为什么到了冬天,我就是怎么都不想动?为什么生病的时候整个人提不起劲?明明我都好好休息了,但是怎么还是这么累?这一期内容蝌蚪和奶树就围绕“累”这个关键词,一起来漫谈一下身体和精神不同的疲劳,聊聊怎么从免疫、神经、激素、代谢的角度分析累的原因与现象,由应该如何应对不同的疲劳感,也许某个主题,就戳中了你的问题!时间点:00:01:16 身体与精神疲惫的感受与定义00:03:26 疲惫的不同程度叫法不同00:06:26 工作上的“燃烧殆尽”——burn out 倦怠综合征00:12:11 如何确定自己是否burn out了00:13:51 血常规与生化检测如何发现疲惫问题15:51 特别更正:“大脖子病”既不是甲亢也不是甲减,而是地方性甲状腺肿。一般是碘摄入过少导致的基本。甲亢是指甲状腺分泌过多,虽然也会有出现甲状腺肿大的症状,但是是碘过量导致的。甲减则是甲状腺分泌过少,虽然也可能脖子肿大,但病因也可能是药物、手术与自身免疫性疾病等。00:17:44 其他检测疲惫的技术手段00:19:32 免疫系统与炎症如何导致疲惫00:24:31 外周神经传递不畅带来的疲惫感00:28:14 运动后觉得发酸真的是乳酸导致的吗?00:30:23 蹲厕所为什么会腿麻了?00:32:59 大脑有多么的耗能00:34:07 我们到底有多么不乐意动脑子00:37:02 大脑的疲惫有什么样的表现形式与特点00:40:30 什么样的休息才能缓解中枢神经系统的疲惫?我们真的在休息吗?00:43:50 什么也不做的时候,大脑也有个默认工作的系统00:50:05 脑力的疲劳时如何累加的?00:53:44 肾上腺素的失调如何导致疲惫的状态00:58:54 不同的性激素在我们人生不同阶段影响我们的疲惫感01:02:12 睡眠节律为什么会直接影响疲惫感01:06:35 喝咖啡酒精为什么即放松但也会很累01:08:36 能量代谢本身如何解释疲惫01:09:44 各种疾病相关的疲劳感01:13:06 累与猝死、过劳死01:21:04 为什么吃饭会越吃越累01:24:36 “班味”的疲惫感体现在哪?01:27:39 不同感官的疲劳提及相关资料:与Burnout相关的心理量表:与免疫系统相关的动画《工作细胞》相关的推送:mp.weixin.qq.com《如何学习》课程:coursera.org相关书籍《精力管理》:book.douban.com涉及BGM:肾宝片广告片段George Benson - Thunder Walk明天的烦恼交给明天 - Mr.Miss部分参考资料:疲劳和生物机制:Klimas NG, Broderick G, Fletcher MA. Biomarkers for chronic fatigue. Brain Behav Immun. 2012;26(8):1202-1210. doi:10.1016/j.bbi.2012.06.006慢性病与疲劳:Adamowicz JL, Vélez-Bermúdez M, Thomas EBK. Fatigue severity and avoidance among individuals with chronic disease: A meta-analysis. J Psychosom Res. 2022;159:110951. doi:10.1016/j.jpsychores.2022.110951癌症和疲劳:Bower JE. Cancer-related fatigue--mechanisms, risk factors, and treatments. Nat Rev Clin Oncol. 2014;11(10):597-609. doi:10.1038/nrclinonc.2014.127Thong MSY, van Noorden CJF, Steindorf K, Arndt V. Cancer-Related Fatigue: Causes and Current Treatment Options [published correction appears in Curr Treat Options Oncol. 2022 Mar;23(3):450-451. doi: 10.1007/s11864-021-00916-2]. Curr Treat Options Oncol. 2020;21(2):17. Published 2020 Feb 5. doi:10.1007/s11864-020-0707-5疲劳和心理疾病:Porr, C., Olson, K., & Hegadoren, K. (2010). Tiredness, Fatigue, and Exhaustion in the Context of a Major Depressive Disorder. Qualitative Health Research, 20(10), 1315–1326. doi:10.1177/1049732310370841Burnout:Edú-Valsania S, Laguía A, Moriano JA. Burnout: A Review of Theory and Measurement. Int J Environ Res Public Health. 2022;19(3):1780. Published 2022 Feb 4. doi:10.3390/ijerph19031780外周肌肉疲劳:Sesboüé B, Guincestre J Y. Muscular fatigue[C]//Annales de réadaptation et de médecine physique. Elsevier Masson, 2006, 49(6): 348-354.大脑中枢疲劳:Vogel T A, Savelson Z M, Otto A R, et al. Forced choices reveal a trade-off between cognitive effort and physical pain[J]. elife, 2020, 9: e59410.Matthews J, Pisauro M A, Jurgelis M, et al. Computational mechanisms underlying the dynamics of physical and cognitive fatigue[J]. Cognition, 2023, 240: 105603.Wiehler A, Branzoli F, Adanyeguh I, et al. A neuro-metabolic account of why daylong cognitive work alters the control of economic decisions[J]. Current Biology, 2022, 32(16): 3564-3575. e5.
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