导致循环中有害代谢物氧化三甲胺水平的升高。
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