这篇于2025年6月4期发表在Nature杂志，由Simon R. V. Knott和Dan Theodorescu领导的名为“Y Chromosome Loss in Cancer and T Cells”的article，探讨了Y染色体丢失（LOY）在男性癌症进展中的作用，既考察了肿瘤细胞中的LOY，也考察了肿瘤微环境（TME）中良性细胞（特别是T细胞）的LOY。研究通过对人类肿瘤和鼠模型进行全面的泛癌分析，揭示了癌细胞LOY与TME中其他细胞的LOY之间存在关联。值得注意的是，T细胞中的LOY与免疫抑制相关联，这表明LOY可能通过影响免疫功能来促进肿瘤生长。这些发现表明，上皮细胞和T细胞中同时存在LOY与患者预后不佳独立相关，并为解释外周血单个核细胞（PBMC）中的LOY与癌症死亡率增加之间的关联提供了一个模型。
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